CN100404083C - Nitric oxide gas supply system of respiratory failure salvage instrument - Google Patents
Nitric oxide gas supply system of respiratory failure salvage instrument Download PDFInfo
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- CN100404083C CN100404083C CNB2005100192163A CN200510019216A CN100404083C CN 100404083 C CN100404083 C CN 100404083C CN B2005100192163 A CNB2005100192163 A CN B2005100192163A CN 200510019216 A CN200510019216 A CN 200510019216A CN 100404083 C CN100404083 C CN 100404083C
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- gas
- pulse
- arc discharge
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- nitric oxide
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Abstract
The present invention relates to a nitric oxide gas supply system of a respiratory failure therapeutic instrument, which belongs to a disease therapeutic apparatus and avoids the use of a high-concentration NO gas cylinder, a high-pressure dry air cylinder or a nitrogen-oxygen mixed gas cylinder. The nitric oxide gas supply system of the present invention can generate NO by taking air as raw material at any time as required and does not need to be stored when NO is not required. Via controlling discharge conditions, NO gas can be generated as much as possible and NO2 as a harmful gas can be generated as less as possible in the discharge process so as to obtain the low ratio of NO2/NO. The concentration of NO ranges from 0 ppm to 200 ppm at the pulse frequency of 1Hz to 90Hz. The nitric oxide gas supply system of the present invention comprises an air pump, a clean and dry air generating device, a flow meter, a pulse generating and control circuit, an arc discharge reactor, a particle filter film, an NO2 catalytic reduction conversion device, a cooler, a particle filter film, a selective absorber and a gas monitor, wherein all the components except for the gas monitor are connected in series to and communicated with a gas passage.
Description
Technical field
The invention belongs to treatment of diseases equipment, particularly a kind of air supply system that is used for the inhalable nitric oxide gas of respiratory failure treatment instrument.
Background technology
Suck nitric oxide (NO) and begin to be applied to clinical first aid respirator new technique the nineties in 20th century, because of have curative effect soon, advantages such as atraumatic and high selectivity come into one's own.At present, NO as treatment as acute respiratory failure syndrome, hypertension and some and lung relevant disease, and the new method of the pneumonopathy that causes of altitude sickness has obtained increasing application clinically.
The inhalable nitric oxide gas that uses when giving treatment to as the acute respiratory failure syndrome clinically at present trends towards adopting the NO (3-20ppm, the highest 80ppm that is no more than) that sucks low concentration, all is by the bottled nitrogen (N that contains
2) higher concentration NO (500-800ppm) mist dilution form.And the supply of this bottled gas is not all easily to obtain anywhere.
The higher concentration NO of 500-800ppm is diluted to the 3-20ppm low concentration level that clinical treatment needs, be a time-consuming and very difficult technical process.And in dilution and use, following point takes place probably:
(1) decompression and dilution exist and may generate patient and the extremely deleterious nitrogen dioxide (NO of medical worker because misoperation makes NO leak into the room air from steel cylinder, and the NO of leakage will react with airborne oxygen
2) danger.
(2) when NO is diluted by air or oxygen, in dilution and in the mist transmission, the possible and O of NO
2Chemical reaction takes place generate NO
2, especially carry out high concentration O
2All the more so during dilution.Therefore, even the NO in nitric oxide gaseous mixture steel cylinder
2Under the very low situation of concentration, when arriving patient's respirator, also have a certain amount of NO through air or oxygen dilution back
2Generate.
(3) the daily gases at high pressure that are stored in steel cylinder middle and high concentration NO when not using, also exist the danger that may leak in the room air.
(4) owing to NO respiratory failure treatment air supply system uses pressure gas cylinder and decompression diluent facilities, mobile very inconvenient, make this method be unfavorable for the use of some special occasions, as outdoor first aid, plateau first aid etc.And the complexity of system, cause the cost of nitric oxide anapnotherapy higher.
Therefore, can produce at any time when being necessary to design a kind of the needs and don't the nitric oxide production therapy system of inhalable that needs store, to guarantee medical personnel and patient's safety.
H.Akiyama and T.Namihira etc. adopted the mist steel cylinder of high pressure dry air or high pressure nitrogen and oxygen since 1999, provided pulse arc discharge to synthesize the necessary N of NO gas
2And O
2, carried out that pulse arc discharge produces medical nitric oxide production research in the dry air; See [1] H.Akiyama, T.Namihira, D.Wang, S.Tsukamoto, K.Tusji, S.Katsuki, et al.Nitric oxide inhalation system using pulsed discharge.First InternationalSymposium on Non-thermal Medical/Biological Treatments[C] UsingElectromagnetic Field and Ionized Gases, Virginia, USA, 1999:111; [2] T.Namihira, S.Tsukamoto, D.Wang, S.Katsuki, H.Akiyama, R.Hackam, K.Okamoto Production of nitric monoxide in dry air using pulsed discharge[C] .Proc.12
ThIEEE Intern.Pulsed Power Conf. (USA), 1999,2:1313-1316; [3] T.Namihira, S.Tsukamoto, D.Wang, S.Katsuki, R.Hackam, K.Okamoto, H.Akiyama Production of nitric monoxide using pulsed discharge for a medicalapplication[J] .IEEE Trans.Plasma Sci.2000,28 (1): 109-113; [4] TakaoNamihira, Sunao Katsuki, Reuben Hackam, Hidenori Akiyama, KazufumiOkamoto Production of nitric monoxide using pulsed arc discharge[J] .IEEETrans.Plasma Sci.2002,30 (5): 1993-1997; [5] T.Namihira, D.Wang, S.Katsuki, H.Akiyama, K.Okamoto.Development of NO production systemfor medical applications[C] .The 15th International Conference on GasDischarges and their Applications, Toulouse, France, 2004:725-728.They adopt capacitor charging/discharging and positive pulse discharge mode, and the impulse hunting frequency is about 1.25 * 10
6Hz, the time that impulse hunting finishes is about 8 μ s.Therefore still do not solve complicated operation and inconvenient problem with use, because produce the N of NO as pulse arc discharge with pressure gas cylinder
2And O
2During the source, still need dry air or high pressure nitrogen and oxygen decompression; They do not solve the higher concentration NO that arc discharge process itself produces
2Harmful gas, and high NO
2/ (NO+NO
2) ratio (about 25%) problem, and the NO of high concentration
2Can accelerate the inactivation or the inefficacy of catalyst and adsorbent; Simultaneously, NO produces system and NO, NO
2And O
2Concentration measurement system separates, and moves and uses inconvenience.
Summary of the invention
The invention provides a kind of nitric oxide air supply system of respiratory failure treatment instrument, avoid prior art to use high-concentration NO gas bomb or high pressure dry air or high pressure mixed nitrogen-oxygen gas bomb, be raw material directly with the air under the atmospheric pressure, by regulating and the control impuls arc discharge condition, make generation NO gas as much as possible in the process air discharge, the least possible NO
2Harmful gas obtains low NO
2/ NO ratio.
The invention provides a kind of nitric oxide air supply system of respiratory failure treatment instrument, be included in air pump, the clean dry air that series connection is communicated with on the gas circuit and form device, effusion meter, pulse arc discharge reactor, the first micro particle filtering film, NO
2Catalytic reduction reforming unit, cooler, the second micro particle filtering film and selective absorption device; Described pulse arc discharge reactor is pin-plate electrode structure, is placed in the box of Teflon material, is placed in the casing of anti-electromagnetic interference again; Native system also is provided with gas monitoring instrument, analyzes NO, NO from described selective absorption device output gas
2And O
2Concentration;
Pin-the plate electrode of described pulse arc discharge reactor is respectively stainless steel anode and molybdenum hollow cathode, and it is 30-45 ° taper pin that stainless steel material is processed into tapering; It is circular, the inner plate that has aperture for hollow and side that metal molybdenum materials processing becomes the cross section; Electrode spacing is adjustable; Air pump, clean dry air form device, effusion meter, pulse arc discharge reactor, the first micro particle filtering film, NO
2Catalytic reduction reforming unit, cooler, the second micro particle filtering film, selective absorption device and gas monitoring instrument can be placed in the same casing.
The nitric oxide air supply system of described respiratory failure treatment instrument, it is characterized in that: the required pulse voltage of described pulse arc discharge reactor, provided by the pulse generation control loop, it comprises Switching Power Supply, pulse width modulation (PWM) inverter, high-frequency ac power transformator, high-frequency output transformer and controller; Switching Power Supply provides DC voltage, the pulse width modulation (PWM) inverter changes DC voltage into the alternating voltage with certain pulsewidth, provide high-frequency alternating current directly to charge to the electric capacity of cross-over connection through the high-frequency ac power transformator in the former limit of high-frequency output transformer by first IGCT, and, has the pulse voltage of certain frequency by high-frequency output transformer output through the discharge of second IGCT; Controller two is terminated at the negative electrode of first IGCT and second IGCT, discharge voltage that the control impuls arc discharge is required and discharge frequency; First resistance, diode cathode, diode anode and second resistance are connected in series in the negative electrode of first IGCT and second IGCT successively, play the protection discharge loop.
The present invention is a raw material with the air under the atmospheric pressure in the natural environment directly, produce medical NO gas, therefore, as long as the place of air is arranged, use the present invention just can provide medical treatment needed NO gas, can produce at any time when needing NO and need not store when not required, easy to operate, economical and practical; In pulse frequency was 1-90Hz, the NO concentration of generation was in 0-200ppm; The NO that produces during discharge
2/ (NO+NO
2) ratio is about 10%, therefore, follow-up NO
2Catalytic reduction transforms the catalyst of usefulness and the life-span of adsorbent can prolong greatly.The present invention collects NO and produces system and NO, NO
2And O
2Concentration measurement system moves easy to use in one.
Description of drawings
Fig. 1 is a system schematic of the present invention;
Figure 2 shows that pulse arc discharge generation systems circuit diagram of the present invention;
Figure 3 shows that pulse voltage and current waveform that the pulse arc discharge generation systems produces.
The specific embodiment
Fig. 1 is a system schematic of the present invention.This system forms device 2 by air pump 1 and clean dry air, effusion meter 3, pulse arc discharge reactor 4, micro particle filtering film 5, NO
2Catalytic reduction reforming unit 6, cooler 7 and adsorber 8 and NO, NO
2And O
2Gas monitoring instrument 9 is formed.Wherein: pulse arc discharge reactor 4 is pin-plate electrode structures, and material is respectively rustless steel and molybdenum hollow cathode, and pin-plate electrode is placed in the box of heat-resisting, a corrosion resistant Teflon material, and electrode spacing can be regulated arbitrarily within the specific limits; The dried and clean air that pulse arc discharge reactor 4 needs, forming device 2 by air pump 1 and clean dry air provides, and the clean dry air flow is by effusion meter 3 controls; The metallic that spills from electrode in the arc discharge is removed by micro particle filtering film 5; NO
2Catalytic reduction reforming unit 6 is used to remove that pulse arc discharge produces on a small quantity to the deleterious O of patient
3And NO
2Deng gas, remove NO
2The catalyzed conversion reducing substances be the metal molybdenum filament; From NO
2The mist that catalytic reduction reforming unit 6 comes out is gone into microgranule filter membrane 5 through subcooler 7 is laggard, to remove air-flow from NO
2The micro-small molybdenic metal-oxide crystal grain that catalyzed conversion heating reduction apparatus is taken out of; Gas monitoring instrument 9 adopts electrochemical process, analyzes NO, NO from the gas that comes out through selective absorption device 8
2And O
2Concentration.Pulse arc discharge reactor 4 is placed in the casing of anti-electromagnetic interference; , gas monitoring instrument 9, air pump 1, clean dry air form device 2, effusion meter 3, pulse arc discharge reactor 4, micro particle filtering film 5, NO
2-NO (N
2) catalytic reduction reforming unit 6, cooler 7 and selective absorption device 8, be placed in the same casing.
Be raw material directly, form clean dry air by air pump, desiccant and activated carbon capillary filter membrane and form device, obtain the needed dried and clean air of pulsed discharge with the air under the atmospheric pressure under the natural environment state.It is 30-45 ° taper pin that stainless steel material is processed into tapering, as anelectrode; It is circular, inner for hollow and side have the plate of aperture that metal molybdenum materials processing becomes the cross section, makes negative electrode.Add the pulse voltage of a certain frequency at the two poles of the earth of pulse arc discharge reactor, just can produce pulse arc discharge, form the metastable NO gas of concentration, NO in the mist
2/ (NO+NO
2) ratio about 10%.The small amount of N O that produces in the discharge process
2Gas is by a NO who is built-in with the metal molybdenum filament
2Catalyzed conversion heating reduction apparatus under certain heating-up temperature (greater than 500 ℃), carries out NO
2The one-level of gas is removed, and goes into NO through subcooler is laggard
2After the selective absorption device carries out the secondary removal, NO in the mist of output
2/ NO ratio has reached clinical medical treatment and has required NO less than 2%
2/ NO ratio is less than 5% standard.NO
2In the selective absorption device, be built-in with the selectivity carbon adsorbent, this adsorbent is the Red copper oxide that load has trace in common raw material of wood-charcoal material, makes by modification.When not needing NO, the switch of cutting off the electricity supply gets final product.
The pulse voltage that the pulse arc discharge reactor is required is provided by pulse generation control loop shown in Figure 2, and it comprises Switching Power Supply, pulse width modulation (PWM) inverter, high-frequency ac power transformator T
1(KHz), high-frequency output transformer T
2And controller.Switching Power Supply is used to provide galvanic current and presses (E=12V, after rectification, filtering, change or accumulator provides by civil power 220V), the pulse width modulation (PWM) inverter changes DC voltage into certain pulsewidth alternating voltage, through high-frequency ac power transformator T
1Provide high-frequency alternating current directly by the first IGCT SCR
1Give the capacitor C charging of cross-over connection in the former limit of high-frequency output transformer, and through the second IGCT SCR
2Discharge is by high-frequency output transformer T
2, output has the pulse voltage of certain frequency; Controller two is terminated at the negative electrode of first IGCT and second IGCT, discharge voltage that the control impuls arc discharge is required and discharge frequency; First resistance R
1, diode D negative electrode, diode D anode and second resistance R
2Be connected in series in the negative electrode of first IGCT and second IGCT successively, play the protection discharge loop.The pulse generation control loop can be regulated within the specific limits automatically, produces the needed voltage of arc discharge, and the pulse frequency of 1-90Hz can be provided, and pulse voltage is greater than 9KV.
Impulse circuit shown in Figure 2 can produce pulse voltage and current waveform as shown in Figure 3.Wherein 1〉be voltage waveform, the 2〉current waveform that records for sample resistance.
Claims (2)
1. the nitric oxide air supply system of respiratory failure treatment instrument is included in air pump, the clean dry air that series connection is communicated with on the gas circuit and forms device, effusion meter, pulse arc discharge reactor, the first micro particle filtering film, NO
2Catalytic reduction reforming unit, cooler, the second micro particle filtering film and selective absorption device, and pulse generation and control loop; Described pulse arc discharge reactor is pin-plate electrode structure, is placed in the box of Teflon material, is placed in the casing of anti-electromagnetic interference again; Native system also is provided with gas monitoring instrument, analyzes NO, NO from described selective absorption device output gas
2And O
2Concentration;
Pin-the plate electrode of described pulse arc discharge reactor is respectively stainless steel anode and molybdenum hollow cathode, and it is 30-45 ° taper pin that stainless steel material is processed into tapering; It is circular, the inner plate that has aperture for hollow and side that metal molybdenum materials processing becomes the cross section; Electrode spacing is adjustable; Described air pump, clean dry air formation device, effusion meter, pulse generation and control loop and arc discharge reactor, the first micro particle filtering film, NO
2Catalytic reduction reforming unit, cooler, the second micro particle filtering film, selective absorption device and gas monitoring instrument are placed in the same casing.
2. the nitric oxide air supply system of respiratory failure treatment instrument as claimed in claim 1, it is characterized in that: the required pulse voltage of described pulse arc discharge reactor, provided by pulse generation and control loop, it comprises Switching Power Supply, pulse width modulation (PWM) inverter, high-frequency ac power transformator, high-frequency output transformer and controller; Switching Power Supply provides DC voltage, the pulse width modulation (PWM) inverter changes DC voltage into the alternating voltage with certain pulsewidth, provide high-frequency alternating current directly to charge to the electric capacity of cross-over connection through the high-frequency ac power transformator in the former limit of high-frequency output transformer by first IGCT, and, has the pulse voltage of certain frequency by high-frequency output transformer output through the discharge of second IGCT; Controller two is terminated at the negative electrode of first IGCT and second IGCT, discharge voltage that the control impuls arc discharge is required and discharge frequency; First resistance, diode cathode, diode anode and second resistance are connected in series in the negative electrode of first IGCT and second IGCT successively, play the protection discharge loop.
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|---|---|---|---|
| CNB2005100192163A CN100404083C (en) | 2005-08-03 | 2005-08-03 | Nitric oxide gas supply system of respiratory failure salvage instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100192163A CN100404083C (en) | 2005-08-03 | 2005-08-03 | Nitric oxide gas supply system of respiratory failure salvage instrument |
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|---|---|
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| CN100404083C true CN100404083C (en) | 2008-07-23 |
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| CNB2005100192163A Expired - Fee Related CN100404083C (en) | 2005-08-03 | 2005-08-03 | Nitric oxide gas supply system of respiratory failure salvage instrument |
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Cited By (7)
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|---|---|---|---|---|
| US10946163B2 (en) | 2017-02-27 | 2021-03-16 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| US11033705B2 (en) | 2017-02-27 | 2021-06-15 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| US11045620B2 (en) | 2019-05-15 | 2021-06-29 | Third Pole, Inc. | Electrodes for nitric oxide generation |
| US11479464B2 (en) | 2019-05-15 | 2022-10-25 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| US11691879B2 (en) | 2020-01-11 | 2023-07-04 | Third Pole, Inc. | Systems and methods for nitric oxide generation with humidity control |
| US11827989B2 (en) | 2020-06-18 | 2023-11-28 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| US11833309B2 (en) | 2017-02-27 | 2023-12-05 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
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| EP2646365B1 (en) | 2010-12-03 | 2016-08-03 | Koninklijke Philips N.V. | Method and arrangement for generating nitric oxide |
| ES2768250T5 (en) | 2011-10-03 | 2023-12-21 | Nitricgen Inc | Apparatus and method for generating nitric oxide in controlled and precise quantities |
| SI2928531T1 (en) * | 2012-12-04 | 2017-07-31 | Ino Therapeutics LLC Perryville III Corporate Park | Cannula for minimizing dilution of dosing during nitric oxide delivery |
| RU2692953C2 (en) | 2013-03-15 | 2019-06-28 | Взе Дженерал Хоспитал Корпорейшн | Synthesis of gaseous nitrogen oxide for inhalation |
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| CN110114307B (en) * | 2016-12-14 | 2022-09-23 | 欧利景有限公司 | Apparatus and method for producing high concentration, low temperature nitric oxide |
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| CN108821250A (en) * | 2018-09-04 | 2018-11-16 | 中国医学科学院生物医学工程研究所 | A kind of reaction cabin and nitrogen monoxide generating device |
| NO345196B1 (en) * | 2018-10-25 | 2020-11-02 | N2 Applied As | Low pressure plasma reactor loop process and system |
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Cited By (12)
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|---|---|---|---|---|
| US10946163B2 (en) | 2017-02-27 | 2021-03-16 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| US11033705B2 (en) | 2017-02-27 | 2021-06-15 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| US11376390B2 (en) | 2017-02-27 | 2022-07-05 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| US11524134B2 (en) | 2017-02-27 | 2022-12-13 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| US11554240B2 (en) | 2017-02-27 | 2023-01-17 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| US11833309B2 (en) | 2017-02-27 | 2023-12-05 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| US11911566B2 (en) | 2017-02-27 | 2024-02-27 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| US11045620B2 (en) | 2019-05-15 | 2021-06-29 | Third Pole, Inc. | Electrodes for nitric oxide generation |
| US11478601B2 (en) | 2019-05-15 | 2022-10-25 | Third Pole, Inc. | Electrodes for nitric oxide generation |
| US11479464B2 (en) | 2019-05-15 | 2022-10-25 | Third Pole, Inc. | Systems and methods for generating nitric oxide |
| US11691879B2 (en) | 2020-01-11 | 2023-07-04 | Third Pole, Inc. | Systems and methods for nitric oxide generation with humidity control |
| US11827989B2 (en) | 2020-06-18 | 2023-11-28 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
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