CN100455319C - Preparation of Chinese traditional medicine for treating baby's cough, and preparation method - Google Patents

Abstract

The present invention relates to a preparation of Chinese traditional medicine for treating infantile cough and a preparation method thereof. The weight proportion of medicinal materials used by the preparation comprises: 5 to 20 of fineleaf schizonepeta herb, 5 to 20 of radix asteris, 5 to 20 of stemona root, 5 to 20 of common coltsfoot flower, 5 to 20 of dried tangerine peel, 5 to 20 of poria coco, 5 to 20 of platycodon, 5 to 20 of Fructus Aurantii, 2 to 15 of great burdock achene, 5 to 20 of dwarf lilyturf tuber, 5 to 20 of malt and 5 to 20 of licorice. The preparation method of the granules comprises the following steps: A: water is added to the medicinal materials, the medicinal materials are decocted for two times, the medicinal materials are decocted for 2 hours for the first time, and the medicinal materials are decocted for 1.5 hours for the second time; B: a decoction solution obtained from the two times is merged and filtered, and the filtrate is put in a still mode for 24 hours; C: the supernatant fluid of the filtrate is taken and concentrated into thick paste and is cooled, and ethanol is added to the thick paste and fully stirred so that the alcohol content reaches 60%; after the mixture is put in a still mode for 24 hours, the supernatant fluid is filtered and taken; D: the ethanol is removed; E: the rest is concentrated into thick paste, a proper quantity of powdered sugar is added to the thick paste, and the mixture is uniformly mixed and made into granules; F: the granules are dried, the whole granule of each of the granules is packed, and the preparation is obtained. For treating the infantile cough, the preparation has the advantages of conspicuous curative effect, convenient taking and no toxic and side effects.

Description

A kind of treatment infantile cough Chinese medicine preparation and preparation method

[technical field]

The present invention relates to a kind of treatment infantile cough Chinese medicine preparation and preparation method, particularly be applicable to the Chinese medicine preparation of infantile respiratory tract infection repeatedly cough and cough variant asthma.

[background technology]

Cough variant asthma, have another name called the allergic cough, be a kind of potential concealment form asthma, its unique symptom is a chronic cough, does not have obvious positive sign, be bronchitis easily by mistaken diagnosis, recurrent respiratory tract infection is the commonly encountered diseases of Pediatric Clinic, and many heads of a family constantly use treatments such as multiple antibiotic and bronchiectasis because of infant, cough repeatedly, protracted course of disease, seek medical advice and worried everywhere, seriously influenced the health and the orthobiosis of infant.Western medicine thinks that the pathogeny of primary disease is identical with asthma, be characteristics also to continue airway inflammation and airway hyperreactivity, think the bronchiolar epithelium chronic inflammatory disease and impaired, the vagus nerve tip sensor that exposes is caused local little vasoconstriction by small stimulation institute excitation, this shrinks stimulates tip cough sensor just to cause the generation of cough, so type asthma is without any symptoms of asthma and sign, but because of the essence of primary disease is asthma, so still take the treatment of asthma principle in the treatment.At present, the western medical treatment allergic cough, multiselect is separated the phlegm and relieving cough Western medicine with antiallergic, and the side effect of right Western medicine is difficult to avoid, and the later old expectorant of a few hours drug effect is recurred, and cough is multiple to be done.So develop Chinese medicine relieving cough and resolving phlegm preparation effective, that be convenient to take, the cough of treatment children's chronic is the very significant problem that urgent clinical needs solve.

[summary of the invention]

The present invention be remedy the above-mentioned deficiency of prior art propose a kind of evident in efficacy, be convenient to the treatment infantile cough taking and have no side effect, particularly recurrent respiratory tract infection cough and cough variant asthma Chinese medicine preparation and preparation method.

Technical scheme of the present invention is as follows: a kind of treatment infantile cough Chinese medicine preparation is characterized in that it is to be made by the medical material of following weight proportion:

Herba Schizonepetae 5-20, Radix Asteris 5-20, Radix Stemonae 5-20, Flos Farfarae 5-20, Pericarpium Citri Reticulatae 5-20, Poria 5-20, Radix Platycodonis 5-20, Fructus Aurantii 5-20, Fructus Arctii 2-15, Radix Ophiopogonis 5-20, Fructus Hordei Germinatus 5-20, Radix Glycyrrhizae 5-20

Wherein the weight proportion of used each medical material is:

Herba Schizonepetae 10, Radix Asteris 10, the Radix Stemonae 10, Flos Farfarae 10, Pericarpium Citri Reticulatae 10, Poria 10,

Radix Platycodonis 10, Fructus Aurantii 10, Fructus Arctii 5, Radix Ophiopogonis 10, Fructus Hordei Germinatus 10, Radix Glycyrrhizae 10

As optimization, the used medical material of the present invention also comprises:

Radix Peucedani 5-20, Lasiosphaera Seu Calvatia 2-15, Rhizoma Belamcandae 2-15, Bulbus Lilii 10-30, Massa Medicata Fermentata 5-20, Fructus Crataegi 5-20

Wherein the weight proportion of used each medical material is:

Radix Peucedani 10, Lasiosphaera Seu Calvatia 5, Rhizoma Belamcandae 5, Bulbus Lilii 15, Massa Medicata Fermentata 10, Fructus Crataegi 10

The present invention also comprises the adjuvant of suitable kind.

A kind of preparation method for the treatment of the granule of infantile cough Chinese medicine preparation is characterized in that:

A: above all medical materials are decocted with water secondary, 2 hours for the first time; 1.5 hours for the second time;

B: merge the secondary decocting liquid, filter, filtrate was left standstill 24 hours;

C: get the supernatant concentration thick paste, put coldly, add ethanol, and fully stir to make and contain the alcohol amount and reach 60%, leave standstill leaching supernatant after 24 hours;

D: remove ethanol;

E: be concentrated into thick paste, add an amount of Icing Sugar mixed pelletization;

F: dry, granulate is packed promptly.

Among the we, Herba Schizonepetae: acrid in the mouth, slightly warm in nature, expelling pathogenic wind from the body surface.Radix Asteris: bitter in the mouth, suffering, warm in nature, return lung meridian.Main cough with dyspnea is coughed up and is coughed not wellly, and Zhichuan is throbbed with fear, soft and moist having a surplus, though day toil and temperature is non-scorching comparable is specially can the using pungent drugs for dispersion and bitter drugs for purgation lung strongly fragrant, cough sending down the abnormal ascending QI surely, and a surname is logical to stop up stagnantly, holds concurrently and dredges the man QI and blood of lung.The Radix Stemonae: sweet in the mouth, hardship, slightly warm in nature.Return lung meridian; The cough-relieving of effect nourishing the lung to keep the adverse QI downward, the antitussive and antiasthmatic effect is arranged.Flos Farfarae: the hot temperature of its property, go into lung meridian, have cough-relieving, an effect of eliminating the phlegm, relieving asthma, the antitussive action of Flos Farfarae is stronger, but expectorant strength a little less than, with the compatible same usefulness of Radix Asteris, strengthened expectorant effect, but the expectorant therapeutic method to keep the adverse QI flowing downwards.Pericarpium Citri Reticulatae: nature and flavor suffering, hardship, temperature.People's spleen, lung meridian, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Poria: sweet in the mouth, light, property is flat; Promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Radix Platycodonis: lung qi dispersing sore-throat relieving, the evacuation of pus of eliminating the phlegm.Fructus Aurantii: bitter in the mouth, acid, cold nature.Promoting the circulation of QI to alleviate the stagnation in middle-JIAO, help digestion, reduce phlegm.Fructus Arctii: arduous and tremble with fear dispelling wind and heat pathogens, resolving toxin and disinhibiting the throat.Radix Ophiopogonis: clearing away heart-fire and moistening the lung, nourishing the stomach to promote the production of body fluid.Fructus Hordei Germinatus: help digestion and in.Radix Glycyrrhizae: nature and flavor are sweet flat, return 12 warps, coordinating the actions of various ingredients in a prescription.

With the Chinese traditional treatment primary disease, report the lung qi dispersing spleen invigorating, remove the method for phlegm and relieving cough, both gone the disease of cough, again except that cough because of, so simple Chinese medicine preparation is significant on clinical treatment.

The beginning of the nineties, diagnosis and treatment to cough variant asthma come into one's own at home, Chinese traditional treatment primary disease clinical report day by day increases in recent years, have from the spleen opinion person of controlling, the subduing the hyperfunction of the liver of opinion reason lung method person is arranged, the lung heat clearing dispersing lung-QI and dissipating phlegm person that expels the heat-evil is arranged, have stage of attack to take stopgap measures, the catabasis effects a permanent cure, stage by stage Therapeutic Method.Some scholar has observed children's's changes in immune function simultaneously or has observed pulmonary function situation etc.Lack tight design and go deep into systematic research though research method is a lot, and, no unified clinical development standard.

This research is guidance with the theory of Chinese medical science, on the empirical basis of further investigation treatment cough at all times, in conjunction with secular clinical observation on the therapeutic effect, be developed into children's's antitussive electuary, form by Herba Schizonepetae, Radix Asteris, the Radix Stemonae, Flos Farfarae, Pericarpium Citri Reticulatae, Poria, Radix Platycodonis, Fructus Aurantii etc., have the effect of lung qi dispersing spleen invigorating, eliminating phlegm and stopping cough; And then it is carried out deep clinical research and experimentation, for cough variant asthma provides pure Chinese medicinal preparation.

Research to cough variant asthma comprises experiment and clinical two aspects:

The experimentation content:

The child cough granule agent has certain influence to asthmatic guinea pigs serum interleukin I L-5:

The influence of ordinary circumstance is: general spirit is relatively poor after model group, cough-relieving group and the Western medicine group Cavia porcellus sensitization, and bradykinesia is not liked activity, and feed drinking-water reduces, and returns to normal gradually in 3-4 days.To the variations in temperature sensitivity, hogback was gregarious when temperature descended, and was slow in action than normal group for model group, cough-relieving group and Western medicine group Cavia porcellus.When Changes in weather, model group, cough-relieving group and Western medicine group respectively have 1 example lure breathe heavily the back asthma acutely show effect, tics that fall down to the ground, though give oxygen uptake, cardiac massage, all rescue measures proved ineffectual and death.

Influence to IL-5 in each group guinea pig serum is: confirmed that cough variant asthma is a kind of potential form of asthma at present, its Pathophysiology is similar to typical asthma, has the air flue chronic inflammatory disease that eosinophilic granulocyte (EOS) and mastocyte participate in.IL-5 is by activation CD4T lymphocytic emiocytosis, to differentiation, maturation, chemotactic, the activation of EOS and prolong aspects such as its survival and play important regulatory role, can promote the generation of mucosa secretory IgA, sIgA (sIgA), sIgA then mediates EOS and takes off granule and cause tardy phase asthma reaction.This explanation IL-5 occupies an important position in the developing of asthma.

It is specific that IL-5 induces eosinophilic granulocyte, is mainly to regulate eosinophilic granulocyte growth, differentiation and active cytokine thereof.IL-5 also can activate a series of eosinophilic granulocyte reactions in addition, also has the eosinophilic granulocyte degranulation of chemotactic eosinophilic granulocyte and antigen induction, and can strengthen the cell-mediated cytotoxic effect that antibody relies on.IL-5 plays an important role to generation, the regulation and control of eosinophilic granulocyte.

Tardy phase asthma reaction can reflect the many features such as the airway allergy inflammation of asthma, and airway hyperreactivity etc. are the better models of laboratory research bronchial asthma.Eosinophilic granulocyte is in close relations with tardy asthma reaction mutually and airway hyperreactivity, and in to the influential cytokine of EOS function, specificity with IL-5 is the highest, it can induce EOS to assemble at air flue specifically, promote EOS at the local organization differentiation and maturation, prolong the time-to-live of EOS in tissue.

Therefore can think that tardy phase asthma reaction experimental model and IL-5 can reflect the essence of asthma chronic inflammatory disease and airway hyperreactivity.

This experimental selection in the tardy phase asthma reaction stage of asthmatic guinea pigs model, get hematometry serum il-5, observe the influence of child cough granule agent to guinea pig serum IL-5.Display model group, cough-relieving group and Western medicine group IL-5 level all are higher than normal group as a result, and prompting IL-5 increases with the generation of asthma closely related.The equal end of cough-relieving group IL-5 level, illustrate that in model group the child cough granule agent can reduce the IL-5 level.

IL-5 is produced by immune effector cell, this experimental result shows that the child cough granule agent can reduce serum il-5 level, therefore the agent of deducibility child cough granule has immunoregulatory effect, thereby the effect of treatment cough variant asthma is played in the generation of blocking-up airway inflammation.

The child cough granule agent to the influence of asthmatic guinea pigs serum superoxide dismutases, malonaldehyde is: confirmed that cough variant asthma is a kind of potential form of asthma at present, its Pathophysiology is similar to typical asthma, has the air flue chronic inflammatory disease that eosinophilic granulocyte and mastocyte participate in.Oxygen-derived free radicals is important inflammatory mediator, oxygen-derived free radicals and airway inflammation are accompanied row mutually, promote each other, form vicious cycle, their existence causes the disorder of body antioxidant system, increase the weight of airway epithelia infringement. peripheral nervous fiber is exposed and local reflex is active, finally cause air flue that the reactivity of various stimulations is increased, form air flue and continue high reaction.

It is direct detection that the ideal of oxygen-derived free radicals detects, but owing to reasons such as instrument cost an arm and a leg, can not be widely used, and selects for use indirect index to detect usually.The reinforcement of inflammatory reaction has caused the free radical generation to increase during asthma attack, lipid peroxidation is strengthened, so product MDA content increases in the middle of it.SOD plays a crucial role in the free radical scavenging system in vivo, constantly removes the caused chain reaction of superoxide anion, and the protection cell membrane is avoided radical damage.But so level of the interior oxygen-derived free radicals of the variation antimer of SOD and MDA.

The process that asthma patient sucks anaphylactogen generation asthma is divided into speed phase asthma reaction and tardy asthma reaction mutually by duration of seizure.Past is all sent out the experimental model of phase asthma reaction as asthma research with speed, has now confirmed to send out in the phase asthma reaction in speed, and what influence the airway pressure function mainly is the airway smooth muscle spasm, there is no airway inflammation and bronchial hyperreactivity.In recent years some laboratorys find that tardy phase asthma reaction can reflect many features such as airway allergy inflammation, the airway hyperreactivity etc. of asthma, and think that tardy phase asthma reaction is the better model of laboratory research bronchial asthma.

This experimental selection in the tardy phase asthma reaction stage of asthmatic guinea pigs model, get hematometry serum MDA, SOD, observe the influence of child cough granule agent to guinea pig serum MDA, SOD.This experimental result shows that model group Cavia porcellus MDA is higher than normal group, and SOD then is lower than normal group, illustrates that radical metabolism takes place relevant with asthma unusually.Cough-relieving group MDA is lower than Western medicine group, model group, and SOD is higher than Western medicine group, model group, MDA, SOD and normal group be there was no significant difference relatively, prompting is after child cough granule agent treatment, guinea pig serum MDA content descends and the SOD rising, illustrates that the child cough granule agent can reduce the generation and the release of oxygen-derived free radicals.

Oxygen-derived free radicals then is " effector substance " that immunocyte plays a role, and final result is to form the air flue chronic inflammatory disease.This experimental result shows the generation and the emission levels of child cough granule agent can minimizing oxygen-derived free radicals, so the agent of deducibility child cough granule has immunoregulatory effect, thereby brings into play anti-chronic inflammatory disease effect, and then the treatment cough variant asthma.

Child cough granule agent cough-relieving experimentation is as follows: in order to inquire into child cough granule agent cough-relieving pharmacological action, the inventor is with reference to " herbal pharmacology research methodology " method, adopt mice ammonia to draw the method for coughing, observe the cough suppressing effect of child cough granule mice is caused by ammonia agent cough.Experimental result shows that the child cough granule agent can postpone mice by the time that ammonia causes cough, illustrates that the child cough granule agent has antitussive action.

Consequently, medication group and normal saline group compare its R value greater than 130%, illustrate that the child cough granule agent has antitussive action.Child cough granule agent high dose group is compared with low dose group, is caused that by ammonia the time of mouse cough shortens to some extent, but middle dosage group and high dose group compare there was no significant difference (P＞0.05); But with the codeine group relatively, the medication group causes that by ammonia the time ratio codeine group of mouse cough will lack (P＜0.05).This shows that the child cough granule agent has cough suppressing effect, but do not have certain dose-effect relationship.

Above result is because the child cough granule agent is made up of Herba Schizonepetae, Radix Asteris, Radix Platycodonis, Lasiosphaera Seu Calvatia etc., has relieving cough and resolving phlegm, effects such as moistening lung and nourishing throat.Disease satisfactory effects such as clinical application child cough granule agent treatment infantile respiratory tract infection repeatedly cough and cough variant asthma, the cough-relieving time is short with the Western medicine antibiotic, is consistent with The pharmacological results.Its pharmacological action may be the release that the child cough granule agent can suppress Catecholamine matter, alleviates the spasm of bronchial smooth muscle, acts on coughing centre, partly suppresses coughing centre and vagal irritability, thereby produces cough suppressing effect.

Simultaneously child cough granule thinner expectorant has been carried out experimentation.In order to understand the resolve phlegm effect mechanism of child cough granule agent, the author is with reference to " herbal pharmacology research methodology " III method, utilize phenol red partly from the characteristics of trachea excretion, take the phenol red method of trachea section, detect medication and respectively organize the phenol red amount that mouse breathing road mucosa is discharged with not medication, analyze the power of resolve phlegm effect, from experiment gained result, the child cough granule agent has tangible resolve phlegm effect.

As can be seen from the results: dosage, high dose group and normal saline group are relatively in the child cough granule agent, the all obvious high ten normal saline groups of its phenol red excretion amount, do the t check, P＜0.05, significant difference has been described, and with ammonium chloride group high dose group there was no significant difference P＞0.05 relatively, middle dosage group and the comparison of ammonium chloride group there were significant differences P＜0.05, the agent of proof child cough granule has the phenol red excretion amount of the trachea section of increasing, and promotes the effect of expectoration.

Above result is because contain medicines such as Herba Schizonepetae, Radix Asteris, Radix Platycodonis, Lasiosphaera Seu Calvatia in the child cough granule agent, has relieving cough and resolving phlegm, and effects such as moistening lung and nourishing throat have the phenol red excretion amount of the trachea section of increasing, and promote the effect of expectoration, and have certain dose-effect relationship.The mechanism of action may be that the child cough granule agent can be diluted sputum, promotes the motion of cilium, thereby reaches the effect of reducing phlegm.This shows, the cough of clinical application child cough granule agent treatment infantile respiratory tract infection repeatedly, and disease such as cough variant asthma, the cough transference cure is very fast, and it is that certain pharmacological basis is arranged that expectorant easily brings up.

Relate to following content in the clinical research: the curative effect of 1, observing children's's antitussive electuary; Antitussive effect generation and time relation; The relation of antitussive electuary administration time and curative effect.

2, with the western medicine group, promptly GINA (G1NA) scheme medication group is carried out check analysis.

3, observe children's's antitussive electuary to influence of Pulmonary Function.

4, the influence of children's's antitussive electuary to asthma specific IgE, T cell subtype TH1TH2 and this value thereof taken in observation, and the granulocytic influence of blood eosinophil.

Diagnosis was by the ordered standard of national pediatric asthma cooperative groups in 1993, and the place case is divided into treatment group and matched group at random.

This preparation uses time-proven for many years through preliminary clinical research, has no side effect and zest, and is safe and reliable, treats example surplus the case 2000 altogether, and effectively, total effective rate is more than 90% within three days.

[specific embodiment]

A kind of treatment infantile cough Chinese medicine preparation is characterized in that it is to be made by the medical material of following weight proportion:

Herba Schizonepetae 5-20, Radix Asteris 5-20, Radix Stemonae 5-20, Flos Farfarae 5-20, Pericarpium Citri Reticulatae 5-20, Poria 5-20,

Radix Platycodonis 5-20, Fructus Aurantii 5-20, Fructus Arctii 2-15, Radix Ophiopogonis 5-20, Fructus Hordei Germinatus 5-20, Radix Glycyrrhizae 5-20

Among a kind of embodiment, the weight proportion of used each medical material is:

Herba Schizonepetae 10, Radix Asteris 10, the Radix Stemonae 10, Flos Farfarae 10, Pericarpium Citri Reticulatae 10, Poria 10,

Radix Platycodonis 10, Fructus Aurantii 10, Fructus Arctii 5, Radix Ophiopogonis 10, Fructus Hordei Germinatus 10, Radix Glycyrrhizae 10

As optimization, the used medical material of the present invention also comprises:

Radix Peucedani 5-20, Lasiosphaera Seu Calvatia 2-15, Rhizoma Belamcandae 2-15, Bulbus Lilii 10-30, Massa Medicata Fermentata 5-20, Fructus Crataegi 5-20

Wherein the weight proportion of used each medical material is:

Radix Peucedani 10, Lasiosphaera Seu Calvatia 5, Rhizoma Belamcandae 5, Bulbus Lilii 15, Massa Medicata Fermentata 10, Fructus Crataegi 10

The present invention also comprises the adjuvant of suitable kind.

The described dosage form of present embodiment is a granule.

The preparation method of the granule of described infantile cough Chinese medicine preparation is as follows:

A: above all medical materials are decocted with water secondary, 2 hours for the first time; 1.5 hours for the second time;

B: merge the secondary decocting liquid, filter, filtrate was left standstill 24 hours;

C: get the supernatant concentration thick paste, put coldly, add ethanol, and fully stir to make and contain the alcohol amount and reach 60%, leave standstill leaching supernatant after 24 hours;

D: remove ethanol;

E: be concentrated into thick paste, add an amount of Icing Sugar mixed pelletization;

F: dry, granulate is packed promptly.

The preparation method of present embodiment can be described as:

More than all medicines decoct with water twice, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and filtrate was left standstill 24 hours, get supernatant concentration to thick paste, put coldly, add ethanol, make ethanol content reach 60%, fully stir evenly, left standstill 24 hours, get supernatant, be concentrated into thick paste after reclaiming ethanol, add an amount of Icing Sugar mixed pelletization.Dry, granulate is packed promptly.

Embodiment 1: a kind of granule for the treatment of infantile cough, select the used medical material weight proportion of prescription to be preferably:

Herba Schizonepetae 10g, Radix Asteris 10g, Radix Stemonae 10g, Flos Farfarae 10g, Pericarpium Citri Reticulatae 10g, Poria 10g,

Radix Platycodonis 10g, Fructus Aurantii 10g, Fructus Arctii 5g, Radix Ophiopogonis 10g, Fructus Hordei Germinatus 10g, Radix Glycyrrhizae 10g

As optimization, add Radix Peucedani 10g, Lasiosphaera Seu Calvatia 5g, Rhizoma Belamcandae 5g, Bulbus Lilii 15g, Massa Medicata Fermentata 10g, Fructus Crataegi 10g

The preparation method of present embodiment state into:

More than all medicines decoct with water twice, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filters, and filtrate was left standstill 24 hours, get supernatant concentration to thick paste, put coldly, add ethanol, make ethanol content reach 60%, fully stir evenly, left standstill 24 hours, get supernatant, be concentrated into thick paste after reclaiming ethanol, add an amount of Icing Sugar mixed pelletization.Dry, granulate is packed promptly.

Use product of the present invention and can adopt aluminum-plastic composite membrane packing, every bag 10g.During use, take after mixing it with hot water, each 1 bag reduces by half below 2 years old or follows the doctor's advice more than 2 years old.

Claims (8)

1, a kind of treatment infantile cough Chinese medicine preparation is characterized in that it is to be made by the medical material of following weight proportion:

Herba Schizonepetae 5-20, Radix Asteris 5-20, Radix Stemonae 5-20, Flos Farfarae 5-20, Pericarpium Citri Reticulatae 5-20, Poria 5-20,

Radix Platycodonis 5-20, Fructus Aurantii 5-20, Fructus Arctii 2-15, Radix Ophiopogonis 5-20, Fructus Hordei Germinatus 5-20, Radix Glycyrrhizae 5-20,

2, according to the described a kind of treatment infantile cough Chinese medicine preparation of claim 1, wherein the weight proportion of used each medical material is:

Herba Schizonepetae 10, Radix Asteris 10, the Radix Stemonae 10, Flos Farfarae 10, Pericarpium Citri Reticulatae 10, Poria 10,

Radix Platycodonis 10, Fructus Aurantii 10, Fructus Arctii 5, Radix Ophiopogonis 10, Fructus Hordei Germinatus 10, Radix Glycyrrhizae 10,

3, a kind of treatment infantile cough Chinese medicine preparation is characterized in that it is to be made by the medical material of following weight proportion:

Herba Schizonepetae 5-20, Radix Asteris 5-20, Radix Stemonae 5-20, Flos Farfarae 5-20, Pericarpium Citri Reticulatae 5-20, Poria 5-20,

Radix Platycodonis 5-20, Fructus Aurantii 5-20, Fructus Arctii 2-15, Radix Ophiopogonis 5-20, Fructus Hordei Germinatus 5-20, Radix Glycyrrhizae 5-20,

Radix Peucedani 5-20, Lasiosphaera Seu Calvatia 2-15, Rhizoma Belamcandae 2-15, Bulbus Lilii 10-30, Massa Medicata Fermentata 5-20, Fructus Crataegi 5-20,

4, according to the described a kind of treatment infantile cough Chinese medicine preparation of claim 3, wherein the weight proportion of used each medical material is:

Herba Schizonepetae 10, Radix Asteris 10, the Radix Stemonae 10, Flos Farfarae 10, Pericarpium Citri Reticulatae 10, Poria 10,

Radix Platycodonis 10, Fructus Aurantii 10, Fructus Arctii 5, Radix Ophiopogonis 10, Fructus Hordei Germinatus 10, Radix Glycyrrhizae 10,

Radix Peucedani 10, Lasiosphaera Seu Calvatia 5, Rhizoma Belamcandae 5, Bulbus Lilii 15, Massa Medicata Fermentata 10, Fructus Crataegi 10,

5,, wherein also comprise adjuvant suitable and kind according to claim 1,2 or 3 described a kind of treatment infantile cough Chinese medicine preparation.

6, a kind of treatment infantile cough Chinese medicine preparation according to claim 5, it is a said dosage form on any pharmaceutics.

7, a kind of children's's Anshen Bunao Chinese medicine preparation according to claim 6, it is a granule.

8, a kind of preparation method for the treatment of the granule of infantile cough Chinese medicine preparation according to claim 7 is characterized in that:

A: above all medical materials are decocted with water secondary, 2 hours for the first time; 1.5 hours for the second time;

B: merge the secondary decocting liquid, filter, filtrate was left standstill 24 hours;

C: get the supernatant concentration thick paste, put coldly, add ethanol, and fully stir to make and contain the alcohol amount and reach 60%, leave standstill leaching supernatant after 24 hours;

D: remove ethanol;

E: be concentrated into thick paste, add an amount of Icing Sugar mixed pelletization;

F: dry, granulate is packed promptly.