CN100531712C - Dasatini sustained-release implants for treating entity tumor - Google Patents
Dasatini sustained-release implants for treating entity tumor Download PDFInfo
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- CN100531712C CN100531712C CNB2007102027742A CN200710202774A CN100531712C CN 100531712 C CN100531712 C CN 100531712C CN B2007102027742 A CNB2007102027742 A CN B2007102027742A CN 200710202774 A CN200710202774 A CN 200710202774A CN 100531712 C CN100531712 C CN 100531712C
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- bms
- cancer
- tumor
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- sustained
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Tumor cell | Suppression ratio (%) |
Hepatocarcinoma | 60 |
Pulmonary carcinoma | 72 |
The esophageal carcinoma | 68 |
Gastric cancer | 70 |
Breast carcinoma | 68 |
Cancer of pancreas | 72 |
Thyroid carcinoma | 68 |
Nasopharyngeal carcinoma | 70 |
Ovarian cancer | 76 |
Carcinoma of endometrium | 80 |
Cervical cancer | 70 |
Renal carcinoma | 78 |
Carcinoma of prostate | 74 |
Bladder cancer | 72 |
Colon cancer | 76 |
Rectal cancer | 78 |
Skin carcinoma | 58 |
Carcinoma of testis | 58 |
Claims (3)
- [claim 1] a kind of Dasatini sustained-release implants for the treatment of entity tumor is characterized in that this sustained-release implant contains the BMS 354825 and the slow-release auxiliary material of effective anticancer, and wherein the weight ratio of each constituent is:(1) anticancer effective component is 30% BMS 354825, and slow-release auxiliary material is that 70% molecular weight peak value is poly-(the L-lactide-co-etherophosphoric acid) of 10000-25000;(2) anticancer effective component is 20% BMS 354825, and slow-release auxiliary material is that 80% molecular weight peak value is poly-(the L-lactide-co-etherophosphoric acid) of 10000-25000;(3) anticancer effective component is 10% BMS 354825, and slow-release auxiliary material is that 90% molecular weight peak value is poly-(the L-lactide-co-etherophosphoric acid) of 10000-25000;(4) anticancer effective component is 5% BMS 354825, and slow-release auxiliary material is that 95% molecular weight peak value is poly-(the L-lactide-co-etherophosphoric acid) of 10000-25000;(5) anticancer effective component is 30% BMS 354825, and slow-release auxiliary material is that 70% molecular weight peak value is poly-(the L-lactide-co-phosphoric acid propyl ester) of 10000-25000;(6) anticancer effective component is 20% BMS 354825, and slow-release auxiliary material is that 80% molecular weight peak value is poly-(the L-lactide-co-phosphoric acid propyl ester) of 10000-25000;(7) anticancer effective component is 10% BMS 354825, and slow-release auxiliary material is that 90% molecular weight peak value is poly-(the L-lactide-co-phosphoric acid propyl ester) of 10000-25000; Or(8) anticancer effective component is 5% BMS 354825, and slow-release auxiliary material is that 95% molecular weight peak value is poly-(the L-lactide-co-phosphoric acid propyl ester) of 10000-25000.
- The sustained-release implant that [claim 2] claim 1 is described is characterized in that this sustained-release implant is in the tumor or the slow releasing injection and the solid sustained-release implant of all injections of tumor or placement.
- The sustained-release implant that [claim 3] is according to claim 1 is characterized in that described sustained-release implant is used for the preparation treatment cerebral tumor, hepatocarcinoma, pulmonary carcinoma, the esophageal carcinoma, gastric cancer, breast carcinoma, cancer of pancreas, thyroid carcinoma, nasopharyngeal carcinoma, ovarian cancer, carcinoma of endometrium, cervical cancer, renal carcinoma, carcinoma of prostate, bladder cancer, colon cancer, rectal cancer, carcinoma of testis, skin carcinoma, tumor of head and neck and originate from gallbladder, the oral cavity, peripheral nervous system, mucosa, body of gland, blood vessel, osseous tissue, lymph node, former or the cancer of secondary of eyes, the pharmaceutical preparation of sarcoma or carcinosarcoma.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB2007102027742A CN100531712C (en) | 2007-11-29 | 2007-11-29 | Dasatini sustained-release implants for treating entity tumor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007102027742A CN100531712C (en) | 2007-11-29 | 2007-11-29 | Dasatini sustained-release implants for treating entity tumor |
Publications (2)
Publication Number | Publication Date |
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CN101161235A CN101161235A (en) | 2008-04-16 |
CN100531712C true CN100531712C (en) | 2009-08-26 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2007102027742A Expired - Fee Related CN100531712C (en) | 2007-11-29 | 2007-11-29 | Dasatini sustained-release implants for treating entity tumor |
Country Status (1)
Country | Link |
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CN (1) | CN100531712C (en) |
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2007
- 2007-11-29 CN CNB2007102027742A patent/CN100531712C/en not_active Expired - Fee Related
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CN101161235A (en) | 2008-04-16 |
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