CN100431435C - Use of four kinds of porphyrin compounds to remove carcinogenic substances from smoke of cigarette - Google Patents
Use of four kinds of porphyrin compounds to remove carcinogenic substances from smoke of cigarette Download PDFInfo
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- CN100431435C CN100431435C CNB2005101131190A CN200510113119A CN100431435C CN 100431435 C CN100431435 C CN 100431435C CN B2005101131190 A CNB2005101131190 A CN B2005101131190A CN 200510113119 A CN200510113119 A CN 200510113119A CN 100431435 C CN100431435 C CN 100431435C
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Abstract
The present invention relates to a method for removing cancinogenic substances (condensed aromatics, tobacco specific nitrite amine and aromatic amine) in the smoke of cigarettes. The method relates to an additive which is prepared by using porphyrin compounds and is added in filter tips and tobacco shreds so that the content of the carcinogenic substances in the smoke of cigarettes can be obviously reduced. The additive does not have harmful effects on the sucking quality of the smoke of the cigarettes. The toxicity and the mutagenicity of the cigarettes which use the material are obviously lower than those of blank cigarettes through the indication of animal experiments. The present invention has the advantages of simple and convenient operation, low cost and easy realization of industrialization.
Description
Technical field
The present invention relates to a kind of method of removing a few class carcinogenic substances (condensed-nuclei aromatics, tobacco-specific nitrosamine and aromatic amine) in the cigarette smoke.This method relates to porphyrins preparation additives of filter tip and tobacco shred additive, to remove a few class carcinogenic substances in the cigarette smoke.This additive has no adverse effects to the sucking quality of cigarette smoke, can not change the physical characteristic of filter tip itself again.Simultaneously show that through animal experiment the cigarette that utilizes this additive obviously is better than blank cigarette.It is simple to operation, with low cost, is easy to realize industrialization.
Background technology
Conventional cigarette is difficult to remove a few class carcinogenic substances (condensed-nuclei aromatics, tobacco-specific nitrosamine and aromatic amine) in the cigarette smoke, and for this reason, the scientific worker explores several different methods and reduces its content.Wherein, mainly be hemoglobin, ferroheme and protoporphyrin etc. with porphyrin substance or the material relevant as additive with the porphyrin class.
U.S. Pat 5909736 disclosed by with active carbon be the carrier impregnation hemoglobin or attached transferrins, hydrogen peroxide, protoporphyrin and cytochromes make additives of filter tip, the hazardous compound in the detention flue gas (NO, NO
x, carcinogenic nitroso compound, free radical, H
2O
2, CO, aldehydes and trace element).U.S. Pat 4414988 discloses a kind of filter tip that contains the porous material (as active carbon) of the Protoporphyrins compound solution that floods chelating ferrous ion, can effectively remove CO, benzo [a] pyrene (BaP) and derivative thereof etc. in the flue gas.Chinese patent CN1252245A proposes to select for use the biological tobacco tar reducing agent of making as primary raw material with the similar metalloporphyrin of biology enzyme structure, this biological tobacco tar reducing agent is made cigarette filter with filter-tip material, can reduce tar content and the pernicious gas CO, the NO content that reduce in the smog in the cigarette.Dai Ya etc. (Dai Ya etc. the preliminary experiment [J] of N-content of nitrosamines in the extraction of hemoglobin and the reduction cigarette. tobacco science and technology, 2001, (1): 19-21.) find, will be added in the cigarette filter, can make the N-nitrosamine in the cigarette smoke reduce about 50% by the hemoglobin that chicken blood extracts.Liu Shaomin (Liu Shaomin. the research that NOx holds back in the cigarette mainstream flue gas [J]. environment and health magazine, 2002, (3): 186-187.) inquired in cigarette filter and to add porphyrin and ferriporphyrin, the result shows that porphyrin and ferriporphyrin have nitrogen oxide in the cigarette mainstream flue gas and significantly holds back effect.Zhang Aihua (Zhang Aihua. ferroheme reduces the quadrature analysis [J] of tar content in cigarette. tobacco science and technology, 1992, (2): result of the test 27-28.) shows that the filter tip that adds ferroheme can make coke tar in cigarette reduce by 17.00%.
These additives are being brought into play certain effect aspect reducing tar and reducing harm, the assorted gas of minimizing and the excitant, but some additive is bigger to the cigarette odor-absorbing influence, has increased the difficulty of tobacco leaf formulation and blending.Some additives unstable or in cigarette, use difficult, for example: the free hemoglobin instability, easily depolymerization is α, β dimer half point, the general inanimate object activity of subunit after the depolymerization has only complete quaternary structure that biologically active is just arranged, and the half life in blood circulation only is 2～4h.No matter have the liposome embedded Hb of human to obtain artificial red blood cell (artificial blood), but this is at liquid system, concerning cigarette, be to add in filter tip or pipe tobacco, is solid, uses difficult; The ferroheme poor stability is subjected to easily to change after light, the heat.Simultaneously some additive complex manufacturing technology, loaded down with trivial details, cost is high, is difficult to realize industrialization.Therefore, be necessary that further seeking more to be appropriate to cigarette removes carcinogenic additive, to satisfy the actual demand of cigarette industry.
Summary of the invention
The present invention is in order to remove a few class carcinogenic substances (condensed-nuclei aromatics, tobacco-specific nitrosamine and aromatic amine) in the cigarette smoke better, by one or more porphyrinses, make additive with a certain amount of antioxidant, stabilizing agent, emulsifying agent and water, spray be added to make on the suitable carriers composite filter tip or (with) directly evenly spray with above-mentioned additive and to be added on the pipe tobacco rolling cigarette again, can effectively remove above-mentioned carcinogenic substance.
Cigarette additive of the present invention be the additive with porphyrins preparation add to cigarette with filter tip or (with) in the pipe tobacco.As additives of filter tip: carrier is that 6～12mg/ props up (cigarette), and additive is 0.1%～5.0% of a carrier quality; As tobacco shred additive: additive is 0.005%～1.0% of a tobacco quality.Contain one or more porphyrinses, antioxidant, stabilizing agent, emulsifying agent and water in the additive, its material relative amount is: deuteroporphyrin, haematoporphyrin, uroporphyrin, ProtoporphyrinIX 0.001～5.0%, V
C, V
EIn stabilizing agents such as antioxidant 0.001%～2.0%, beta-schardinger dextrin-, sodium carboxymethylcellulose, shitosan, gum arabic 0.001%～3.0%, tween, kation alkyl polysaccharide glycosides etc. emulsifying agent 0.1%～5.0% and water 85%～99%.
With the additive with method for preparing add on the carrier make composite filter tip or (with) add rolling cigarette on the pipe tobacco to.Carry out sensory evaluating smoking, conventional flue gas analysis, carcinogenic substance detection and animal experiment.Experiment shows, the aesthetic quality has no adverse effects to cigarette, tobacco-specific nitrosamine in the cigarette smoke (N-nitrosonornicotine, N-nitroso anabasine, N-nitroso anabasine, 4-(methyl nitrosamino group)-1-(3-pyridine radicals)-1-butanone) total amount reduces by 45% or more, benzo [a] pyrene reduces by 20% or more, benzo [a] anthracene reduction more than 20%, Chrysene reduction by 22%, four kind of aromatic amine (1-amino naphthalenes, 2-amino naphthalenes, 3-aminobphenyl, 4-aminobphenyl) total amount reduce more than 24%, compares with blank that toxicity reduces, mutagenicity obviously weakens.
Use the carcinogenic substance of removing in the cigarette smoke with the additive of porphyrins preparation of the present invention to have the following advantages:
1. make a few class carcinogenic substances (condensed-nuclei aromatics, tobacco-specific nitrosamine and aromatic amine) in the flue gas have tangible reduction, stability higher, be a kind of suitable low harm cigarette use harmful additive effectively falls;
2. cigarette odor-absorbing is had no adverse effects, can coordinate with cigarette smoke;
Wide material sources, simple for production, with low cost, be easy to realize industrialization;
The specific embodiment
Embodiment 1: take by weighing carrier 20Kg, add additive 100ml, wherein contain haematoporphyrin 3.00g, Vc1.00g, sodium carboxymethylcellulose 2.00g, tween 2.50g in the additive, water is that solvent obtains emulsion, evenly be sprayed onto on the carrier, the amount adding filter-tip cigarette making composite filter tip that props up (cigarette) with 9mg/ rolls into cigarette.Carry out sensory evaluating smoking, conventional flue gas analysis, carcinogenic substance detection and animal experiment.The result shows: the cigarette aesthetic quality is influenced not quite, coordinate with cigarette smoke, excitant alleviates, fragrance exquisiteness, soft, comfortable taste; T/N is constant substantially; A few class carcinogenic substances reduce obviously; Compare with blank cigarette that toxicity reduces, mutagenicity obviously weakens.
Embodiment 2: take by weighing the 50Kg pipe tobacco, add additive 250ml, wherein contain deuteroporphyrin 2.75g, V in the additive
E1.00g, beta-schardinger dextrin-2.00g, kation alkyl polysaccharide glycosides 2.50g, water be that solvent obtains emulsion, evenly is sprayed onto on the pipe tobacco rolling cigarette.Detect by analysis etc., function is with being similar to embodiment 1.
Embodiment 3: take by weighing carrier 20Kg, add additive 125ml, wherein contain uroporphyrin 2.00g, ProtoporphyrinIX 1.50g, V in the additive
E1.00g, gum arabic 3.00g, tween 3.00g, water be that solvent obtains emulsion, evenly is sprayed onto on the carrier, the amount of propping up (cigarette) with 6mg/ adds filter-tip cigarette and makes composite filter tip and roll into cigarette.Detect by analysis etc., function class is similar to embodiment 1, and a few class carcinogenic substance reduces more remarkable effect.
Embodiment 4: take by weighing the 50Kg pipe tobacco, add additive 200ml, wherein containing deuteroporphyrin 1.75g, uroporphyrin 1.50g, Vc1.00g, beta-schardinger dextrin-1.80g, kation alkyl polysaccharide glycosides 12.5ml, water in the additive is that solvent obtains emulsion, evenly is sprayed onto on the pipe tobacco rolling cigarette.Detect by analysis etc., function class is similar to embodiment 1, and a few class carcinogenic substance reduction effect is obvious relatively.
Claims (3)
1. carcinogenic method of removing in the cigarette smoke, it is characterized in that: the water that will account for 0.001%～5.0% porphyrins, 0.001%～2.0% antioxidant, 0.01%～5.0% stabilizing agent, 0.01%～5% emulsifying agent and 85%～99% mixes makes additive, spray be added to make composite filter tip on the suitable carriers or/and evenly spray be added on the pipe tobacco rolling cigarette again.
2. according to right 1 described method, it is characterized in that: the additive that adds carrier to is 0.1%～5.0% of a carrier quality, and the additive that adds pipe tobacco to is 0.005%～1.0% of a tobacco quality.
3. according to right 1 described method, it is characterized in that porphyrins is deuteroporphyrin, haematoporphyrin, uroporphyrin or ProtoporphyrinIX.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101131190A CN100431435C (en) | 2005-10-26 | 2005-10-26 | Use of four kinds of porphyrin compounds to remove carcinogenic substances from smoke of cigarette |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101131190A CN100431435C (en) | 2005-10-26 | 2005-10-26 | Use of four kinds of porphyrin compounds to remove carcinogenic substances from smoke of cigarette |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1757337A CN1757337A (en) | 2006-04-12 |
| CN100431435C true CN100431435C (en) | 2008-11-12 |
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|---|---|---|---|
| CNB2005101131190A Expired - Fee Related CN100431435C (en) | 2005-10-26 | 2005-10-26 | Use of four kinds of porphyrin compounds to remove carcinogenic substances from smoke of cigarette |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2517584A1 (en) * | 2009-12-23 | 2012-10-31 | China Tobacco Chuanyu Industrial Corporation | Composite filter comprising biological composition |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548673B (en) | 2009-05-12 | 2012-07-18 | 湖北省烟草科研所 | Tobacco alkalinity reducing agent used in field tobacco cultivation |
| CN102715654B (en) * | 2012-06-15 | 2014-02-26 | 川渝中烟工业有限责任公司 | Filter additive for reducing nitrosamines in cigarette smoke and application of filter additive |
| CN102697183B (en) * | 2012-06-15 | 2014-02-26 | 川渝中烟工业有限责任公司 | Cigarette filter additive with harm reduction effect and preparation method and application thereof |
| CN103211289B (en) * | 2013-05-10 | 2015-08-05 | 湖北中烟工业有限责任公司 | The preparation method of the reconstituted tobacco of extract flavor component microencapsulation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414988A (en) * | 1980-08-23 | 1983-11-15 | Kabushiki Kaisha Advance Kaihatsu Kenkyujo | Tobacco smoke filter |
| US5909736A (en) * | 1994-06-27 | 1999-06-08 | Stavridis; Ioannis | Removal of noxious oxidants and carcinogenic volatile nitrosocompounds from cigarette smoke using biological substances |
| CN1252245A (en) * | 1999-11-23 | 2000-05-10 | 郭灿城 | Biological tobacco tar reducing agent |
-
2005
- 2005-10-26 CN CNB2005101131190A patent/CN100431435C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4414988A (en) * | 1980-08-23 | 1983-11-15 | Kabushiki Kaisha Advance Kaihatsu Kenkyujo | Tobacco smoke filter |
| US5909736A (en) * | 1994-06-27 | 1999-06-08 | Stavridis; Ioannis | Removal of noxious oxidants and carcinogenic volatile nitrosocompounds from cigarette smoke using biological substances |
| CN1252245A (en) * | 1999-11-23 | 2000-05-10 | 郭灿城 | Biological tobacco tar reducing agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2517584A1 (en) * | 2009-12-23 | 2012-10-31 | China Tobacco Chuanyu Industrial Corporation | Composite filter comprising biological composition |
| EP2517584A4 (en) * | 2009-12-23 | 2013-12-25 | China Tobacco Chuanyu Ind Co | Composite filter comprising biological composition |
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| Publication number | Publication date |
|---|---|
| CN1757337A (en) | 2006-04-12 |
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