CN100522169C - Ranolazine hydrochloride slow-release preparation and its preparing method - Google Patents
Ranolazine hydrochloride slow-release preparation and its preparing method Download PDFInfo
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- CN100522169C CN100522169C CNB2005100439289A CN200510043928A CN100522169C CN 100522169 C CN100522169 C CN 100522169C CN B2005100439289 A CNB2005100439289 A CN B2005100439289A CN 200510043928 A CN200510043928 A CN 200510043928A CN 100522169 C CN100522169 C CN 100522169C
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Abstract
The present invention relates to a ranolazine hydrochloride delayed-release preparation and its preparation method. Said ranolazine hydrochloride delayed-release preparation contains 25-95 wt% of ranolazine hydrochloride and one or several kind of medicinal inert auxiliary materials, including delayed-release matrix, adhesive, disintegrating agent, diluent, lubricating agent, flow aid or moistening agent.
Description
(1) technical field
The present invention relates to a kind of ranolazine hydrochloride slow-release preparation and preparation method thereof, be specifically related to oral slow-releasing preparation of a kind of hydrochloric ranolazine and preparation method thereof.
(2) background technology
Ranolazine hydrochloride is N-(2, the 6-3,5-dimethylphenyl)-2-{4-[2-hydroxyl-3-(2-methoxy phenoxy) propyl group] piperazinyl } the acetamide dihydrochloride.U.S. Pat 4567264 discloses ranolazine (±)-N-(2, the 6-3,5-dimethylphenyl)-4-[2-hydroxyl-3-(2-methoxyl group phenoxy group)-propyl group]-1-piperazine acetamide and pharmaceutically acceptable salt thereof, and disclose them and be used for the treatment of the purposes of the cardiovascular disease that comprises arrhythmia, variability and mobility's angina pectoris and myocardial infarction.
U.S. Pat 5506229 discloses the purposes that ranolazine and pharmaceutically acceptable salt and ester thereof are used for the treatment of the tissue that is subjected to physics or chemical damage, comprise the anoxia or the reperfusion injury of cardioplegia, heart or skeletal muscle or cerebral tissue, and the purposes that is used to transplant.Disclose common oral and parenteral formulation, comprised controlled release preparation.Particularly, the embodiment 7D of US5506229 has described a kind of controlled release preparation of capsule form, and this capsule is made up of the ranolazine of outsourcing sustained release polymer and the micropill of microcrystalline Cellulose.
Chinese patent CN1193757 discloses the lasting release pharmaceutical dosage form of the pH dependency binding agent of a kind of ranolazine that comprises 50%～95% weight and 1%～20% weight.This pH dependency binding agent is those binding agents that can suppress medicine rapid release from tablet in stomach (its pH is lower than about 4.5) between residual period, and (its pH is generally greater than about 4.5) this binding agent can promote the ranolazine of therapeutic dose to discharge from dosage form in the gastrointestinal tract bottom.The oral dose of the IR formulation of Chinese patent CN1193757 is with the capsule of dihydrochloride or tablet form administration; Oral dose in the extended release preparation of this patent is with the tablet form administration of ranolazine alkali.Chinese patent CN1193757 discloses ranolazine alkali and has been insoluble to pH relatively greater than about 6.5 aqueous solution, and pH increases suddenly less than 6 o'clock dissolubility.Because slightly soluble is to soluble,very slightly in intestinal juice for ranolazine alkali, and the digital proof pH dependency binding agent that this patent is failed to provide definite promotes ranolazine alkali to discharge in intestinal, thereby so the release of ranolazine alkali may not exclusively cause absorption of human body incomplete.The antianginal and the ischemia effect that show the instant-free ranolazine formulation in this patent working example 4 can not continue whole dosing interval, show that the ranolazine common oral preparation is effective and toleration is good, but it can't provide the persistence protective effect to heart.
Thereby therefore being necessary to prepare a kind of can release fully absorbs fully to give full play to ranolazine at the medicative slow releasing preparation of human body planted agent people's physical ability.
(3) summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of ranolazine hydrochloride slow-release preparation and preparation method thereof is provided, have that toxic and side effects reduces, a taking convenience, advantage that bioavailability is high.Taking said preparation makes the ranolazine in the human plasma maintain treatment level.
Ranolazine hydrochloride slow-release preparation of the present invention contains ranolazine hydrochloride and one or more pharmaceutically acceptable inert excipients of 25～95wt%, and pharmaceutically acceptable inert excipients comprises sustained-release matrix, binding agent, disintegrating agent, diluent, lubricant, fluidizer or wetting agent.Release in sustainable 12 hours.
Ranolazine hydrochloride slow-release preparation of the present invention is a sustained-release matrix with non-pH dependency material, and sustained-release matrix is selected from hydroxypropyl emthylcellulose (HPMC), ethyl cellulose (EC), methylcellulose (MC), hydroxyethyl-cellulose (HEC), hymetellose (HEMC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose (CMC), sodium carboxymethyl cellulose (CMC-Na), polyvinyl alcohol (PVA), polyvinylpyrrolidone, chitosan, alginate, carbomer (Carbomer), hexadecanol, octadecanol, glyceryl monostearate, Glyceryl Behenate, hydrogenated vegetable oil, Cera Flava, in magnesium stearate or the non-pH dependency acrylic resin one or more.
Hydroxypropyl emthylcellulose is meant E4M CR, E10M CR, K100-LV CR, K4M CR, K15M CR or K100M CR in the above-mentioned sustained-release matrix, can buy with the many elegant trade names of U.S. from LG-DOW (Dow) company.
Ethyl cellulose is meant the ethyl cellulose of the micro powder grade that particle diameter 150 μ m are following in the above-mentioned sustained-release matrix, and viscosity is 6～100 centipoises.
Non-pH dependency acrylic resin is selected from quaternary amine ylmethyl acrylate copolymer A type and Type B or neutral polymethacrylates in the above-mentioned sustained-release matrix.
Above-mentioned binding agent is selected from hydroxypropyl emthylcellulose (HPMC), ethyl cellulose (EC), methylcellulose (MC), hydroxyethyl-cellulose (HEC), hymetellose (HEMC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose (CMC), sodium carboxymethyl cellulose (CMC-Na), polyvinyl alcohol (PVA), polyvinylpyrrolidone, chitosan, alginate, starch, carbomer (Carbomer), or in the non-pH dependency acrylic resin one or more, non-pH dependency acrylic resin is quaternary amine ylmethyl acrylate copolymer A type and Type B, neutral polymethacrylates.
Above-mentioned disintegrating agent is selected from one or more in carboxymethyl starch sodium, microcrystalline Cellulose, pregelatinized Starch, cross-linking sodium carboxymethyl cellulose, the crospolyvinylpyrrolidone;
Above-mentioned diluent is selected from one or more in lactose, starch, dextrin, microcrystalline Cellulose, the calcium sulfate;
Above-mentioned fluidizer is selected from one or more in micropowder silica gel, microcrystalline Cellulose, the aluminium hydroxide;
Above-mentioned lubricant is selected from one or more in magnesium stearate, calcium stearate, Pulvis Talci, hydrogenated vegetable oil, Polyethylene Glycol or the sucrose ester.
Above-mentioned wetting agent is ethanol, ethanol water or water.
Sustained-release matrix is preferably as follows one of combination:
(1) hydroxypropyl emthylcellulose, ethyl cellulose and non-pH dependency acrylic resin;
(2) hydroxypropyl emthylcellulose, carbomer and non-pH dependency acrylic resin;
(3) hydroxypropyl emthylcellulose, hydrogenated vegetable oil and ethyl cellulose.
Combinations thereof can make the heavy minimum of sheet and slow release effect the best.
Ranolazine hydrochloride is N-(2, the 6-3,5-dimethylphenyl)-2-{4-[2-hydroxyl-3-(2-methoxy phenoxy) propyl group] piperazinyl } the acetamide dihydrochloride.Except as otherwise noted, the oral dose of slow releasing preparation of the present invention and ordinary preparation all is that the specification of preparation all is to represent with the level of ranolazine free alkali with the form administration of ranolazine hydrochloride.When representing dosage with alkali and dihydrochloride dual mode, the transformation ratio that dihydrochloride is converted into alkali is 0.854 (for example: 500mg free alkali ÷ 0.854=585.5mg dihydrochloride).All blood plasma levels and pharmacokinetic parameter are all represented with the level of free alkali.
The ranolazine hydrochloride ordinary preparation is meant at external rapidly-soluble preparation or dosage unit, and said preparation dissolves fully and absorbs at stomach or upper gastro-intestinal tract.Usually these preparations discharge at least 90% active component in administration in 30 minutes.
Ranolazine hydrochloride slow-release preparation is meant in about 6 hours or longer time the preparation of the present invention or the dosage unit of slow and continuous-dissolution and absorption in the harmonization of the stomach gastrointestinal tract.Preferred slow releasing preparation is no more than twice administration every day, each no more than two preparation of dosage.
As shown in table 1, the ranolazine hydrochloride good water solubility, equilbrium solubility (37 ℃) in the phosphate buffer of hydrochloric acid, pH5.8 and the pH6.8 of distilled water, 0.1mol/L is all greater than 1g/mL, the dissolubility that ranolazine hydrochloride is described gastrointestinal tract (its pH is about in 1～6.8 scope) hardly the variation with pH change, therefore have at least and be beneficial to the advantage of medicine in gastrointestinal absorption with the slow releasing preparation of the form administration of ranolazine hydrochloride.
The equilbrium solubility (37 ℃) of table 1 ranolazine hydrochloride in various media
Ranolazine hydrochloride slow-release preparation of the present invention, the ranolazine hydrochloride of 30～600mg is contained in each preparation unit, and surplus is sustained-release matrix and medicine acceptable carrier, and sheet focuses on 120～1200mg.
The content of ranolazine hydrochloride is 25～95wt% in the slow releasing preparation of the present invention, is preferably 40～90wt%;
The content of sustained-release matrix is 2～90wt% in the slow releasing preparation of the present invention, is preferably 7～40wt%;
The content of binding agent is 1～20wt% in the slow releasing preparation of the present invention, is preferably 2～15wt%;
The content of lubricant is 0.2～20wt% in the slow releasing preparation of the present invention, is preferably 0.5～5wt%.
In the slow releasing preparation of the present invention, diluent is optional, but diluent can be regulated the weight or the release of each preparation unit, and is convenient to preparation processing.The content of diluent is about 0.5～20wt%, preferably is about 1～10wt%.
The preferred sustained-release matrix of ranolazine hydrochloride slow-release preparation of the present invention is hydroxypropyl emthylcellulose and/or ethyl cellulose; The preferred non-pH dependency acrylic resin of binding agent; Non-pH dependency acrylic resin is quaternary amine ylmethyl acrylate copolymer A type and Type B, can from Romo Co.,Ltd (Rohm Pharma) with You Teqi (
) trade name of RL100, RL PO, RS100 or RS PO bought.
The diluent preferably microcrystalline cellulose;
The preferred magnesium stearate of lubricant.
Ranolazine hydrochloride slow-release preparation of the present invention also can cover outward appearance, the sense of taste and the stability etc. of coatings to improve preparation at skin, and coatings weightening finish is 0.1～20% with the weight ratio of compressed tablet, and is preferred 0.5～10%, and the best is 1.0～3.0%.
Particularly preferred ranolazine hydrochloride slow-release preparation of the present invention is as shown in the table:
| Component | Weight range (%) | Preferable range (%) | Best preferred (%) |
| |
25～95 | 40～90 | 77 |
| Hydroxypropyl emthylcellulose | 1～60 | 5～20 | 10 |
| Ethyl cellulose | 1～30 | 2～20 | 5 |
| Non-pH dependency acrylic resin | 1～20 | 2～15 | 6 |
| Magnesium stearate | 0.2～20 | 0.5～5 | 2.0 |
| Ethanol water | To wetting amount | To wetting amount | To wetting amount |
Wherein alcoholic acid concentration of volume percent is 50～100% in the ethanol water, preferred 70～100%.Ethanol water evaporates in the formulation preparation process.
Ranolazine hydrochloride slow-release preparation preparation method of the present invention is as follows:
(1) will fill a prescription in each component cross 60～100 mesh sieves, ethanol water, need to add except adjuvant that dissolving back in the ethanol water uses as binding agent and the adjuvant that needs to use behind the heating and melting;
(2) method of progressively increasing by equivalent adds the ranolazine hydrochloride of formula ratio and sustained-release matrix, disintegrating agent, diluent etc. successively, fully mixing.Granulation connects step (3), and tabletting connects step (5).
Or with the binding agent dry directly with the abundant mixing of above-mentioned substance, granulate and connect step (3), tabletting connects step (5).
Or in proportion with ranolazine hydrochloride and adjuvant separated into two parts, mixing is granulated and is connect step (3) respectively, and tabletting connects step (6).
Or earlier with the sustained-release matrix heating and melting of formula ratio, add the ranolazine hydrochloride mix homogeneously of formula ratio again, with the material cooling, pulverize then, sieve, below (5) operation set by step.
(3) in dehydrated alcohol, add an amount of purified water in proportion, be made into the ethanol water of certain volume percent concentration, standby as wetting agent.Or in proportion the binding agent dry is added in the above-mentioned ethanol water, be stirred to dissolving, it is standby to be made into binding agent.Or (5) operation directly set by step.
(4) wetting agent for preparing or binding agent are added in the mixture of step (2), the preparation soft material is granulated, and wet grain is in 40～50 ℃ of dryings 2 hours, the dried granule granulate that sieves,
(5) add lubricant, fluidizer, disintegrating agent or slow releasing agent in proportion, abundant mixing, tabletting.
(6) do interior chip granule with the part of batch mixing earlier and be pressed into interior chip, another part of reuse batch mixing is done the outer-skin sheet granule, is pressed into clad sheet together.
Prepare coated tablet as need, can continue next step:
(7) in coating equipment, cover one deck coatings for the skin of above-mentioned tablet.
The weightening finish of above-mentioned coatings is 0.1～20% with the weight ratio of tabletting, and is preferred 0.5～10%, and the best is 1.0～3.0%.
Ranolazine hydrochloride slow-release preparation of the present invention is a tablet, comprises plain sheet, the plain sheet of bag core, coated tablet or coating clad sheet.The shape of tablet can be circular piece or special-shaped sheet, the preferred capsule shape abnormity of the present invention plate shape.
Preferred method of granulating is to stir to granulate or the boiling granulating after drying.
Ranolazine hydrochloride slow-release preparation of the present invention is used to prepare the medicine of treatment angina pectoris, acute coronary syndrome, heart failure and other cardiovascular disease.Be suitable for oral 1～2 time of patient every day, each 1～2 preparation unit is with treatment angina pectoris, acute coronary syndrome, heart failure and other cardiovascular disease.Contain ranolazine hydrochloride in the preparation unit, so that the ranolazine level was kept 24 hours at least in the blood plasma, wherein this dosage is to divide to give once or twice in 24 hours.
The mixed matrix material that an advantage of the invention is compositions such as adopting hydroxypropyl emthylcellulose, ethyl cellulose and non-pH dependency acrylic resin is made slow releasing preparation, total consumption of sustained-release matrix is reduced, the sheet that has reduced slow releasing preparation to greatest extent is heavy, facilitates patients.
Compared with prior art, excellent results of the present invention is as follows
(1) adopts the mixed matrix material of compositions such as hydroxypropyl emthylcellulose, ethyl cellulose and the dependent acrylic resin of non-pH to make slow releasing preparation, make the final release of slow releasing preparation more complete, be more conducive to absorption of human body, help improving bioavailability;
(2) shape of preparation needing to be more suitable for the patient of ranolazine treatment;
(3) preparation technology is simple, is suitable for domestic production technology and equipment condition.
The oral slow-releasing preparation of the hydrochloric ranolazine of treatment cardiovascular disease of the present invention provides following treatment advantage:
Preparation of the present invention is to be the slow releasing preparation of feedstock production with the ranolazine hydrochloride, since the dissolubility of ranolazine hydrochloride gastrointestinal tract (its pH is about in 1～6.8 scope) hardly the variation with pH change, therefore medicine discharges more fully at gastrointestinal tract, and this slow releasing preparation has and is beneficial to the advantage of medicine in gastrointestinal absorption.This slow releasing preparation makes the plasma concentration minimize variations of ranolazine, and medicining times has only 1～2 time every day, and patient's compliance is increased, and the shape of preparation is more suitable for the medication crowd and takes.
Slow releasing preparation of the present invention, release in sustainable 12 hours.By study on the stability to this slow releasing preparation, the result confirms, the good stability of principal agent ranolazine hydrochloride in the ranolazine hydrochloride slow-release preparation, under different experiment conditions, outward appearance, drug content, catabolite, drug release rate etc. there is no significant change and meet the requirement of quality standard.Ranolazine hydrochloride slow-release preparation was being placed 6 months under 40 ℃ ± 2 ℃, the accelerated test condition of relative humidity 75% ± 5% under the commercially available back condition, and under the room temperature condition of 25 ℃ ± 2 ℃ of temperature, relative humidity 60% ± 10%, placed 6 months, good stability, outward appearance, drug content, catabolite, drug release rate etc. there is no significant change and meet the requirement of quality standard.
Ranolazine hydrochloride slow-release preparation is tested in intravital pharmacokinetics of beasle dog and relative bioavailability.Article 6, beasle dog is divided into two groups of A, B at random, 3 every group.The single oral dose that intersects respectively is subjected to test preparation (ranolazine hydrochloride slow-release sheet) and reference preparation (ranolazine hydrochloride ordinary tablet), pharmacokinetics and relative bioavailability behind the mensuration single-dose; Article 6, beasle dog intersection successive administration is 5 days, stable state pharmacokinetics behind the mensuration multiple dose administration.Blood drug level with different time after the administration of LC-MS (LC-MS) method mensuration.The result shows that after beasle dog intersection single oral dose ranolazine hydrochloride ordinary tablet (333.3mg base/sheet * 1) and the slow releasing tablet (500mg base/sheet * 1), the peak time Tmax of slow releasing tablet significantly is longer than ordinary tablet; The peak concentration Cmax of slow releasing tablet is starkly lower than ordinary tablet; The relative bioavailability of slow releasing tablet is 84.3%.Article 6, the stable state pharmacokinetic of beasle dog intersection multi-dose oral ranolazine hydrochloride ordinary tablet and slow releasing tablet shows that blood drug level reached stable state substantially in the 5th day, and the Tmax of slow releasing tablet significantly is longer than ordinary tablet.Result of study confirms, no matter single or multiple administration, and slow releasing tablet reaches the peak and all obviously postpones, the blood drug level peak steadily and broadening shows that the ranolazine hydrochloride slow-release sheet has certain slow release effect, and the relative bioavailability of slow releasing tablet〉80%.
The medicinal effects of ranolazine hydrochloride slow-release preparation of the present invention is described below by result of the test.
Compare pharmacokinetics and relative bioavailability that beasle dog is taken ranolazine hydrochloride slow-release sheet and ranolazine hydrochloride ordinary tablet, and the experiment of the slow release dynamic characteristic of definite ranolazine hydrochloride slow-release sheet.
Animal subject: beasle dog
One, single dose test
Table 2. beasle dog single oral dose ranolazine ordinary tablet (333.3mg/ sheet * 1) back blood plasma Chinese medicine concentration (μ g/ml)
| Time (h) | 0.25 | 0.5 | 0.75 | 1 | 1.5 | 2 | 3 | 4 | 6 | 8 | 12 | 24 |
| A | 3.85 | 7.07 | 8.94 | 6.50 | 6.35 | 4.24 | 1.98 | 1.37 | 0.72 | 0.69 | 0.31 | 0.23 |
| B | 0.70 | 2.26 | 4.92 | 10.36 | 5.53 | 6.07 | 5.11 | 3.20 | 1.19 | 1.26 | 0.83 | 0.33 |
| C | 2.28 | 16.11 | 16.50 | 12.74 | 9.06 | 7.24 | 4.41 | 2.00 | 2.25 | 0.63 | 0.42 | 0.23 |
| D | 1.93 | 1.83 | 4.28 | 7.97 | 8.53 | 2.86 | 2.05 | 1.13 | 0.81 | 0.61 | 0.55 | 0.22 |
| E | 5.20 | 7.06 | 10.36 | 9.20 | 9.21 | 5.44 | 2.37 | 1.69 | 0.34 | 0.54 | 0.36 | 0.20 |
| F | 1.79 | 8.78 | 12.02 | 14.34 | 7.48 | 3.98 | 2.40 | 1.08 | 0.70 | 0.51 | 0.34 | 0.20 |
| Meansigma methods ± SD | 2.96 1.66 | 7.04 5.39 | 9.50 4.57 | 10.18 2.94 | 7.69 1.51 | 4.97 1.58 | 3.05 1.35 | 1.75 0.79 | 1.00 0.67 | 0.71 0.28 | 0.47 0.20 | 0.24 0.05 |
ND is lower than 0.094 μ g/ml.
Table 3. beasle dog single oral dose ranolazine sustained release tablets (500mg/ sheet * 1) back blood plasma Chinese medicine concentration (μ g/ml)
| Time (h) | 0.25 | 0.5 | 0.75 | 1 | 1.5 | 2 | 3 | 4 | 6 | 8 | 12 | 24 |
| A | 0.81 | 2.74 | 9.07 | 13.24 | 10.35 | 4.66 | 2.36 | 1.16 | 0.80 | 1.01 | 0.62 | 0.34 |
| B | 1.70 | 2.36 | 2.68 | 4.12 | 7.08 | 17.93 | 11.12 | 3.75 | 1.55 | 1.33 | 0.64 | 0.26 |
| C | 2.34 | 4.99 | 4.73 | 13.23 | 14.98 | 13.54 | 7.86 | 3.98 | 1.11 | 1.68 | 1.12 | 0.41 |
| D | 0.70 | 0.79 | 2.12 | 3.82 | 5.06 | 7.68 | 6.01 | 3.37 | 0.89 | 0.55 | 0.44 | 0.21 |
| E | 1.16 | 2.59 | 5.08 | 14.37 | 10.36 | 7.86 | 3.24 | 1.69 | 1.14 | 0.84 | 0.46 | 0.26 |
| F | 0.58 | 1.71 | 2.80 | 10.33 | 16.10 | 8.35 | 2.91 | 1.38 | 0.89 | 0.69 | 0.43 | 0.27 |
| Meansigma methods ± SD | 1.21 0.69 | 2.53 1.41 | 4.41 2.57 | 9.85 4.75 | 10.66 4.30 | 10.00 4.83 | 5.58 3.44 | 2.55 1.28 | 1.06 0.27 | 1.02 0.42 | 0.62 0.26 | 0.29 0.07 |
ND is lower than 0.094 μ g/ml.
Pharmacokinetic parameters behind the table 4. beasle dog single oral dose ranolazine ordinary tablet (333.3mg/ sheet * 1)
| No | Cmax μg/ml | Tmax h | t 1/2h | MRT h | AUC 0-τ μg.h/ml | AUC 0-∞ μg.h/ml | Cl/F l/kg/h | V β/F l/kg |
| A | 8.94 | 0.75 | 11.78 | 9.57 | 25.17 | 29.06 | 1.83 | 31.12 |
| B | 10.36 | 1 | 8.51 | 8.91 | 37.91 | 42.01 | 1.23 | 15.07 |
| C | 16.50 | 0.75 | 11.49 | 7.04 | 42.00 | 45.80 | 1.21 | 20.11 |
| D | 8.53 | 1.5 | 10.19 | 9.41 | 24.30 | 27.47 | 1.78 | 26.25 |
| E | 10.36 | 0.75 | 11.79 | 7.99 | 29.07 | 32.49 | 1.65 | 28.16 |
| F | 14.34 | 1 | 12.83 | 8.53 | 28.61 | 32.37 | 1.51 | 28.03 |
| Meansigma methods ± SD | 11.51 3.20 | 1.0 0.3 | 11.10 1.52 | 8.57 0.95 | 31.18 7.17 | 34.87 7.36 | 1.54 0.27 | 24.79 6.00 |
Table 5. beasle dog single oral dose ranolazine sustained release tablets (500mg/ sheet * 1) back pharmacokinetic parameters
| No | Cmax μg/ml | Tmax h | t 1/2 h | MRT h | AUC 0-τ μg.h/ml | AUC 0-∞ μg.h/ml | F | Cl/F l/kg/h | V β/F l/kg |
| A | 13.24 | 1 | 10.77 | 10.21 | 32.49 | 37.74 | 86.0％ | 1.41 | 21.90 |
| B | 17.93 | 2 | 7.23 | 6.24 | 50.74 | 53.45 | 89.1％ | 0.96 | 10.06 |
| C | 14.98 | 1.5 | 7.99 | 7.55 | 58.10 | 62.85 | 92.1％ | 0.88 | 10.20 |
| D | 7.68 | 2 | 11.35 | 8.69 | 29.91 | 33.32 | 82.0％ | 1.47 | 24.09 |
| E | 14.37 | 1 | 10.47 | 8.26 | 34.49 | 38.48 | 79.0％ | 1.40 | 21.11 |
| F | 16.10 | 1.5 | 12.52 | 9.32 | 33.33 | 38.14 | 77.6％ | 1.29 | 23.23 |
| Meansigma methods ± SD | 14.05 3.50 | 1.5 0.5 | 10.06 2.03 | 8.38 1.39 | 39.85 11.62 | 44.00 11.51 | 84.3％ 5.7％ | 1.24 0.25 | 18.43 6.51 |
MRT: average residence time, AUC
0-τ: the area under the drug-time curve in the dosing interval, Cmax: peak concentration, Tmax: peak time,
t
1/2: eliminate the half-life.
By measurement result as seen, blood drug level rises slow, steady after the administration of ranolazine hydrochloride slow-release sheet.After beasle dog single oral dose ranolazine hydrochloride ordinary tablet (333.3mg base/sheet * 1) and the slow releasing tablet (500mg base/sheet * 1), both Cmax are respectively 11.51 ± 3.20 and 14.05 ± 3.50 μ g/ml; Tmax is respectively 1.0 ± 0.3 and 1.5 ± 0.5h; t
1/2Be respectively 11.10 ± 1.52 and 10.06 ± 1.39h; AUC
0-τBe respectively 31.18 ± 7.17 and 39.85 ± 11.62 μ g.h/ml.The relative bioavailability of slow releasing tablet is 84.3%.
Two, multiple dose test
Blood medicine-valley concentration (μ g/ml) after table 6. beasle dog oral multiple dose ranolazine hydrochloride ordinary tablet or the slow releasing tablet
| No | Second day IRCR | The 3rd day IRCR | The 4th day IRCR | The 5th day IRCR |
| A B C D E F | 0.47 0.78 0.34 0.94 0.44 0.54 0.79 0.23 0.48 0.36 0.76 0.40 | 0.46 0.26 0.52 0.73 0.37 0.29 0.84 1.24 0.57 0.47 0.57 0.97 | 0.21 1.00 0.73 0.88 0.28 0.83 0.48 0.43 1.00 0.52 1.06 0.52 | 0.21 0.74 1.03 1.60 0.70 0.33 0.80 0.23 0.31 0.27 0.91 1.04 |
| Meansigma methods ± SD | 0.55 0.57 0.19 0.30 | 0.55 0.66 0.16 0.39 | 0.63 0.70 0.36 0.24 | 0.66 0.70 0.33 0.54 |
IR: ordinary tablet; CR: slow releasing tablet
The oral multiple dose ranolazine of table 7. beasle dog ordinary tablet reaches blood plasma Chinese medicine concentration (μ g/ml) after the stable state
| Time (h) | A | B | C | D | E | F | Meansigma methods | ± |
| 0 | 0.21 | 1.03 | 0.70 | 0.80 | 0.31 | 0.91 | 0.66 | 0.33 |
| 0.25 | 0.89 | 2.62 | 11.09 | 0.97 | 0.34 | 1.51 | 2.90 | 4.08 |
| 0.5 | 3.31 | 5.56 | 8.07 | 2.51 | 1.15 | 6.82 | 4.57 | 2.68 |
| 1 | 2.83 | 6.50 | 4.99 | 7.11 | 7.48 | 8.54 | 6.24 | 2.04 |
| 3 | 2.53 | 4.14 | 4.42 | 4.21 | 3.82 | 6.43 | 4.26 | 1.26 |
| 5 | 0.64 | 1.68 | 1.77 | 1.37 | 1.16 | 1.72 | 1.39 | 0.44 |
| 8 | 0.64 | 1.08 | 0.73 | 0.64 | 0.70 | 0.64 | 0.74 | 0.17 |
| 8.25 | 0.90 | 2.19 | 0.60 | 3.46 | 4.73 | 0.62 | 2.08 | 1.71 |
| 8.5 | 2.45 | 6.09 | 0.89 | 4.15 | 7.77 | 0.64 | 3.67 | 2.87 |
| 9 | 5.59 | 5.94 | 1.82 | 7.51 | 5.83 | 3.25 | 4.99 | 2.07 |
| 11 | 2.03 | 3.07 | 3.94 | 2.73 | 1.53 | 2.54 | 2.64 | 0.84 |
| 13 | 1.12 | 1.03 | 2.79 | 1.68 | 0.91 | 1.66 | 1.53 | 0.70 |
| 16 | 0.66 | 0.88 | 0.29 | 0.80 | 0.52 | 1.22 | 0.73 | 0.32 |
| 24 | 0.11 | 0.24 | 0.15 | 0.09 | 0.11 | 0.40 | 0.18 | 0.12 |
The oral multiple dose ranolazine sustained release tablets of table 8. beasle dog reaches blood plasma Chinese medicine concentration (μ g/ml) after the stable state
| Time (h) | A | B | C | D | E | F | Meansigma methods | ± |
| 0 | 0.74 | 1.60 | 0.33 | 0.23 | 0.27 | 1.05 | 0.70 | 0.55 |
| 0.25 | 2.10 | 1.33 | 0.30 | 0.86 | 0.57 | 1.10 | 1.04 | 0.64 |
| 0.5 | 2.20 | 1.84 | 0.42 | 5.37 | 2.22 | 2.12 | 2.36 | 1.63 |
| 0.75 | 2.56 | 4.07 | 1.15 | 5.61 | 1.80 | 3.06 | 3.04 | 1.62 |
| 1 | 2.53 | 2.79 | 1.76 | 7.91 | 3.78 | 4.64 | 3.90 | 2.21 |
| 1.5 | 3.32 | 4.32 | 2.77 | 2.73 | 5.56 | 7.14 | 4.31 | 1.76 |
| 2 | 2.24 | 7.83 | 5.40 | 5.48 | 4.94 | 7.19 | 5.51 | 1.96 |
| 3 | 6.71 | 8.42 | 4.55 | 3.74 | 2.83 | 5.28 | 5.25 | 2.04 |
| 4 | 4.80 | 5.06 | 3.02 | 2.68 | 1.93 | 4.30 | 3.63 | 1.27 |
| 6 | 3.52 | 2.77 | 1.89 | 2.38 | 1.39 | 2.09 | 2.34 | 0.74 |
| 8 | 0.54 | 1.57 | 1.67 | 3.15 | 1.36 | 2.06 | 1.73 | 0.86 |
| 12 | 0.36 | 3.67 | 0.58 | 1.10 | 0.93 | 1.32 | 1.33 | 1.20 |
| 24 | 0.14 | 0.37 | 0.15 | 0.12 | 0.20 | 0.24 | 0.20 | 0.10 |
Pharmacokinetic parameters behind the oral multiple dose ranolazine of the table 9. beasle dog ordinary tablet
| Common | Cmax | Tmax | Cmin | Cav | DF | AUCss |
| A | 4.45 | 0.5 | 0.43 | 1.96 | 2.04 | 15.65 |
| B | 6.30 | 1 | 0.96 | 3.12 | 1.71 | 24.93 |
| C | 7.52 | 0.25 | 0.50 | 2.97 | 2.26 | 23.78 |
| D | 7.31 | 1 | 0.64 | 3.01 | 2.21 | 24.11 |
| E | 7.63 | 1 | 0.42 | 2.62 | 2.76 | 20.94 |
| F | 5.89 | 1 | 0.63 | 3.12 | 1.57 | 24.98 |
| Meansigma methods ± SD | 6.52 1.23 | 0.79 0.33 | 0.60 0.23 | 2.80 0.45 | 2.09 0.42 | 22.40 3.62 |
Pharmacokinetic parameters behind the oral multiple dose ranolazine sustained release tablets of table 10. beasle dog
| Slow release | Cmax | Tmax | Cmin | Cav | DF | AUCss |
| A | 6.71 | 3 | 0.36 | 2.45 | 2.59 | 29.38 |
| B | 8.42 | 3 | 1.33 | 3.73 | 1.90 | 44.70 |
| C | 5.40 | 2 | 0.30 | 2.13 | 2.39 | 25.61 |
| D | 7.91 | 1 | 0.23 | 2.97 | 2.59 | 35.60 |
| E | 5.56 | 1.5 | 0.27 | 1.96 | 2.70 | 23.54 |
| F | 7.19 | 2 | 1.04 | 3.09 | 1.99 | 37.10 |
| Meansigma methods ± SD | 6.86 1.22 | 2.1 0.8 | 0.59 0.47 | 2.72 0.66 | 2.36 0.34 | 32.66 7.96 |
By measurement result as seen, after beasle dog oral multiple dose ranolazine hydrochloride ordinary tablet and the slow releasing tablet, its peak concentration Cmax is respectively 6.52 ± 1.23 and 6.86 ± 1.22 μ g/ml; Paddy concentration C min is respectively 0.60 ± 0.23 and 0.59 ± 0.47 μ g/ml; Peak time Tmax is respectively 0.79 ± 0.33 and 2.10 ± 0.8h; Stable state area under the drug-time curve AUC
SsBe respectively 22.4 ± 3.62 and 32.66 ± 7.96 μ g.h/ml; Both coefficient of variation DF are respectively 2.09 ± 0.42 and 2.36 ± 0.34.Cav is average blood drug level.Result of study confirms, no matter single or multiple administration, and slow releasing tablet reaches the peak and all obviously postpones, the blood drug level peak steadily and broadening shows that the ranolazine hydrochloride slow-release sheet has certain slow release effect, and the relative bioavailability of slow releasing tablet〉80%.
Above result of the test shows, ranolazine hydrochloride slow-release preparation of the present invention has rate of release equilibrium, production technology advantage simple, easy to use, can provide convenience for the patient of numerous cardiovascular disease, practical, effect good quality production, have obvious social and economic benefit.
(4) description of drawings
Fig. 1 is the average blood drug level-time graph after beasle dog single oral dose ranolazine hydrochloride ordinary tablet (333.3mg) and the slow releasing tablet (500mg); Fig. 2 is the average blood drug level-time graph after beasle dog oral multiple dose ranolazine hydrochloride ordinary tablet and the slow releasing tablet; Wherein, reference is meant the average blood drug level-time graph behind the beasle dog oral hydrochloride ranolazine ordinary tablet, is tried to be meant the average blood drug level-time graph behind the beasle dog oral hydrochloride ranolazine sustained release tablets.
Fig. 3 is the release in vitro curve of the ranolazine hydrochloride slow-release sheet of embodiment 4,6,11.
Fig. 4 is the external stripping curve of the ranolazine hydrochloride ordinary tablet of Comparative Examples 1.
(5) specific embodiment
The present invention will be further described below in conjunction with embodiment.
Embodiment 1
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) hydroxypropyl emthylcellulose and the ethyl cellulose of formula ratio are crossed 5 times abundant mixings of 40 mesh sieves.
(2) ranolazine hydrochloride is mixed with the equivalent method of progressively increasing with material in (1), cross 5 times abundant mixings of 40 mesh sieves.
(3) in the material of above-mentioned mix homogeneously, add 85% an amount of ethanol water, mix homogeneously, the system soft material is crossed 20 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(4) magnesium stearate of adding formula ratio, dried granule is crossed 20 mesh sieve granulate, and fully mixing is measured granule content, and it is heavy to calculate sheet, tabletting.
(5) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
As described in embodiment 1, different is, replaces hydroxypropyl emthylcellulose HPMC K100M CR with hydroxypropyl emthylcellulose HPMC K4M CR,
RS PO consumption increases to 60g, replaces ethyl cellulose EC10CP STD.PREM.FP and consumption to reduce to 25.8g with ethyl cellulose EC100CPSTD.PREM.FP.
Embodiment 3
As described in embodiment 1, different is that hydroxypropyl emthylcellulose (HPMC K100M CR) consumption increases to 90g, uses
RL PO replaces
RS PO, the ethyl cellulose consumption reduces to 27g.
As described in embodiment 1, different is, replaces hydroxypropyl emthylcellulose (HPMC K100M CR) and consumption to increase to 90g with hydroxypropyl emthylcellulose (HPMC K4M CR), and the ethyl cellulose consumption reduces to 30g, uses
RL PO replaces
RS PO and consumption reduce to 35g.
As described in embodiment 1, different is, replaces hydroxypropyl emthylcellulose (HPMC K100M CR) consumption to reduce to 62g with hydroxypropyl emthylcellulose (HPMC K4M CR), and the ethyl cellulose consumption reduces to 30g, uses
RLPO replaces
RS PO and consumption increase to 80g, and the magnesium stearate consumption reduces to 8g.
As described in embodiment 1, different is, replaces hydroxypropyl emthylcellulose (HPMC K100M CR) consumption to increase to 90g with hydroxypropyl emthylcellulose (HPMC K4M CR), and the ethyl cellulose consumption reduces to 10g, uses
RLPO replaces
RS PO and consumption increase to 80g, and the magnesium stearate consumption reduces to 8g.
Embodiment 7
As described in embodiment 1, different is, replaces hydroxypropyl emthylcellulose (HPMC K100M CR) consumption to reduce to 50g with hydroxypropyl emthylcellulose (HPMC K4M CR), and the ethyl cellulose consumption reduces to 20g, uses
RLPO replaces
RS PO and consumption increase to 80g, and the magnesium stearate consumption reduces to 8g, replace 85% ethanol water with 70% ethanol water.
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) hydroxypropyl emthylcellulose and the ethyl cellulose of formula ratio are crossed 5 times abundant mixings of 40 mesh sieves.
(2) ranolazine hydrochloride is mixed with the equivalent method of progressively increasing with material in (1), cross 5 times abundant mixings of 40 mesh sieves.
(3) will
RL100 is dissolved in the 85% an amount of ethanol water as binding agent.
(4) will
85% ethanol water of RL100 adds in the material of above-mentioned mix homogeneously, mix homogeneously, and the system soft material is crossed 20 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(5) magnesium stearate of adding formula ratio, dried granule is crossed 20 mesh sieve granulate, and fully mixing is measured granule content, and it is heavy to calculate sheet, tabletting.
(6) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
Embodiment 9
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) hydroxypropyl emthylcellulose, carbomer, the microcrystalline Cellulose of formula ratio are crossed 5 times abundant mixings of 40 mesh sieves.
(2) ranolazine hydrochloride is mixed with the equivalent method of progressively increasing with material in (1), cross 5 times abundant mixings of 40 mesh sieves.
(3) magnesium stearate of adding formula ratio, fully mixing is measured granule content, and it is heavy to calculate sheet, direct powder compression.
(4) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
As described in embodiment 9, different is, replaces hydroxypropyl emthylcellulose (HPMC K100M CR) and consumption to increase to 70g with hydroxypropyl emthylcellulose (HPMC K4M CR), removes microcrystalline Cellulose.
Embodiment 11
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) hydroxypropyl emthylcellulose and the ethyl cellulose of formula ratio are crossed 5 times abundant mixings of 40 mesh sieves.
(2) ranolazine hydrochloride is mixed with the equivalent method of progressively increasing with material in (1), cross 5 times abundant mixings of 40 mesh sieves.
(3) in the material of above-mentioned mix homogeneously, add an amount of dehydrated alcohol, mix homogeneously, the system soft material is crossed 20 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(4) magnesium stearate of adding formula ratio, dried granule is crossed 20 mesh sieve granulate, and fully mixing is measured granule content, and it is heavy to calculate sheet, tabletting.
(5) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) with the Cera Flava of formula ratio in 100 ℃ of heating in water bath fusions, add the ranolazine hydrochloride of formula ratio, make its mix homogeneously.
(2) with the cooling of (1) material, pulverize, cross 40 mesh sieves, add the magnesium stearate of formula ratio, mix homogeneously is measured granule content, and it is heavy to calculate sheet, tabletting.
(3) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
Embodiment 13
As described in embodiment 12, different is to replace Cera Flava and consumption to increase to 450g with stearic acid.
As described in embodiment 12, different is, replaces Cera Flava and consumption to increase to 300g with hydrogenated vegetable oil, increases to 150g with ethyl cellulose place of magnesium stearate magnesium and consumption.
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) ranolazine hydrochloride and the hydrogenated vegetable oil of formula ratio are crossed 5 times abundant mixings of 40 mesh sieves.
(2) ethyl cellulose is mixed with the equivalent method of progressively increasing with material in (1), cross 5 times abundant mixings of 40 mesh sieves.
(3) sucrose ester of adding formula ratio, fully mixing is measured granule content, and it is heavy to calculate sheet, direct powder compression.
(4) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
Embodiment 16
As described in embodiment 15, different is, with micropowder silica gel place of sucrose ester, the hydrogenated vegetable oil consumption increases to 300g, and the ethyl cellulose consumption reduces to 150g.
Embodiment 17
The ranolazine hydrochloride slow-release slice prescription:
Per 1000 ranolazine hydrochloride slow-release sheets contain
(1) ranolazine hydrochloride and the hydrogenated vegetable oil of formula ratio are crossed 5 times abundant mixings of 40 mesh sieves.
(2) ethyl cellulose is mixed with the equivalent method of progressively increasing with material in (1), cross 5 times abundant mixings of 40 mesh sieves.
(3) hydroxypropyl emthylcellulose is mixed with the equivalent method of progressively increasing with material in (2), cross 5 times abundant mixings of 40 mesh sieves.
(4) in the material of above-mentioned mix homogeneously, add 8% an amount of polyvinylpyrrolidone K
30Ethanol solution, mix homogeneously, the system soft material is crossed 20 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(5) 20 mesh sieve granulate are crossed in the micropowder silica gel of adding formula ratio, and fully mixing is measured granule content, calculate sheet and weigh tabletting.
(6) can pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation at this slow releasing tablet skin, the coatings weightening finish is about 1.0～3.0%.
Embodiment 18
As described in embodiment 17, different is, replaces HPMC K4M CR and consumption to reduce to 50g with lactose, and the hydrogenated vegetable oil consumption increases to 375g, and the ethyl cellulose consumption reduces to 25g.
Embodiment 19
Ranolazine hydrochloride bag core slow releasing tablet prescription:
The interior chip of per 1000 ranolazine hydrochloride slow-release sheets contains
The outer-skin sheet of per 1000 ranolazine hydrochloride slow-release sheets contains
1, the preparation of interior chip:
(1) ranolazine hydrochloride and the cross-linking sodium carboxymethyl cellulose with formula ratio mixes with the equivalent method of progressively increasing, and crosses 5 times abundant mixings of 40 mesh sieves.
(2) in the material of above-mentioned mix homogeneously, add 10% an amount of polyvinylpyrrolidone K
3050% ethanol water, mix homogeneously, the system soft material is crossed 24 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(3) magnesium stearate of adding formula ratio is crossed 20 mesh sieve granulate, and fully mixing is measured granule content, calculates sheet and weighs, and is pressed into the interior chip of diameter 9mm.
2, the preparation of clad sheet:
(1) formula ratio by outer-skin sheet takes by weighing hydroxypropyl emthylcellulose and ethyl cellulose, crosses 5 times abundant mixings of 40 mesh sieves.
(2) take by weighing ranolazine hydrochloride by the formula ratio of outer-skin sheet and mix with the equivalent method of progressively increasing, cross 5 times abundant mixings of 40 mesh sieves with material in (1).
(3) in the material of above-mentioned mix homogeneously, add 90% an amount of ethanol water, mix homogeneously, the system soft material is crossed 20 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(4) magnesium stearate of adding formula ratio is crossed 20 mesh sieve granulate, and fully mixing is measured granule content, calculates sheet and weighs.
(5) the outer granule with the moiety formula ratio places nib, then label is placed nib central authorities, adds second half outer granule, is pressed into the clad sheet of diameter 12mm together.
(6) can wrap core slow releasing tablet skin at this and pack outward appearance, the sense of taste and the stability etc. of one deck coatings to improve preparation, the coatings weightening finish is about 1.0～3.0%.
Comparative Examples 1
Ranolazine hydrochloride ordinary tablet prescription:
Per 1000 ranolazine hydrochloride ordinary tablets contain
(1) ranolazine hydrochloride and the cross-linking sodium carboxymethyl cellulose with formula ratio mixes with the equivalent method of progressively increasing, and crosses 5 times abundant mixings of 40 mesh sieves.
(2) in the material of above-mentioned mix homogeneously, add 95% an amount of ethanol water, mix homogeneously, the system soft material is crossed 24 mesh sieves and is granulated, 40～50 ℃ of dryings 2 hours.
(3) magnesium stearate of adding formula ratio is crossed 20 mesh sieve granulate, and fully mixing is measured granule content, calculates sheet and weighs tabletting.
Experimental example 1
The release in vitro of ranolazine hydrochloride ordinary tablet and slow releasing tablet relatively
According to dissolution method (two appendix XC first methods of Chinese Pharmacopoeia version in 2005), be dissolution medium with 0.1mol/LHCL, rotating speed is that per minute 100 changes, 37 ℃ ± 0.5 ℃ of temperature is measured ordinary tablet at 5,10,15,20,30,45 minutes dissolution.The results are shown in Table 11, Fig. 4.
According to drug release determination method (two appendix XD first methods of Chinese Pharmacopoeia version in 2005), adopt dissolution method (two appendix XC first methods of Chinese Pharmacopoeia version in 2005) device, with 0.1mol/LHCL (0～1 hour)+pH5.8 phosphate buffer (1～3 hour)+pH6.8 phosphate buffer (3～12 hours) 900ml is release medium, rotating speed is that per minute 150 changes, 37 ℃ ± 0.5 ℃ of temperature, measure slow releasing tablet 1,2,3,5,8,10, the release of 12h.The results are shown in Table 12, Fig. 3.
The cumulative in vitro dissolution of the ranolazine hydrochloride ordinary tablet of table 11. embodiment 1
By table 11,12 as can be seen, the ranolazine hydrochloride ordinary tablet is being no more than stripping fully in 30 minutes, and the release in vitro time of ranolazine hydrochloride slow-release sheet obviously prolongs.
Above embodiment describes ranolazine hydrochloride slow-release preparation of the present invention and preparation method thereof in detail, is to representative illustration of the present invention, rather than limiting the scope of the invention.
Claims (7)
1. ranolazine hydrochloride slow-release preparation is characterized in that being made by the ethanol water of non-pH dependency acrylic resin, 2wt% magnesium stearate and the wetting amount of the ethyl cellulose of the hydroxypropyl emthylcellulose of the ranolazine hydrochloride of 77wt%, 10wt%, 5wt%, 6wt%.
2. ranolazine hydrochloride slow-release preparation as claimed in claim 1 is characterized in that described hydroxypropyl emthylcellulose is E4MCR, E10M CR, K100-LV CR, K4M CR, K15M CR or K100M CR.
3. ranolazine hydrochloride slow-release preparation as claimed in claim 1 is characterized in that described ethyl cellulose is the ethyl cellulose of the following micro powder grade of particle diameter 150um, and viscosity is 6～100 centipoises.
4. ranolazine hydrochloride slow-release preparation as claimed in claim 1 is characterized in that described non-pH dependency acrylic resin is quaternary amine ylmethyl acrylate copolymer A type or Type B or neutral polymethacrylates.
5. ranolazine hydrochloride slow-release preparation as claimed in claim 1 is characterized in that per 1000 ranolazine hydrochloride slow-release preparations are by 600g ranolazine hydrochloride, 78g hydroxypropyl emthylcellulose, 39g ethyl cellulose, 46.8g
PO, 15.6g magnesium stearate and an amount of 85% ethanol water are made.
6. a ranolazine hydrochloride slow-release preparation is characterized in that per 1000 ranolazine hydrochloride slow-release preparations are by 300g ranolazine hydrochloride, 250g hydroxypropyl emthylcellulose, 100g hydrogenated vegetable oil, 100g ethyl cellulose, 10g micropowder silica gel and 8% an amount of polyvinylpyrrolidone K
30Ethanol solution is made.
7. ranolazine hydrochloride slow-release preparation as claimed in claim 1 is characterized in that described preparation is a tablet.
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| CN102144986B (en) * | 2011-04-18 | 2012-10-17 | 沈阳药科大学 | Potassium chloride cyclopenthiazide sustained release tablet and preparation method thereof |
| CN103565767B (en) * | 2012-08-07 | 2018-03-02 | 上海开拓者生物医药有限公司 | Ranolazine sustained release tablets label, coating tablet and preparation method thereof |
| TW201717919A (en) * | 2015-07-02 | 2017-06-01 | 國際藥品股份公司 | Ranolazine multiple compressed tablets |
| WO2018001582A1 (en) | 2016-06-30 | 2018-01-04 | Interquim, S.A. | Ranolazine multiple compressed tablets |
| US20220062305A1 (en) * | 2018-12-18 | 2022-03-03 | DDP Specialty Electronic Materials US, Inc. | Sustained release composition comprising an ethylcellulose |
| CN111000818A (en) * | 2020-01-04 | 2020-04-14 | 东莞市东阳光仿制药研发有限公司 | Ranolazine composition and preparation method thereof |
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