CN100417320C - Radiopaque animal chew - Google Patents
Radiopaque animal chew Download PDFInfo
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- CN100417320C CN100417320C CNB2004800028764A CN200480002876A CN100417320C CN 100417320 C CN100417320 C CN 100417320C CN B2004800028764 A CNB2004800028764 A CN B2004800028764A CN 200480002876 A CN200480002876 A CN 200480002876A CN 100417320 C CN100417320 C CN 100417320C
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- radiopaque
- barium sulfate
- additive
- animal chew
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- Expired - Lifetime
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- 239000000463 material Substances 0.000 claims description 27
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 16
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- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
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- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
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- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
An animal chew toy comprising a radiopaque polymer. The radiopaque polymer may comprise a polymer that is inherently radiopaque or a polymer that has been made radiopaque by the addition of an additive that provides radiopaque characteristics. The radiopaque polymers of the present invention may be manufactured by melt processing techniques, such as extrusion, compression and/or injection molding.
Description
The cross reference of related application
The application requires the novel application 10/390,125 of U.S. utility submitted on March 17th, 2003, and the priority of the U.S. Provisional Application sequence number of submitting on January 9th, 2,003 60/438,862, by reference the instruction of described application is combined in this.
Invention field
The present invention relates to radiopaque animal's chewing matter and manufacture method thereof, wherein a kind of suitable main polymer as animal's chewing matter is manufactured into radip-opaque.The part chaw is not inadvertently built up in animal body situation in life-threatening mode under, just can diagnose more quickly now and processing more quickly.
Background of invention
For many years, polymeric material has been widely used in medical treatment and the tooth application.This application comprises the implantation of surgery and health, and other reparation device (for example, cardiac valves, blood vessel etc.).In dentistry, for example, polymeric material has been used to activity in production artificial tooth, temporary dental crown and bridge of the nose material, has helped and recover material, moulage or the like.
Usually require medical implant opaque, so that can in main body, accurately detect its position by the X-ray detection to radiography.In addition, advantageously this medical implant is an optics or visually transparent, passes through therefrom so that can observe fluid.Therefore, a large amount of prior aries has related to the preparation of the polymeric material that is used for medical science or dental applications, and described polymeric material can be detected by x-ray analysis.
Yet in the animal chew toys field, unquestionable situation is to exist a lot of detailed description special resin and particular design to strengthen the disclosure of chew toy to the animal attraction.In addition, for chew toy product, exist the disclosure that a large amount of proofs are used special material, special additive and special mold condition.
According to this thinking, the United States Patent (USP) 3,871,334 of Axelrod has received concern, but this patent disclosure by the chewing article with fragrance or smell extract of nylon manufacturing.Also be concerned about United States Patent (USP) 4,513,014, this patent manages to provide a kind of more masticable product, and this product contains polyurethane elastomer, also fragrance or smell extract has been introduced wherein simultaneously.
Then, applicant's United States Patent (USP) 5,827,565 has received concern, this patent disclosure a kind of method of making hot inflatable dog chaw, it mainly comprises the potato starch particle and the decoy of injection moulding.Described decoy comprises chicken meal, liver powder, ham, turkey, beef and or fish.Also can add plant additive such as spinach or carrot.Resulting mixture is molded as the shape of requirement, for example dog bone under heat and pressure.The dog bone of Sheng Chaning can pass through heating subsequently like this, is preferably to heat in micro-wave oven to change quality or hardness.
Disclose a kind of dog chaw in the United States Patent (USP) series 09/138,804 of the part continuation application of applicant's United States Patent (USP) 5,827,565, this chaw has natural fruit aroma, to increase the appetite of dog to this chaw.The dog chaw of this fruit aroma can also comprise natural food coloring, to improve the attraction of chaw to the dog owner.Food coloring also can be corresponding with fruit aroma, and dog chaw disclosed herein also can comprise the breath sweetener of dog, and for example peppermint, spearmint, peppermint or Chinese ilex can also comprise parsley.The preferred form of this edible chew is for keeping the basis such as the potato starch of hot expandable starch.Flavoring agent of fruit can be added in the compound particles of potato starch, water, calcium carbonate and natural fruit flavor enhancement.
Following United States Patent (USP) that the assignee owned together and common pending application by here also have been concerned about: United States Patent (USP) 5,476,069; In on September 3rd, 1997 submit to be entitled as " Vegetable Based Dog Chew ", now be the U.S. Patent application 08/923,070 of United States Patent (USP) 6,093,427; In on October 25th, 1997 submit to be entitled as " Edible DogChew ", now be the application 08/738,423 of United States Patent (USP) 5,827,565; In on January 17th, 1997 submit to be entitled as " Carrot-Based Dog Chew ", now be the application 08/784,834 of United States Patent (USP) 5,941,197; In on July 7th, 1997 submit to be entitled as " Vegetable DogChew ", existing resigned application 08/888,611; The application of submitting on July 14th, 1,998 09/114,872 that is entitled as " Heat Modifiable Edible Dog Chew "; In on August 21st, 1998 submit to be entitled as " Improved Edible Dog Chew ", now be the application 09/138,804 of United States Patent (USP) 6,126,978; " the Wheat that is entitled as in submission on July 15th, 1998; Casein Dow Chew With Modifiable Texture ", now be United States Patent (USP) 6,110,521 application 09/116,070; In on July 15th, 1998 submit to be entitled as " Heat Modifiable Peanut Dog Chew ", now be the application 09/116,555 of United States Patent (USP) 6,093,441; The application of submitting on January 8th, 1,999 09/227,767 that is entitled as " Method of MoldingEdible Starch ".Except such patent and application, also be concerned about the technology of being quoted in described patent and the application, for example relate to the technology of field of molded starch products.
Therefore, look back as can be seen by above all, exist many disclosures, these disclosures have pointed out to use the importance to the radiopaque polymeric system of human body.This disclosure at be the position of monitoring implant by x-ray analysis.In addition, a plurality of disclosures are at the animal's chewing matter product.
Yet, up to now, the manufacturing of animal chew toys is not considered the situation of x-ray analysis, or in fact, the chew toy of manufacturing makes them transparent to the X-ray detection in essence, like this, if when this chew toy is swallowed irrelevantly, it just can not be detected in animal body.Therefore, exist so a kind of demand for a long time: develop and a kind of method of producing animal's chewing matter is provided, so that this chew toy can be detected by the x-ray analysis of trained medical professional with standard.
In addition, compare relatively rareness though animal swallows the contingency of large scale plastics chewed-off part with swallowing other foreign matter, this thing can cause serious medical emergency, or even dead.The potential seriousness of this accident makes promotion become important to the diagnosis and the removing of this foreign matter, and no matter this incident is the fact that normally reaches outside the rational expectation.
Therefore, what need is a kind of material or material compositions, and it can make the radiation opaque maximization of animal's chewing matter, does not influence the physical features of animal's chewing matter simultaneously negatively.This chew toy also should keep swallows safety, and also is necessary for animal and keeps the relevant experience of chewing.
Therefore, an object of the present invention is to produce the animal chew toy of a kind of maintenance to the animal attraction, and provide the healthy and charming experience of chewing thus, when but if this chew toys is swallowed under any life-threatening situation irrelevantly, it can arrive by the X-ray detection, and can dispose in animal body more quickly.
More specifically, determine critical, the safe and effectively saturating radiation additive concentration in the host polymer resins, make that it also is purpose of the present invention that the X-ray detection is provided when a certain size chaw partly exists, the typical case of the chaw of this size part is chaw that the activity of chewing owing to animal the causes piece that comes off.
Summary of the invention
A kind of animal chew toys, this toy comprises radiopaque polymer.Described radiopaque polymer can comprise radiopaque polymer inherently or provide not the additive of the saturating radiation characteristic radiopaque polymer that becomes by adding.Can by melt processing as extrude, compacting and/or injection moulding make radiopaque polymer of the present invention.
Description of Preferred Embodiments
As mentioned above, the present invention relates to a kind of animal chew toys that comprises radiopaque polymer.Therefore, term " radiopaque polymer " is defined as and is radiopaque inherently or can be manufactured into radiopaque any suitable polymeric material as animal's chewing matter by adding radiopaque additive aptly.Then, this radiopaque polymer material is used to make animal chew toys.Term " not saturating radiation " itself is meant that polymeric material can be by the detected characteristic of x-ray analysis.
Be suitable for polymer among the present invention for the first kind, those introduce inherently that the polymer of radiopaque structure has received concern.According to this thinking, an example is included in halogen-containing polymer on the main polymer chain.The typical polymers of this method has United States Patent (USP) 4,722, and disclosed those polymer in 344,5,177,170 and 5,346,981 are combined in this with its instruction by reference.
Another kind method is to disperse not see through the material of X-ray, for example barium sulfate, halogenation bismuth, or halogen-containing plasticizer, glycol or other this halogen containing material in polymer.Referring to people such as for example Y.Delaviz, and Polymer Preprints (Polymer Division, Am.Chem.Soc.), 30,215-216 page or leaf (1989), and United States Patent (USP) 3,608,555,3,645,955,3,749,134,3,901,829 and 4,282,876, by reference its instruction is combined in this.
About the use of preferred additives barium sulfate, preferably the concentration of this additive that is adopted makes and can detect for example 1.0 inches * 1.0 inches * 1.0 inches (length/width/height) polymeric material size, that contain this additive by x-ray analysis.Find that in this regard preferably, the content of barium sulfate is about 0.5-15% weight, comprise wherein any increment and any scope.Therefore, the content of barium sulfate can be in main polymer 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%....2.0%...3.0%....4.0%....5.0%....6.0%..... etc., until 15.0% weight.
In addition, in the context of the present invention, preferred barium sulfate source is with general chemical name barite with trade name
Product sold, this product are by the Huber Engineered Materials marketing and distribution of QuincyIllinois.More specifically, this product is described to naturally occurring mineral matter, by concentration be barium sulfate, the 1.0-4.0% weight of 97-99% weight calcium carbonate, and the silica of 0.1-1.0% weight form.Usually, the content that silica exists is about 0.4% weight, should also be noted that the concentration of barium sulfate can change to the scope that exceeds above-mentioned 97-99% weight, and drops in the scope of 93-99% weight.In addition, according to
MSDS table, expose measurement result based on history, it is non-hazardous that described product is regarded as for skin contact, skin absorbs and absorption.
In addition, should be noted that, in text of the present invention, there is no need to adopt the barium sulfate of American Pharmacopeia (USP) approved grades, and the above is preferred
The use of product is just enough good.Therefore, so just caused producing the very economical and useful method of radiopaque animal chew toys of the present invention.
About main polymer, preferably, described main polymer is a polyurethane, though can adopt suitable any other polymer or material as animal's chewing matter.In this regard, can use polymer such as nylon, and by natural or synthetic rubber, thermoplastic elastomer (TPE) and/or thermo-setting elastomer, natural polymer such as starch, vegetable material, casein, and/or the animal's chewing matter of greenhide material manufacturing.
Preferably barium sulfate itself is mixed in above-mentioned polymer or the material, and it is distributed in the whole chew toy, guarantee that thus those are chewed the chew toy part of swallowing up by animal and can be detected by x-ray analysis.In this regard, find,, barium sulfate or other suitable radiopaque additive are attached in the polymer preferably by melt blending technology (extruding or injection moulding).In a most preferred embodiment, at first with barium sulfate or above-mentioned preferred
Product is extruded with high relatively content (20-85% weight, and therebetween any percentage or any scope therebetween) and is blended in the polymer body, produces the polymer condensation product of barium sulfate additive.For example, preferably with barium sulfate at first with the concentration blend of about 70% weight in flexible polyurethane.Preferred this blend realizes by extruding blend, in the case, has produced the polyurethane particles that contains 70% barium sulfate.Then, this polyurethane concentrate is mixed in the chew toy injection moulding with the polyurethane of additional quantity, have the 0.5-15% of being preferably weight to provide, more preferably the chew toy of the ultimate density of 5.0% weight.
In addition, in wide scope of the present invention, the blend of the different polymer that wherein at least a polymer is a radiopaque polymer is suitable to be used here as animal's chewing matter.Therefore, in wide scope of the present invention, a kind of polymers compositions can be radiopaque, and another kind of polymers compositions is can right and wrong radiopaque, and blend is radiopaque, and has the performance that is enough to show as animal's chewing matter.
Claims (21)
1. animal chew toys, this toy comprises main polymer material and radiopaque additive, and wherein said radiopaque additive comprises the mixture of barium sulfate, calcium carbonate and silica.
2. the animal chew toys of claim 1, wherein said mixture comprises the barium sulfate of 93-99% weight, the calcium carbonate of 1-4% weight, and the silica of 0.1-1.0%.
3. claim 1 or 2 animal chew toys, wherein said radiopaque additive is dispersed in the whole animal chew toys with the concentration of the content of barium sulfate in described main polymer material that 0.5-15% weight is provided, and X-is provided ray detection.
4. the animal chew toys of claim 3, the content that wherein said barium sulfate exists is 1-15% weight.
5. claim 1 or 2 animal chew toys, wherein said main polymer material is a thermoplastic elastomer (TPE).
6. claim 1 or 2 animal chew toys, wherein said main polymer material is a polyurethane.
7. claim 1 or 2 animal chew toys, wherein said main polymer material is a polyamide.
8. claim 1 or 2 animal chew toys, wherein said main polymer material is a starch.
9. the animal chew toys of claim 1, wherein said additive is made up of the mixture of barium sulfate, calcium carbonate and silica basically.
10. one kind radiopaque additive introduced polymeric material, and this polymeric material is shaped to the method for animal chew toys, this method comprises:
A., polymeric material is provided;
B., radiopaque additive is provided;
C. described radiopaque additive melt blending is advanced in the described polymeric material, make the concentration of described additive in described polymer reach first and require level;
D. the product of recycling step (c), and described product mixed with the described polymeric material of additional quantity, so that the concentration that requires of second level of described additive in described polymer to be provided, wherein said second level is lower than described first level;
E. the product of step (d) is molded as the form of animal's chewing matter.
11. the method for claim 10, wherein said polymeric material are thermoplastic elastomer (TPE).
12. the method for claim 10, wherein said polymeric material are polyurethane.
13. the method for claim 10, wherein said polymeric material are starch.
14. the method for claim 10, wherein said polymeric material are polyamide.
15. it is 20-85% weight that the method for claim 10, first of wherein said additive concentration require level.
16. the method for claim 10, second level that requires concentration of wherein said additive is a 0.5-15% weight.
17. the method for claim 10, wherein said radiopaque additive comprises the mixture of barium sulfate, calcium carbonate and silica.
18. the method for claim 17, wherein said radiopaque additive is made up of the mixture of barium sulfate, calcium carbonate and silica basically.
19. the method for claim 17 or 18, wherein said mixture comprise the barium sulfate of 93-99% weight, the calcium carbonate of 1-4% weight, and the silica of 0.1-1.0% weight.
20. the method for claim 17 or 18, the content of wherein said barium sulfate in chew toy is 1.0-10.0% weight.
21. the animal chew toys of claim 17 or 18, the content of wherein said barium sulfate in chew toy is 5.0% weight.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43886203P | 2003-01-09 | 2003-01-09 | |
| US60/438,862 | 2003-01-09 | ||
| US10/390,125 | 2003-03-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1741738A CN1741738A (en) | 2006-03-01 |
| CN100417320C true CN100417320C (en) | 2008-09-10 |
Family
ID=36093899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004800028764A Expired - Lifetime CN100417320C (en) | 2003-01-09 | 2004-01-08 | Radiopaque animal chew |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100417320C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8935992B2 (en) * | 2011-02-11 | 2015-01-20 | T.F.H. Publications, Inc. | Animal chew including interchangeable components |
| CN110064060A (en) * | 2019-04-23 | 2019-07-30 | 焦俊 | A kind of barium agent label of colonic transportation test and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999031172A1 (en) * | 1997-12-17 | 1999-06-24 | Bayer Aktiengesellschaft | X-ray opaque thermoplastic moulding compound |
| CN1272308A (en) * | 1999-05-03 | 2000-11-08 | T·F·H·出版物公司 | Improved animal mastax |
| US6178922B1 (en) * | 1997-04-15 | 2001-01-30 | Seefar Technologies, Inc. | Mastication article possessing microbe-inhibiting properties |
| CN1296740A (en) * | 1999-11-19 | 2001-05-30 | T·F·H·出版公司 | Improved animal's chewing matter |
-
2004
- 2004-01-08 CN CNB2004800028764A patent/CN100417320C/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6178922B1 (en) * | 1997-04-15 | 2001-01-30 | Seefar Technologies, Inc. | Mastication article possessing microbe-inhibiting properties |
| WO1999031172A1 (en) * | 1997-12-17 | 1999-06-24 | Bayer Aktiengesellschaft | X-ray opaque thermoplastic moulding compound |
| CN1272308A (en) * | 1999-05-03 | 2000-11-08 | T·F·H·出版物公司 | Improved animal mastax |
| CN1296740A (en) * | 1999-11-19 | 2001-05-30 | T·F·H·出版公司 | Improved animal's chewing matter |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1741738A (en) | 2006-03-01 |
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