CN100455295C - Dripping pill made from red rice and its preparing method - Google Patents
Dripping pill made from red rice and its preparing method Download PDFInfo
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- CN100455295C CN100455295C CNB2005101234604A CN200510123460A CN100455295C CN 100455295 C CN100455295 C CN 100455295C CN B2005101234604 A CNB2005101234604 A CN B2005101234604A CN 200510123460 A CN200510123460 A CN 200510123460A CN 100455295 C CN100455295 C CN 100455295C
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- monas cuspurpureus
- cuspurpureus went
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- extract
- polyethylene glycol
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Abstract
The present invention relates to a kind of dripping pill for treating hyperlipemia and its preparation process. The dripping pill is prepared with red rice extract and polyglycol in the weight ratio of 1 to 1-3 as material. The red rice extract is prepared through the following steps: extracting red rice with 75 % concentration ethanol solution, filtering and concentrating the filtrate to obtain concentrate of density 0.9-1.1; crushing small amount of red rice; spraying the concentrate to the red rice powder and fluid-bed drying; and grinding to obtain the red rice extract. The dripping pill of the present invention has the features of high bioavailability, fast medicine release, quick acting, etc.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, drop pill of particularly a kind of treatment hyperlipidemia made from Monas cuspurpureus Went and preparation method thereof.
Background technology
Owing to reasons such as technologies of preparing, the oral formulations of most drug, especially the oral formulations of Chinese medicine, exist all after taking that dissolve scattered time limit is long, dissolution is low, absorption is relatively poor, problem such as liver sausage first pass effect and bioavailability are lower, thereby influence the performance of drug effect, also directly affect therapeutic effect.In addition, conventional peroral dosage form is as tablet, capsule, granule (electuary) etc., in preparation process because the technology of granulation is arranged, therefore can produce bigger dust pollution, can staff's health be worked the mischief to a certain extent, also can cause certain pollution simultaneously to environment.Moreover, the complex manufacturing of conventional oral formulations, production cost is higher, thereby patient's drug cost is also improved thereupon, is unfavorable for improving the ability of seeking medical advice of extensive patients, also is unfavorable for improving the general health level of society.
The drop pill that adopts solid dispersion technology to be prepared from has just thoroughly changed the existing defective of conventional drug composition oral preparation from the frame mode of medicine.Owing to make the active component of medicine and substrate fusion be one and form liquid in advance, make active constituents of medicine fully dissolve and be dispersed in uniformly in the chemical lattice of substrate fused solution, thereby make the effective surface area of drug molecule (group) increase greatly, improved the contact area of active constituents of medicine dissolving back with gastrointestinal tract mucosa; Owing to the ease of solubility of substrate, make drop pill after taking, can dissolve rapidly, and absorbed simultaneously, played high speed, good effect efficiently by gastrointestinal tract mucosa.In addition, because the medicament contg height of drop pill, volume is little, dissolution velocity is fast, dissolving back mouthfeel is good, also can adopt the mode of sublingual administration, can make effective ingredient directly absorb and enter blood circulation by the Sublingual mucosa without gastrointestinal tract and liver, avoid the first pass effect of conventional oral formulations effectively, also avoided some drugs gastrointestinal tract to be produced the side effect that stimulates.Application number is in the open source literature of Chinese invention patent " is the Chinese medicine Monas cuspurpureus Went and the preparation thereof of main active with lovastatin salt " of 03135632.X, discloses a kind of dropping pill formulation that utilizes Monas cuspurpureus Went to make.
When utilizing solid dispersion technology to prepare drop pill, the character of medicine, the kind of substrate and with the ratio of medicament mixed, condensing agent and temperature thereof, drip many factors such as system speed and all affect the molding and the quality of drop pill, according to the prepared dropping pill formulation that forms of disclosed preparation method in the above-mentioned prior art, the certified products of its rounding rate are only about 60% in test, and the different qualification rate of the ball method of double differences only reaches 50%～58%, hardness is also relatively poor simultaneously, differ bigger with the quality index of the relevant dropping pill formulation of defined in the national drug standards, such product is in use having a strong impact on the accuracy of dosage, make also that aborning the qualification rate of product reduces greatly, thereby increased production cost, also directly increased patient's drug cost, moreover such qualification rate also is difficult to obtain New Drug Certificate and produces official written reply because of the quality standard that does not reach the relevant dropping pill formulation of national drug management board, thereby makes its practicality also reduce greatly thereupon.
Summary of the invention
The object of the invention is to provide a kind of drop pill for the treatment of hyperlipidemia and preparation method thereof.
The present invention seeks to be achieved through the following technical solutions.
Drop pill of the present invention is to make with the raw material of following weight portion:
Monas cuspurpureus Went extract: Polyethylene Glycol=1: 1～3.
Preferred weight part of described drop pill raw material is:
Monas cuspurpureus Went extract: Polyethylene Glycol=1: 1.5,1: 2 or 1: 2.5.
Described Polyethylene Glycol can be a Polyethylene Glycol
2000～20000, comprise Polyethylene Glycol
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
10000Or Polyethylene Glycol
20000Deng, preferred Polyethylene Glycol
4000
Described Monas cuspurpureus Went extract can be by disclosed method preparation in patent No. zl97103970.4 or the zl97116744.3 patented technology, and also prepared or purchase acquisition on market routinely also can be prepared by following method:
Get Monas cuspurpureus Went, with 75% ethanol extraction 1～3 time, add 2～3 times of amount ethanol at every turn, extracted 2～3 hours at every turn, filter, merging filtrate reclaims ethanol, is concentrated into 55～60 ℃ of temperature measuring relative densities and is 0.9～1.1 concentrated solution; Other is taken as the Monas cuspurpureus Went of aforementioned Monas cuspurpureus Went 1/10～1/6 weight (preferred 1/7,1/8 or 1/9), is ground into fine powder, and concentrated solution is constantly sprayed in the Monas cuspurpureus Went fine powder, and airpillow-dry gets dry extract; With dry extract, be ground into fine powder, promptly get Monas cuspurpureus Went extract.
The condition of above-mentioned airpillow-dry is: temperature of charge is preferably 60～80 ℃, hydrojet speed and is preferably 25～35 liters/hour.
The preparation method of drop pill of the present invention is:
After the Polyethylene Glycol heat fused, add Monas cuspurpureus Went extract, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.Specification can be 75mg/ ball (piller) or 375mg/ ball (big ball).
Described coolant can be selected from any one in simethicone, liquid paraffin or the vegetable oil.
Drop pill of the present invention is that Monas cuspurpureus Went extract and Polyethylene Glycol are made the drop pill that forms through melting to drip, and is the aubergine drop pill, and abnormal smells from the patient acid is lightly seasoned.Contain lovastatin (C in every 1g drop pill
24H
36O
5) must not count and be lower than 3.3mg.
The present invention utilizes the solid dispersion technology principle to prepare drop pill, at different suitable crowd and indications, can be designed to two kinds of specifications, first kind of drop pill (or claiming piller) that specification is the 75mg/ ball, second kind of drop pill (or claiming big ball) that specification is the 375mg/ ball.Confirm that through the test of groping property of repeated multiple times molding two kinds of specifications are all with Polyethylene Glycol especially Polyethylene Glycol
4000(PEG
4000) be substrate, a system effect is best.PEG
4000After appropriate ratio and medicament mixed, the easiest fusion or the uniform dispersion of miscible formation, also the easiest dissolubility and the dissolution velocity of making type and can improving medicine.
On the drop pill raw material screening basis to two kinds of specifications, through Monas cuspurpureus Went extract and substrate Polyethylene Glycol ratio (A), fluid temperature (B), condensing agent temperature (C) 3 factors are investigated, each factor is got 3 levels, presses L
9(3)
4Orthogonal test table contrived experiment scheme.Droplet ball result of the test shows: three factors of ABC all have certain influence to the result, and its primary and secondary is A＞B＞C in proper order, and optimum process condition is A
3B
2C
3Be Monas cuspurpureus Went extract: PEG
4000=1: 1.5, fluid temperature should be 75 ± 2 ℃; Coolant temperature is 20 ± 2 ℃.The large dripping pillar result of the test shows: the A factor all has appreciable impact to the result, and the BC factor does not have obvious influence to the result.Optimum process condition is A
1B
2C
3Be Monas cuspurpureus Went extract: PEG
4000=1: 1.5, fluid temperature is 75 ± 2 ℃; Coolant temperature is 20 ± 2 ℃.
Experimental study shows that drop pill of the present invention compared with prior art has the bioavailability height, fast release, produce effects fast, medicament contg height, accurate measurement, taking convenience, characteristics such as cheap and pollution-free aborning.
1. drop pill rounding rate height of the present invention, the ball method of double differences are different little, can satisfy the quality standard of stipulating in the national drug standards fully about dropping pill formulation, therefore make that the accuracy of dosage greatly improves clinically, production cost reduces, and has therefore also possessed industrial applicibility.
2. drop pill of the present invention is substrate with the surfactant; make solid dispersion with the extract that contains the Monas cuspurpureus Went active pharmaceutical ingredient; making medicine be molecule, colloid or microcrystalline state is scattered in the substrate; the total surface area of medicine increases, and substrate is hydrophilic, and medicine is had wetting action; can make medicine molten microgranule or the solution of loosing into rapidly; thereby make the dissolving of medicine and absorb to accelerate, thereby improved bioavailability, bring into play efficient, quick-acting effects etc.
3. drop pill of the present invention contacts promptly with saliva and dissolves rapidly, and is absorbed by oral mucosa, and is not only rapid-action, and the influence of not taken food, be all can containing to take after meal ante cibum, also can not produce any residual harmful substance, thereby make that patient's medication is safer at gastric; Also have medication convenience, characteristic of accurate simultaneously.
4. the present invention mixes the extract that contains active constituents of medicine mutually with molten matrix, splashes in the not miscible condensed fluid and makes.Therefore, the stability of drug height, not facile hydrolysis, oxidation, and the operation be under liquid state, to carry out, no dust pollution is not subject to the influence of crystal formation, thereby has guaranteed the quality of medicine, has increased stability.
5. the production technology of drop pill of the present invention, equipment are simple, easy to operate, the automaticity height, and labor intensity is low, the production efficiency height; Workshop does not have dust simultaneously, helps labor protection and environmental protection yet.
Experimental example 1 Monas cuspurpureus Went extraction process airpillow-dry condition research
Behind 75% ethanol extraction Monas cuspurpureus Went, by temperature of charge is 40～60 ℃, 60～80 ℃, 80～100 ℃, 20～25 liters/hour of hydrojet speed, 25～35 liters/hour, 35～40 liters/hour screen, result: when temperature of charge is 40～60 ℃, temperature of charge is low excessively, powder is difficult for dry, easily caking.Hydrojet speed is 20～25 liters/hour, and hydrojet speed is low, and flow is little, influences efficient.Hydrojet speed is 35～40 liters/hour, and hydrojet speed is fast, and powder is difficult for fully dry, easily caking.When temperature of charge was 80～100 ℃, temperature of charge was too high, may cause the decomposition of effective ingredient in the Monas cuspurpureus Went.So selecting temperature of charge is that the condition of 25～35 liters/hour of 60～80 ℃, hydrojet speed is carried out airpillow-dry as the airpillow-dry condition.
Experimental example 2 drop pill raw material screening experiments of the present invention
To The selection result, be that index is estimated with hardness, roundness, dissolve scattered time limit, yield, stability on the 7th, simultaneously test drop pill raw material is screened.According to different suitable crowds and the compliance of taking medicine thereof, the preparation of two kinds of specifications of design, first kind of drop pill (or claiming piller) that specification is the 75mg/ ball, second kind of drop pill (or claiming big ball) that specification is the 375mg/ ball the results are shown in following table.
The little drop pill of table 1 Xuezhikang (the little drop pill of the present invention) (75mg) is developed mesostroma and coolant The selection result table
Table 2 Xuezhikang large dripping pillar (large dripping pillar of the present invention) development mesostroma and coolant The selection result table
The result shows, uses PEG respectively separately
10000And PEG
6000And no matter S__40 leads when doing substrate: auxilliary=1: 1.0, still be 1: 2.0 at 1: 1.5, and its drop pill mouldability all relatively poor relatively (integration is lower) is especially poorer in liquid paraffin.What molding effect was best is to use PEG separately
4000Do substrate, medicine-assist proportioning at 1: 1.5 o'clock, integration the highest (23).This product is when dripping the big ball of system, and its used substrate is also with PEG
4000For good, and medicine-auxilliary proportioning and the condensing agent range of choice with drip when making piller similar.
Experimental example 3 optimum process condition screening experiment
Respectively three kinds of factors such as the ratio of medicine in the development of the little drop pill of the present invention and large dripping pillar and substrate, fluid temperature, coolant temperature are investigated with orthogonal experiment, every factor is got three levels; With hardness, roundness, dissolve scattered time limit, yield evaluation index as this product key property, set standards of grading and test and assess, and do statistical analysis, find out optimum process condition, see the following form:
Table 3 Xuezhikang drop pill (piller of the present invention) factor level table
Table 4 Xuezhikang drop pill (piller of the present invention) L
9(3)
4Orthogonal test scheme and result
Table 5 Xuezhikang drop pill (piller of the present invention) orthogonal test analysis of variance table
Table 6 Xuezhikang drop pill (the big ball of the present invention) factor level table
Table 7 Xuezhikang drop pill (the big ball of the present invention) L
9(3)
4Orthogonal test scheme and result
Table 8 Xuezhikang drop pill (the big ball of the present invention) orthogonal test analysis of variance table
Orthogonal experiments is estimated: the set A of orthogonal test, B, three kinds of factors of C all have certain influence to droplet ball Forming Quality of the present invention.Wherein A factor extreme difference maximum (5.667) proves that the A factor is the main factor of influence test; Next is B factor (extreme difference is 1.667); Be C factor (extreme difference is 1.000) once more; That is: A＞B＞C.A in the A factor
3(be A
K3) value maximum (18.667), prove A
3Be the auxilliary proportioning of best medicine; B in the B factor
2(be B
K2) value maximum (16.667), prove B
2Be the suitableeest fluid temperature; C in the C factor
2And C
3(be C
K2And C
K3) be worth big (16.000), prove C
2Or
C3Be the suitableeest condensing agent temperature.The main factor that the A factor is really tested for influence, and the tool significant difference (P＜0.05=, the B factor also has clearly influence to test, and the C factor also has certain influence to result of the test.
The set A of large dripping pillar orthogonal test, B, three kinds of factors of C also all have certain influence to large dripping pillar Forming Quality of the present invention.Wherein A factor extreme difference maximum (6.000) proves that the A factor is the main factor of influence test; The B factor is taken second place (extreme difference is 1.667), and the C factor influences minimum (extreme difference is 1.000), that is: A＞B＞C to experiment.All the other results are similar to droplet ball situation.The A factor really is the main factor of influence test, and the tool significant difference (P＜0.05=, B factor and C factor also have certain influence to test.
The result shows that this is A about the proportioning raw materials of large and small drop pill and the optimum condition of technical study
3B
2C
3Be that the drop pill raw material is Monas cuspurpureus Went extract: PEG
4000=1: 1.5, fluid temperature should be 75 ± 2 ℃; Coolant temperature is 20 ± 2 ℃.
Following embodiment all can realize the described effect of above-mentioned experimental example.
Embodiment 1:Drop pill of the present invention (piller)
The prepared Monas cuspurpureus Went extract is got 20.0g routinely, with PEG
600030.0g after the heat fused, add Monas cuspurpureus Went extract, mix homogeneously, 75 ℃ of insulations; Select suitable water dropper, splash in the refrigerative liquid paraffin, wherein the temperature of coolant fluid paraffin body is 20 ℃, after the molding drop pill is taken out, and removes surface liquid paraffin, and packing promptly.The 75mg/ ball.
Embodiment 2:Drop pill of the present invention (big ball)
The prepared Monas cuspurpureus Went extract is got 200.0g routinely, with PEG
10000400.0g after the heat fused, add Monas cuspurpureus Went extract, mix homogeneously, 74 ℃ of insulations; Select suitable water dropper, splash in the refrigerative vegetable oil, wherein the temperature of coolant vegetable oil is 21 ℃, after the molding drop pill is taken out, and removes plants on surface oil, and packing promptly.The 375mg/ ball.
Embodiment 3:Drop pill of the present invention (big ball)
Get Monas cuspurpureus Went extract 200.0g, with PEG
20000500.0g after the heat fused, add Monas cuspurpureus Went extract, mix homogeneously, 76 ℃ of insulations; Select suitable water dropper, splash in the refrigerative vegetable oil, wherein the temperature of coolant vegetable oil is 19 ℃, after the molding drop pill is taken out, and removes plants on surface oil, and packing promptly.The 375mg/ ball.
Embodiment 4:Drop pill of the present invention (piller)
Monas cuspurpureus Went extract 30.0g
Polyethylene Glycol
400045.0g
Make 1000 balls
Get Monas cuspurpureus Went 112.5g, with 75% ethanol extraction secondary, added triplication 3 hours for the first time, filter, added qdx 2 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the concentrated solution of relative density 0.9～1.1 (55～60 ℃); In addition the 16.5g Hongqu powder (red colouring agent) is broken into fine powder, concentrated solution is constantly sprayed in the Monas cuspurpureus Went fine powder, airpillow-dry, wherein temperature of charge is 30 liters/hour of 70 ℃, hydrojet speed, dry extract; With dry extract, be ground into fine powder, get Monas cuspurpureus Went extract 30.0g, standby; With PEG
4000(Polyethylene Glycol
4000) after the heat fused, add above-mentioned Monas cuspurpureus Went extract, mix homogeneously, 75 ℃ of insulations; Select suitable water dropper, splash in the refrigerative simethicone, wherein the temperature of coolant simethicone is 20 ℃, after the molding drop pill is taken out, and removes surperficial simethicone, and packing promptly.The 75mg/ ball.
Embodiment 5:Drop pill of the present invention (big ball)
Monas cuspurpureus Went extract 150.0g
Polyethylene Glycol
2000150.0g
Make 1000 balls
Get Monas cuspurpureus Went 562.5g,, added triplication 3 hours for the first time, filter with 75% ethanol extraction three times, for the second time added qdx 2 hours, filter, added qdx for the third time 2 hours, filter, merging filtrate reclaims ethanol, is concentrated into the concentrated solution of relative density 0.9～1.1 (55～60 ℃); In addition the 82.5g Hongqu powder (red colouring agent) is broken into fine powder, concentrated solution is constantly sprayed in the Monas cuspurpureus Went fine powder, airpillow-dry, wherein temperature of charge is that 78 ℃, hydrojet speed are 27 liters/hour, dry extract.With dry extract, be ground into fine powder, get Monas cuspurpureus Went extract 150.0g, standby.With PEG
2000After the heat fused, add above-mentioned Monas cuspurpureus Went extract, mix homogeneously, 77 ℃ of insulations.Select suitable water dropper, splash in the refrigerative simethicone, wherein the temperature of coolant simethicone is 18 ℃, after the molding drop pill is taken out, and removes surperficial simethicone, and packing promptly.The 375mg/ ball.
Embodiment 6:Drop pill of the present invention (piller)
Monas cuspurpureus Went extract 60.0g
Polyethylene Glycol
6000120.0g
Make 2000 balls
Get Monas cuspurpureus Went 225g, with 75% ethanol extraction three times, added qdx 3 hours for the first time, filter, the back added triplication 3 hours twice, filtered, and merging filtrate reclaims ethanol, is concentrated into the concentrated solution of relative density 0.9～1.1 (55～60 ℃); In addition the 25g Hongqu powder (red colouring agent) is broken into fine powder, concentrated solution is constantly sprayed in the Monas cuspurpureus Went fine powder, airpillow-dry, wherein temperature of charge is that 66 ℃, hydrojet speed are 33 liters/hour, dry extract; With dry extract, be ground into fine powder, get Monas cuspurpureus Went extract 60.0g, standby; With PEG
6000(Polyethylene Glycol
6000) after the heat fused, add above-mentioned Monas cuspurpureus Went extract, mix homogeneously, 73 ℃ of insulations; Select suitable water dropper, splash in the refrigerative liquid paraffin, wherein the temperature of coolant fluid paraffin body is 22 ℃, after the molding drop pill is taken out, and removes surface liquid paraffin, and packing promptly.The 75mg/ ball.
Claims (6)
1, a kind of drop pill made from Monas cuspurpureus Went is characterized in that this drop pill made by following method:
Get the raw material of following weight portion:
Monas cuspurpureus Went extract: Polyethylene Glycol=1: 1～3;
Get Monas cuspurpureus Went, with 75% ethanol extraction 1～3 time, add 2～3 times of amount ethanol at every turn, extracted 2～3 hours at every turn, filter, merging filtrate reclaims ethanol, is concentrated into 55～60 ℃ of temperature measuring relative densities and is 0.9～1.1 concentrated solution; Other is taken as the Monas cuspurpureus Went of aforementioned Monas cuspurpureus Went 1/10-1/6 weight, is ground into fine powder; Concentrated solution is constantly sprayed in the Monas cuspurpureus Went fine powder, and airpillow-dry gets dry extract; With dry extract, be ground into fine powder, promptly get Monas cuspurpureus Went extract; The condition of described airpillow-dry is: temperature of charge is 60～80 ℃, 25～35 liters/hour of hydrojet speed; After the Polyethylene Glycol heat fused, add above-mentioned Monas cuspurpureus Went extract, mix homogeneously, 75 ± 2 ℃ of insulations; Go in the coolant with dropping-pill machine, wherein the temperature of coolant is 20 ± 2 ℃, after the molding drop pill is taken out, and removes the coolant on surface, and packing promptly.
2, drop pill as claimed in claim 1 is characterized in that this drop pill is to make with the raw material of following weight portion:
Get the raw material of following weight portion:
Monas cuspurpureus Went extract: Polyethylene Glycol=1: 1.5.
3, drop pill as claimed in claim 1 is characterized in that this drop pill is to make with the raw material of following weight portion:
Get the raw material of following weight portion:
Monas cuspurpureus Went extract: Polyethylene Glycol=1: 2.
4, drop pill as claimed in claim 1 is characterized in that this drop pill is to make with the raw material of following weight portion:
Get the raw material of following weight portion:
Monas cuspurpureus Went extract: Polyethylene Glycol=1: 2.5.
5,, it is characterized in that Polyethylene Glycol is a Polyethylene Glycol as claim 1,2,3 or 4 described drop pill
2000, Polyethylene Glycol
4000, Polyethylene Glycol
6000, Polyethylene Glycol
10000Or Polyethylene Glycol
20000
6, drop pill as claimed in claim 1 is characterized in that this Monas cuspurpureus Went extract made by following method:
Get Monas cuspurpureus Went, with 75% ethanol extraction secondary, for the first time added triplication 3 hours, filter, added qdx 2 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into 55～60 ℃ of temperature measuring relative densities and is 0.9～1.1 concentrated solution; The Hongqu powder (red colouring agent) that other is taken as aforementioned Monas cuspurpureus Went 1/7,1/8 or 1/9 weight is broken into fine powder; Concentrated solution is constantly sprayed in the Monas cuspurpureus Went fine powder, and airpillow-dry gets dry extract; With dry extract, be ground into fine powder, promptly get Monas cuspurpureus Went extract.
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|---|---|---|---|
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| CN200510087010.4 | 2005-07-22 | ||
| CNB2005101234604A CN100455295C (en) | 2005-07-22 | 2005-11-21 | Dripping pill made from red rice and its preparing method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102617533A (en) * | 2011-02-01 | 2012-08-01 | 北京北大维信生物科技有限公司 | Compound separated from red yeast rice, its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579367B (en) * | 2008-05-15 | 2012-07-18 | 北京北大维信生物科技有限公司 | Medicinal dripping pill for treating rickets |
| CN103239459B (en) * | 2012-02-02 | 2015-03-11 | 北京北大维信生物科技有限公司 | Use of sterol derivative in preparation of medicines for preventing and/or treating and/or adjunctively treating cancers |
| CN103372051B (en) * | 2012-04-20 | 2015-04-15 | 北京北大维信生物科技有限公司 | Red rice and kudzuvine root medicinal composition for regulating blood fat and preparation method of the composition |
| CN103372114B (en) * | 2012-04-20 | 2015-01-21 | 北京北大维信生物科技有限公司 | Red rice and rhizoma alismatis medicinal composition for regulating blood fat and preparation method of composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528291A (en) * | 2003-10-08 | 2004-09-15 | 南昌弘益科技有限公司 | Lovastatin drop pill and preparing method thereof |
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2005
- 2005-11-21 CN CNB2005101234604A patent/CN100455295C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528291A (en) * | 2003-10-08 | 2004-09-15 | 南昌弘益科技有限公司 | Lovastatin drop pill and preparing method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102617533A (en) * | 2011-02-01 | 2012-08-01 | 北京北大维信生物科技有限公司 | Compound separated from red yeast rice, its preparation method and application |
| CN102617533B (en) * | 2011-02-01 | 2014-08-27 | 北京北大维信生物科技有限公司 | Compound separated from red yeast rice, its preparation method and application |
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