CN100475223C - Medicament box used for treating acute anhelation syndrome - Google Patents
Medicament box used for treating acute anhelation syndrome Download PDFInfo
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- CN100475223C CN100475223C CNB03147747XA CN03147747A CN100475223C CN 100475223 C CN100475223 C CN 100475223C CN B03147747X A CNB03147747X A CN B03147747XA CN 03147747 A CN03147747 A CN 03147747A CN 100475223 C CN100475223 C CN 100475223C
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Abstract
A medicine kit for treating acute respiratory distress syndrome (ARDS) is composed of Qingkailing and Xuesaitong.
Description
Technical field
The present invention relates to a kind of kit, particularly a kind of kit that is used for the treatment of adult respiratory distress syndrome.
Background technology
Since in December, 2002, the severe acute respiratory syndrome that is caused by the variation coronavirus is popular in China, and national economy and people's life are inflicted heavy losses on.ARDS is the serious pathological process of atypical pneumonia, is to cause the forfeiture of patient's pulmonary function hypoxemia to occur to cause dyspnea and even the depleted dead important step of whole body.At present clinical still do not have other effective measures except that adopting oxygen uptake to maintain with the suction nitric oxide the life.The development of Chinese medicine and pharmacy is of long standing and well established, especially in that bigger advantage is arranged aspect the treatment of infectious disease, through clinical proof, but therapy of combining Chinese and Western medicine atypical pneumonia mitigation symptoms, shortens the course of disease, reduces mortality rate.The inventor has accepted the whole nation on April 30th, 2003 and has prevented and treated the Chinese medicine screening research tackling of key scientific and technical problems task that atypical pneumonia headquarter tackling of key scientific and technical problems group is listed the great special project of " 15 " 863 Program " sars prevention and control key technology and product development " in.
Summary of the invention
The objective of the invention is to disclose a kind of kit that is used for the treatment of adult respiratory distress syndrome.
The adult respiratory distress syndrome kit that is used for the treatment of of the present invention is made up of the Qingkailing preparation of unit dose and the 'Xuesaitong ' formulation of unit dose.
Described unit dose can also be meant each conventional application quantity of adult or the each conventional application quantity of child; Described Qingkailing preparation, 'Xuesaitong ' formulation, both are can dosage form identical also can be different; Described preparation comprises clinical practice dosage forms such as injection, tablet, granule, capsule, oral liquid, masticatory, aerosol, soft capsule, suppository, drop pill.
Preparation optimizing injection in the kit of the present invention, unit dose are QINKAILING ZHUSHEYE 10-20ml, XUESAITONG ZHUSHEYE 200-400mg.The low dosage of QINKAILING ZHUSHEYE and XUESAITONG ZHUSHEYE is used for the state that respiratory distress syndrome takes place the child, and high dose is used to be grown up the state of adult respiratory distress syndrome takes place.
The present invention is convenient to be used, and anti-inflammatory is oozed out and improved the lungs microcirculation good effect, can improve when hanging down the blood oxygen pressure state, has significantly reduced moisture content of lung.
Following experimental example further specifies the present invention.
Experimental example:
Content of the present invention and main points are: at alveolar ooze out, two important steps that cause ARDS of interstitial lung infringement lung microcirculation disturbance, experimental result shows: kit QINKAILING ZHUSHEYE heat-clearing and toxic substances removing of the present invention and XUESAITONG ZHUSHEYE blood circulation promoting and blood stasis dispelling use in conjunction, when improving the low blood oxygen pressure state of rabbit model, significantly reduced moisture content of lung.
The present invention experiment is to utilize that pulmonary capillary damage lung microcirculation disturbance, vascular endothelial cell and the alveolar epithelium damage permeability of rabbit ARDS model increases due to the oleic acid, the destruction that causes interstitial edema, pathological change such as hemorrhage and alveolar surfactant, the pathomorphism and the physiopathologic change of simulation atypical pneumonia.
Its concrete grammar is:
Healthy Japanese white big ear rabbit is about body weight 2kg.If normal group, model group, positive control drug (dexamethasone sodium phosphate injection) group, the large and small dosage group of each investigational agent (small dose group is given the clinical equivalent amount, and heavy dose of group is given 2 times of clinical equivalent amount), 8 every group, male and female half and half.Wherein:
A. normal control group: give normal saline 10ml.
B. model group: give normal saline 10ml.
C. positive control drug (dexamethasone sodium phosphate injection) is organized: dosage is the 0.5ml/Kg body weight, and normal saline complements to 10ml.
D. QINGKAILING+XUESAITONG ZHUSHEYE small dose group (abbreviation purifies the blood little): dosage is a QINGKAILING 2.5ml/Kg body weight, XUESAITONG 0.5ml/Kg body weight, and normal saline complements to 10ml and closes and push away.
E. QINGKAILING+XUESAITONG ZHUSHEYE heavy dose is organized (abbreviation purifies the blood greatly): dosage is a QINGKAILING 5ml/Kg body weight, and XUESAITONG 1ml/Kg body weight is closed and pushed away.
F. Herba Erigerontis injection small dose group (be called for short lamp tiny): dosage is the 2.5ml/Kg body weight, and normal saline complements to 10ml.
G. Herba Erigerontis injection is heavy dose of organizes (it is carefully big to be called for short lamp): dosage is the 5ml/Kg body weight.
H. QINKAILING ZHUSHEYE small dose group (be called for short QINGKAILING little): dosage is the 2.5ml/Kg body weight, and normal saline complements to 10ml.
I. QINKAILING ZHUSHEYE is heavy dose of organizes (it is big to be called for short QINGKAILING): dosage is the 5ml/Kg body weight.
After rabbit is weighed, inject 25% urethane solution from auricular vein and anaesthetize by the 5ml/kg body weight, dorsal position is fixed on the rabbit experiment platform, separates a side femoral artery and threading to be on the waiting list blood.From auricular vein injection oleic acid, dosage is 0.08ml/kg, causes the adult respiratory distress syndrome model.After the modeling 10 minutes, auricular vein injectable drug (model group is with the 10ml physiologic saline for substitute), the speed of injecting is 1ml/min.Respectively at getting blood 1ml from femoral artery 60,120,180 minutes the time before the modeling and after the modeling, blood gas analysis is made in airtight cold preservation and censorship immediately.After the modeling 180 minutes, the common carotid artery blood-letting caused death, and opened breast and took off lungs, observed the lungs mode of appearance and took a picture.Take by weighing left lung weight in wet base, and after 48 hours constant weights of 60 ℃ of baking boxs baking, take by weighing dry weight, calculate moisture content of lung.Get right lung and go into 10% neutral formalin fixative and fix, make pathology section microscopy routinely.Relatively t check between data analysis employing group or before and after self.
The result shows:
One, blood oxygen pressure (PaO
2) variation:
(1) compares in the group: (seeing Table 1)
Table 1:PaO
2Variation (unit: mmHg)
With before the modeling relatively: * p＜0.05, * * p＜0.01;
Compare with modeling 60min: #p＜0.05, ##p＜0.01
The result shows: 4 blood gas analysis partial pressure of oxygens of intact animal do not have significant difference.1h, 2h and 3h blood oxygen pressure significantly are lower than (p＜0.01) before the modeling after the modeling.Heavy dose of group of Herba Erigerontis and QINKAILING ZHUSHEYE small dose group after modeling 1,2,3h all can improve the low blood oxygen pressure state of plan ARDS.The heavy dose of group of QINKAILING ZHUSHEYE+XUESAITONG ZHUSHEYE small dose group, QINKAILING ZHUSHEYE 2h after modeling can improve the low blood oxygen pressure state of intending ARDS, and effect in 3 hours significantly to the modeling.The heavy dose of group of QINKAILING ZHUSHEYE+XUESAITONG ZHUSHEYE, Herba Erigerontis small dose group 3h after modeling have the effect that improves blood oxygen pressure.Positive control drug does not have obvious effect.
(2) compare between the group:
At first carry out 4 period normal group partial pressure of oxygen statistical analysiss, find zero difference between 4 period normal group partial pressure of oxygen numerical value, explanation can be carried out the comparison of model group, each administration group " after the modeling with modeling before partial pressure of oxygen difference " and normal group " after the modeling with modeling before partial pressure of oxygen difference ".(seeing Table 2)
Table 2: the variation (unit: mmHg) of the difference of blood oxygen pressure before each time point and the modeling after the modeling
Compare with normal group: * p＜0.05, * * p＜0.01;
Compare with model group: #p＜0.05, ##p＜0.01
The result shows that the blood oxygen pressure of animal significantly descends after the modeling, and drop-out value from 60 minutes to 180 minutes blood oxygen pressures and normal group more all have extremely significant significant difference, P＜0.01.Two dosage of QINKAILING ZHUSHEYE, Herba Erigerontis injection heavy dose and QINKAILING ZHUSHEYE share the XUESAITONG ZHUSHEYE low dose for injury of lung after the resistance inhibitor action that reduces of blood oxygen pressure, and model group relatively has difference between significant group, P＜0.05 or P＜0.01.The time trend of its variation and blood oxygen pressure variation have concordance.
Two, the variation of blood oxygen saturation: (seeing Table 3)
Table 3: the variation (unit: %) of blood oxygen saturation
With before the modeling relatively: * p＜0.05, * * p＜0.01;
Compare with modeling 60min: #p＜0.05, ##p＜0.01
The result shows: 4 blood gas analysis oxygen saturations of intact animal do not have significant difference.1h, 2h and 3h oxygen saturation significantly are lower than (p＜0.01) and (p＜0.05) before the modeling after the modeling.The 1h oxygen saturation significantly is lower than (p＜0.05) before the modeling after the modeling of positive control drug group, does not all have significant difference after the modeling before 2h, 3h and the modeling.QINGKAILING+XUESAITONG ZHUSHEYE group: all do not have significant difference before 1h, 2h, 3h oxygen saturation and the modeling after the small dose group modeling, the 3h oxygen saturation is significantly higher than modeling 1h (p＜0.05) after the modeling; The 1h oxygen saturation significantly is lower than (p＜0.05) before the modeling, the preceding no significant difference of 2h, 3h and modeling after the modeling after the modeling of heavy dose of group.The Herba Erigerontis injection group: all do not have significant difference before 1h, 3h oxygen saturation and the modeling after the small dose group modeling, 2h is lower than (p＜0.05) before the modeling after the modeling; All there is not significant difference before 1h, 2h, 3h oxygen saturation and the modeling after the modeling of heavy dose of group.QINGKAILING group: all do not have significant difference before 1h, 2h, 3h oxygen saturation and the modeling after the small dose group modeling; All do not have significant difference before 1h, 2h, 3h oxygen saturation and the modeling after the modeling of heavy dose of group, the 3h oxygen saturation is significantly higher than 1h (p＜0.05) after the modeling after the modeling.As seen, the variation of the variation of blood oxygen saturation and blood oxygen pressure has proximate trend.
Three, the variation of moisture content of lung: (seeing Table 4)
Table 4: the variation (unit: %) of moisture content of lung
Compare with normal group: ##p＜0.01
Compare with model group: * * p＜0.01
The result shows, compares with normal group, and model group lung tissue water content significantly increases (p＜0.01).The left moisture content of lung of QINGKAILING+XUESAITONG ZHUSHEYE small dose group significantly is lower than model group (p＜0.01).All the other respectively organize water content and the more not significant reduction of model group.
Four, lungs PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM
Normal rabbit lung tissue naked eyes are seen and are pale red, smooth surface, quality softness.After the modeling 15 minutes, infringement widely took place in the bilateral lungs, is petechial hemorrhage; 30 minutes hemorrhage slabbings, the hemorrhage and generation swelling of lungs in 60 minutes, lung volume increases, and pink foam sample liquid is arranged in the trachea; Lung tissue was crineous in 120-180 minute, significantly swelling, and toughness increases, visible little focal necrosis.After the modeling 180 minutes pathology microscopies as seen, the alveolar wall vascular lesion, interstitial edema has albumen transudate and hemorrhage in the alveolar, the part alveolar is underwent compensatory enlargement, the part alveolar withers and shows that the part do not open.Sight of dexamethasone injection positive controls lungs naked eyes and micromorphology feature and model group do not have marked difference.
QINKAILING ZHUSHEYE and XUESAITONG ZHUSHEYE combination group naked eyes sight lung tissue are fresh and alive, and most samples are petechial hemorrhage, and lung swelling causes volume increase degree and model group significantly alleviates, and remarkable minimizing of pink foam sample liquid or no liquid are overflowed in the trachea.Displaing microstructure observing, alveolar space are slightly and ooze out, and accidental hemorrhage, interstitial lung inflammation and blood vessel injury are slight, with model group relatively the alveolar structure damage envelope reduce.
It is hemorrhage based on point, lamellar that QINKAILING ZHUSHEYE group naked eyes are seen lung tissue, and lung swelling causes volume increase degree and model group alleviates more to some extent, and pink foam sample liquid also significantly reduces in the trachea.Displaing microstructure observing, as seen kitchen range shape alveolar duct and alveolar wall structural damage, between light weight degree edema, between see alveolar blood capillary congestion and hemocyte caulked, the alveolar structure point-like is destroyed, be dispersed in lamellar albumen liquid and hemorrhage in the alveolar, with model group relatively the alveolar structure damage envelope also reduce to some extent, but inferior to the XUESAITONG ZHUSHEYE combination group.
Herba Erigerontis injection treatment group lungs naked eyes are seen and to be scarlet and kermesinus, are point-like or lamellar is hemorrhage, as seen are dispersed in little focal necrosis, and lobe of the lung swelling is remarkable; Visible alveolar duct of displaing microstructure observing and alveolar wall structural damage, interstitial edema, accidental alveolar wall blood capillary congestion and hemocyte caulked have albumen liquid in the structural deterioration place alveolar, rarely hemorrhage.
Draw based on the above results to draw a conclusion:
1, QINKAILING ZHUSHEYE, Herba Erigerontis injection show the low blood oxygen pressure state that can improve plan ARDS, and significantly improve blood oxygen saturation.
2, QINKAILING ZHUSHEYE and XUESAITONG ZHUSHEYE are share, and significantly improving the low blood oxygen pressure state of intending ARDS, when improving blood oxygen saturation, moisture content of lung are had remarkable reduction effect, shown its anti-alveolar and between the good action that oozes out of matter.
3, the effect basis of said medicine application is the pathological lesion that has alleviated an alveolar and a matter, has improved the gas dispersion exchange capacity of lungs, thereby has brought into play the effect of anti-ARDS.
4, the drug combination advantage is remarkable.When ARDS took place injury of lung, under the situation of implementing reliable modern medicine emergency measures, it was effective way that anti-inflammatory is oozed out with improving lungs microcirculation drug combination.Chinese medicine QINKAILING ZHUSHEYE heat-clearing and toxic substances removing and XUESAITONG ZHUSHEYE blood circulation promoting and blood stasis dispelling use in conjunction when improving the low blood oxygen pressure state of rabbit model, have significantly reduced moisture content of lung.This inflammation that alleviates alveolar space with it is oozed out with hemorrhage, mediation interstitial lung blood vessel, the cell caulked of alveolar wall blood capillary, congestion, and the reactions that reduce inflammation etc. are relevant.
Further specify the present invention by the following examples, should be noted that, these embodiment only are used for illustrative purposes, do not constitute the restriction to scope of the present invention.It will be apparent to those skilled in that under situation without departing from the spirit and scope of the present invention, can make some variations and improvement, these include in category of the present invention.
Description of drawings
Fig. 1, blood oxygen pressure (PaO
2) variation
The variation of Fig. 2, blood oxygen saturation
The variation of Fig. 3, moisture content of lung
Embodiment 1
QINKAILING ZHUSHEYE 1000ml XUESAITONG ZHUSHEYE (Radix Notoginseng total arasaponins 20g) 1000ml makes 50 kits, and each kit contains each one bottle of QINKAILING ZHUSHEYE, XUESAITONG ZHUSHEYE.Respectively with 200ml and the intravenous drip successively of 250ml normal saline solution dilution back, every day 1 time.The adult respiratory distress syndrome that is used to be grown up and takes place.
Embodiment 2
QINKAILING ZHUSHEYE 1000ml XUESAITONG ZHUSHEYE (Radix Notoginseng total arasaponins 20g) 1000ml makes 100 kits, and each kit contains each one bottle of QINKAILING ZHUSHEYE, XUESAITONG ZHUSHEYE.Respectively with 100ml and the intravenous drip successively of 250ml normal saline solution dilution back, every day 1 time.Be used for the adult respiratory distress syndrome that the child is taken place.
Claims (1)
1, a kind of kit improves the application in the medicine that hangs down the blood oxygen pressure state and reduce moisture content of lung in preparation treatment adult respiratory distress syndrome, this kit is made up of QINGKAILING ZHUSHEJI and XUESAITONG injection, and wherein QINGKAILING ZHUSHEJI and XUESAITONG injection volume ratio are 5: 1.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03147747XA CN100475223C (en) | 2003-06-25 | 2003-06-25 | Medicament box used for treating acute anhelation syndrome |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03147747XA CN100475223C (en) | 2003-06-25 | 2003-06-25 | Medicament box used for treating acute anhelation syndrome |
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| Publication Number | Publication Date |
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| CN1475265A CN1475265A (en) | 2004-02-18 |
| CN100475223C true CN100475223C (en) | 2009-04-08 |
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| CNB03147747XA Expired - Fee Related CN100475223C (en) | 2003-06-25 | 2003-06-25 | Medicament box used for treating acute anhelation syndrome |
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Granted publication date: 20090408 Termination date: 20110625 |