CN100515505C - Method for preparing artificial breast wall and artificial bone material - Google Patents
Method for preparing artificial breast wall and artificial bone material Download PDFInfo
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- CN100515505C CN100515505C CNB200610026296XA CN200610026296A CN100515505C CN 100515505 C CN100515505 C CN 100515505C CN B200610026296X A CNB200610026296X A CN B200610026296XA CN 200610026296 A CN200610026296 A CN 200610026296A CN 100515505 C CN100515505 C CN 100515505C
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Abstract
The present invention relates to a preparation method of artificial thoracic wall and artificial bone material. Said method includes the following steps: mixing polylactic acid fibre and chitosan fibre, weaving them into fabric with 100 um-350 um holes; mixing polylactic acid chips and polycaprolactone chips according to weight ratio of 1:0.05-1.25, then mixing them with chitosan fibre and pressing them to obtain plate material; wrapping said plate material with the above-mentioned obtained fabric, and adopting sewing mode to make three layers be connected together. Said material can be used for repairing thoracic wall with large-area deficiency and forming new bone.
Description
Technical field
The present invention relates to a kind of preparation method of medical artificial bone, particularly relate to the artificial breast wall of " sandwich " formula that a kind of degradable fabric and sheet material forms or artificial bone and preparation method thereof
Background technology
Artificial breast wall can have a variety of materials to prepare according to report.Human body self tissue and allosome tissue, comprising using musculo cutaneous flap, the periosteum lobe is from body fascia lata, diaphram, rib etc.Metal material comprises tantalum piece, titanium sheet, the wire netting that titanium alloy, rustless steel etc. are made, metallic plate, bonding jumper and metal bar.Inorganic material and ceramic material, for example, bioceramic, bio-vitric, calcium phosphate, bone cement, hydroxyapatite etc.Synthetic material, wherein using polypropylene and polyester is to use more clinically and successful artificial breast wall material for " sandwich " formula material of at present main fibers encapsulation bone cement.The porous sheet material that also has polylactic acid and polycaprolactone in addition, Gore-Tex sticking patch and prolene net, teflon plate and the artificial rib of porous lucite; Use terylene, what real silk net enwrapped granule shape calcium phosphate made that artificial rib and breastbone etc. all have article report and a success is applied to clinical large tracts of land (in the operation that the chest wall defect of 10cm * 10cm) is repaired.
Recently, by two armies big cooperate to prepare with the enhanced polycaprolactone artificial breast wall of chitosan fiber rib with the university of communications also be successfully applied in the clinical experiment of Canis familiaris L..Yet above-mentioned kinds of artificial thoracic wall or artificial bone all can not be degraded at inside of human body, or degradation time is oversize, and major part does not all have to create the objective condition that osteoblast is creeped.
Up to now, still none uses clinically, and is degradable, and large tracts of land is repaired, and can impel osteoblast to creep, the report of artificial breast wall material or artificial bone.
Recently, the lot of domestic and international scientist all to how to solve degradable and the problem of impelling osteoblast to creep on study.Everybody wishes the material that can find to meet the following conditions:
(1) can be fixed in the thoracic wall, keep the tensile strength of regular period, wait until that new rib forms, the degraded of energy synchronous biological disappears;
(2) good biocompatibility.
(3) avirulence and carcinogenecity.
(4) can impel osteoblast to creep, form new bone on the surface.
(5) after biodegradable being absorbed by the body, discharge be avirulent micromolecule.
(6) can make random size and the impaired bone wound of support bulk.
(7) can regulate degradation time etc. according to clinical demand.
(8) cost performance inexpensive, that good processability is become reconciled.
Summary of the invention
Technical problem to be solved by this invention provides the preparation method of a kind of artificial breast wall or artificial bone, to remedy the deficiencies in the prior art or defective, satisfies the needs of medical science and specific crowd.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: the preparation method of a kind of artificial breast wall or artificial bone comprises the steps:
(1) adopt melt-spun, dry-spinning or dry-jet wet-spinning to carry out the polylactic acid-based section of spinning and chitosan section with 1: 0.1～1.5 weight ratio blend, braiding that reuse is conventional or manual or knitting method are made has 100um～two dimension or the three-dimensional fabric of 350um hole;
(2) section of polylactic acid-based section and polycaprolactone is 1: 0.05～1.25 ratio blend with weight ratio, adopting part by weight with polylactic acid-based section is that 1: 0.001～0.25 chitosan fiber is as reinforcing material, with fiber and the equidirectional mode blend of length, reuse high pressure tablet machine is at 70 ℃～200 ℃, and 3～9 atmospheric pressure are suppressed down and formed sheet material;
(3) the prepared fabric of step (1) size is as required wrapped up the prepared sheet material of step (2), adopt the mode of sewing up that three layers are linked together.
As optimized technical scheme: described poly lactic acid comprises long fibre or short fiber, and the viscosity of its raw material is IV=1.5～2.75.
Described poly lactic acid is Poly-L-lactic acid fiber, dextrorotation acid fiber by polylactic or the left and right acid fiber by polylactic with various ratio blend, poly-Acetic acid, hydroxy-, bimol. cyclic ester or the lactide copolymer fibre of revolving.
Described chitosan fiber comprises long fibre or short fiber, and molecular weight is 50,000～150,000.
The viscosity of described polycaprolactone section is IV=1.5-2.50.
Described polylactic acid-based (D-PLLA, DL-PLLA, L-PLLA, PGLA) Qie Pian viscosity IV=1.75-8.75
The invention has the beneficial effects as follows: the artificial breast wall or the artificial bone of prepared " sandwich " formula, have after repairing the thoracic wall of large defect, can be fixed in keep long-term tensile strength, good biocompatibility, nontoxic non-carcinogenesis in the thoracic wall, can impel osteocyte to creep to form new bone on the surface, biodegradable, absorbed the back, discharge nontoxic micromolecule, can make random size and support the impaired bone wound of bulk by human body and have the advantage of anti-inflammation.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further elaborated.
Embodiment 1
(1) is that the Poly-L-lactic acid long fibre of dry-jet wet-spinning of IV=2.75 and molecular weight are 100,000 chitosan long fibres with 1: 1 ratio blend with viscosity, is made into the fabric that a slice has the two dimension of 350um hole;
(2) with the section of the polycaprolactone of the Poly-L-lactic acid of IV=6.75 and the IV=2.50 ratio blend with 1: 0.75, the weight ratio that adds again with polylactic acid-based section is 1: 0.005 chitosan long fibre;
(3) blend that step (2) is obtained does not have and is put into longly for 10cm, width are 5cm, and the degree of depth is in the mould of 4cm; Mould is placed in the high pressure tablet machine,, is pressed into sheet material under 6 atmospheric pressure at 180 ℃;
(4) with the prepared fabric of step (1) the described sheet material of step (3) size is as required wrapped up, promptly obtain the artificial breast wall or the artificial bone of " sandwich " formula.
Embodiment 2
(1) is that the Poly-L-lactic acid long fibre of dry-jet wet-spinning of IV=1.5 and molecular weight are 150,000 chitosan long fibres with 1: 1.5 ratio blend with viscosity, is made into the fabric that a slice has the two dimension of 100um hole;
(2) with the section of the polycaprolactone of the Poly-L-lactic acid of IV=1.75 and the IV=1.5 ratio blend with 1: 0.05, the weight ratio that adds again with polylactic acid-based section is 1: 0.25 chitosan long fibre;
(3) blend that step (2) is obtained does not have and is put into longly for 10cm, width are 5cm, and the degree of depth is in the mould of 4cm; Mould is placed in the high pressure tablet machine,, is pressed into sheet material under 9 atmospheric pressure at 70 ℃;
(4) the prepared fabric of step (1) wraps up the described sheet material of step (3) size as required, promptly obtains the artificial breast wall or the artificial bone of " sandwich " formula.
Embodiment 3
(1) is that the Poly-L-lactic acid long fibre of dry-jet wet-spinning of IV=2 and molecular weight are 50,000 chitosan long fibre with 1: 0.1 ratio blend with viscosity, is made into the fabric that a slice has the two dimension of 200um hole;
(2) with the section of the polycaprolactone of the Poly-L-lactic acid of IV=8.75 and the IV=2 ratio blend with 1: 1.25, the weight ratio that adds again with polylactic acid-based section is 1: 0.001 chitosan long fibre;
(3) blend that step (2) is obtained does not have and is put into longly for 10cm, width are 5cm, and the degree of depth is in the mould of 4cm; Mould is placed in the high pressure tablet machine,, is pressed into sheet material under 3 atmospheric pressure at 200 ℃;
(4) with the prepared fabric of step (1) the described sheet material of step (3) size is as required wrapped up, promptly obtain the artificial breast wall or the artificial bone of " sandwich " formula.
Claims (6)
1, the preparation method of a kind of artificial breast wall or artificial bone is characterized in that, comprises the steps:
(1) adopt melt-spun, dry-spinning or dry-jet wet-spinning to carry out the poly lactic acid of spinning and chitosan fiber with 1: 0.1～1.5 weight ratio blend, braiding that reuse is conventional or manual or knitting method are made has 100um～two dimension or the three-dimensional fabric of 350um hole;
(2) section of polylactic acid-based section and polycaprolactone is 1: 0.05～1.25 ratio blend with weight ratio, adopting part by weight with polylactic acid-based section is that 1: 0.001～0.25 chitosan fiber is as reinforcing material, with fiber and the equidirectional mode blend of length, reuse high pressure tablet machine is at 70 ℃～200 ℃, and 3～9 atmospheric pressure are suppressed down and formed sheet material;
(3) the prepared fabric of step (1) size is as required wrapped up the prepared sheet material of step (2), adopt the mode of sewing up that three layers are linked together.
2, preparation method according to claim 1 is characterized in that: described poly lactic acid comprises long fibre or short fiber, and its raw material viscosity is IV=1.5～2.75.
3, preparation method according to claim 1 is characterized in that: described poly lactic acid is Poly-L-lactic acid fiber, dextrorotation acid fiber by polylactic or the left and right acid fiber by polylactic with various ratio blend, poly-Acetic acid, hydroxy-, bimol. cyclic ester or the lactide copolymer fibre of revolving.
4, preparation method according to claim 1 is characterized in that: described chitosan fiber comprises long fibre or short fiber, and molecular weight is 50,000～150,000.
5, preparation method according to claim 1 is characterized in that: the viscosity of described polycaprolactone section is IV=1.5～2.50.
6, preparation method according to claim 1 is characterized in that: viscosity IV=1.75～8.75 of described polylactic acid-based section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610026296XA CN100515505C (en) | 2006-04-30 | 2006-04-30 | Method for preparing artificial breast wall and artificial bone material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610026296XA CN100515505C (en) | 2006-04-30 | 2006-04-30 | Method for preparing artificial breast wall and artificial bone material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1850294A CN1850294A (en) | 2006-10-25 |
| CN100515505C true CN100515505C (en) | 2009-07-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610026296XA Expired - Fee Related CN100515505C (en) | 2006-04-30 | 2006-04-30 | Method for preparing artificial breast wall and artificial bone material |
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| CN (1) | CN100515505C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100582152C (en) * | 2008-02-02 | 2010-01-20 | 厦门大学 | Method for preparing chitosan reinforced bars |
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- 2006-04-30 CN CNB200610026296XA patent/CN100515505C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1850294A (en) | 2006-10-25 |
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Granted publication date: 20090722 Termination date: 20120430 |