CN100471503C - 海绵核苷（2-甲氧腺苷）在制备治疗疼痛的药物中的用途 - Google Patents

海绵核苷（2-甲氧腺苷）在制备治疗疼痛的药物中的用途 Download PDF

Info

Publication number
CN100471503C
CN100471503C CNB2003801055073A CN200380105507A CN100471503C CN 100471503 C CN100471503 C CN 100471503C CN B2003801055073 A CNB2003801055073 A CN B2003801055073A CN 200380105507 A CN200380105507 A CN 200380105507A CN 100471503 C CN100471503 C CN 100471503C
Authority
CN
China
Prior art keywords
pain
spongosine
purposes
inflammatory
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2003801055073A
Other languages
English (en)
Chinese (zh)
Other versions
CN1723026A (zh
Inventor
P·理查森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cbt Development Ltd
Offen Beal Witt Rom Open Corp Sweden
Swedish Orphan Biovitrum AB
Original Assignee
Cambridge Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Biotechnology Ltd filed Critical Cambridge Biotechnology Ltd
Publication of CN1723026A publication Critical patent/CN1723026A/zh
Application granted granted Critical
Publication of CN100471503C publication Critical patent/CN100471503C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB2003801055073A 2002-12-09 2003-12-09 海绵核苷（2-甲氧腺苷）在制备治疗疼痛的药物中的用途 Expired - Fee Related CN100471503C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0228723.3A GB0228723D0 (en) 2002-12-09 2002-12-09 Treatment of pain
GB0228723.3 2002-12-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2008100922507A Division CN101264097B (zh) 2002-12-09 2003-12-09 海绵核苷作为镇痛剂的用途

Publications (2)

Publication Number Publication Date
CN1723026A CN1723026A (zh) 2006-01-18
CN100471503C true CN100471503C (zh) 2009-03-25

Family

ID=9949371

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2003801055073A Expired - Fee Related CN100471503C (zh) 2002-12-09 2003-12-09 海绵核苷（2-甲氧腺苷）在制备治疗疼痛的药物中的用途
CN2008100922507A Expired - Fee Related CN101264097B (zh) 2002-12-09 2003-12-09 海绵核苷作为镇痛剂的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2008100922507A Expired - Fee Related CN101264097B (zh) 2002-12-09 2003-12-09 海绵核苷作为镇痛剂的用途

Country Status (18)

Country Link
US (2) US8252766B2 (https=)
EP (1) EP1581235B1 (https=)
JP (2) JP4836454B2 (https=)
KR (1) KR101122495B1 (https=)
CN (2) CN100471503C (https=)
AT (1) ATE430572T1 (https=)
AU (1) AU2003288451B2 (https=)
CA (1) CA2507918A1 (https=)
CY (1) CY1109229T1 (https=)
DE (1) DE60327557D1 (https=)
DK (1) DK1581235T3 (https=)
ES (1) ES2326532T3 (https=)
GB (2) GB0228723D0 (https=)
NO (1) NO20053042L (https=)
NZ (1) NZ540353A (https=)
PT (1) PT1581235E (https=)
SI (1) SI1581235T1 (https=)
WO (1) WO2004052377A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228723D0 (en) 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
GB0305149D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Compounds for the treatment of pain
US20080221060A1 (en) * 2004-03-05 2008-09-11 Martyn Pritchard Therapeutic Compounds
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
US8778634B2 (en) 2004-12-01 2014-07-15 Syntaxin, Ltd. Non-cytotoxic protein conjugates
US8399400B2 (en) * 2004-12-01 2013-03-19 Syntaxin, Ltd. Fusion proteins
GB0426394D0 (en) * 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
US8603779B2 (en) 2004-12-01 2013-12-10 Syntaxin, Ltd. Non-cytotoxic protein conjugates
US8512984B2 (en) 2004-12-01 2013-08-20 Syntaxin, Ltd. Non-cytotoxic protein conjugates
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
GB0610867D0 (en) 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
BRPI0713902A2 (pt) 2006-06-27 2012-11-27 Biovitrum Ab compostos terapêuticos
AU2007263728A1 (en) 2006-06-27 2008-01-03 Biovitrum Ab (Publ) Adenosine derivatives for the treatment of pain
US7906518B2 (en) 2006-06-27 2011-03-15 Cbt Development Limited Therapeutic compounds
CN101938904A (zh) * 2008-01-09 2011-01-05 PGx健康有限责任公司 用a2ar激动剂鞘内治疗神经性疼痛
US8221791B1 (en) 2008-12-10 2012-07-17 University Of Central Florida Research Foundation, Inc. Silica-based antibacterial and antifungal nanoformulation
RU2012104552A (ru) * 2009-07-09 2013-08-20 СиБиТи ДЕВЕЛОПМЕНТ ЛИМИТЕД Комбинированный препарат для применения в качестве лекарственного средства
WO2011143442A1 (en) * 2010-05-12 2011-11-17 Trovis Pharmaceuticals, Llc. A method of treating multiple sclerosis with adenosine receptor agonists
EP2631345B1 (en) * 2012-02-27 2019-09-04 Electrolux Home Products Corporation N.V. Washing tub unit and washing machine
US20140056870A1 (en) 2012-08-27 2014-02-27 Allergan, Inc. Fusion proteins
MX380313B (es) * 2016-02-04 2025-03-12 Univ Johns Hopkins Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos.
US11066416B2 (en) 2016-02-04 2021-07-20 The Johns Hopkins University Rapafucin derivative compounds and methods of use thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792155A (fr) 1971-12-01 1973-05-30 Takeda Chemical Industries Ltd Nouveaux derives de l'adenosine et leur procede de production
JPS4861498A (https=) 1971-12-01 1973-08-28
JPS5549594B2 (https=) 1972-12-08 1980-12-12
DE2359536C2 (de) 1972-12-08 1984-08-02 Takeda Chemical Industries, Ltd., Osaka 2,6-Diaminonebularinderivate
JPS5461194A (en) 1977-10-21 1979-05-17 Takeda Chem Ind Ltd Preparation of n22substituted 2*66diaminonebularin
JPS5461195A (en) 1977-10-21 1979-05-17 Takeda Chem Ind Ltd N2-substituted phenyl-2,6-diaminonebularin
US4705758A (en) 1984-06-19 1987-11-10 Warner-Lambert Company Adenosine receptor assay and kit
US5231086A (en) * 1985-09-24 1993-07-27 Item Development Aktiebolag Continuous administration adenosine to increase myocardial blood flow
US5104859A (en) * 1985-09-24 1992-04-14 Solimedco Aktiebolag Continuous administration of adenosine to reduce pulmonary vascular resistance
US5310732A (en) 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US5140015A (en) 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US6180616B1 (en) * 1990-05-10 2001-01-30 Atsuo F. Fukunaga Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
US5677290A (en) * 1990-05-10 1997-10-14 Fukunaga; Atsuo F. Therapeutic use of adenosine compounds as surgical anesthetics
US6004945A (en) * 1990-05-10 1999-12-21 Fukunaga; Atsuo F. Use of adenosine compounds to relieve pain
WO1994023723A1 (en) 1993-04-15 1994-10-27 New York University Adenosine receptor agonists for the promotion of wound healing
US5683989A (en) * 1993-12-17 1997-11-04 Novo Nordisk A/S Treatment of ischemias by administration of 2,N6 -substituted adenosines
SE9401499D0 (sv) 1994-05-02 1994-05-02 Item Dev Ab New method of treatment
JPH09512823A (ja) 1994-05-10 1997-12-22 サンド・リミテッド アデノシン誘導体
US5596094A (en) 1994-05-26 1997-01-21 Sandoz Ltd. Process for preparing 2' -0- alkyl adenosine derivatives
US5877180A (en) 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
IT1275420B (it) 1995-06-02 1997-08-05 Schering Plough S P A Metodo per misurare l'affinita' di legame al recettore a2a dell'adenosina di componenti di interesse farmacologico mediante l'uso del ligando triziato (3h)-sch 58261
AU7449598A (en) 1997-05-23 1998-12-11 Nippon Shinyaku Co. Ltd. Medicinal composition for prevention or treatment of hepatopathy
US6110902A (en) 1997-06-23 2000-08-29 Moehler; Hanns Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
JP2003517423A (ja) 1997-07-29 2003-05-27 メドコ リサーチ、インコーポレイテッド アデノシンレセプターモジュレーターとしてのｎ６−置換アデノシン−５′−ウロナミド
US6440455B1 (en) 1997-09-02 2002-08-27 Children's Medical Center Corporation Methods for modulating the axonal outgrowth of central nervous system neurons
GB9723590D0 (en) 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
CA2317093A1 (en) 1998-01-08 1999-07-15 Joel M. Linden A2a adenosine receptor agonists
GB9913932D0 (en) 1999-06-15 1999-08-18 Pfizer Ltd Purine derivatives
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0228723D0 (en) 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
US20060034941A1 (en) 2002-12-23 2006-02-16 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
GB0305153D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
GB0305150D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds
GB0305149D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Compounds for the treatment of pain
US20080221060A1 (en) 2004-03-05 2008-09-11 Martyn Pritchard Therapeutic Compounds
US8407664B2 (en) 2005-12-30 2013-03-26 Sap Ag Software model business objects

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
2-Alkoxyadenosines: potent and selective agonists at thecoronary artery A2 adenosine receptor. Ueeda M, et al.J. Med. Chem.,Vol.34 . 1991
2-Alkoxyadenosines: potent and selective agonists at thecoronary artery A2 adenosine receptor. Ueeda M, et al.J. Med. Chem.,Vol.34 . 1991 *
adenosine receptor activation and nociception. Jana Sawynok.European journal of pharmacology,Vol.317 . 1998
adenosine receptor activation and nociception. Jana Sawynok.European journal of pharmacology,Vol.317 . 1998 *
The safety and efficacy of intrathecal adenosine in patientswith chronic neuropathic pain. Belfrage M, et al.Anesthesia and analgesia,,Vol.89 . 1999
The safety and efficacy of intrathecal adenosine in patientswith chronic neuropathic pain. Belfrage M, et al.Anesthesia and analgesia,,Vol.89 . 1999 *

Also Published As

Publication number Publication date
NO20053042L (no) 2005-06-21
CN101264097B (zh) 2011-10-05
KR20050089815A (ko) 2005-09-08
CA2507918A1 (en) 2004-06-24
ATE430572T1 (de) 2009-05-15
EP1581235B1 (en) 2009-05-06
CY1109229T1 (el) 2013-09-04
JP2006514638A (ja) 2006-05-11
DK1581235T3 (da) 2009-08-31
HK1086186A1 (zh) 2006-09-15
SI1581235T1 (sl) 2009-10-31
PT1581235E (pt) 2009-07-07
KR101122495B1 (ko) 2012-03-15
AU2003288451A1 (en) 2004-06-30
US20070010475A1 (en) 2007-01-11
US8252766B2 (en) 2012-08-28
CN1723026A (zh) 2006-01-18
GB0228723D0 (en) 2003-01-15
WO2004052377A1 (en) 2004-06-24
JP2011132229A (ja) 2011-07-07
ES2326532T3 (es) 2009-10-14
NZ540353A (en) 2006-11-30
AU2003288451B2 (en) 2009-06-04
JP4836454B2 (ja) 2011-12-14
EP1581235A1 (en) 2005-10-05
GB0328548D0 (en) 2004-01-14
CN101264097A (zh) 2008-09-17
GB2396108A (en) 2004-06-16
DE60327557D1 (de) 2009-06-18
US20110184065A1 (en) 2011-07-28
GB2396108B (en) 2005-08-03

Similar Documents

Publication Publication Date Title
CN100471503C (zh) 海绵核苷（2-甲氧腺苷）在制备治疗疼痛的药物中的用途
CN100579533C (zh) 治疗疼痛的化合物
ES2236185T3 (es) Una composicion farmaceutica para el tratamiento del dolor agudo, cronico y/o neuropatico y migrañas.
ES2272754T3 (es) Uso de antagonistas mglur5 en la fabricacion de un medicamento en el tratamiento de sindrome x fragil, autismo y retardo mental.
US20240016790A1 (en) Methods of using a phenoxypropylamine compound to treat pain
HK1125031A (en) Use of spongosine as an analgesic
HK1086186B (en) Use of spongosine (2-methoxyadenosein) for preparing pharmaceutical for the treatment of pain
JP7365696B2 (ja) 鎮痛剤及び鎮静剤
JP2007523827A (ja) 混合性白血病遺伝子の再構成を伴う急性リンパ芽球性白血病の処置方法
HK1087629B (en) Compounds for the treatment of pain
WO2021018824A1 (en) Use of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one for the treatment of nociceptive pain, neuropathic pain, osteoarthritis pain and cancer pain, while having reduced side effects compared to opioids
JP2010222347A (ja) Ｐｄｅ５阻害剤及びカルニチンを含有する医薬組成物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1086186

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1086186

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: BIOVITRUM AB

Free format text: FORMER OWNER: CAMBRIDGE BIOTECHNOLOGY LTD.

Effective date: 20110228

Owner name: CBT DEVELOPMENT CO., LTD.

Free format text: FORMER OWNER: SWEDEN OFFENBI OVERSTROM PUBLIC CO., LTD.

Effective date: 20110228

Owner name: SWEDEN OFFENBI OVERSTROM PUBLIC CO., LTD.

Free format text: FORMER OWNER: BIOVITRUM AB

Effective date: 20110228

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: CAMBRIDGE, UK TO: STOCKHOLM, SWEDEN

Free format text: CORRECT: ADDRESS; FROM: STOCKHOLM, SWEDEN TO: LONDON, UK

TR01 Transfer of patent right

Effective date of registration: 20110228

Address after: London, England

Patentee after: CBT DEVELOPMENT LTD.

Address before: Stockholm

Patentee before: Offen Beal Witt Rom open Corporation, Sweden

Effective date of registration: 20110228

Address after: Stockholm

Patentee after: Offen Beal Witt Rom open Corporation, Sweden

Address before: Stockholm

Patentee before: Biovitrum AB

Effective date of registration: 20110228

Address after: Stockholm

Patentee after: BIOVITRUM AB

Address before: cambridge

Patentee before: Cambridge Biotechnology Ltd.

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090325

Termination date: 20121209