CN100420662C - Cyclohexane selectively oxidizing process to prepare cyclohexanone and cyclohexanol - Google Patents
Cyclohexane selectively oxidizing process to prepare cyclohexanone and cyclohexanol Download PDFInfo
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- CN100420662C CN100420662C CNB2006100241821A CN200610024182A CN100420662C CN 100420662 C CN100420662 C CN 100420662C CN B2006100241821 A CNB2006100241821 A CN B2006100241821A CN 200610024182 A CN200610024182 A CN 200610024182A CN 100420662 C CN100420662 C CN 100420662C
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- China
- Prior art keywords
- molecular sieve
- alpo
- sieve catalyst
- cyclohexane
- pimelinketone
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
Abstract
The present invention discloses a method for preparing cyclohexanone pimelic ketone and cyclohexanol by cyclohexane selective oxidation, which comprises the procedures that cyclohexane is used as a monoreactant and is injected into a reactor, high pressure oxygen gas is led in the reactor, an AlPO-5 molecular sieve catalyst loaded with Ce is added in the reactor after the mixture is uniformly stirred, the amount of the AlPO-5 molecular sieve catalyst is 0.005 to 0.015 g/ml, and reaction products are obtained after 4 to 10 hours and 130 to 160 DEG G of reaction. The selectivity of the cyclohexanone pimelic ketone of the present invention is 50%, the overall selectivity of the generated cyclohexanol and the cyclohexanone pimelic ketone is 90%, and the conversion rate of cyclohexane is 13%. The catalyst in the reaction can be recycled for use and has no environmental pollution, and the method for preparing cyclohexanone pimelic ketone and cyclohexanol is convenient, economic and environment-friendly.
Description
Technical field
The present invention relates to a kind of preparation method of ketone or alcohol of six-ring, relate to the preparation method of a kind of pimelinketone and hexalin in particular.
Background technology
Pimelinketone is an important chemical material, is widely used in industry such as fiber, synthetic rubber, industrial coating, medicine, agricultural chemicals, organic solvent.At present, the main method of producing pimelinketone both at home and abroad is a cyclohexane oxidation process, the one, and the catalyzed oxidation of hexanaphthene, the 2nd, the non-catalyst oxidation of hexanaphthene, wherein important with the catalytic oxidation of hexanaphthene again.It is catalyzer that the hexanaphthene catalytic oxidation adopts cobalt salt, boric acid or metaboric acid usually.Cobalt salt generally adopts cobalt salt compounds such as cobalt naphthenate, cobalt octoate, cobalt oleate, cobalt stearate, cobalt naphthenate chromium complexes.Hexanaphthene under catalyst action with air generation oxidizing reaction, reaction process at first forms cyclohexyl hydroperoxide by free radical reaction, superoxide decomposes under catalyst action generates pimelinketone, hexalin then.Studied multiple catalyst system up till now, N.Perkas for example, Y.Wang, Y.Koltypin, A.Gedanken, people such as S.Chandrasekaran are catalyzer with mesopore titania supported nano-sized iron oxide, can under the condition of gentleness, realize the oxidation of hexanaphthene, obtain hexalin and pimelinketone, generate but have a large amount of by products in reaction process, solvent acetic acid also is the co-catalyst (Chem.Commun. (2001) 988) of reaction.A.Sakthivel, P.Selvam, (Cr) MCM-41 (J.Catal.211 (2002) 134) and the K.Suanta of people such as Selvam research and development, (Fe) MCM-41 (Chem.Lett.33 (2004) 198) catalyst system of people such as P.Selvam research and development, though also obtained the yield of hexalin and pimelinketone preferably, but still can not solve the non-green composition problem that acetate brings as reaction solvent, and in reaction system, must use methyl ethyl ketone to be initiator, thereby also limit the further Application and Development of this catalyst system.C.Guo, M.Chu, Q.Liu, Y.Liu, D.Guo, the pyridine cobalt salt catalyst of people such as X.Liu research and development has overcome the shortcoming of preceding two kinds of catalyst system, can be implemented in preparation hexalin and pimelinketone under the non-solvent condition, but high catalyzer cost has limited the use (Appl.Catal.A246 (2003) 303) of this type of catalyzer equally.Because pimelinketone, hexalin are than the easier oxidation of hexanaphthene, there is a large amount of by products to generate in the cyclohexane oxidation process, in order to reduce the generation of by product, improve product selectivity and yield, the researchist must control conversion of cyclohexane, and pimelinketone, the hexalin residence time when reaction.If but transformation efficiency is too low, a large amount of hexanaphthenes have neither part nor lot in reaction, and then the separation costs of product, raw material can strengthen, and investment simultaneously is also big, and economic benefit is descended.If pimelinketone, the hexalin residence time are oversize, then pimelinketone, hexalin are easily by deep oxidation, and the selectivity and the yield of reaction all descend.Therefore, to develop more suitable catalyzer be one of emphasis of current research work for the hexanaphthene catalyzed oxidation prepares pimelinketone, hexalin.
Summary of the invention
Technical problem to be solved by this invention provides the method that a kind of selectivity is good, transformation efficiency is high, the cyclohexane oxidation of environmentally safe prepares pimelinketone and hexalin.
The technical solution used in the present invention: a kind of cyclohexane selectively oxidizing prepares the method for pimelinketone and hexalin, its technical characterictic is: with the AlP0-5 molecular sieve that has supported Ce is catalyzer, the described AlP0-5 molecular sieve that has supported Ce prepares with hydrothermal synthesis method, may further comprise the steps: with cyclohexane give is that monoreactant is injected into reactor, feed high pressure oxygen, the back adding that stirs has supported the AlPO-5 molecular sieve catalyst of Ce, and consumption is 0.005～0.015gml
-1, obtained reaction product in 4～10 hours 130～160 ℃ of reactions.
The described AlPO-5 molecular sieve catalyst that has supported Ce is that wherein reactive metal Ce is+3 valencys with the molecular sieve catalyst of hydrothermal synthesis method preparation, and the loading of Ce is no more than 3.20wt%.
The described AlPO-5 molecular sieve catalyst of Ce that supported is with Ce (NO
3)
36H
2O is the Ce source.
The described AlPO-5 molecular sieve catalyst of Ce that supported is with Ce
2(SO
4)
42H
2O is the Ce source.
Described with Ce (NO
3)
36H
2O comprises the following steps: for the Ce source prepares the AlPO-5 molecular sieve catalyst that supports Ce
(a) with water and H
3PO
4Mix, obtain H
3PO
4Mixing solutions;
(b) to H
3PO
4Add Ce (NO in the mixing solutions
3)
36H
2O, and stir;
(c) triethylamine is dropwise added above-mentioned H
3PO
4And Ce (NO
3)
36H
2In the mixing solutions of O;
(d) under stirring at room, aluminum isopropylate is slowly joined in the above-mentioned mixing solutions restir 2h at room temperature after adding;
(e) with F
-Mix with water in the source, obtains containing F
-The ionic aqueous solution;
(f) solution with steps d and step e gained mixes and stirs 2h mutually;
(g) above-mentioned material is presented in the stainless steel cauldron, behind 180 ℃ of following crystallization 6h, filtering separation is used deionized water wash, and drying is 600 ℃ of roasting 4-10h in air afterwards, has obtained supporting the AlPO-5 molecular sieve catalyst of Ce.
Beneficial effect of the present invention: use conversion of cyclohexane of the present invention and can reach 1 3%, the pimelinketone selectivity can reach 50%, and the overall selectivity that generates hexalin and pimelinketone can reach 90%.Reaction one step that cyclohexane oxidation prepares hexalin and pimelinketone among the present invention finishes, and preparation process is simple.Compare with the conventional oxidation agent hydrogen peroxide, the present invention is oxygenant with high pressure oxygen, and is more cheap, environmentally safe.Catalyzer of the present invention can reuse, and whole reaction system is carried out under condition of no solvent, hexanaphthene be reactant be again reaction solvent, be a kind of economy and eco-friendly preparation method.
Description of drawings
Fig. 1 is the influence curve figure of reaction times to reaction;
Fig. 2 is the influence curve figure of temperature of reaction to reaction.
Embodiment
Below by embodiment the present invention is described in further detail: the present invention is synthetic and chemical coprecipitation technique by hydro-thermal, has synthesized the AlPO-5 microporous molecular sieve catalyst that supports Ce.CeO
2Partition content has been widely used in glass, pottery, catalyzer, metal alloy and luminescent material etc. more than 40% in rare earths, is to use the widest a kind of element at most in the rare earth.CeO
2Have unique catalysis characteristics, such as: (1) CeO
2Have redox characteristic, easily+3 valencys and+change between 4 valencys, and O is arranged
2Absorption and emit ability; (2) CeO
2Behind the nanometer, specific surface area is bigger, and surfactivity strengthens; (3) have higher electric charge, easily form stable novel crystal structure; (4) the rare earth ion radius is big, has stronger coordination ability, and it is low to transform energy barrier between the different coordination structures, so rare earth is suitable as catalyzer.As traditional catalyzer and solid support material, micropore AlPO-5 molecular sieve is showing excellent catalytic performance because of having the strong acid performance aspect the petroleum cracking.Simultaneously, the four-coordination Al atom in the molecular sieve can also demonstrate characteristics such as redox after being replaced by other bridging atoms.Therefore, in traditional molecular sieve catalyst, introduce heteroatoms, can improve the performance of catalyzer greatly.In the present invention, utilize hydrothermal synthesis method, make Ce
3+Al atom in the ionic replacement part micropore AlPO-5 molecular sieve is this catalyzer synthetic key.We find that different Ce sources can influence the performance of catalyzer.Ce (NO with+3 valency Ce
3)
36H
2O is the Ce of Ce source than+4 valency Ce
2(SO
4)
42H
2O is the excellent performance of the catalyzer of Ce source preparation.At F
-There is down water-fast Ce (NO
3)
36H
2O can be preferentially and F
-Form water-soluble more stable title complex, and then can easily replace the catalyzer that the Al atom site obtains superior activity.The Ce/AlPO-5 catalyzer that while obtains than traditional pickling process, that water thermal synthesis and chemical coprecipitation technique can not only obtain is comparatively single+Ce-AlPO-5 microporous molecular sieve catalyst that 3 valency Ce support, can also be easily and solution separating, reuse, environmentally safe and whole reaction system be by any solvent, hexanaphthene be reactant be again dissolvant of reaction system.
The present invention program is as follows: a kind of cyclohexane selectively oxidizing prepares the method for pimelinketone and hexalin, its technical characterictic is: with the AlP0-5 molecular sieve that has supported Ce is catalyzer, the described AlP0-5 molecular sieve that has supported Ce prepares with hydrothermal synthesis method, may further comprise the steps: with cyclohexane give is that monoreactant is injected into reactor, feed high pressure oxygen, the back adding that stirs has supported the AlPO-5 molecular sieve catalyst of Ce, and consumption is 0.005～0.015gml
-1, obtained reaction product in 4～10 hours 130～160 ℃ of reactions.The described AlPO-5 molecular sieve catalyst that has supported Ce is that wherein reactive metal Ce is+3 valencys with the molecular sieve catalyst of hydrothermal synthesis method preparation, and the loading of Ce is no more than 3.20wt%.The described AlPO-5 molecular sieve catalyst of Ce that supported is with Ce (NO
3)
36H
2O or Ce
2(SO
4)
42H
2O is the Ce source.Described with Ce (NO
3)
36H
2O comprises the following steps: that for the Ce source prepares the AlPO-5 molecular sieve catalyst that supports Ce (a) is with water and H
3PO
4Mix, obtain H
3PO
4Mixing solutions; (b) to H
3PO
4Add Ce (NO in the mixing solutions
3)
36H
2O, and stir; (c) triethylamine is dropwise added above-mentioned H
3PO
4And Ce (NO
3)
36H
2In the mixing solutions of O; (d) under stirring at room, aluminum isopropylate is slowly joined in the above-mentioned mixing solutions restir 2h at room temperature after adding; (e) with F
-Mix with water in the source, obtains containing F
-The ionic aqueous solution; (f) solution with steps d and step e gained mixes and stirs 2h, F mutually
-Ion and Ce (NO
3)
36H
2O forms water-soluble stable title complex; (g) above-mentioned material is presented in the stainless steel cauldron, behind 180 ℃ of following crystallization 6h, filtering separation is used deionized water wash, and drying is 600 ℃ of roasting 4-10h in air afterwards, has obtained supporting the AlPO-5 molecular sieve catalyst of Ce.
Embodiment
The synthetic embodiment that has supported the AlPO-5 molecular sieve catalyst of Ce of hydro-thermal coprecipitation method:
(1) with 7gH
2O and 3.84gH
3PO
4Mix mutually;
(2) a certain amount of Ce source being added the system of going up stirs;
(3) the 2.07g triethylamine is dropwise added above-mentioned H
3PO
4In the solution, system presents muddiness;
(4) under stirring at room, the 5.23g aluminum isopropylate is joined in the above-mentioned solution at leisure restir 2h at room temperature after adding;
(5) with 0.82gHF (other F sources) and 89.2gH
2O mixes mutually;
(6) solution with (4) and (5) middle gained mixes and stirs 2h mutually;
Above-mentioned material is added in the stainless steel cauldron of a 150mL Teflon lining, behind 180 ℃ of following crystallization 6h, filtering separation and with 100mL deionized water wash four times, dry back gray behind 600 ℃ of roasting 4-10h in air, product generally is about 40～50 μ m of hexagonal prism shape.Characterize through XRD, highest peak is d=11.84,5.93,4.48,4.20,3.96 and 3.42, and compositional analysis is Al
2O
3P
2O
5
Embodiment 1-3 is the comparison of different catalysts catalytic selective oxidation hexanaphthene preparing cyclohexanone.Experiment condition is: 100ml stainless steel autoclave, 2ml C
6H
12, catalyzer CeO
2(embodiment 1), Ce/AlPO-5 (hydrothermal method) (embodiment 2), Ce/AlPO-5 (pickling process) (embodiment 3), 10mg, 0.5MPaO
2, 140 ℃ of reaction 4-10h.Embodiment 1～3 comparing result sees Table 1.
Table 1
Embodiment 4-6 be on the same catalyst Ce content to the influence of reaction result: experiment condition is: 100ml stainless steel autoclave, 2ml C
6H
12, 0.5MPa O
2, 140 ℃ of reaction 4-10h.Embodiment 4～6 comparing results see Table 2.
Table 2
Embodiment 7-12 is the influence of reaction times to reaction: experiment condition is the 100ml stainless steel autoclave, 2ml C
6H
12, catalyzer Ce/AlPO-5 10mg, 0.5MPa O
2, 140 ℃ the reaction 1,2,3,4,5,6h, embodiment 7～12 comparing results are seen Fig. 1.
The influence of embodiment 13-16 temperature of reaction to reacting: experiment condition is the 100ml stainless steel autoclave, 2ml C
6H
12, catalyzer Ce/AlPO-5 12mg, 0.5MPa O
2, reaction 4h, temperature of reaction is 130 ℃, 140 ℃, 150 ℃, 160 ℃, embodiment 13～16 comparing results are seen Fig. 2.
Embodiment 17-21 is the influence of dissolvant of reaction system to reaction: experiment condition is the 100ml stainless steel autoclave, 2ml C
6H
12, catalyzer Ce/AlPO-5 12mg, 0.5MPa O
2, reaction 4h, temperature of reaction is 140 ℃, solvent 10ml.Embodiment 17～21 comparing results see Table 3.
Table 3
Above said content only is the basic explanation of the present invention under conceiving, and according to any equivalent transformation that technical scheme of the present invention is done, all should belong to protection scope of the present invention.
Claims (5)
1. a cyclohexane selectively oxidizing prepares the method for pimelinketone and hexalin, its technical characterictic is: with the AlPO-5 molecular sieve that has supported Ce is catalyzer, the described AlPO-5 molecular sieve that has supported Ce prepares with hydrothermal synthesis method, may further comprise the steps: with cyclohexane give is that monoreactant is injected into reactor, feed high pressure oxygen, the back adding that stirs has supported the AlPO-5 molecular sieve catalyst of Ce, and consumption is 0.005～0.015gml
-1, obtained reaction product in 4～10 hours 130～160 ℃ of reactions.
2. the method for preparing pimelinketone and hexalin according to the described a kind of cyclohexane selectively oxidizing of claim 1, it is characterized in that: the described AlPO-5 molecular sieve catalyst that has supported Ce is the molecular sieve catalyst with the hydrothermal synthesis method preparation, wherein reactive metal Ce is+3 valencys, and the loading of Ce is no more than 3.20wt%.
3. prepare the method for pimelinketone and hexalin according to the described a kind of cyclohexane selectively oxidizing of claim 2, it is characterized in that: the described AlPO-5 molecular sieve catalyst of Ce that supported is with Ce (NO
3)
36H
2O is the Ce source.
4. prepare the method for pimelinketone and hexalin according to the described a kind of cyclohexane selectively oxidizing of claim 2, it is characterized in that: the described AlPO-5 molecular sieve catalyst of Ce that supported is with Ce
2(SO
4)
42H
2O is the Ce source.
5. prepare the method for pimelinketone and hexalin according to the described a kind of cyclohexane selectively oxidizing of claim 3, it is characterized in that: described with Ce (NO
3)
36H
2O comprises the following steps: for the Ce source prepares the AlPO-5 molecular sieve catalyst that supports Ce
(a) with water and H
3PO
4Mix, obtain H
3PO
4Mixing solutions;
(b) to H
3PO
4Add Ce (NO in the mixing solutions
3)
36H
2O, and stir;
(c) triethylamine is dropwise joined above-mentioned H
3PO
4And Ce (NO
3)
36H
2In the mixing solutions of O;
(d) under stirring at room, aluminum isopropylate is slowly joined in the above-mentioned mixing solutions restir 2h at room temperature after adding;
(e) with F
-Mix with water in the source, obtains containing F
-The ionic aqueous solution;
(f) solution with steps d and step e gained mixes and stirs 2h mutually;
(g) above-mentioned material is presented in the stainless steel cauldron, behind 180 ℃ of following crystallization 6h, filtering separation is used deionized water wash, and drying is 600 ℃ of roasting 4-10h in air afterwards, has obtained supporting the AlPO-5 molecular sieve catalyst of Ce.
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|---|---|---|---|
| CNB2006100241821A CN100420662C (en) | 2006-02-28 | 2006-02-28 | Cyclohexane selectively oxidizing process to prepare cyclohexanone and cyclohexanol |
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|---|---|---|---|
| CNB2006100241821A CN100420662C (en) | 2006-02-28 | 2006-02-28 | Cyclohexane selectively oxidizing process to prepare cyclohexanone and cyclohexanol |
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| CN100420662C true CN100420662C (en) | 2008-09-24 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102295524B (en) * | 2011-06-21 | 2013-11-20 | 华东理工大学 | Method for preparing cyclohexanol and cyclohexanone by selective oxidation of cyclohexane |
| CN105646223B (en) * | 2014-12-04 | 2017-12-26 | 中国科学院大连化学物理研究所 | A kind of method that levulic acid catalysis oxidation esterification prepares succinate |
| CN111747832B (en) * | 2020-07-17 | 2022-08-30 | 东营市金虹利工贸有限责任公司 | Method for preparing cyclohexanone |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1659391A1 (en) * | 1989-06-05 | 1991-06-30 | Ровенское Производственное Объединение "Азот" Им.50-Летия Ссср | Method for obtaining hexabromobenzene |
| EP1518849A1 (en) * | 2003-09-29 | 2005-03-30 | Sumitomo Chemical Company, Limited | Process for producing cycloalkanol and/or cycloalkanone |
-
2006
- 2006-02-28 CN CNB2006100241821A patent/CN100420662C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1659391A1 (en) * | 1989-06-05 | 1991-06-30 | Ровенское Производственное Объединение "Азот" Им.50-Летия Ссср | Method for obtaining hexabromobenzene |
| EP1518849A1 (en) * | 2003-09-29 | 2005-03-30 | Sumitomo Chemical Company, Limited | Process for producing cycloalkanol and/or cycloalkanone |
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