CN100393366C - Manufacturing method of medical absorpable suture - Google Patents
Manufacturing method of medical absorpable suture Download PDFInfo
- Publication number
- CN100393366C CN100393366C CNB031392679A CN03139267A CN100393366C CN 100393366 C CN100393366 C CN 100393366C CN B031392679 A CNB031392679 A CN B031392679A CN 03139267 A CN03139267 A CN 03139267A CN 100393366 C CN100393366 C CN 100393366C
- Authority
- CN
- China
- Prior art keywords
- carbon dioxide
- copolymer
- dioxide copolymer
- pelletize
- maleic anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a manufacturing method of a medical absorbable suture. A medical absorbable suture uses carbon dioxide copolymer as raw material. The carbon dioxide copolymer is melted in the temperature of 120 to 160 DEG C. Maleic anhydride, or maleic anhydride, or acetic anhydride of 0.1 to 4 wt% of the weight of the copolymer is added. The carbon dioxide copolymer, and the maleic anhydride, or the maleic anhydride, or the acetic anhydride are mixed to be pelletized. The pelletized carbon dioxide copolymer is melted in the temperature of 150 to 180 DEG C. 10 to 40 wt% of polylactic acid or poly hydroxybutyric acid ester is added. The fused mass is mixed and extruded to be pelletized. The pellets of the pelletized mixture are melted in the temperature of 160 to 180 DEG C in a solution spinning method. Air bubbles are removed. The primary fiber of 0.8 to 10 millimeters is formed by a spinneret plate of which the hole diameter is 1 to 20 millimeters. The primary fiber is stretched for the second time in the water bath of 30 to 50 DEG C, and sutures of different types are manufactured. The present invention has the advantages of high intensity, good toughness, and high retention breaking strength. The reaction of a sutured tissue is little, a scar is small after a wound is healed, the memory effect of body temperature is obvious, the degradation of the present invention can be controlled, and the present invention can be completely absorbed.
Description
Technical field
The present invention relates to a kind of preparation method of medical material, specifically a kind of preparation method of medical absorbable suture.
Background technology
We know that medical absorbable suture is the development trend of current suture, has important application prospects.Mainly contain several classes such as catgut, collagen line, biodegradable synthetic polymer stitching thread such as polylactic acid line at present.The major requirement of absorbable medical suture is that tissue reaction is little, the wound cicatrix is little, soak time is controlled, the knot knot is easy etc.Catgut is the at present domestic absorbable suture that generally uses, but has problems such as stitching thread fragility is big, length is subjected to the Intestinum caprae seu ovis length restriction, gutstring intensity is relevant with the animal individual age, knot knot performance is undesirable.Chinese invention patent publication number CN1371919A discloses a kind of preparation method of human collagen operation suture thread, has overcome animal collagen and has had problems such as possible viral hidden danger and poor in processability.Chinese invention patent publication number CN1051510A has proposed the preparation method that a kind of collagen one polyvinyl alcohol can absorb operation suture thread, has advantages such as raw material is easy to get, postoperative tissue reaction is little, the wound cicatrix is little.But the degraded in vivo of collagen line is first generation " hydrolysis ", and promptly the solubilization of water is then degraded, and is easy to generate stitching thread and expands, and makes the stitching thread ligation not firm.Collagen line poor in flexibility in addition at Digestive system with to infect under the environment tensile strength consume fast, weakness and fiber tearing can occur on the stitching thread sometimes.Polyglycolic acid stitching thread and the employing of adopting poly-Acetic acid, hydroxy-, bimol. cyclic ester (PGA) spinning to form form the polylactic-co-glycolic acid stitching thread with poly (glycolide-lactide) (PGLA) spinning, have and advantage such as can absorb, tissue reaction is light, but also there are knot knot portion poor stability, the not firm shortcoming of knotting, when undergoing surgery, must many dozen several knots than common spun silk stitching thread.In addition, application for a patent for invention number is 98125655.4 and 00136189.9 to have proposed a kind of high efficiency preparation method of carbon dioxide copolymer respectively, can prepare the carbon dioxide copolymer of different molecular weight.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned the deficiencies in the prior art, a kind of intensity height, good, the retention fracture strength height of pliability are provided, have the suture tissue response light, the wound healing cicatrix is little, has tangible body temperature memory effect, may command degraded, and the preparation method of the absorbable medical suture that can absorb fully.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of preparation method of medical absorbable suture:
(1) it is raw material with the carbon dioxide copolymer, and the carbon dioxide copolymer structural formula is:
x＝0.5-1.0
R＝H，CH
3，
N is an integer, between 200 to 5000, is equivalent to number-average molecular weight between 20000 to 500000;
(2) carbon dioxide copolymer of described structure adds maleic anhydride or the acetic anhydride of the 0.1-4wt% of copolymer weight, the blend pelletize 120-160 ℃ of following fusion; With the copolymer after the pelletize 120-180 ℃ of down fusing, remove bubble after, be the spinneret of 1-20 millimeter by the aperture, form the primary filament of 0.8-10 millimeter; Primary filament carries out succeeding stretch again under 20-40 ℃ of water-bath, make the pure carbon dioxide copolymer stitching thread of different model.
The present invention is based on the preparation method of the medical absorbable suture of carbon dioxide copolymer, and the carbon dioxide copolymer of said structure adds maleic anhydride or the acetic anhydride of the 0.1-4wt% of copolymer weight, the blend pelletize 120-160 ℃ of following fusion; Carbon dioxide copolymer after the pelletize 150-180 ℃ of fusing down, is added polylactic acid or poly butyric ester, and content is the 10-40wt% of blend, melt blended back extruding pelletization; Adopt the melt spinning method 160-180 ℃ of fusing down the blend pellet after the pelletize, remove bubble after, be the spinneret of 1-20 millimeter by the aperture, form the primary filament of 0.8-10 millimeter; Primary filament carries out succeeding stretch again under 30-50 ℃ of water-bath, make the stitching thread of different model.
The present invention is owing to adopt complete biolytic carbon dioxide copolymer to prepare absorbable stitching thread, the stitching thread that carbon dioxide copolymer is made is through biological test, not only have advantages such as tissue reaction is light, the wound healing cicatrix is little, simultaneously since the vitrification point of selected carbon dioxide copolymer at 35-38 ℃, suitable with human body temperature, also have tangible body temperature memory effect.This moment, sutural extensibility can be controlled between the 50-500%, and good springiness can firmly be sewed up wound surface and not become flexible, knot knotting strength height.In addition and since the degraded of carbon dioxide copolymer be from skin gradually to internal layer, degraded mode is layer by layer carried out, so problem such as stitching thread can not expand, the difficulty of tiing a knot and knot are not firm, have intensity height, pliability good, retain many advantages such as fracture strength height.Introducing by comonomer is the may command degradation time also, makes degradation time controlled at 5-60 days, absorbs fully in 6 months.
The specific embodiment
The present invention is further described below in conjunction with embodiment:
A kind of preparation method of medical absorbable suture:
(1) it is raw material with the carbon dioxide copolymer, and the carbon dioxide copolymer structural formula is:
x＝0.5-1.0
R＝H，CH
3，
N is an integer, between 200 to 5000, is equivalent to number-average molecular weight between 20000 to 500000.
The above-mentioned carbon dioxide copolymer of the present invention can be carbon dioxide-ethylene oxide copolymer, or carbon dioxide-epoxy propane copolymer, or carbon dioxide-oxidizing ethyle alkyl copolymer, or carbon dioxide-styrene oxide copolymer, or carbon dioxide-epoxy propane-7-oxa-bicyclo[4.1.0 terpolymer, or one or both of carbon dioxide-epoxy propane-oxirane terpolymer.
The preparation method of the above-mentioned carbon dioxide copolymer of the present invention is not done detailed description here as 98125655.4 and 00136189.9 method of announcing.
The carbon dioxide copolymer of said structure adds maleic anhydride or the acetic anhydride of the 0.1-4wt% of copolymer weight, the blend pelletize 120-160 ℃ of following fusion.Maleic anhydride or acetic anhydride play the end capped effect of melt.With the copolymer after the pelletize 120-180 ℃ of down fusing, remove bubble after, be the spinneret of 1-20 millimeter by the aperture, form the primary filament of 0.8-10 millimeter; Primary filament carries out succeeding stretch again under 20-40 ℃ of water-bath, make the pure carbon dioxide copolymer stitching thread of different model.
The present invention is based on the preparation method of the medical absorbable suture of carbon dioxide copolymer, and the carbon dioxide copolymer of said structure adds maleic anhydride or the acetic anhydride of the 0.1-4wt% of copolymer weight, the blend pelletize 120-160 ℃ of following fusion; Carbon dioxide copolymer after the pelletize 150-180 ℃ of fusing down, is added polylactic acid or poly butyric ester, and content is the 10-40wt% of blend, melt blended back extruding pelletization; Adopt the melt spinning method 160-180 ℃ of fusing down the blend pellet after the pelletize, remove bubble after, be the spinneret of 1-20 millimeter by the aperture, form the primary filament of 0.8-10 millimeter; Primary filament carries out succeeding stretch again under 30-50 ℃ of water-bath, make the stitching thread of different model.
The carbon dioxide copolymer stitching thread that the present invention makes can be monofilament, multifilament or twisted filament, specification between 12-0 to 5 line, monofilament lines footpath between 0.010～0.799mm, not the intensity in collinear footpath between 0.25～71.44N, specifically as shown in table 1.
The specification of the medical absorbable suture of table 1 carbon dioxide copolymer, line footpath and intensity
| Specification | Silk footpath (mm) | Intensity (N), 〉= |
| 12-0 | 0.001～0.009 | / |
| 11-0 | 0.010～0.019 | / |
| 10-0 | 0.020～0.029 | 0.25 |
| 9-0 | 0.030～0.039 | 0.49 |
| 8-0 | 0.040～0.049 | 0.69 |
| 7-0 | 0.050～0.069 | 1.37 |
| 6-0 | 0.070～0.099 | 2.45 |
| 5-0 | 0.100～0.149 | 6.66 |
| 4-0 | 0.150～0.199 | 9.31 |
| 3-0 | 0.200～0.249 | 17.35 |
| 2-0 | 0.300～0.339 | 26.26 |
| 0 | 0.350～0.399 | 38.22 |
| 1 | 0.400～0.499 | 49.78 |
| 2 | 0.500～0.599 | 62.23 |
| 3 and 4 | 0.600～0.699 | 71.44 |
| 5 | 0.700～0.799 | / |
Compare with existing absorbable suture, the present invention has following advantage: (1) stitching thread has the advantage that tissue reaction is light, the wound healing cicatrix is little through biological test; (2) since the vitrification point of selected carbon dioxide copolymer at 35-38 ℃, suitable with human body temperature, have tangible body temperature memory effect.This moment, sutural extensibility can be controlled between the 50-500%, and good springiness can firmly be sewed up wound surface and not become flexible, knot knotting strength height.(3) since the degraded of carbon dioxide copolymer be from skin gradually to internal layer, degraded mode is layer by layer carried out, so problem such as stitching thread can not expand, the difficulty of tiing a knot and knot are not firm, have intensity height, pliability good, retain many advantages such as fracture strength height.(4) spinning process is a melt spinning, without any organic solvent, and the therefore side effect of having avoided organic solvent to bring.
Carbon dioxide copolymer of the present invention is carbon dioxide-epoxy propane-oxirane terpolymer, and wherein the content of carbon dioxide-epoxy propane unit in copolymer is between 50%-100%, and the copolymer number-average molecular weight is between 20000 to 500000.In addition, the content in copolymer by adjustable ring Ethylene Oxide and ethylene oxide unit, the may command degradation time makes degradation time controlled at 1-30 days, and soak time is in 6 months fully.
By introducing polylactic acid or the poly butyric ester of 20-40%, the sutural mechanical strength of scalable; Filament strength can improve.Maleic anhydride or acetic anhydride play the end capped effect of melt.
Embodiment 1
Carbon dioxide copolymer (carbon dioxide-epoxy propane unit content 58%, number-average molecular weight 21000, molecular weight distributing index 4.2) 120 ℃ of following fusions, is added blend pelletize behind the maleic anhydride of 4wt% of copolymer weight.Carbon dioxide copolymer after the pelletize is adopted the spinning mechanical spinning or fusing under 155 ℃, after removing bubble, it by the aperture 4 millimeters spinneret, form 2 millimeters fiber after the preliminary drawing-off, primary filament carries out succeeding stretch again under 25 ℃ of water-baths, prepare the 2-0 stitching thread, intensity 26.50N.
Embodiment 2
Carbon dioxide copolymer (carbon dioxide-epoxy propane unit content 100%, number-average molecular weight 198000, molecular weight distributing index 5.3) 150 ℃ of following fusions, is added blend pelletize behind the maleic anhydride of 1.2wt% of copolymer weight.Carbon dioxide copolymer after the pelletize is adopted the spinning mechanical spinning or fusing under 160 ℃, after removing bubble, it by the aperture 6 millimeters spinneret, form 4 millimeters primary filament after the preliminary drawing-off, primary filament carries out succeeding stretch again under 25 ℃ of water-baths, prepare the 6-0 stitching thread, intensity 2.50N.
Embodiment 3
Carbon dioxide copolymer (carbon dioxide-epoxy propane unit content 92%, number-average molecular weight 423000, molecular weight distributing index 5.7) 160 ℃ of following fusions, is added blend pelletize behind the maleic anhydride of 0.6wt% of copolymer weight.Carbon dioxide copolymer after the pelletize is adopted the spinning mechanical spinning or fusing under 165 ℃, after removing bubble, it by the aperture 8 millimeters spinneret, form 6 millimeters primary filament after the preliminary drawing-off, primary filament carries out succeeding stretch again under 38 ℃ of water-baths, prepare the 8-0 stitching thread, intensity 0.70N.
Embodiment 4
Carbon dioxide copolymer (expoxy propane-carbon dioxide unit content 82%, number-average molecular weight 89000, molecular weight distributing index 3.6) 140 ℃ of following fusions, is added blend pelletize behind the acetic anhydride of 1wt% of copolymer weight.Carbon dioxide copolymer after the pelletize is adopted the spinning mechanical spinning or fusing under 155 ℃, after removing bubble, it by the aperture 5 millimeters spinneret, form 2 millimeters fiber after the preliminary drawing-off, primary filament carries out succeeding stretch again under 28 ℃ of water-baths, prepare the 3-0 stitching thread, intensity 17.53N.
Embodiment 5
To melt down at 170 ℃ after the carbon dioxide copolymer pelletize among the embodiment 4, add the polylactic acid (number-average molecular weight 320000, molecular weight distributing index 2.4) of 38wt%, melt blended back extruding pelletization.Blend pellet after the pelletize adopted the spinning mechanical spinning or 170 ℃ of fusings down, remove bubble after, be 8 millimeters spinneret by the aperture, form 4 millimeters fiber; Primary filament carries out succeeding stretch again under 40 ℃ of water-baths, prepare the 6-0 stitching thread, intensity 3.00N.
Embodiment 6
To melt down at 170 ℃ after the carbon dioxide copolymer pelletize among the embodiment 3, add the polylactic acid (number-average molecular weight 440000, molecular weight distributing index 2.6) of 18wt%, melt blended back extruding pelletization.Blend pellet after the pelletize adopted the spinning mechanical spinning or 170 ℃ of fusings down, remove bubble after, be 10 millimeters spinneret by the aperture, form 5 millimeters fiber; Primary filament carries out succeeding stretch again under 45 ℃ of water-baths, prepare stitching thread No. 8, fibre strength 0.74N.
Embodiment 7
To melt down at 170 ℃ after the carbon dioxide copolymer pelletize among the embodiment 4, add the poly butyric ester (number-average molecular weight 230000, molecular weight distributing index 4.9) of 28wt%, melt blended back extruding pelletization.Blend pellet after the pelletize adopted the spinning mechanical spinning or 175 ℃ of fusings down, remove bubble after, be 10 millimeters spinneret by the aperture, form 4 millimeters primary filament; Primary filament carries out succeeding stretch again under 40 ℃ of water-baths, prepare the 5-0 stitching thread, intensity 6.85N.
Embodiment 8
To melt down at 170 ℃ after the carbon dioxide copolymer pelletize among the embodiment 1, add the poly butyric ester (number-average molecular weight 281000, molecular weight distributing index 5.4) of 35wt%, melt blended back extruding pelletization.Blend pellet after the pelletize adopted the spinning mechanical spinning or 175 ℃ of fusings down, remove bubble after, be 8 millimeters spinneret by the aperture, form 4 millimeters primary filament, primary filament carries out succeeding stretch again under 35 ℃ of water-baths, prepare the 4-0 stitching thread, intensity 10.05N.
Claims (3)
1. the preparation method of a medical absorbable suture: it is characterized in that:
(1) it is raw material with the carbon dioxide copolymer, and the carbon dioxide copolymer structural formula is:
x＝0.5-1.0
R＝H，CH
3，
N is an integer, between 200 to 5000, is equivalent to number-average molecular weight between 20000 to 500000;
(2) carbon dioxide copolymer of described structure adds maleic anhydride or the acetic anhydride of the 0.1-4wt% of copolymer weight, the blend pelletize 120-160 ℃ of following fusion; With the copolymer after the pelletize 120-180 ℃ of down fusing, remove bubble after, be the spinneret of 1-20 millimeter by the aperture, form the primary filament of 0.8-10 millimeter; Primary filament carries out succeeding stretch again under 20-40 ℃ of water-bath, make the pure carbon dioxide copolymer stitching thread of different model.
2. the preparation method of a medical absorbable suture, it is characterized in that: the carbon dioxide copolymer with the described structure of claim 1 is a raw material, it adds maleic anhydride or the acetic anhydride of the 0.1-4wt% of copolymer weight, the blend pelletize 120-160 ℃ of following fusion; Carbon dioxide copolymer after the pelletize 150-180 ℃ of fusing down, is added polylactic acid or poly butyric ester, and content is the 10-40wt% of blend, melt blended back extruding pelletization; Adopt the melt spinning method 160-180 ℃ of fusing down the blend pellet after the pelletize, remove bubble after, be the spinneret of 1-20 millimeter by the aperture, form the primary filament of 0.8-10 millimeter; Primary filament carries out succeeding stretch again under 30-50 ℃ of water-bath, make the stitching thread of different model.
3. the preparation method of medical absorbable suture according to claim 1 and 2, it is characterized in that: carbon dioxide copolymer is carbon dioxide-epoxy propane-oxirane terpolymer, wherein the content of carbon dioxide-epoxy propane unit in copolymer is between 50%-100%, and the copolymer number-average molecular weight is between 20000 to 500000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031392679A CN100393366C (en) | 2003-09-18 | 2003-09-18 | Manufacturing method of medical absorpable suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031392679A CN100393366C (en) | 2003-09-18 | 2003-09-18 | Manufacturing method of medical absorpable suture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1596992A CN1596992A (en) | 2005-03-23 |
| CN100393366C true CN100393366C (en) | 2008-06-11 |
Family
ID=34659313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031392679A Expired - Fee Related CN100393366C (en) | 2003-09-18 | 2003-09-18 | Manufacturing method of medical absorpable suture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100393366C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100422405C (en) * | 2005-07-05 | 2008-10-01 | 中国石化仪征化纤股份有限公司 | Method for producing antibacterial polylactic acid fiber |
| CN1923892B (en) * | 2005-08-30 | 2010-11-10 | 吉林金源北方科技发展有限公司 | Degradation type composite material |
| KR101712560B1 (en) | 2008-06-24 | 2017-03-06 | 바이오엑티브 써지컬, 아이엔씨. | Surgical sutures incorporated with stem cells or other bioactive materials |
| CN105999377A (en) * | 2016-06-15 | 2016-10-12 | 湖州科达化工燃料有限公司 | Medical absorbable suture line with antibacterial effect |
| CN110075366A (en) * | 2019-04-01 | 2019-08-02 | 杨青青 | A kind of anti-oxidant lifting esthetic line of biological absorbable and its preparation method and application |
| CN113679875A (en) * | 2021-08-31 | 2021-11-23 | 长春圣博玛生物材料有限公司 | Absorbable medical operation line and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145525A (en) * | 1977-10-03 | 1979-03-20 | Air Products And Chemicals, Inc. | End capped polyalkylene carbonates |
| CN1408440A (en) * | 2001-09-18 | 2003-04-09 | 威海威高创新有限公司 | Medical composite material and preparation method thereof |
| US6599577B2 (en) * | 2001-07-19 | 2003-07-29 | Changchun Institute Of Applied Chemistry-Chinese Academy Of Sciences | Method of preparation for a degradable, water and oil resistant protective membrane |
-
2003
- 2003-09-18 CN CNB031392679A patent/CN100393366C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145525A (en) * | 1977-10-03 | 1979-03-20 | Air Products And Chemicals, Inc. | End capped polyalkylene carbonates |
| US6599577B2 (en) * | 2001-07-19 | 2003-07-29 | Changchun Institute Of Applied Chemistry-Chinese Academy Of Sciences | Method of preparation for a degradable, water and oil resistant protective membrane |
| CN1408440A (en) * | 2001-09-18 | 2003-04-09 | 威海威高创新有限公司 | Medical composite material and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1596992A (en) | 2005-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7641825B2 (en) | Method of making a polyhydroxyalkanoate filament | |
| US4621638A (en) | Hard elastic sutures | |
| US5695879A (en) | Surgical suture material and method of making and using same | |
| Gupta et al. | Poly (lactic acid) fiber: An overview | |
| JP4716570B2 (en) | Absorbable polymer and surgical article made therefrom | |
| US20130300018A1 (en) | Polyhydroxyalkanoate Medical Textiles and Fibers | |
| CN101265621A (en) | Collagen protein-polyvinyl alcohol-chitosan blending medical fibre and method for making same | |
| US6048947A (en) | Triblock terpolymer, its use for surgical suture material and process for its production | |
| JPS6025975B2 (en) | Surgical suture derived from segmented polyether block copolymer | |
| CN100393366C (en) | Manufacturing method of medical absorpable suture | |
| CN115305600B (en) | Fiber yarn and preparation method and application thereof | |
| CA1098668A (en) | Isotactic polypropylene surgical sutures | |
| CN112316198A (en) | Absorbable and degradable suture line | |
| CN115627559A (en) | Degradable filament and special material thereof | |
| CN108295319B (en) | Medical nanofiber-reinforced hydrophilic composite material and preparation method and application thereof | |
| CN113694246A (en) | Biodegradable surgical suture and preparation method thereof | |
| CN109183191A (en) | A kind of flexibility P3HB4HB/PLA blended fiber and preparation method thereof | |
| CN115637506B (en) | Filament, preparation method and application thereof | |
| CN111558092A (en) | Preparation of bio-based degradable medical stent membrane | |
| US6500193B1 (en) | Sutures | |
| CN113249815A (en) | Biodegradable PGA melt spinning forming method | |
| KR20000073912A (en) | Kitosan staple fibers, chemically modified kitosan fibers, and a process for preparation thereof | |
| AU612358B2 (en) | Surgical closure device | |
| WO2024104374A1 (en) | Degradable filament, preparation method therefor, and use thereof | |
| KR0126599B1 (en) | Biodegradable suture |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20060526 Address after: Room 416, building 4000, Silicon Valley Avenue, hi tech Development Zone, Jilin, Changchun Applicant after: Jilin Jinyuan North Technology Development Co.,Ltd. Address before: Weihai Shandong hi tech Zone Road Science and Technology Development Co., Ltd. Applicant before: SAILUTE SCIENCE AND TECHNOLOGY DEVELOPMENT Co.,Ltd. WEIHAI |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Feng Chao Document name: Notification of registration procedures and notice of patent for invention |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080611 Termination date: 20210918 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |