CN100509785C - 通过反相制备色谱法分离和纯化芬太尼的工业方法 - Google Patents

通过反相制备色谱法分离和纯化芬太尼的工业方法 Download PDF

Info

Publication number
CN100509785C
CN100509785C CNB2004800321721A CN200480032172A CN100509785C CN 100509785 C CN100509785 C CN 100509785C CN B2004800321721 A CNB2004800321721 A CN B2004800321721A CN 200480032172 A CN200480032172 A CN 200480032172A CN 100509785 C CN100509785 C CN 100509785C
Authority
CN
China
Prior art keywords
acid
fentanyl
column
solution
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800321721A
Other languages
English (en)
Chinese (zh)
Other versions
CN1874999A (zh
Inventor
恩里科·A·安东尼尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of CN1874999A publication Critical patent/CN1874999A/zh
Application granted granted Critical
Publication of CN100509785C publication Critical patent/CN100509785C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/287—Non-polar phases; Reversed phases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CNB2004800321721A 2003-10-29 2004-10-22 通过反相制备色谱法分离和纯化芬太尼的工业方法 Expired - Fee Related CN100509785C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51527403P 2003-10-29 2003-10-29
US60/515,274 2003-10-29

Publications (2)

Publication Number Publication Date
CN1874999A CN1874999A (zh) 2006-12-06
CN100509785C true CN100509785C (zh) 2009-07-08

Family

ID=34572823

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800321721A Expired - Fee Related CN100509785C (zh) 2003-10-29 2004-10-22 通过反相制备色谱法分离和纯化芬太尼的工业方法

Country Status (11)

Country Link
US (1) US7728145B2 (enExample)
EP (1) EP1682505B1 (enExample)
JP (1) JP2007509945A (enExample)
CN (1) CN100509785C (enExample)
AT (1) ATE418544T1 (enExample)
AU (1) AU2004287815B2 (enExample)
CA (1) CA2544195A1 (enExample)
DE (1) DE602004018674D1 (enExample)
ES (1) ES2320136T3 (enExample)
MX (1) MX264489B (enExample)
WO (1) WO2005044798A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104994924A (zh) * 2013-01-29 2015-10-21 诺伊兰健康科学私人有限公司 使用在反相柱上的替代固定相纯化有机化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7486949B2 (en) * 2004-03-10 2009-02-03 Broadcom Corporation Method for re-establishing telephone calls after unintended termination
WO2006055321A2 (en) * 2004-11-10 2006-05-26 Boehringer Ingelheim Chemicals, Inc. Process of making fentanyl intermediates
US20100076198A1 (en) * 2008-09-19 2010-03-25 Mallinckrodt Inc. Crystalline forms of Fentanyl Alkaloid
US20160237112A1 (en) * 2013-09-20 2016-08-18 Davuluri, Ramamohan Rao Purification of organic compounds by surfactant mediated preparative hplc
US20220395767A1 (en) * 2021-06-15 2022-12-15 Perkinelmer Health Sciences, Inc. Enhancing lcms analyte signals

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164600A (en) * 1961-10-10 1965-01-05 Res Lab Dr C Janssen N V 1-aralkyl-4-(n-aryl-carbonyl amino)-piperidines and related compounds
US4317903A (en) * 1981-01-26 1982-03-02 The Upjohn Company Process for the purification of lincomycin
US4916142A (en) * 1987-02-02 1990-04-10 Boc, Inc. N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics
WO1999039195A1 (en) * 1998-02-03 1999-08-05 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
WO2001040184A2 (en) * 1999-12-06 2001-06-07 Mallinckrodt Inc. Methods for the syntheses of alfentanil, sufentanil and remifentanil
WO2003074526A2 (en) * 2002-02-28 2003-09-12 Mallinckrodt Inc. Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234684A (en) * 1979-12-11 1980-11-18 Eli Lilly And Company Method of preparing mycophenolic acid glucoside
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4336333A (en) * 1981-03-13 1982-06-22 Eli Lilly And Company Process for preparing tunicamycin
US4904590A (en) * 1988-12-27 1990-02-27 Eli Lilly And Company Antibiotic A80915 and process for its production
US5780589A (en) * 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
ITRM20020458A1 (it) 2002-09-13 2004-03-14 Ambiotec S A S Di Ammendola Sergio Procedimento per la separazione preparativa degli epimeri di steroidi.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164600A (en) * 1961-10-10 1965-01-05 Res Lab Dr C Janssen N V 1-aralkyl-4-(n-aryl-carbonyl amino)-piperidines and related compounds
US4317903A (en) * 1981-01-26 1982-03-02 The Upjohn Company Process for the purification of lincomycin
US4916142A (en) * 1987-02-02 1990-04-10 Boc, Inc. N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics
WO1999039195A1 (en) * 1998-02-03 1999-08-05 Arqule, Inc. Rapid method for separation of small molecules using reverse phase high performance liquid chromatography
WO2001040184A2 (en) * 1999-12-06 2001-06-07 Mallinckrodt Inc. Methods for the syntheses of alfentanil, sufentanil and remifentanil
WO2003074526A2 (en) * 2002-02-28 2003-09-12 Mallinckrodt Inc. Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104994924A (zh) * 2013-01-29 2015-10-21 诺伊兰健康科学私人有限公司 使用在反相柱上的替代固定相纯化有机化合物

Also Published As

Publication number Publication date
MXPA06004711A (es) 2006-07-20
US7728145B2 (en) 2010-06-01
MX264489B (en) 2009-02-12
ATE418544T1 (de) 2009-01-15
CA2544195A1 (en) 2005-05-19
CN1874999A (zh) 2006-12-06
DE602004018674D1 (de) 2009-02-05
US20070123710A1 (en) 2007-05-31
EP1682505B1 (en) 2008-12-24
ES2320136T3 (es) 2009-05-19
AU2004287815A1 (en) 2005-05-19
JP2007509945A (ja) 2007-04-19
WO2005044798A1 (en) 2005-05-19
EP1682505A1 (en) 2006-07-26
AU2004287815B2 (en) 2009-05-28

Similar Documents

Publication Publication Date Title
CN102134189B (zh) 从发酵液分离有机酸及氨基酸的方法
US7935821B2 (en) Method for separation and purification of naltrexone by preparative chromatography
KR20100120180A (ko) 펩타이드 정제 방법
US20110180482A1 (en) Methods and devices for dynamic filtration of pharmaceutical products
CN100509785C (zh) 通过反相制备色谱法分离和纯化芬太尼的工业方法
CN108456264A (zh) 一种舒更葡糖钠的纯化方法
TWI488862B (zh) Separation and Purification of Cyclohexyl Compounds and Their Salts
US7692013B2 (en) Method for separation and purification of hydrocodone by preparative chromatography
EP1613409A1 (en) Regeneration of chromatographic stationary phases
CA2586700A1 (en) Method of purifying tacrolimus
US5869679A (en) Methods for preparing l-2-oxothiazolidine-4-carboxylate and its carboxylic acid
JP2007509945A5 (enExample)
EP4431179A1 (en) A novel stationary phase for large scale reverse-phase hplc purification
EP1258488A1 (en) Process for producing metal complex of aminooligosaccharide derivative
CN104447790A (zh) 一种银杏内酯b的分离纯化方法
JPH01190695A (ja) グリチルリチンの精製法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090708

Termination date: 20091123