CN100454477C - Single-particle aerosol online ionization source and realization method thereof - Google Patents

Single-particle aerosol online ionization source and realization method thereof Download PDF

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CN100454477C
CN100454477C CN 200510102354 CN200510102354A CN100454477C CN 100454477 C CN100454477 C CN 100454477C CN 200510102354 CN200510102354 CN 200510102354 CN 200510102354 A CN200510102354 A CN 200510102354A CN 100454477 C CN100454477 C CN 100454477C
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aerosol
low pressure
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quadrupole
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CN1838370A (en )
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忠 傅
振 周
盛国英
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广州禾信自动化系统有限公司
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Abstract

本发明提供一种单颗粒气溶胶在线电离源,设置于飞行时间质量分析器的加速区之外,包括电离激光器、低压射频四极杆,所述电离激光器发射的激光束垂直于低压射频四极杆入射至其内切圆心。 The present invention provides a single-line aerosol particle ionization source disposed at the acceleration time of flight mass analyzer region outside, including a laser ionization, a quadrupole radio frequency low pressure, the ionizing laser emits a laser beam perpendicularly to the low pressure RF quadrupole endo rod enters its center. 一种利用前述电离源实现的方法,主要是对单颗粒气溶胶利用空气动力学测径后,在其进入飞行时间质量分析器之前,利用电离激光将其电离成等离子体,所产生的正负离子利用低压射频四极杆聚焦成相空间很小的离子束再送入飞行时间质量分析器中。 A method implemented using the ionization source is mainly the use of a single caliper aerodynamic aerosol particles, before it enters the Time of Flight mass analyzer, which is ionized by ionizing laser beam into a plasma, the positive and negative ions low pressure RF quadrupole focused into a very small space relative to the ion beam and then into a time of flight mass analyzer. 本发明将电离区与空气动力学测径区连为一体,测径结束的同时气溶胶电离,最大程度缩小了气溶胶的漂移距离,明显提高了传输效率;低压射频四极杆的聚焦作用明显提高了飞行时间质量分析器的分辨率。 Ionization zone of the present invention with an aerodynamic diameter measuring area as a single entity, while the end of the caliper aerosol ionization, the maximum reduction degree of the drift distance aerosol, significantly improve the transmission efficiency; low pressure RF quadrupole focusing effect significantly increasing the resolution time of flight mass analyzer.

Description

单IMt气瀋鑛在饞电离羅及其实现方法 Single IMt gas ionization Luo Shen ore greedy and implementation

技术领域 FIELD

本发明涉及气溶胶颗粒在线测量技术,特别涉及一种单颗粒气溶胶在线电离源及其实现方法。 The present invention relates to the online measurement of the aerosol particles, and particularly relates to a particulate aerosol ionization source line and a single implementation.

背景技术 Background technique

气溶胶的大小及其化学成分对全球气候、大气质量、生态健康造成蜜 Aerosol size and chemical composition of honey cause global climate, air quality, ecological health

大影响。 Big impact. 单颗粒气溶胶在线监测飞行时间质谱仪(Aerosol Time-of-flight Mass Spectrometer, ATOFMS)是近年发展起来的一种新技术,可以实吋在线监测单颗粒气溶胶空气动力学直径及其大气污染成分,是判定气溶胶形成和来源的重要手段,其基本原理是通过空气动力学方法测量气溶胶直径, 再将气溶胶电离,电离形成的离子用质谱分析器进行检测。 Single aerosol particles online monitoring TOFMS (Aerosol Time-of-flight Mass Spectrometer, ATOFMS) in recent years developed a new technology may be a single solid line monitoring inch aerodynamic particle diameter of the aerosol composition and Air Pollution , is an important means of determining the source of aerosol formation and its basic principle is measured by an aerodynamic diameter of the aerosol method, and then an aerosol ionization, ions formed by ionization mass spectrometer for detection. 具体的空气动力学测量气溶胶粒径的方法及飞行时间质量分析器检测离子的方法参阅文献Mass Spectrometry of Aerosols, David T. Suess and Kimberly A. Prathei', Chem.Rev. 1999, 99, 3007-3035。 Specific methods for measuring the aerodynamic diameter of the aerosol and detection method of time of flight mass analyzer ions are found in the literature Mass Spectrometry of Aerosols, David T. Suess and Kimberly A. Prathei ', Chem.Rev. 1999, 99, 3007- 3035. 单颗粒气溶胶的在线电离通常采用激光电离源,并以飞行时间质量分析器作为离子信号检测器,为了同时监测个颗粒中的正负离子,需要两个飞行时间质量分析器。 Single particle aerosol online laser ionization source ionizing commonly used, and to the time of flight mass analyzer as the ion signal detector, in order to simultaneously monitor the positive and negative ions in the particles, requires two time-of-flight mass analyzer.

由于气溶胶是电中性颗粒,而电中性颗粒在真空中的传输无法用电f 离子光学系统进行调制,传输距离越远气溶胶的检测效率就越低。 Because the aerosol is electrically neutral particles, electrically neutral particles transmitted in vacuo f of electricity can not be modulated ion optical system, the lower the transmission distance aerosol detection efficiency. 目前已有的设备中,气溶胶的空气动力学测径距离一般为5〜!0掉:米,离子源离测径区还有另外的10〜20厘米,因此气溶胶的传输距离一般达到15〜3() 厘米。 Currently available devices, the aerosol aerodynamic diameter measurement generally from -5 to 0 out:! M, from the ion source region has another diameter measuring 10-20 cm, thus the transmission distance of up to 15 typically aerosols ~ 3 () cm. 这是由于在已有的设备中,电离源(激光电离源)设置在t行时间质量分析器中,气溶胶需要进入飞行时间质量分析器内才能被电离,所以其传输距离相对较远,由此产生了气溶胶检测效率较低的问题。 This is because in the conventional apparatus, the ionization source (a laser ionization source) provided on the time line t mass analyzer, the aerosol is required to enter the ionization time of flight mass analyzer, so that the transmission distance is relatively far from this produces a lower aerosol detection efficiency. 同时山于在已有设备中激光电离直接发生在飞行时间质量分析器中,电离产生的离子具有较大的初始动能分散,造成飞行时间质量分析器的质量分辨率偏低, 仅500左右。 Hill at the same time in the prior apparatus directly laser ionization time of flight mass analyzer occurs, ions having a large ionization initial kinetic energy dispersion, resulting in a time of flight mass resolution mass analyzer is low, only about 500.

发明内容 SUMMARY

本发明的目的在于克服现有技术的缺点与不足,提供一种结构合理的, 可提高气溶胶传输效率及电离命中率的,并可提高飞行时间质量分析器的质量分辨率的单颗粒气溶胶在线电离源。 Object of the present invention is to overcome the disadvantages and deficiencies of the prior art, to provide a reasonable structure, can improve the transmission efficiency and ionization of the aerosol hit rate, and improve the mass resolution of the TOF mass analyzer single aerosol particles online ionization source.

本发明的另一目的在于提供上述单颗粒气溶胶在线电离源的一种实现方法。 Another object of the present invention is to provide the single-line aerosol particle ionization source of an implementation method.

本发明的目的通过下述技术方案实现: 一种单颗粒气溶胶在线电离源, 设置于飞行时间质量分析器的加速区之外,包括电离激光器、低压射频四极杆,所述电离激光器发射的激光束垂直于低压射频四极杆入射至低压射频四极杆的内切圆心,将到达内切圆心位置的气溶胶电离。 Object of the present invention is achieved by the following technical solution: a particulate aerosol single ionization source line disposed at the acceleration time of flight mass analyzer region outside, including a laser ionization, a quadrupole radio frequency low pressure, the ionizing laser emits a laser beam perpendicularly to a low pressure radio frequency quadrupole is incident to the low pressure RF of four rods endo-center, to the center position of the aerosol Da Neiqie ionization.

所述电离激光器发射的激光束垂直于低压射频四极杆并于低压射频叫极杆轴向的中心位置入射。 The ionizing laser emits a laser beam perpendicularly to the low pressure RF quadrupole RF and low pressure rods called axial center position of incidence.

所述的低压射频四极杆是指在一定气压下的四极杆离子传输器。 The low pressure RF quadrupole means quadrupole ion transport vessel under a constant pressure. 所述低压射频四极杆具有四个方向的间隙,分别为气溶胶的引入l!、 激光测径系统的次级测径激光入射口、次级散射光出射口和激光电离系统的电离激光入射口。 The low pressure RF quadrupole having a gap of four directions, respectively, is introduced into an aerosol l !, laser diameter of the laser system of the caliper secondary entrance, the secondary scattered laser light exit port and the incident laser ionization ionization system mouth.

所述电离激光器与激光测径系统的次级测径光电倍增管相连接,电离激光器的触发脉冲由次级测径光电倍增管的输出信号提供。 Secondary caliper photomultiplier tube and the ionizing laser of a laser diameter measuring system is connected to the trigger pulse ionizing the laser output signal by the secondary PMT caliper provided.

所述低压射频四极杆的每根杆机械上由多节杆段组成,各节杆段之间设置有间隙以保证电绝缘,相邻两节杆段之间的间隙小于0.3mm。 The low pressure RF four on each of the rods by mechanical rods multilevel rod segments, a gap is provided between the rod segment sections in order to ensure electrical insulation, the gap between two adjacent rod segments is less than 0.3mm.

所述低压射频四极杆设置有轴向直流电场;所述激光束垂直入射点对应的低压射频四极杆位置的直流电位设置为0V,往低压射频四极杆方向相反的两端直流电位分别增加及减少,形成轴向直流电场以保证正离子往负电压端迁移,负离子往正电压端迁移。 The low pressure radio frequency quadrupole is provided with an axial DC electric field; low voltage DC level of the laser beam perpendicularly incident on a radio frequency corresponding to the point quadrupole position set to 0V, to a low pressure radio frequency quadrupole opposite ends respectively opposite DC potential increases and decreases, an axial DC electric field in order to ensure positive ions migrate to the negative voltage terminal, negative ions migrate toward the positive voltage terminal.

所述低压射频四极杆的各节杆段施加相同的射频电压以聚焦离子,所述射频电压和直流电压由电感、电阻和电容耦合在一起。 The low pressure RF quadrupole rod segment sections apply the same RF voltage to focus the ion, the RF voltage and DC voltage together with the inductance, resistance and capacitance coupling.

所述低压射频四极杆位于一个腔体内,所述腔体内的气体一般为化学稳定性良好的气体,如:氦气、氮气、氩气等;所述气体的气压视待测试离子的大小设置在0.1 Pa〜1 OOPa之间的范围。 The low pressure RF quadrupole in a cavity, the cavity gas is generally good gas chemical stability, such as: helium, nitrogen, argon and the like; depending on the pressure of the gas to be tested is sized ion in the range of between 0.1 Pa~1 OOPa.

本单颗粒气溶胶在线电离源的飞行时间质量分析器为垂直引入式飞行时间质量分析器,所述垂直引入式飞行时间质量分析器设置有两个,分别 Time of Flight mass analyzer of the present single-particle aerosol ionization source is a vertical line introduction time of flight mass analyzer, said vertical introduction time of flight mass analyzer is provided with two, respectively

检测正负离子。 Detect positive and negative ions. 此外,如果对气溶胶某成分的分子结构感兴趣,可以在低压射频四极杆后连接串级质谱仪即可以提供串级分析。 In addition, if interested in the molecular structure of a component of the aerosol, may be connected to a low pressure after the tandem mass spectrometer may be a radio frequency quadrupole analysis provides i.e. cascade.

本单颗粒气溶胶在线电离源与空气动力学测径区连为一体,次级测径激光与电离激光作用的位置相同,即在完成空气动力学测径的同时,进行电离。 This single-line aerosol particle ionization source aerodynamic diameter measuring area as a single entity, with the same secondary sizing laser ionization laser action position, i.e. in the completion of the aerodynamic caliper, ionized. 本发明涉及的气溶胶空气动力学测径技术与现有技术相同。 Aerosol aerodynamic diameter measurement techniques of the present invention is the same as the prior art.

为了使所有的离子得到检测,正负离子可以分别在低压射频四极杆两端累积几十个微秒再送入垂直引入式飞行时间质量分析器。 In order to detect all of the ions to give, respectively, positive and negative ions can be accumulated in the tens of microseconds Low voltage RF quadrupole and then introduced into the vertical time of flight mass analyzer. 带轴向场的低压射频四极杆原理与现有的技术相同,离子在四极杆两端的累积技术与现有技术也相同。 With axial low pressure RF quadrupole field principle the same as the prior art, the ion accumulation same technology in the prior art quadrupole ends.

一种利用上述单颗粒气溶胶在线电离源实现的方法,其特征在于:对单颗粒气溶胶利用空气动力学测径后,在其进入飞行时间质量分析器的加速区之前,利用激光将其电离成等离子体,所产生的正负离子利用低压射频四极杆聚焦成相空间很小的离子束再送入飞行时间质量分析器中进行检测。 The aerosol particles of the above single-line method implemented using the ionization source, wherein: single aerosol particle aerodynamics calipers after, before it enters the acceleration region of the Time of Flight mass analyzer, which is ionized by laser into a plasma, the positive and negative ions generated by low pressure RF quadrupole focused into a very small space relative to the ion beam and then into a time of flight mass analyzer for testing.

利用低压射频四极杆设置的轴向直流电场使电离后产生的正负离f分开并分别向低压射频四极杆的两端迁移(其中的正离子往低电位方向迁移, 而负离子同时往高电位方向迁移),然后分别被不同的飞行时间质量分析器检测。 Low pressure generated after the RF ionizing four negative pole rod arranged axially separated and DC electric field of each radio frequency f from both ends of the quadrupole migration into the low pressure (positive ions migrate to the low potential wherein the direction and the negative ion to a higher potential migration direction), and are different from the detection time of flight mass analyzer.

利用空气动力学测径系统的第二个光电倍增管产生的脉冲即时触发电 Instant pulse aerodynamic diameter measurement system using a second photomultiplier tube generated trigger

离激光器发出激光脉冲,利用该激光脉冲将单颗粒气溶胶电离成等离子体; 由于测径完成的同时立即发生电离,这样可提高电离命中率。 Laser pulse emitted from the laser, with the laser pulse single-particle aerosol ionized into a plasma; caliper since the ionization occurs immediately done simultaneously, so that the hit rate can be increased ionization.

本发明的作用原理是:设w/g、 (/,:/、 0>、"分别为离子质荷比、四极杆 Mechanisms of this invention is: Let w / g, (/,: /, 0>, "respectively, the ion mass to charge ratio, quadrupole

的射频电压、射频频率、四极杆内切圆半径,四极杆对离开内切圆屮心距 The RF voltage, the RF frequency, the radius of the inscribed circle within the quadrupole, the quadrupole exiting from the center of the inscribed circle Che

('// 4 、 ( '// 4,

离为r的离子形成一个有效位阱"#,其大小为,r。 ,选择适当的参数,可以使得该有效位阱达到几个甚至十几电子伏特。因此本发明将传统的气溶胶电离区从高真空的飞行时间质量分析器移到低真空的气溶胶传输区,并将电离发生在低压射频四极杆的中心,利用低压射频四极杆的位阱对离子的束缚和聚集作用,收集所有从气溶胶中电离得到的离子,并聚焦成相空间很小的离子束再送到飞行时间质量分析器中。由于具有轴向电场,正负离子分别向低压射频四极杆两端迁移得以分离,由于粒径测量 R is formed from the ion trap a valid bit "#, its size, r., Select the appropriate parameters, such that the effective potential wells can reach several or even hundreds of electron volts. Thus, the present invention will be conventional aerosol ionization region high vacuum from a time of flight mass analyzer vacuum moved aerosol low transmission region, and ionization of a low pressure RF four centers of rods, bound by low pressure RF and four rods aggregation potential well for ions collected all obtained from the aerosol ionized ions, and focused into a very small space with respect to the ion beam and then using the mass analyzer due to the electric field has an axial, positive and negative, respectively, to the low-frequency quadrupole rod ends can be separated migrate, Since the particle size measurement

和电离在同一空间位置发生,提高了电离命中率,又由于气溶胶的电离与离子质量检测完全分离,离子源对分析器的影响减到最小,明显提高了飞行时间质量分析器的质量分辨率。 And ionization occur at the same spatial position, to improve the hit rate of ionization, ionization and because the aerosol detector completely separated ion mass, ion source of the analyzer is minimized, significantly improve the mass resolution of the TOF mass analyzer .

本发明相对现有技术具有如下的优点及效果:(1)本发明将电离IX:与空气动力学测径区连为一体,空气动力学测径完成的同时将气溶胶电离, 最大程度地縮小了气溶胶的漂移距离,明显提高了传输效率和电离命中率。 The present invention relative to the prior art has the following advantages and effects: (1) The present invention will be ionized IX: aerodynamic diameter measuring area as a single entity, the aerodynamic diameter measurement performed simultaneously ionized aerosol, maximally reduced the drift distance aerosol transmission efficiency and significantly improve the hit rate of ionization. (2)随着气溶胶中被测成分分子量的增大,结构分析越来越重要,进行结构分析需要用到串级质谱技术,而传统的单颗粒气溶胶在线监测质谱技术不能达到此目的。 (2) As the molecular weight of the aerosol component to be measured is increased, more and more important structural analysis, structural analysis need to use tandem mass spectrometry, the traditional single-line monitoring mass spectrometry aerosol particles can not achieve this purpose. 由于本发明技术先将离子收集在射频四极杆中,因而可以与串级质谱分析器联用,所产生的离子可以被串级质谱检测,为分了离 Since the first technique of the present invention collected in the ion RF quadrupole, which can be used in combination with tandem mass analyzer, ions can be generated tandem mass spectrometric detection, as the isolated points

子的结构分析提供了可能。 Sub-structure analysis possible. (3)利用本发明可使得气溶胶粒径测量和电离 (3) the use of the present invention may be such that ionization and aerosol size measurements

在同一空间位置发生,并与离子质量检测完全分离,同时利用低压射频四 Occur at the same spatial position, and completely separated from the mass of the ion detected, while using a low pressure radio frequency four

极杆预先减小离子束的相空间,可提高飞行时间质量分析器的质量分辨净:。 Rods advance the phase space of the ion beam is reduced, it can improve the quality of the time of flight mass analyzer net resolution:.

附图说明图1是本发明装置的结构示意图。 BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a schematic view of the apparatus of the present invention.

图2是图1所示装置的低压射频四极杆的直流偏置电压和射频电压的耦合示意图。 FIG 2 is a schematic diagram of a DC coupled bias voltage and the RF voltage of the low voltage electrode rod 1 RF device shown in FIG. IV.

图3是本发明方法的原理图及脉冲时序图。 And FIG. 3 is a schematic diagram of pulse timing diagram of a method of the present invention.

具体实施方式 detailed description

下面结合实施例及附图对本发明作进一步详细的描述,但本发明的实施方式不限于此。 And the following description in conjunction with the accompanying drawings of the embodiments of the present invention will be further detailed embodiment, the embodiment of the present invention is not limited thereto. 实施例 Example

图1〜图3示出了本发明装置的具体结构,由图1可见,本单颗粒气溶胶在线电离源包括仪器真空腔体1、气溶胶进样器2、低压射频四极杆3及四极杆腔体4、激光测径及激光电离系统以及同时检测正、负离子的垂直引入式飞行时间质量分析器5、 6; 7为由气溶胶进样器2引入的气溶胶:低压射频四极杆3位于四极杆腔体4内,所述四极杆腔体内的气体一般为纯度高于99.99%的化学稳定性良好的气体,如:氮气、氮气、氩气等气体或其它惰性气体;所述气体的气压视待测试离子的大小设置在0.1Pa〜100Pa 1 ~ FIG. FIG. 3 shows a specific configuration of the apparatus of the present invention, seen from FIG. 1, the single-particle aerosol online ionization source includes an instrument vacuum chamber 1, an aerosol sampler 2, a low pressure RF quadrupole and four 3 rods chamber 4, and the laser diameter of the laser ionization system and simultaneously detecting positive and negative ions are introduced into the vertical time of flight mass analyzer 5, 6; 7 aerosol injector 2 by introducing aerosol: a low pressure RF quadrupole lever 3 is located within a cavity quadrupole 4, the quadrupole gas cavity is generally a purity greater than 99.99% good chemical stability gases, such as: nitrogen, nitrogen, argon gas or other inert gas; the pressure of the gas depends on the size of the ion to be tested is disposed 0.1Pa~100Pa

之间的范围。 Range between.

如图3所示,低压射频四极杆3具有四个方向的间隙,其中水平方向的两个间隙分别为气溶胶7的引入口和电离激光束19的引入口;垂直方向的上、下两个方向的间隙分别为激光测径系统的次级测径激光17的入射【! Two gaps, the gap 3 having a low pressure RF quadrupole four directions, which are the horizontal direction in FIG. 3 as an aerosol introduction port and the ionizing laser beam 19 is introduced into the port 7; the vertical direction, the two gap directions are incident laser diameter of the secondary system of the laser caliper 17 [! 和次级散射光21的测量口;电离激光器18发射的电离激光束19垂直于低压射频四极杆3,并于低压射频四极杆3轴向的中心位置入射至低压射频四极杆3的内切圆心,电离激光器18与次级测径光电倍增管20相连接,由其提供的脉冲触发;低压射频四极杆3的两端分别与垂直引入式飞行时间质量分析器5、 6相连接。 Measuring scattered light and the secondary port 21; ionization ionization laser 18 emitted laser light beam 19 perpendicular to the low pressure RF quadrupole 3, and the low pressure RF quadrupole axial center position 3 is incident to the low pressure RF quadrupole 3 endo center, secondary ionization laser 18 and the caliper 20 is connected to a photomultiplier tube, by providing a trigger pulse; Low voltage RF quadrupole 3 are introduced into a vertical flight time type mass analyzer 5, 6 is connected .

所述低压射频四极杆3的每根杆机械上由多节杆段8组成,具体结构如图2 (a)所示,各节杆段8之间设置有间隙以保证电绝缘,相邻两节杆段8之间的间隙小于0.3mm;在相邻两节杆段8之间并联设置有电阻9和电容10;各节杆段8所加的射频电压和直流偏置电压由电阻9和电容10 耦合在一起,直流偏置负电压加在节点11上,直流偏置正电压加在节点12 上,其它各节直流偏置电压由电阻9分压形成,而射频电压加在节点13匕并由电容10传到各节杆段,因而各节杆段所加的射频电压相同。 The low pressure RF quadrupole rod 3 of each machine section bar segments by a plurality of composition 8, a specific configuration of FIG. 2 (a), a gap is provided between the rod sections 8 to ensure that the sections electrically insulated from the adjacent 8, the gap between the two rod sections is less than 0.3 mm; two adjacent rod sections 8 are provided in parallel between the resistor 9 and capacitor 10; sections rod segment 8 and the RF voltage applied by the DC bias voltage resistor 9 and a coupling capacitor 10 together, a negative DC bias voltage applied to the node 11, a positive DC bias voltage applied to the node 12, a DC bias voltage to any other section is formed by a voltage division resistor 9, and the RF voltage applied at node 13 dagger transmitted by the capacitance sections rod segment 10, the same sections rod segment thus the applied RF voltage. 图2 (b) 所示为低压射频四极杆3沿轴向的直流偏置电位分布,中心位置电压为()V, FIG 2 (b) shown in the DC bias potential of the low-pressure 3 RF quadrupole distribution along the axial direction, the center position of the voltage of () V,

左端节点12设置正电位以吸引负离子,右端节点11设置负电位以吸引it: 离子,往低压射频四极杆方向相反的两端直流电位分别增加及减少,形成轴向直流电场,两端的电位差zlv可以控制离子的迁移速率。 Left node 12 is provided to a positive potential attract negative ions, a negative potential is provided right node 11 to attract it: ion, to a low pressure radio frequency quadrupole opposite ends opposite DC potential increases and decreases, respectively, form an axial DC electric field, the potential difference across the zlv may control the rate of migration of ions.

图3 (a)为气溶胶颗粒的测径及电离过程示意图,如图3 (a)所小, 激光测径及激光电离系统的测径激光器14、 16处于常开状态并发出激光束15、 17。 FIG. 3 (a) of the aerosol particles and the ionization process schematic caliper, as shown in FIG 3 (a) is small, laser diameter measuring diameter laser and laser ionization system 14, 16 in a normally open state and emits a laser beam 15, 17. 从大气中被气溶胶进样器2引入的气溶胶7经过激光束15、 ! The aerosol injector 2 from the atmosphere introduced through the aerosol 7 the laser beam 15,! 7所产生的散射光束2K 23分别被光电倍增管20、 22记录,并产生两个f]一定时间间隔f的电脉冲24、 25,如图3 (b)所示,根据两脉冲的时间间隔/及两束激光】5、 17的空间距离/可以计算出气溶胶的漂移速度v : / /, 通过校正气溶胶的漂移速度与颗粒直径的关系可以测出气溶胶的空气动力学直径。 7 2K 23 scattered light beam generated by the photomultiplier tube 20 are, record 22, and generates two f] f at intervals of electrical pulses 24, 25, FIG. 3 (b), according to a two-pulse time interval / 5], and the two laser beams, the spatial distance of 17 / drift velocity v can be calculated aerosol: / /, can be measured by the relationship between the drift velocity correction aerosol particle diameter and aerodynamic diameter of the aerosol. 光电倍增管20记录到的气溶胶到达脉冲25作为电离激光器l8的触发脉冲26,即当气溶胶到达低压射频四极杆3内切圆心位置吋,施加电离激光脉冲19,将气溶胶电离。 The photomultiplier tube 20 to the aerosol reaches the recording pulse 25 as the trigger l8 ionization laser 26, i.e., when the aerosol to the low pressure RF of the inscribed circle center 3 inch quadrupole ionizing laser pulse 19 is applied, ionization of the aerosol. 在电离激光脉冲19的作用下,气溶胶被电离产生等离子体,其中的正离子往低电位方向(图2 (a)中的节点ll端) Ionizing laser pulse at 19, the aerosol ionized plasma is generated, wherein the positive ions toward the direction of the low potential (ll end node (a) in FIG. 2)

迁移,而负离子同时往高电位方向(图2 (a)中的节点12端)迁移,敲后分别被垂直引入式飞行时间质量分析器5、 6检测。 Migration, while negative ions migrate toward the high potential direction (end nodes 212 (a)), the vertical are introduced into the time of flight mass analyzer 5, 6 detects the knock.

由于本发明装置中,离子的产生与离子的质量检测完全分离,所产生的离子可以送到任何质谱分析器中进行分析。 Since the apparatus of the present invention, the mass ion detector and the ion generating complete separation of the produced ions to be analyzed may be any mass spectrometer. 将本发明装置与串级质谱分析器联用,即可进行气溶胶成分的结构分析。 The analysis device of the present invention coupled with tandem mass spectrometer, the aerosol contents can be carried out structure.

上述实施例为本发明较佳的实施方式,但本发明的实施方式并不^上述实施例的限制,其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化,均应为等效的置换方式,都包含在本发明的保护范围之内。 The above-described preferred embodiment of the present invention embodiment, but the embodiment of the present invention is not limited to the above embodiments ^, changes made to any other without departing from the spirit and principle of the present invention, modifications, substitutions, combinations, simplified equivalent effect replacement method, are included within the scope of the present invention.

Claims (10)

  1. 1、一种单颗粒气溶胶在线电离源,其特征在于:设置于飞行时间质量分析器的加速区之外,包括电离激光器、低压射频四极杆,所述电离激光器发射的激光束垂直于低压射频四极杆入射至低压射频四极杆的内切圆心。 1, a single-line aerosol particle ionization source, comprising: acceleration provided in the region other than the time of flight mass analyzer, including a laser ionization, a quadrupole radio frequency low pressure, the ionizing laser emits a laser beam perpendicularly to a low pressure a radio frequency quadrupole is incident to the low pressure RF quadrupole inscribed circle.
  2. 2、 根据权利要求1所述的单颗粒气溶胶在线电离源,其特征在于: 所述电离激光器发射的激光束垂直于低压射频四极杆并于低压射频四极杆轴向的中心位置入射。 2, according to claim 1, the single-line aerosol particle ionization source, wherein: the ionizing laser emits a laser beam perpendicularly to the low pressure RF quadrupole and low pressure RF quadrupole axial center position of incidence.
  3. 3、 根据权利要求1或2所述的单颗粒气溶胶在线电离源,其特征在于:所述低压射频四极杆具有四个方向的间隙,其中水平方向间隙分别为气溶胶的引入口和电离徵光束的引入口,垂直方向的间隙分别为激光測径系统的次级测径澉光束的引入口和次级散射激光束的引出口。 3, according to claim 1 or 2, single-particle aerosol ionization source line, wherein: said gap has a low pressure RF quadrupole four directions, respectively, wherein a horizontal direction of the gap and ionization aerosol introduction port introducing port outlet gap intrinsic beam introduction port, respectively, in the vertical direction of the secondary laser system caliper caliper Gan beam and the secondary scattered laser beam.
  4. 4、 根据权利要求1或2所述的单颗粒气溶胶在线电离源,其特征在于:所述电离激光器与激光测径系统的次级测径光电倍增管相连接,由其提供的脉冲触发。 4, according to claim 1 or 2, single-line aerosol particle ionization source, wherein: the ionizing laser and laser diameter measuring diameter of the secondary system is connected to a photomultiplier tube, by providing a trigger pulse.
  5. 5、 根据权利要求1或2所述的单颗粒气溶胶在线电离源,其特征在于:所述低压射频四极杆的每根杆由多节杆段组成,各节杆段之间设置有绝缘间隙,相邻两节杆段之间的绝缘间隙小于0.3111111。 5, according to claim 1 or 2, single-particle aerosol ionization source line, wherein: each of the low RF quadrupole rod by a plurality of segmented rod segments, the insulation between the sections is provided with a rod segments gap, the insulating gap between two adjacent rod segments is less than 0.3111111.
  6. 6、 根据权利要求1或2所述的单颗粒气溶胶在线电离源,其特征在于:所述低压射频四极杆设置有轴向直流电场;所述激光束垂直入射点对应的低压射频四极杆位置的直流电位设置为0V,往低压射频四极杆方向相反的两端直流电位分别增加及减少,形成轴向直流电场;所述低压射频四极杆的各节杆段施加相同的射频电压,所述射频电压和直流电压由电阻和电容耦合在一起。 6, according to claim 1 or 2, single-line aerosol particle ionization source, wherein: the low pressure radio frequency quadrupole is provided with an axial DC electric field; the laser beam incident point corresponding to the vertical low pressure RF quadrupole DC potential lever position is set to 0V, to a low pressure radio frequency quadrupole directions opposite ends, respectively, increases and decreases in DC potential, an axial DC electric field; the low RF quadrupole rod segment sections apply the same RF voltage the RF voltage and DC voltage together by resistance and capacitance coupling.
  7. 7、 根据权利要求1或2所述的单颗粒气溶胶在线电离源,其特征在于:所述飞行时间质i分析器为垂直引入式飞行时间质量分析器或串级质谱分析器。 7, according to claim 1 or 2, single-particle aerosol ionization source line, wherein: i said time of flight mass analyzer is introduced into a vertical or time of flight mass analyzer tandem mass spectrometer.
  8. 8、 一种利用权利要求1〜7任一项所述的单颗粒气溶胶在线电离源实现的方法,其特征在于:对单顆粒气溶胶利用空气动力学澜径后,在其进入飞行时间质量分析器的加速区之前,利用电离激光将其电离成等离子体,所产生的正负离子利用低压射频四极杆聚焦成相空间很小的离子束再送入飞行时间质量分析器中。 8. A use as claimed in single-line aerosol particle method according to any ionization source implemented claims 1~7, wherein: the single aerosol particle aerodynamic diameter Lan use, it enters the time of flight mass before the acceleration zone of the analyzer, which is an ionizing laser ionized into a plasma, the positive and negative ions generated by low pressure RF quadrupole focused into a very small space relative to the ion beam and then into a time of flight mass analyzer.
  9. 9、 根据权利要求8所述的利用单颗粒气溶胶在线电离源实现的方法, 其特征在于:利用低压射频四极杆设置的轴向直流电场使电离后产生的正负离子分开并分别向低压射频四极杆的两端迁移,然后分别被不同极性的飞行时间质量分析器检测。 9. The use of the single-particle aerosol method of claim 8 implemented ionization source line, characterized in that: the use of positive and negative ions generated after ionizing axial DC electric field of a low pressure RF quadrupole and are provided separately to the low RF quadrupole migration ends, and are of different polarity detection time of flight mass analyzer.
  10. 10、 一种利用权利要求4所述的单颗粒气溶胶在线电离源实现的方法, 其特征在于:对单颗粒气溶胶利用空气动力学测径后,在其进入飞行时间质量分析器的加速区之前,利用电离激光将其电离成等离子体,所产生的正负离子利用低压射频四极杆聚焦成相空间很小的离子束再送入飞行时间质量分析器中;利用空气动力学测径系统的次级光电倍增管产生的脉冲即时触发电离激光器产生电离激光脉冲将单颗粒气溶胶电离成等离子体。 10. A method as claimed in claim 4 using a single-particle aerosols to achieve ionization source line, wherein: single aerosol particle aerodynamics calipers after it enters the acceleration region of the Time of Flight mass analyzer before, it is ionized by ionizing laser beam into a plasma, the positive and negative ions generated by low pressure RF quadrupole focused into a very small space relative to the ion beam and then into a time of flight mass analyzer; aerodynamics calipers secondary system instant pulse generating stage photomultiplier trigger ionizing laser pulse to laser ionization single-particle aerosol ionized into a plasma.
CN 200510102354 2005-12-16 2005-12-16 Single-particle aerosol online ionization source and realization method thereof CN100454477C (en)

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