CN100531703C - Oral compositions and use thereof - Google Patents

Abstract

The invention comprises the use of oral compositions of defined rheological characteristics in oral treatment systems, especially a hand-held electric toothbrush, comprising a reservoir and means for pumping the oral composition from the reservoir to an applicator such as a toothbrush head. Pumpable oral compositions having good stand-up on a brush head are also provided.

Description

Oral cavity composition and application thereof

Technical field

The invention provides the oral cavity composition that is used for integrated mouth care system.

Background of invention

Recently, electric toothbrush is subjected to consumer and the similar crowd's of odontologist welcome deeply.Compare with the traditional-handwork brushing, these equipment are considered to and can provide better cleaning and massage effect to oral surfaces.Yet electric toothbrush still needs before use dentifrice to be assigned on the bristle.Beginning is brushed the concentration that causes dentifrice on the bristle fast and is reduced, and might cause being lower than desired dental surface cleaning effect.

Therefore, wish to have a kind of mouth care system that comprises oral cavity composition, wherein during brushing automatically or arbitrarily brushing, this oral cavity composition distributes by the bristle point, and is distributed on the bristle.Above-mentioned idea is not novel.For example, US 3,217, and 720 disclose the toothbrush that has the liquid dentifrice container.US 5,909, and 977 disclose the toothbrush that distributes dentifrice, and this toothbrush has used the recharged box that is used to store dentifrice material, and the compressibility elastic button that is used for dentifrice material is pumped into toothbrush head.This idea further develop the use that comprises the hollow bristle, dentifrice can go out by this hollow brush hair streams, and is as US 5,309, disclosed in 590.

Yet, the combination results of the type relate to the new problem of combination oral cavity composition rheological behavior.Preferably, this oral cavity composition is pumped into application position from reservoir by the conduit of certain form.In a toothbrush, this toothbrush neck must be less than certain maximum gauge, and must be greater than certain minimum length, so that this toothbrush can cosily use in mouth.Restriction to neck bar size must limit wherein used the maximum cross section area and the minimum length that compositions are delivered to the conduit of toothbrush head from reservoir.The increase of high-rate of shear when causing oral cavity composition by the conduit pumping to the restriction of conduit cross section area has increased simultaneously and has been used to send the required pressure of oral cavity composition.And, because the energy requirement in the electronic pumping system, or because consumer's facility is applied to the peak power on the manual pump, so toothbrush must have the pumping pressure of qualification.Therefore, said composition must have specific rheological behavior, so that it can make the required pressure minimization of pumping system simultaneously by given conduit pumping.

In addition, existing oral cavity composition can not be preferably used for the mouth care system, and may cause the pressure of the toothbrush head that consumer uses to oral cavity tissue for cleaning teeth too small or excessive.Use the reduction that too small or excessive pressure may cause mouth care system cleaning efficiency to the bristle point.

Therefore, be desirable to provide the compositions that can be used for the mouth care system, said composition can be easily by the conduit pumping of given diameter and length.In addition, it would also be desirable to provide the mouth care system that comprises Dentrifice composition, wherein said composition has the rheological equationm of state, can make the said composition can be by pumping easily, yet it is retained in the bristle in a minute timing.In addition, it would also be desirable to provide the cover box, this cover box is included in and uses the required device of oral cavity composition in the mouth care system.

In addition, be desirable to provide the oral cavity composition that is preferred in the mouth care system, make when in mouth, using the mouth care system, can and stress on the mouth care system by consumer's control.

From the description of following summary, detailed description and embodiment, it is more apparent that these and other objects of the present invention will become.

Summary of the invention

The invention provides the application of oral cavity composition in the mouth care system, this application comprises that be the conduit of A and length y with oral cavity composition by interior cross-sectional area, is pumped into outlet by reservoir, and wherein A is 0.0025mm ²To 25mm ², and y is 10mm to 300mm, said composition is characterised in that, in shear rate

(with s ^-1Be unit) under, its viscosity is not more than η (is unit with Pa.s), wherein η and

By following formula definition:

$\mathrm{\η}=\frac{250A^2}{4y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{2500}{A^{3/2}};$ With

At 1s ^-1Under the shear rate, said composition also has the viscosity of 10Pas at least.

In the following description:

" unit equipment " or " combination mouth care system " is meant, comprises the equipment or the mouth care system of the embedded reservoir that can comprise oral cavity composition such as dentifrice, to be used for to the oral delivery compositions.

" conduit " is meant that flowable materials can flow to the interior void of the sealing of the other end from the one end;

" longitudinal axis " is the axis that is parallel to flow direction in the conduit;

" interior cross section " is the cross section of conduit, and this cross section is taken from perpendicular to longitudinal axis and the plane that surrounded by the tube material inner surface;

" length " is meant the catheter length of axis longitudinally; With

" pump stroke reversal power " be meant the recharging in the stage of pumping cycle, and is that pump provides or be added on power on the pump.Stop pump to recharge after a release and keep the required minimum force of balance can determine pump stroke reversal power by measuring.

The present invention also provides a kind of oral cavity composition, and it comprises:

A) greater than 0.5% to maximum 4% thickening composition, this composition is selected from Strese Hofmann's hectorite. and derivant thereof, Shionox, ternary and quaternary magnesium silicate derivant, the bentonite xanthan gum, carrageenin and derivant thereof, gellan gum, hydroxypropyl emthylcellulose, fungi plant glue and derivant thereof, amylopectin, rhamsan gum, welan gum, Rhizoma amorphophalli, curdlan, carbomer, Algin, alginic acid, alginate and derivant thereof, hydroxyethyl-cellulose and derivant thereof, hydroxypropyl cellulose and derivant thereof, the starch phosphate derivant, guar gum and derivant thereof, starch and derivant thereof, the copolymer of maleic anhydride and alkene and derivant thereof, cellulose gum and derivant thereof, ethylene glycol/propylene glycol copolymers, poloxamer and derivant thereof, polyacrylate and derivant thereof, methylcellulose and derivant thereof, ethyl cellulose and derivant thereof, agar and derivant thereof, Radix Acaciae senegalis and derivant thereof, pectin and derivant thereof, chitosan and derivant thereof, the Polyethylene Glycol resin is (as PEG-XM, wherein X is more than or equal to 1), karaya, locust bean gum, natto gum, the copolymer of vinylpyrrolidone and alkene, Tragacanth, polyacrylamide, chitin derivative, gelatin, beta glucan, dextrin, glucosan, cyclodextrin, methacrylate, microcrystalline Cellulose, polyquaternary ammonium salt, furan foamed resin (furcellaren gum), ghatti gum, Semen Plantaginis glue, WENBO natural gum, tamarind gum, larch glue, Caesalpinia spinosaKuntze glue, and their mixture;

B) less than 20% insoluble solid;

C) 20% to 70% total moisture; With

D) greater than 20% to 80% wetting agent, this wetting agent is selected from polyhydric alcohol and Polyethylene Glycol;

In shear rate is 20s ^-1Down, the viscosity that said composition had is 0.001Pas to 780Pas, and is 1s in shear rate ^-1Down, its viscosity is 10Pas at least.

On the other hand, the invention provides a kind of oral cavity composition, it comprises the wetting agent (being selected from polyhydric alcohol and Polyethylene Glycol) of 1% to 10% grinding agent, 20% to 70% total moisture and at least 10%; Wherein the RDA that said composition had is greater than 70, and is 1s in shear rate ^-1Down, its viscosity is 10Pas at least.

In addition, provide mouth care cover box, it comprises that according to mouth care system of the present invention and oral cavity composition wherein, this mouth care system comprises reservoir and is used for compositions is pumped into from reservoir the parts of mouth care system outlet.

Except as otherwise noted, in this paper and additional claims related all umbers, percentage ratio and ratio all in the weight of total oral cavity composition.Except as otherwise noted, all measurements of total oral cavity composition are all carried out under 25 ℃.Viscosity used herein is measured with Carrimed CSL2100 flow graph, and this flow graph has the parallel-plate measuring system of 2cm diameter, and the gap of 500 μ m is arranged between the plate.Yet, if comprising, said composition is insoluble to compositions and particle diameter particulate component greater than 50 μ m, the gap between the so used plate should be 10 times of particle diameter.For the purpose of the gap was provided with, the particle diameter of composition should be considered as by weight at least can be by the minimum sieve hole dimension of 90% dry ingredient.

The radioactive dentin abrasion that oral cavity composition as herein described preferably has (RDA) value is at least 70.

The relevant portion of the document of all references all is incorporated into herein for your guidance, and quoting of any document may not be interpreted as its approval as prior art of the present invention.

Detailed Description Of The Invention

Oral cavity composition of the present invention is applicable to that in the mouth care system, wherein this oral cavity composition is included in the reservoir, and can be pumped into outlet from reservoir by conduit.The viscosity that they had can be preferably used for by the conveying of lower pressure pump parts by the conduit of given diameter and length.Lower pressure is meant, required pump pressure is for electrodynamic pump, and being not large enough to needs high-power input, or is not large enough to and need be acted on pump actuator by the finger of user to provide powerful.Carry the lower pressure of oral cavity composition to be meant that driving pump reaches the required power less than 100N of indication transporting velocity.

The oral cavity composition that can be used for this paper can be by the conduit of regulation cross-sectional area and length, sends oral cavity composition with the flow velocity of 0.1mL/s, preferred 0.2mL/s at least.This helps fast and effectively oral cavity composition is transported to the application device head from reservoir.The oral cavity composition that can be used for this paper can be newton's compositions, or the shear thinning compositions, is preferably the shear thinning compositions, so that along with shear rate and the increase of shear stress thus, the viscosity of oral cavity composition reduces gradually.In this paper mouth care system, use oral cavity composition effectively this oral cavity composition to be delivered to application device, and it is retained in the application device, and need not repeatedly to use or negative effect product attractive in appearance.

The mouth care system

Toothbrush

Oral cavity composition of the present invention is applicable in the various mouth care systems, as integrated toothbrush and electric toothbrush.Exemplary mouth care system is disclosed in WO 02/064056 A1 and US 6,402, among the 410B1.Above-mentioned system comprises reservoir, application device and is used for oral cavity composition is transported to from reservoir the parts of application device.Preferably, this mouth care system is to be suitable for the singlehanded handheld portable devices of using.This mouth care system preference comprises integrated casing, and it can cosily be held in the user hands, and this shell preferably includes reservoir and is used to carry the parts of oral cavity composition.

Reservoir

System of the present invention comprises the reservoir that is used to store oral cavity composition.This reservoir can be connected on the nursing system regularly or removably.Preferably, this reservoir can disassemble from shell replaceably, for example, so that reservoir is refilled and insert again, or replaces this reservoir with a basic similarly device, and this device also can comprise a large amount of oral cavity compositions.Any suitable reservoir all can be used among the present invention.Should be appreciated that used reservoir can completely or partially be embedded in the shell of nursing system, or completely or partially be embedded in the shell.

The non-limiting example of suitable reservoir comprises the positive displacement reservoir that has rigid walls usually, as box, and comprises the air pump formula reservoir that has flexible wall usually, as pouch, Nang Hepao.Preferably, this reservoir is flexible wall, air pump formula, more preferably pouch.This reservoir can be made with the material that is suitable for using known to those skilled in the art.For example, the positive displacement reservoir can be made by metal, rigid plastic and other suitable hard material.PE, lamination aluminum and other appropriate materials known to those skilled in the art of the plastics that flexible wall air pump formula reservoir is preferably easily scratched by softness such as PET, PE, plating are made.Preferably, this reservoir qualification inner volume is 5mL to 25mL.

In one embodiment, this reservoir comprises the parts that are used to connect pump.Reservoir need be connected with pump, for example, when the displaced type reservoir is connected to the mouth care system.In another embodiment, this reservoir can comprise bleed parts and the parts that are used to be connected delivery conduit.This helps reservoir and pump are replaced simultaneously as single component.The suitable embodiment that is used to connect the parts of reservoir and pump comprises latch-type joint, gasket seal, bayonet and nipple.

In another embodiment of the invention, supply with by independent filling box, in the outside of system shell, fill reservoir on the spot, this filling box is provided by system, or as object independently.This for nursing during the bigger situation of compositions volume that consumed be favourable, and each with sky inner reservoir abandon not only costliness but also waste.Box is filled in external can form base part, and this can additionally provide the function of holder to the shell of nursing system.Comprise at nursing system under the situation of electrical components that this base position can comprise in addition and recharges parts, to be used for the rechargeable battery charging to nursing system.

Pump and conduit

Mouth care system of the present invention comprises the parts that are used for oral cavity composition is transported to from reservoir application device.Be used to carry the parts of oral cavity composition can comprise pump and/or conduit.Preferably, this mouth care system comprises pump, so that the mechanical pressure that oral cavity composition is transported to application device from reservoir to be provided.This pump can comprise automatically controlled pump or, for example, the mechanical pump of elastic button control, it is positioned at the reservoir top, or with from the conduit of pump guiding reservoir in a straight line.Preferably, this pump comprises positive displacement pump.Positive displacement pump (referring to, " ChemicalEngineering " of R.K.Sinnott design for example, the 155th page of the 6th volume, Permagon Press, nineteen eighty-three) covered the different designs of various pumps, wherein when pump did not start, material can not pass through the pump adverse current.Be applicable to that the concrete positive displacement pump design in the such a device comprises compressor pump, reciprocating pump and membrane pump.

The membrane pump of this paper typically comprises the pump housing, wherein comprises pump chamber (being full of the space for the treatment of the pumping product), constitutes pump mobile, inlet valve and the outlet valve be made up of elastic diaphragm on pump chamber surface.This pump mobile can comprise spring in addition, to be returned to maximum pump chamber volume after helping mobile to press down.This pump housing also comprises entry nozzle and outlet nozzle, and entry nozzle has the groove that links to each other with inlet valve, and outlet nozzle has the groove that links to each other with outlet valve.This inlet valve is between entry nozzle and pump chamber, and when pressure in the pump was lower than the pressure of this valve inlet end, this valve was opened, and when pressure in the pump was higher than the pressure of this valve inlet end, this valve cut out.Typically, this inlet valve is made of the elastomeric material that can cut out suddenly when the indoor low pressure of excavationg pump; Suitable material is PET.This outlet valve is between pump chamber and outlet nozzle, and when pressure in the pump was higher than the pressure of this valve outlet port end, this valve was opened, and when pressure in the pump was lower than the pressure of this valve outlet port end, this valve cut out.Typically, outlet valve has and the similar character of inlet valve.This valve can be installed on the valve pocket, supporting its structure, and guarantee that they can only open in one direction.

When pressing down, mobile can make the volume of pump case reduce, and the pressure in the pump case increases, and product is discharged by outlet valve.This mobile props up on spring, so that it can be returned to maximum volume when discharging.When mobile was released, the volume of pump case increased, and makes that the pressure in the pump case reduces, and product is drawn in the pump case by inlet valve.Typically, this mobile is made of thermoplastic elastomer (TPE) such as TPE (polyether ester).

In another embodiment, this pump can comprise piston.Piston (as, syringe) no longer need to recharge pump with product.This paper preferred diaphragm pump.

The mouth care system of this paper comprises the parts that oral cavity composition are transported to application device by pump from reservoir.Suitable transfer unit comprises conduit.The non-limiting example of conduit comprises silica gel tube, forming plastic groove and plastic tube.Preferably, this conduit has enough little interior cross-sectional area, so that it can be comprised in the neck bar of application device, and can not increase the diameter of application device self neck bar.Can be defined as the shape of any closure perpendicular to the interior cross section of the conduit inner surface of longitudinal axis, for example circular, ellipse or polygon are as square or rectangular.

In one embodiment, this conduit has enough little interior cross-sectional area, so that it can handle the neck bar that the power transmission shaft of application device head is comprised in application device together with being used for transmission, enough narrow of the neck bar of application device is so that it keeps the ergonomics effect of application device.The interior cross-sectional area of conduit is preferably 0.0025mm ²To 25mm ²The interior cross-sectional area of conduit is 0.01mm more preferably ²To 20.25mm ², 0.25mm more preferably also ²To 16mm ²The interior cross-sectional area of conduit is 0.5mm more preferably also ²To 10mm ²

In addition, this conduit needs certain length, so that reservoir and pump can be placed on apart from the place of application device head certain distance, is touched so that pump can possess the hands of mouth care system like a cork.The length that this conduit had is preferably 10mm to 300mm, more preferably 50mm to 250mm, more preferably 100mm to 200mm also.The length that this conduit had is 120mm to 180mm more preferably also.

In addition, the ratio (y:A) that can be used for the length that conduit had of this paper and interior cross-sectional area is 1:1mm at least ^-1, be preferably 2:1mm at least ^-1In having multiple difference, this conduit under the situation of cross-sectional area, should be the minimum interior cross-sectional area of conduit to determine the used interior cross-sectional area of minimum permission length according to above-mentioned ratio.When this conduit when flowing of oral cavity composition expanded down, should be the area that conduit maximum swelling place limits according to above-mentioned ratio to determine the minimum used interior cross-sectional area of length that allows.

Application device

Mouth care system of the present invention comprises the application device that is used for to the oral administration oral cavity composition.This application device can be regularly or removably is connected on the shell of mouth care system.This application device preferably removably is connected on the shell of mouth care system, and this helps replacing this application device with a substantially similar device, and need not to replace whole mouth care system.This application device can be any device that is suitable for using to tooth or oral soft tissue this paper oral cavity composition, and can comprise the neck bar part of stretching out and ending at the head part from link, this head partly comprises application surface, and it can be brush or sponge.Preferably, this application device head comprises brush.Typically, the length that neck bar part is had is 20mm to 100mm, and the diameter that is had is 5mm to 115mm.

Except that conduit, this application device also can comprise the parts that are used to drive transmission application device head.The embodiment of above-mentioned parts comprises power transmission shaft or gear drive.

Oral cavity composition

Viscosity

Oral cavity composition of the present invention is the fluid composition with selected viscosity characteristics.Not bound by theory, it is believed that conduit by cross-sectional area in given and length, the pressure that the pumping oral cavity composition is required, proportional with the oral cavity composition viscosity under the shear rate that is limited by the conduit size.Because the restriction of pump pressure, for electrodynamic pump, in order to make the energy minimization, or for manual pump, for fear of the over-drastic strength of needs, oral cavity composition of the present invention 25 ℃ and shear rate is

(with s ^-1Be unit) viscosity that had down preferably is not more than η (is unit with Pas), wherein η and

By following formula definition:

Formula 1 $\mathrm{\η}=\frac{250A^2}{4y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{2500}{A^{3/2}};$ With

Wherein A and y are respectively the interior cross-sectional area (mm that is used for oral cavity composition is transported to from reservoir by pump the conduit of application device head ²) and length (mm) under shear rate γ, the viscosity that is had is suitable for the conduit pumping that limits with A and y by above-mentioned less than the oral cavity composition of η.In this conduit has multiple difference under the situation of cross-sectional area, should as calculating viscosity: the interior cross-sectional area (A) of this conduit total length (y) equals cross-sectional area in conduit minimum.Under the situation that conduit expands when the product that is included in along the catheter length pumping wherein, this cross-sectional area should be decided to be the area of conduit maximum swelling place.

Following table 1 has provided the embodiment of the preferred catheter length that is used for mouth care system of the present invention and the combination of interior cross-sectional area, and the restriction that can be used for the required viscosity in this paper oral cavity composition according to formula 1.

Table 1

In addition, oral cavity composition of the present invention is 20s in shear rate ^-1The viscosity that s is had down is 0.001Pas to 780Pas, preferred 0.1Pas to 500Pas, more preferably 1Pas to 100Pas.

Except as otherwise noted, the related viscosity of this paper is not use under any concrete pre-situation about shearing to compositions, measuring on the present composition.Yet will be appreciated that, in fact unavoidably use shearing in a small amount to compositions, is to carry out when the Carrimed flow graph is increased to special sequencing shear rate because measure.In order to simulate more accurate shear applications effect, the shear applications effect that is obtained when by conduit compositions being pumped into toothbrush head can be measured this viscosity on Carrimed after the established procedure shearing.Oral cavity composition of the present invention is 1s in shear rate ^-1" shearing the back " viscosity that is had down is 10Pas at least.Term used herein " is sheared back viscosity " and is meant that compositions experiences shear rate from 0s in 30s ^-1To 450s ^-1Linear scanning, then in 30s the experience shear rate from 450s ^-1To 0s ^-1Second time behind the linear scanning, 1s ^-1Under composition viscosity, shear back viscosity and be defined as shear rate from 450s ^-1To 0s ^-1Second time scanning in, 1s ^-1Under viscosity.Sample is positioned on the base plate of Carrimed CSL2 100 flow graphs with scraper, uses compressive deformation thereafter, make plate close to suitable spacing (common 500 μ m) by exponential damping.Then, make sample keep balance 5 minutes, begin to carry out test record thereafter.

At 1s ^-1Shear rate under after the desired shearing viscosity be 10Pas at least, in case seam chamber compositions runs off from the application device head in minute timing.Preferably, can be used for the oral cavity composition of this paper at 25 ℃ and 1s ^-1Shear rate under after the shearing that had viscosity be 25Pas at least.

In addition, preferred oral cavity composition of the present invention has limited hysteresis quality, so that when the viscosity of compositions since the increase of shear stress (as passing through the conduit pumping) when reducing, said composition can return to its low-shear viscosity apace after removing shearing force.Preferably, the initial viscosity that oral cavity composition of the present invention has and the ratio of shearing back viscosity less than 10:1, be more preferably less than 5:1, also be more preferably less than 2:1, initial viscosity is at 0s ^-1To 450s ^-1Initial shearing rate scan during in 1s ^-1Measure under the shear rate, shearing back viscosity is at 450s ^-1To 0s ^-1The second time during the shearing rate scan in 1s ^-1Measure under the shear rate.Find that initial viscosity is the indication that is present in the delay degree in the oral cavity composition of the present invention with the ratio of shearing back viscosity.Ratio shows greater than 10, and oral cavity composition shows to have very strong hysteresis quality after the experience high shear, and therefore after removing shear stress, can only return to the viscosity before the high-rate of shear limitedly.

When the parts that are used for the pumping said composition comprise direct displacement pump, in shear rate

(with s ^-1Be unit) under, the viscosity that this oral cavity composition had preferably is not more than η (is unit with Pas), wherein η and

By following formula definition:

Formula 2: $\mathrm{\η}=\frac{10A^2}{y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{\mathrm{10,000}}{A^{3/2}}.$

Following table 2 has provided the embodiment of the preferred catheter length that is used for mouth care system of the present invention and the combination of interior cross-sectional area, and according to the oral cavity composition preferred viscosity limitation of formula 2 for the direct displacement pump use of this paper.

Table 2

More preferably, when the parts that are used for the pumping said composition comprise positive displacement pump, in shear rate (with s ^-1Be unit) under, the viscosity that this oral cavity composition had preferably is not more than η (is unit with Pa.s), wherein η and

By following formula definition:

Formula 3: $\mathrm{\η}=\frac{6A^2}{y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{\mathrm{10,000}}{A^{3/2}}.$

Following table 3 has provided the embodiment of the preferred catheter length that is used for mouth care system of the present invention and the combination of interior cross-sectional area, and according to the oral cavity composition preferred viscosity limitation of formula 3 for the use of this paper positive displacement pump.

Table 3

More preferably, when the parts that are used for the pumping said composition comprise membrane pump, in shear rate

(with s ^-1Be unit) under, the viscosity that this oral cavity composition had preferably is not more than η (is unit with Pas), wherein η and

By following formula definition:

Formula 4: $\mathrm{\η}=\frac{3A^2}{y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{\mathrm{10,000}}{A^{3/2}}.$

Following table 4 has provided the embodiment of the preferred catheter length that is used for mouth care system of the present invention and the combination of interior cross-sectional area, and the preferred viscosity limitation that can be used for this paper oral cavity composition according to formula 4.

Table 4

Also more preferably, when the parts that are used for the pumping said composition comprise membrane pump, in shear rate

(with s ^-1Be unit) under, the viscosity that this oral cavity composition had preferably is not more than η (is unit with Pa.s), wherein η and By following formula definition:

$\mathrm{\η}=\frac{10A^2}{4y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{10000}{A^{3/2}}.$

In a preferred embodiment, when the parts that are used for the pumping said composition comprise membrane pump, in shear rate

(with s ^-1Be unit) under, the viscosity that this oral cavity composition had preferably is not more than η (is unit with Pas), wherein η and

By following formula definition:

$\mathrm{\η}=\frac{3A^2}{4y}$ With $\stackrel{.}{\mathrm{\γ}}=\frac{10000}{A^{3/2}}.$

Have the oral cavity composition of viscosity in above-mentioned formula regulation boundary and can be advantageously used in the mouth care system that comprises these oral cavity composition parts of pumping, wherein this oral cavity composition is pumped to application device from reservoir by conduit.Have viscosity be higher than should use in the compositions thickness too of those viscosity of defined so that can not be effectively by having stipulated the conduit pumping of diameter and length.When these compositionss can be when having stipulated the pipe flow of interior cross-sectional area and length, effectively send the required strength of these compositionss with effective conveying flow velocity, greater than battery-driven pump the energy that can effectively provide, or the energy that can provide greater than manual operation pump mobile of consumer.

Should be appreciated that the equipment (Carrimed CSL2 100 flow graphs as used herein) that is used to measure shear stress and shear rate can't obtain some

The indicated shear rate of formula.In these cases, use the Herschel-Bulkley pattern to measure the viscosity of oral cavity composition under those shear rates.From 0 to 450s ^-1Range of shear rate in or can not cause in the maximum shear speed range of local fracture being applied to oral cavity composition, with the interior equally distributed shear rate of minimum 40 these scopes, the shear stress of oral cavity composition is decided to be the function of shear rate.Cooperate formula, analog data:

$\mathrm{\τ}={\mathrm{\τ}}_0+\mathrm{\κ}{\stackrel{.}{\mathrm{\γ}}}^n,$

Wherein τ is a shear stress, τ ₀Be yield stress,

Be shear rate, κ is denseness (1s ^-1Under viscosity), and n shears index.In case determined τ ₀, κ and n value, can under required shear rate, use following formula, with the viscosity of oral cavity composition under the prediction high-rate of shear:

$\mathrm{\η}=({\mathrm{\τ}}_0\×{\stackrel{.}{\mathrm{\γ}}}^{-1})+\left(\mathrm{\κ}{\stackrel{.}{\mathrm{\γ}}}^{n-1}\right).$

In addition, oral cavity composition of the present invention is 450s in shear rate ^-1The viscosity that has is preferably less than 10Pas down.This oral cavity composition is 450s in shear rate ^-1The viscosity that is had down is more preferably less than 5Pas, also is more preferably less than 2Pas.Be surprisingly found out that under high-rate of shear, the compositions that can be used for this paper needs these low viscosity, can be to guarantee them by the amount of executing fully in the bristle head of mouth care system.Find to have the compositions that shear viscosity is much higher than those viscosity of this paper and have inadequate distribution flow velocity.

In addition, the oral cavity composition that is used for the present invention preferably has certain viscosity, in case so that pump removed wherein contained oral cavity composition by self-acting, oral cavity composition then at least the flow velocity of 0.2mL/s flow in the pump, wherein, the backhaul power of this pump is less than 100N.This need make pump recharge effectively after allocated product.

In addition, when the aqueous slurry solution that with oral cavity composition of the present invention dilution is 16.67%, at 1s ^-1Shear rate under viscosity that it had be preferably greater than 0.1Pas.This helps providing a kind of oral cavity composition, and when this oral cavity composition was diluted in the oral cavity, the viscosity that it had was enough high so that it is retained in the oral cavity, and need not consumer's excessive operation application device or apply too high pressure to application device.In the time will being 16.67% aqueous slurry solution, at 1s according to oral cavity composition of the present invention dilution ^-1Shear rate under, the viscosity that it had is more preferably greater than 0.2Pas, also more preferably greater than 0.3Pas.Find, at 1s ^-1Shear rate under, the diluted viscosity that has can produce bigger use compliance and better cleaning effect greater than the oral cavity composition of 0.1Pas.It is believed that this is that consumer is that the compositions that will dilute is retained in the oral cavity, and on oral cavity tissue, apply the result of less pressure with the mouth care system.Reducing of exerting pressure produced better and more effective cleaning action, and reduced the stimulation to oral cavity tissue.These two characteristics cause improved usability, and have therefore improved the use compliance.

The rheological characteristic of oral cavity composition is subjected to the influence of thickener types and content and optional member type and content.Those skilled in the art is known, and content that can be different uses different thickening agents, so that similar viscosity to be provided under a certain shear rate.Yet this thickening agent can show to have different viscosity characteristicses in range of shear rate.Some thickening agent or thickened systems (as comprise synthetic li-montmorillonite those) are though to need them to be that high shear causes rare, but show to have the hysteresis quality of moderate to height, the viscosity that has limited compositions returns to its initial viscosity under low shear rate after standing high-rate of shear.Other thickening agent is shear thinning fully, and they can not be used for herein.

In order to keep the shear thinning performance of oral cavity composition, preferably avoid a large amount of uses can excessively increase the material of shear viscosity.The embodiment of above-mentioned substance comprises any Newtonian liquid, as glycerol, sorbitol syrups and hydrogenated starch hydrolysates (also being called as hydrogenated glucose syrups).When these expected material as wetting agent and optional member simultaneously when a large amount of addings, it can change the rare performance of causing of compositions, no longer is applicable to this paper to cause compositions to become.The viscosity that most of liquid component is had all be higher than they usually the viscosity of alternate water.This comprises other wetting agent, as propylene glycol and Polyethylene Glycol (PEG).If come place of water with a kind of in these compositions, this oral cavity composition all has higher viscosity under high-rate of shear and low shear rate so.

In addition, preferably avoid using a large amount of granular solids, as grinding agent.These materials have reduced the amount of shear thinning in the oral cavity composition, make them be unsuitable for carrying by pump and conduit.Find that the oral cavity composition that comprises a large amount of granular solids can not be drawn into the pump from reservoir sometimes, thereby causes pump blocked.

Thickening agent

Said preparation needs to have enough low viscosity under high-rate of shear, so that it can pass through unit equipment with suitable flow velocity, after standing high-rate of shear, under low shear rate, have sufficiently high viscosity simultaneously, run off from brush in a minute timing to prevent product.The optimal thickening agent or the thickened systems that are used for the unit equipment preparation should be at low shear rate (1s ^-1) increasing fluid viscosity down, the viscosity that is increased under higher shear rates simultaneously is as far as possible little.In order to reach these targets, this thickening agent or thickened systems should be given the pseudoplastic behavior of preparation height, impel preparation to reduce viscosity significantly when shear rate increases.

Typically, can give at utmost pseudoplastic thickening agent and be by electric charge-electric charge reciprocal action or hydrogen bond and form those of structure, as cabosil and HECTABRITE DP.On the flow velocity viewpoint, these materials have ideal character, and it is rare to be that high shear causes.Form the thickening agent of cross-linked network structure, as comprise the polysaccharide derivates of xanthan gum or synthetic polymer (comprising carbomer), also can give the pseudoplastic behavior of height.Only coming the thickening agent of structural texture by chain entanglement, as cellulose gum, also is pseudoplastic, but with have an ordered 3 D structure those compare, be tending towards having pseudoplastic behavior than low degree.

Can be used alone or in combination thickening agent to form " thickened systems ".Some thickening agent such as Strese Hofmann's hectorite. allow compositions to be separated, and wherein use them under the situation that does not have second kind of thickening agent.Similarly, on the consumption of single thickening agent, be conditional, need to add other thickening agent, to reach required rheological behavior.

As mentioned above, it is rare that the compositions that comprises bentonite clay and HECTABRITE DP (as LAPONITE) is that high shear causes, and therefore be applicable to the present invention.Yet, the compositions display that comprises these thickening agents have moderate to height hysteresis quality, limited their back viscosity of obtainable shearings of institute after standing high-rate of shear.In addition, these thickening agents are unsuitable for using together with some oral care active such as sodium fluoride.Comprise the compositions of preferred polysaccharide glue (as xanthan gum and carrageenin) can't shear thinning to those identical degree that comprise LAPONITE or bentonite clay, but after distribution, show to have lower hysteresis quality.Therefore suitable thickening agent and the content of essential selection is to reach the rheological characteristic requirement of this paper regulation.

For concrete thickening agent or thickening agent combination, for making product keeps compositions after having suitable flow velocity under the high shear and standing high-rate of shear structure, will highly depend on the preparation consumption of thickening agent or thickening agent combination to remain in the bristle and/or the required appropriate rheological behavior that reaches on the bristle.Typically, the increase of amount of thickener will cause the increase of low-shear rate viscosity and high-rate of shear viscosity.Therefore, amount of thickener has a scope, and in this scope, compositions can be pumped and can be retained on the bristle.The desired contents of thickening agent or thickening agent combination also will depend on the grade of material therefor, typically be the function of molecular weight or polymer chain length, have long chain length and can produce higher viscosity.This thickening agent also can show to have collaborative reciprocal action with other composition in the preparation, so that has changed under high-rate of shear and low shear rate to obtaining the suitable required content of viscosity.In concrete preparation, the selection of the concrete thickening agent of many other factors may command.On thickening agent, may need concrete electric charge, for example, to avoid worthless reciprocal action taking place with other composition.

Be applicable to that thickening agent of the present invention comprises organic and inorganic thickening agent, and their mixture.Inorganic thickening agent comprises Strese Hofmann's hectorite. and derivant, Shionox, ternary and quaternary magnesium silicate derivant, bentonite, and their mixture.Preferred inorganic thickening agent is Strese Hofmann's hectorite. and derivant thereof, Shionox, and their mixture.Organic thickening agent comprises xanthan gum, carrageenin and derivant thereof, gellan gum, hydroxypropyl emthylcellulose, fungi plant glue and derivant thereof, amylopectin, rhamsan gum, welan gum, Rhizoma amorphophalli, curdlan, carbomer, Algin, alginic acid, alginate and derivant thereof, hydroxyethyl-cellulose and derivant thereof, hydroxypropyl cellulose and derivant thereof, the starch phosphate derivant, guar gum and derivant thereof, starch and derivant thereof, the copolymer of maleic anhydride and alkene and derivant thereof, cellulose gum and derivant thereof, ethylene glycol/propylene glycol copolymers, poloxamer and derivant thereof, polyacrylate and derivant thereof, methylcellulose and derivant thereof, ethyl cellulose and derivant thereof, agar and derivant thereof, Radix Acaciae senegalis and derivant thereof, pectin and derivant thereof, chitosan and derivant thereof, the Polyethylene Glycol resin is (as PEG-XM, wherein X is more than or equal to 1), karaya, locust bean gum, natto gum, the copolymer of vinylpyrrolidone and alkene, Tragacanth, polyacrylamide, chitin derivative, gelatin, beta glucan, dextrin, glucosan, cyclodextrin, methacrylate, microcrystalline Cellulose, polyquaternary ammonium salt, the furan foamed resin, ghatti gum, Semen Plantaginis glue, WENBO natural gum, tamarind gum, larch glue, Caesalpinia spinosaKuntze glue, and their mixture.Preferred xanthan gum, carrageenin and derivant thereof, gellan gum, hydroxypropyl emthylcellulose, fungi plant glue and derivant thereof, amylopectin, rhamsan gum, welan gum, Rhizoma amorphophalli, curdlan, carbomer, Algin, alginic acid, alginate and derivant thereof, hydroxyethyl-cellulose and derivant thereof, hydroxypropyl cellulose and derivant thereof, the starch phosphate derivant, guar gum and derivant thereof, starch and derivant thereof, the copolymer of maleic anhydride and alkene and derivant thereof, cellulose gum and derivant thereof, ethylene glycol/propylene glycol copolymers, poloxamer and derivant thereof, and their mixture.More preferably xanthan gum, carrageenin and derivant thereof, gellan gum, hydroxypropyl emthylcellulose, fungi plant glue and derivant thereof, amylopectin, rhamsan gum, welan gum, Rhizoma amorphophalli, curdlan, and their mixture.

The amount of thickening agent can be by weight greater than 0.5% to maximum 4%, be preferably greater than 0.5% to maximum 3%, more preferably greater than 0.5% to maximum 2%.

Surfactant

Oral cavity composition of the present invention comprises by weight surfactant or the surfactant mixture greater than about 0.1%.Surface-active contents cited herein is based on 100% active substance, though common raw material (as sodium lauryl sulfate) can more SA aqueous solution form provide.

Surfactant is important for oral cavity cleaning, can come cleaning oral cavity with the dirt of being removed that suspends by removing crude removal from the surface and producing foam.By the weight of described total composition, suitable surface-active contents is about 0.1% to about 15%, preferred about 0.25% to about 10%, more preferably from about 0.5% to about 5%.The surfactant that is applicable to this paper comprises anion surfactant, amphoteric surfactant, non-ionic surface active agent, zwitterionic surfactant and cationic surfactant, however preferred anionic surfactant, amphoteric surfactant, non-ionic surface active agent and zwitterionic surfactant (and their mixture).

The anion surfactant that can be used for this paper comprises the alkyl sulfate that has 10 to 18 carbon atoms on the alkyl and the water soluble salt of alkyl ether sulfate, and the water soluble salt with alpha-sulfonated fatty acid monoglyceride of 10 to 18 carbon atoms.Sodium lauryl sulfate and coconut palm acid glycerol monoesters sodium sulfonate are the embodiment of this type anion surfactant.Preferred sodium lauryl sulfate.In preferred embodiments, this oral cavity composition comprise at least about 0.125%, preferably at least about 0.5%, more preferably at least about 2% anion surfactant.

Be applicable to that cationic surfactant of the present invention can be broadly defined as the derivant of the aliphatic quaternary ammonium chemical compound with a long alkyl chain, wherein this alkyl chain comprises about 8 to 18 carbon atoms, as lauryl trimethyl ammonium chloride, cetylpyridinium chloride, alkyl benzyl dimethyl ammonium chloride, cetyl trimethyl ammonium bromide, diisobutyl benzene oxygen ethyl dimethyl benzyl ammonium chloride, cocoyl alkyl trimethyl ammonium nilrite, fluoridize cetyl pyridinium or the like.In compositions disclosed by the invention, some cationic surfactant also can be used as antibacterial.

Be applicable to the non-ionic surface active agent in the present composition, can be broadly defined as the chemical compound that produces with the organic hydrophobic compound condensation that itself can be aliphatic series and/or aromatics by alkylidene oxide group (itself is hydrophilic).The embodiment of suitable non-ionic surface active agent comprises the ethylene oxide condensate of ethylene oxide condensate (as the PEG-30 castor oil hydrogenated), aliphatic alcohol or the alkyl phenol of poloxamer, dehydrated sorbitol derivative (as two isostearic acid sorbitan esters), castor oil hydrogenated, derived from expoxy propane and 1, the product of 2-ethylenediamine and the product of ethylene oxide condensation, long chain tertiary amine oxide, long chain tertiary phosphine oxide, long-chain dialkyl sulphoxide, and the mixture of above-mentioned substance.These materials can be used for stable foam, and can not impel the excess stickiness of oral cavity composition to increase.

Zwitterionic surfactant can be described as the derivant of aliphatic quaternary ammonium, Phosphonium and sulfonium compound widely, wherein aliphatic group can be a straight or branched, and one of them aliphatic substituent group contains 8 to 18 carbon atoms of having an appointment, and an aliphatic substituent group contains water lyotropy anionic group, as carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Preferred zwitterionic surfactant comprises and is disclosed in US-A-5, the beet alkali surface activator in 180,577.

Liquid carrier material

Oral cavity composition of the present invention comprises the liquid carrier material greater than about 50%.Water is to exist usually.In the preparation of commercially available suitable oral cavity composition, used water should be preferably deionization and not have the water of organic impurities.Usually, by the weight of liquid dentifrice composition described herein, the content of water is at least 10%, preferred about 20% to 70%.More preferably, said composition comprises the water at least about 30%, suitable about 30% to about 50%.This tittle of water comprises the water that the free water that added and other material (as sorbitol and surfactant solution) are introduced.

Usually, this liquid-carrier can further comprise one or more wetting agents.Suitable wetting agent comprises that glycerol, sorbitol and other edible polyhydric alcohol are water, is about 15% to about 50% low-molecular-weight Polyethylene Glycol as content.For making foaming characteristic and dry strength reach best balance, the ratio of total moisture and total wetting agent is preferably about 0.65:1 to 1.5:1, preferably about 0.85:1 to 1.3:1.

The high-rate of shear viscosity of this paper oral cavity composition is subjected to being present in the influence of the Newtonian liquid viscosity in the compositions to a great extent.Term used herein " Newtonian liquid " comprises and meets the liquid substance that homogeneous shear stress is this law of product of viscosity coefficient and shear rate.This can be that neat liquid (as glycerol or water) or solute are dissolved in formed solution in the solvent (as the aqueous solution of sorbitol).Newtonian liquid depends on the amount of the Newtonian liquid that is mixed for the influence degree of non newtonian oral cavity composition viscosity.Typically, water is present in the oral cavity composition with significant quantity, and 25 ℃ of Newtonian viscosities that had down are about 1mPas.Wetting agent (as glycerol and sorbitol solution) typically has the Newtonian viscosity that is significantly higher than water.Therefore, the ratio of the total amount of wetting agent, water and wetting agent and the selection of wetting agent, the high-rate of shear viscosity for determining oral cavity composition has conclusive effect.

Can use common wetting agent, as sorbitol, glycerol, Polyethylene Glycol, propylene glycol, and their mixture, but concrete consumption is different with ratio, and this depends on the selection of wetting agent.Can use sorbitol, but because its higher Newtonian viscosity,, typically can not mix, because it has significant contribution for the high-rate of shear viscosity of oral cavity composition with the content more than 45% by the weight of described compositions.On the contrary, can relatively large use propylene glycol, because it is compared with sorbitol, have lower Newtonian viscosity, and, do not have same big contribution therefore for the high-rate of shear viscosity of oral cavity composition.The Newtonian viscosity that glycerol had is between sorbitol and Polyethylene Glycol.

Also can there be ethanol in the oral cavity composition.This tittle can be 0.5% to 5%, most preferably 1.5% to 3.5% by weight.Ethanol can be useful solvent, and also can be used for strengthening the effectiveness of flavoring agent, though for the latter, only need to use a spot of ethanol usually.Also can use non-alcohol solvent, as propylene glycol.Low-molecular-weight Polyethylene Glycol also can be used for herein.

Other component

Oral cavity composition of the present invention typically comprises various other components, as grinding agent, fluorine ion source, chelating agen, antimicrobial, thickening agent, silicone oil and other adjuvant, as antiseptic and coloring agent.

Grinding agent

Oral cavity composition of the present invention can comprise dental abrasive.Grinding agent can be used for polishing tooth and/or removes surface deposits.The abrasive materials that can be used for this paper can be any material that can the excessive wear dentine.Suitable grinding agent comprises the insoluble phosphate buffing compound, as dicalcium phosphate, tricalcium phosphate, calcium pyrophosphate, β-phase calcium pyrophosphate, Tri-Compress, anhydrous calcium phosphate, insoluble Polymeric sodium metaphosphate., or the like.Chalk type grinding agent also suits, as calcium carbonate and magnesium carbonate, silicon dioxide (comprising xerogel, hydrogel, aeroge and precipitation), aluminium oxide and hydrate (as α-Alumina hydrate, aluminosilicate such as aluminium silicate and burnt aluminium silicate), magnesium silicate and Zirconium orthosilicate. (as magnesium trisilicate) and thermosetting polymer resin (as the graininess condensation product of carbamide and formaldehyde, polymethyl methacrylate, polyethylene powder and other, as 25 days US-A-3 of December in 1962, disclosed in 070,510).Also can use the mixture of grinding agent.Usually, the grinding agent polishing mean diameter that material had is that about 0.1 μ m is to about 30 μ m, preferred about 1 μ m to 15 μ m.

The radioactive dentin abrasion that oral cavity composition described herein had (RDA) value is preferably about 70 to about 200, more preferably from about 70 to about 140, most preferably from about 80 to about 125.The mensuration of RDA value can be according to Hefferen at the Journal of in July, 1976 to August DentalResearch, the method for setting forth in the 563rd to 573 page, and Wason United States Patent (USP) 4,340,583,4,420,312 and 4,421, the method described in 527 is carried out.

Non-abrasive material such as Quadrafos also have contribution to the RDA value.Yet, can measure the RDA value that does not have the grinding agent under these materials existence.In compositions of the present invention, when the consumption of grinding agent was 5%, the RDA value that himself had was preferably about 70 to about 140, more preferably from about 80 to about 125.By using following technology, can measure the RDA value of grinding agent under 5% consumption.By xanthan gum is sneaked in the glycerol, add entry and mix, add grinding agent then and mix, prepare test composition, said composition comprises 50% glycerol, 44% water, 5% grinding agent and 1% xanthan gum.Use standard RDA method to measure the RDA value of this test composition then, provide RDA to measure with grinding agent to 5% consumption.

The replaceability assay method of determining this paper compositions clean-up performance is to determine that they are to building up the effect on top layer.Oral cavity composition as herein described also has top layer cleaning ratio (" PCR ") value, and this value is at least about 70, preferred about 70 to about 140, more preferably from about 80 to about 125.PCR cleaning value is determined by the PCR test, it is described in nineteen eighty-two, among J.Dental Research, the 61st volume G.K.Stookey, the T.A.Burkhard and " the In Vitro Removal of Stain With Dentifrice " of B.R.Schemerhorn on the 1236th page to 1239 pages.

Various types of silica dental abrasives can provide superior cleaning of teeth and polishing performance, and can exceedingly not wear and tear dentium nitor or dentine.This silica abrasive can be precipitated silica or silica gel, as the US-A-3 that authorizes people such as Pader that announced on March 2nd, 1970,538, the US-A-3 that authorizes DiGiulio that on June 21st, 230 and 1975 announced, 862, silica xerogel described in 307, for example with trade name " Syloid " by W.R.Grace ﹠amp; The silica xerogel that the Davison Chemical Division of Company sells.Suitable precipitated silica comprises those that sold by INE0S with trade name Sorbosil AC 43 and AC 33.The oil absorption that preferred silicon dioxide is had is: every 100g silicon dioxide oil suction 30g to 100g.Therefore find that the silicon dioxide with low oil absorption ferric is that the structuring degree is lower, and can not make the viscosity of oral cavity composition reach higher and therefore have the identical degree of silicon dioxide of higher oil absorption with those structuring degree.By measure 25 ℃ of following silicon dioxide the maximum of absorbent Semen Lini oil, measure oil absorption used herein.

Suitable abrasive levels be about 0% to about 20%, preferably less than 10%, for example 1% to 10%.Abrasive levels is preferably 3% to 5%.Find that the oral cavity composition with a large amount of grinding agents does not have and is applicable to the rheological equationm of state of the present invention.Not bound by theory, it is believed that the oral cavity composition that comprises relatively large grinding agent, help stable suitable low-shear viscosity though have, under higher shear rates, can not fully cause rarely, so that can't provide suitable pump to recharge and outflow characteristic in minute timing.

Fluorine ion source

For the preventing decayed tooth protection, there is fluorine ion source in the oral cavity composition usually.Fluoride sources comprises sodium fluoride, potassium fluoride, calcium fluoride, stannous fluoride, the inferior stannum of single fluorophosphoric acid and sodium monofluorophosphate.Preferred fluorinated sodium.By the weight of described liquid dentifrice, effectively the suitable content of fluorion is defined as 25ppm to 2500ppm.

Chelating agen

Another preferred optional reagent is chelating agen, is important anti-calculus agent.Suitable chelating agen comprises organic acid and salt thereof, for example tartaric acid and its pharmaceutically useful salt, citric acid and alkali metal citrates, and their mixture.The complexation of chelating agen energy is present in the calcium in the bacteria cell wall.Chelating agen also can destroy dental plaque by remove calcium from the calcium bridge, and described calcium bridge helps to keep Biomass complete.Yet, may use the chelating agen that calcium is had too strong affinity.This can cause the tooth demineralization, and this and purpose of the present invention and being intended that runs in the opposite direction.The calcium binding constant that preferred chelating agen has is about 10 ¹To 10 ⁵, reducing the formation of dental plaque and dental calculus, thereby provide the cleaning effect of improvement.The amount that is applicable to chelating agen of the present invention is about 0.1% to about 2.5%, preferred about 0.5% to about 2.5%, most preferably from about 1.0% to about 2.5%.The tartrate chelating agen can use separately or be used in combination with other optional chelating agen.

Especially being suitable for the another kind of reagent of making chelating agen of the present invention is water-soluble poly-phosphate, polyphosphonate and pyrophosphate, and they can be used as anti-calculus agent.The pyrophosphate that is used for the present composition can be any alkali metal pyrophosphate salts.The pyrophosphate that is used for the effective dose of the present composition is enough to provide at least 1.0% pyrophosphate ion usually, above-mentioned these ions of preferred about 1.5% to about 6%.Pyrophosphate is described in greater detail in Kirk ﹠amp; " the Encyclopedia ofChemical Technology " of Othmer is in second edition the 15th volume (Interscience Publishers, nineteen sixty-eight).

Preferred water-soluble poly-phosphate is as sodium tripolyphosphate, PTPP (potassium tripolyphosphate) and sodium hexameta phosphate.Other long chain anticalculus agents of this type is described among the WO98/22079.Preferred water dissolubility diphosphate also.Suitable soluble diphosphate comprises ethyl-1-hydroxyl-1,1-diphosphate (EHDP) and azacyclo-heptyl diphosphate (AHP).Tripolyphosphate and diphosphate are especially preferred, because they can provide anti-calculus active and decontamination activity simultaneously, and need not to make viscosity to reach the chemical decontamination agent much the same degree relatively poor with water solublity, and they are being stable aspect the hydrolysis of chance water.Since for the grinding agent consumption that keeps low viscosity institute can be included in the present composition limited, so be useful as the active substance that decolours with soluble poly phosphate and diphosphate.Not bound by theory, it is believed that these compositions get off to carry out decontamination by the surface that will stain desorption from the enamel of tooth.The suitable content of water-soluble poly-phosphate and diphosphate counts about 0.1% to about 10%, preferred about 1% to about 5% and more preferably from about 1.5% to about 3% by the weight of described oral cavity composition.What more preferably can be used for this paper is the alkali metal salt of tripolyphosphate.

Also be applicable to the polycarboxylate that other possible chelating agen of the present invention is anionic polymerisation.Above-mentioned substance is well known in the art, and they are used with the form of its free acid or part or preferred complete neutral water-soluble alkali (for example potassium, and preferred sodium) salt or ammonium salt.Other polymeric polycarboxylate is disclosed in the US-A-4 that authorizes Gaffar, 138,477 and authorize people's such as Gaffar US-A-4,183, in 914, and comprise that the copolymer of maleic anhydride and styrene, isobutene. or ethyl vinyl ether, polyacrylic acid, poly-itaconic acid and poly and MW are low to moderate the sulfo-acrylic acid oligomer of 1,000 commodity Uniroyal ND-2 by name.

Antimicrobial

The antimicrobial that is included in the present composition also is useful.Various antimicrobials be can use, tin salt (as ditin diphosphate and the inferior stannum of gluconic acid), zinc salt (as zinc lactate and zinc citrate), mantoquita (cuprous), quaternary ammonium salt (as cetylpyridinium chloride and chlorination myristyl ethylpyridine), connection Guanoctine and nonionic antimicrobial (as triclosan) comprised as glycine.Some flavored oils as thymol, also can have antimicrobial acivity.Mentioned reagent is disclosed in the United States Patent (USP) 2,946,725 and in the JIUYUE, 1977 of authorizing people such as Norris July 26 nineteen sixty and authorized in 27th in people's such as Gieske the United States Patent (USP) 4,051,234.Equally usefully sodium chlorite is described among the WO 99/43290.

If there is antimicrobial, its content is typically about 0.01% to about 10%.Preferably make the content of Ya Xi and cationic antimicrobial agent keep less than 5%, preferably less than 1%, to avoid producing the problem of tooth discoloration.

Preferred antimicrobial is non-cationic antimicrobial agent, as US 5,037, those described in 637.Especially preferred antimicrobial is 2 ', 4,4 '-three chloro-2-dihydroxy diphenyl ethers (triclosan).

Silicone oil

An optional member in the present composition is a silicone oil.Silicone oil can be used as the dental plaque barrier layer, as disclosed among the WO 96/19191.Suitable classes of silicone oils comprises, but be not limited to, polydimethylsiloxane, dimethiconol, dimethicone copolyol and aminoalkyl siloxanes, preferred silicone oil is selected from dimethicone copolyol and aminoalkyl siloxanes, more preferably is selected from dimethicone copolyol.Usually, the content of silicone oil is about 0.1% to about 15%, preferred about 0.5% to about 5%, more preferably from about 0.5% to about 3% by weight.

Other adjuvant

By weight, the content of sweeting agent such as saccharin sodium, ring sodium sulfonate, acesulfame potassium, aspartame, sucrose etc. is about 0.1% to 5%.Also other auxiliary agent be can mix, flavoring agent, antiseptic, opacifier and coloring agent comprised.Typical coloring agent is D﹠amp; C yellow #10, FD﹠amp; C blue #1, FD﹠amp; The red #40 of C, D﹠amp; The red #33 of C, and their combination.The content of coloring agent can be 0.0001% to 0.1%.

Embodiment

The following example will more fully illustrate embodiment of the present invention.

Oral cavity composition

Embodiment # I II III IV V VI VII VIII

Weight percent Weight percent Weight percent Weight percent Weight percent Weight percent Weight percent Weight percent

The material title Than (%) Than (%) Than (%) Than (%) Than (%) Than (%) Than (%) Than (%)

Sorbitol (70%) 43.97 41.9 56.0 41.9 52.0 39.0 43.0 43.0

Glycerol 10.0 10.0 10.0 10.0 10.0 10.0 10.0

Sodium fluoride 0.24 0.32 0.32 0.32 0.32 0.24--

Sodium monofluorophosphate------1.11 1.11

Xanthan gum 1.0 1.0 0.6 1.0 1.0 1.2 0.5-

Synthetic li-montmorillonite ¹------0.6 0.5

Cellulose gum ²-------0.6

Alkyl sodium sulfate, 28% 9.0 9.0 9.0 9.0 9.0 9.0 9.0 9.0

Precipitated silica-3.0 10.0 10.0 5.0 3.0 1.0 1.0

PEG-6 5.0 5.0 4.5 5.0 - 5.0 - -

PEG-12 - - - - 3.0 - - -

PEG-20M - - - 1.3 4.0 - - -

Triclosan-0.3 0.3-----

Saccharin sodium 0.3 0.45 0.45 0.45 0.45 0.3 0.3 0.3

Sodium tripolyphosphate-----1.92--

Flavoring agent 1.7 1.7 1.7 1.9 1.7 1.7 1.7 1.7

Antiseptic 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1

CI 42090 FD﹠amp; The blue #1 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 of C

Water to 100% to 100% to 100% to 100% to 100% to 100% to 100% to 100%

Viscosity under the 1s-1 (Pas) 47.3〉10〉10〉10〉10〉10

20s ^-1Under viscosity (Pas) 3.4＜780＜780＜780＜780＜780

¹Laponite?D

²Bl?anose?7M8SF

The oral cavity composition of the foregoing description is packaged in the collapsible bag of being made by heat-sealing plastic-aluminum laminated material of being pumped into vacuum.This bag is connected on the entry nozzle of membrane pump that the chamber of septum volume is 0.3mL by the latch-type adapter.The delivery side of pump nozzle is connected with the siloxanes conduit with circular cross section, and the interior cross-sectional area of this conduit is 3.14mm ², and length is 120mm.Pump end siloxanes catheter tip slightly is equipped with siloxanes narrow orifice check valve, and this valve is arranged in brush application device head.Whole bag/pump/catheter combination is comprised in the shell of electric toothbrush of the size design that can cosily hand by user, so that this barrier film air chamber of pump can manually be pressed down the pumping compositions from housing exterior.When pressing air chamber of pump, the oral cavity composition of the foregoing description promptly distributes with the flow velocity of about 0.3mL/s, uses over-drastic active force and need not user.After the distribution, this oral cavity composition can obtain 1s fast ^-1Following acceptable viscosity.

Claims (4)

1. oral cavity composition that is used for the reservoir of handheld toothbrush, wherein, described oral cavity composition is pumped into the outlet of toothbrush by conduit from this reservoir, and described oral cavity composition comprises:

A) greater than the thickening composition of 0.5 weight % to maximum 2 weight %, described composition is selected from xanthan gum, carrageenin and derivant thereof, gellan gum, hydroxypropyl emthylcellulose, fungi plant glue and derivant thereof, amylopectin, rhamsan gum, welan gum, Rhizoma amorphophalli, curdlan and their mixture;

B) oil absorption of 1-10 weight % is the silica abrasive of every 100g silicon dioxide oil suction 30g to 100g;

C) total moisture of 30 weight % to 60 weight %;

D) wetting agent of 30-60 weight %, described wetting agent is selected from polyhydric alcohol and Polyethylene Glycol;

Wherein, the radioactive dentin abrasion value of described oral cavity composition is 70-140, at 450s ^-1Shear rate under, the viscosity of described oral cavity composition is less than 5Pas, at 20s ^-1Shear rate under, the viscosity of described oral cavity composition is 0.001Pas to less than 780Pa.s, and at 1s ^-1Shear rate under, viscosity is 25Pas at least after the shearing of described oral cavity composition.

2. oral cavity composition as claimed in claim 1, described oral cavity composition comprise the anticalculus agent of 1 weight % to 5 weight %, and described anticalculus agent is selected from the alkali metal salt of water-soluble poly phosphoric acid or di 2 ethylhexyl phosphonic acid.

3. oral cavity composition as claimed in claim 2 is characterized in that described anticalculus agent is selected from the tripolyphosphate alkali metal salt.

4. oral cavity composition as claimed in claim 1 is characterized in that, described oral cavity composition contains the silica abrasive of 3 weight % to 5% weight.