CN100386054C - Light scattering medium for pulse blood oxygen simulator and its preparation method - Google Patents
Light scattering medium for pulse blood oxygen simulator and its preparation method Download PDFInfo
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- CN100386054C CN100386054C CNB2006100427182A CN200610042718A CN100386054C CN 100386054 C CN100386054 C CN 100386054C CN B2006100427182 A CNB2006100427182 A CN B2006100427182A CN 200610042718 A CN200610042718 A CN 200610042718A CN 100386054 C CN100386054 C CN 100386054C
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Abstract
The present invention discloses a light scattering medium for a pulse blood oxygen simulator and a preparation method of the light scattering medium. The method comprises: 91.5 to 98% of optical filling epoxy resin and 2 to 8.5% of light scattering agent are measured by a measuring cup by the volume percentage, and the light scattering agent is added in the optical filling epoxy resin to uniformly agitate; a mixture of the light scattering agent and the optical filling epoxy resin is poured into a polished mould box, the pouring thickness is from 1 to 2mm; the poured mixture and the mould box are put in a drying box, and are taken out after solidifying for 8 hours at 60-80 DEG C, and the light scattering medium is manufactured after demoulding; the solidified light scattering medium is bonded on a probe head of the simulator. The present invention overcomes the defect of insufficient simulating of living body tissue light scattering characteristics of the existing pulse blood oxygen simulators, and the present invention prevent the overdrive phenomenon from occurring when a pulse blood oxygen instrument is used for calibrating and checking. The operating state of the pulse blood oxygen instrument approaches to the human body actual measurement state, and consequently, the accurate calibration and checking of the pulse blood oxygen instrument can be realized.
Description
Technical field
The present invention relates to be used for the simulation material of medical simulation apparatus, particularly be used for the light scattering medium and the preparation method of pulse blood oxygen simulator.
Background technology
Pulse blood oxygen instrument is a kind of novel medical instrument that does not have wound, continuously monitoring human body arterial oxygen saturation.The pulse blood oxygen instrument of producing both at home and abroad generally is by measuring the absorbance ratio of biological tissue to the light of two kinds of different wave lengths, obtaining arterial oxygen saturation according to corresponding calibration curve at present.Biological tissue is made up of a pulsation of superposition on stable DC quantity of ac the integral dose of incident light wave.The pulsation of ac causes by the full illumination position of arterial blood tremulous pulse, and stable DC quantity is a blood flow when crossing the illumination position, by tissues such as skin, muscle, skeleton, venous blood the absorption of light caused.Two light sources of pulse blood oxygen instrument are generally wavelength X
1The red light-emitting diode of=660nm and wavelength are λ
2The infrared light light emitting diode of=940nm.Under the control of microprocessor with certain frequency sequence starting λ
1, λ
2With three duties of half-light, photoelectric detective circuit will be converted into the signal of telecommunication by the synthetic pair of light pulse signal of being pulsed of finger, calculate the relative intensity in transmission R of two wavelength light through handling, and can draw blood oxygen saturation SpO according to corresponding calibration curve
2
In pulse blood oxygen instrument production and use, it is calibrated accurately with verification be absolutely necessary.Operation principle according to pulse blood oxygen instrument, as the pulse blood oxygen simulator that is used for pulse blood oxygen instrument calibration and verification, generally should at first possess the above-mentioned extinction characteristic of organizing, promptly have the direct current absorption and exchange pulsation modulation absorption dual-use function, and the ac modulation waveform should be the arterial pulse wave waveform for incident illumination from pulse blood oxygen instrument; Secondly, emulator should be in the normal physiological scope that empirical calibration curve for pulse oximetry limited to the direct current absorbtivity and the ac modulation amount ratio R value of two light, and emulator meets normal basic law to the relation of dual-beam ac modulation amount and R value and blood oxygen saturation.
Existing pulse blood oxygen instrument calibration method of calibration is that the pulse blood oxygen simulator by as shown in Figure 1 comes tissue, simulates as the optical absorption characteristics of finger, thereby can realize that the tissue direct current absorbs and the pulsation modulation.Light scattering medium wherein generally adopts materials such as optics lucite, but these light scattering mediums and do not meet the scattering properties of tissue to incident illumination.(600nm～1000nm) has the characteristic of strong scattering, weak absorption, thereby from macrostructure's spectroscopy angle, biological tissue is mainly caused by scattering effect the output attenuatoin of this wave band incident illumination near infrared band in biological tissue.This just make the structure pulse blood oxygen simulator organize emulation optical transmission model the time, organize the reasonable emulation of light scattering characteristic to become a problem that can not be ignored, and whether close with the scattering properties of biological tissue also become of light scattering medium material influence the accurately key of calibration or verification of pulse blood oxygen instrument.
Because the light scattering medium of existing pulse blood oxygen simulator does not also meet the scattering properties of tissue to incident illumination, therefore when pulse blood oxygen instrument is calibrated verification, so-called overdriving (over-driven) phenomenon appears, and pulse blood oxygen instrument duty substantial deviation human body actual measurement this moment state, thereby cause the locked defective that can't calibrate in certain fixed data of reading.
Summary of the invention
The objective of the invention is to overcome the biological tissue light scattering characteristic that has pulse blood oxygen simulator now and simulate insufficient shortcoming, overdrive phenomenon and the pulse blood oxygen instrument duty that occur when avoiding causing that pulse blood oxygen instrument calibrated verification depart from human body actual measurement state phenomenon, provide a kind of and be used for light scattering medium composite and preparation method pulse blood oxygen simulator, similar substantially to the biological tissue optical characteristics, thereby can realize precise calibration and verification pulse blood oxygen instrument.
Result to the research of tissue optical absorption characteristics shows, biological vital tissue is considered as the dense medium of light, and it is a kind of comparatively reasonably tissue scatter's theoretical model that application discrete light submodel is studied its multiple scattering process, need only simulate with the single scattering parameter to get final product.The Mei theory of describing the microgranule electromagnetic scattering has provided the Maxwell equation of the isotropism spherical particle of arbitrary dimension to the plane wave scattering.By this equation as can be known scattering amplitude become the fixed angular distribution size that depends on scattering object along incident direction.Is 1.4 with its microgranule that can calculate the 1um diameter to the coefficient of refraction of 800nm plane wave.Therefrom scattering has intensive preceding tropism's trend as can be seen, and along with the increase of scattering particles dimension, tropism's trend also increases thereupon before the scattering.Therefore, in biological tissue's scattering effect research, suppose that generally tissue scatter's particle diameter is 1um.
According to above theory analysis, the light scattering medium material that is used for pulse blood oxygen simulator must satisfy basic demand down: at first, satisfy the coupling of adulterated heteroplasmon dimension and lambda1-wavelength in the scattering medium material.The preceding tropism of biological tissue's scattering has determined the scattering medium material to should be dimension greater than the adulterated turbid media of the bulky grain of lambda1-wavelength.In order further to strengthen dispersion effect, also can adopt dimension to prepare scattering material less than the oarse-grained mode of mixing in the granule turbid media of lambda1-wavelength; Secondly, the thickness of scattering medium material is control suitably, can realize by the mode that strengthens emulation scattering medium thickness for reaching good dispersion effect, but because the structural requirement of pulse blood oxygen simulator, scattering material thickness can not be too big, thereby, under the prerequisite that increases scattering material thickness to greatest extent, should strengthen dispersion effect by the doping characteristic that changes the scattering medium material.
A kind of light scattering medium that is used for pulse blood oxygen simulator, percentage ratio by volume, it consists of: optical filling epoxy resin 91.5～98%, light scattering agent 2～8.5%; Wherein optical filling epoxy resin is that WL-700A epoxy resin and WL-700B epoxy resin are formed by 1: 1～1.1 volume ratio; Light scattering agent is a DF-090 epoxy resin, its colloidal particle diameter average out to 0.5～1.5um.
The preparation method of above-mentioned light scattering medium comprises the steps:
1) percentage ratio is by volume measured optical filling epoxy resin 91.5～98% with measuring cup, and light scattering agent 2～8.5% adds light scattering agent in the optical filling epoxy resin and to stir;
2) said mixture is poured in the mold box of polishing, cast thickness is 1～2mm;
3) will pour into a mould good mixture and put into baking oven together with mold box, 60～80 ℃ solidify taking-up after 8 hours down, promptly make light scattering medium after the demoulding;
4) at last solidified light scattering medium is bonded on the emulator probe.
In the technique scheme, optical filling used for epoxy resin WL-700A epoxy resin and WL-700B epoxy resin are measured by 1: 1～1.1 volume ratio in the described step 1), earlier WL-700A epoxy resin is heated to 50 ℃, then WL-700B epoxy resin is added in the WL-700A epoxy resin of heating and stirs; Described light scattering agent adopts DF-090 epoxy resin, and its average particulate diameter is 0.5～1.5um; Described step 2) mold box in is made emulator probe shape.
The invention has the beneficial effects as follows, the light scattering medium of comprehensive different-thickness and different proportionings is near infrared band (the absorption characteristic test experiments result of light of 600nm～1000nm), and the basic absorbance parameter of the different parts biological tissue measured simultaneously of reference, emulation light-scattering material provided by the present invention and preparation method, can make the back scattering medium of same thickness reach the basic absorbance at different biological tissues position by control bulky grain light scattering agent doping, and have the scattering properties and the preceding tropism's characteristics of scattering of biological tissue concurrently.Thereby in pulse blood oxygen simulator, (600nm～1000nm) base fixed of incident illumination is decayed and is organized emulation scattering dual purpose near infrared band can to utilize composite scattering medium of the present invention to reach biological tissue, the more approaching light that evenly is scattered behind the biological tissue that sees through of the emergent light of emulator, the duty that makes detected pulse blood oxygen instrument is farthest near biological tissue actual measurement state.
Description of drawings
Fig. 1 organizes the emulator structural representation for pulse blood oxygen.
The specific embodiment
The present invention is described in further detail below in conjunction with drawings and Examples:
Fig. 1 is the pulse blood oxygen simulator structural representation.This emulator comprises that front end has the photosensitive detector 2 of preceding scattering medium film 4, the photomodulator 1 that is connected with the photosensitive detector 2 output signals of telecommunication, the signal of telecommunication output of photomodulator 1 connects luminescent device 3, and the light that luminescent device 3 sends sees through back scattering medium film 5 and evenly scatters out.
The operation principle of above-mentioned pulse blood oxygen simulator is, from the two light pulse Lighg In that calibrated the pulse blood oxygen instrument light emitting diode, after tentatively scattering by preceding scattering medium 4, received by photosensitive detector 2, be converted to the signal of telecommunication and import photomodulator 1, carry out a certain amount of direct current decay by photomodulator 1, it is the direct current modulation, and then exchange pulsation modulation, and with two light pulse light beams through direct current decay and pulse 3 emission process direct current decay of synthetic pair of electric pulse driven for emitting lights device and ac modulation, at last, this pair light pulse light beam warp is the emergent light Light Out of ABSORPTION AND SCATTERING for evenly scattering of scattering medium 5 later, and final arrival calibrated the pulse blood oxygen instrument photoreceiver.
The present invention is used for the light scattering medium of Fig. 1 pulse blood oxygen simulator, scattering medium 4 and back scattering medium 5 before comprising.Preceding scattering medium 4 is an optical filling glue medium sheet, it does not participate in organizing emulation, main effect is that the incident illumination Light In from pulse blood oxygen instrument is done certain scattering, it is evenly scattered, can make photomodulator 1 front end photosensitive detector 2 and more flexible in the pulse blood oxygen simulator like this by the relative position of demarcation blood oxygen instrument light emitting diode; The thickness of preceding scattering medium 4 is 1.5mm, and it consists of example 1, by volume percentage ratio: WL-700A and WL-700B epoxy resin 98%, and light scattering agent DF-090 epoxy resin is 2%; Its colloidal particle diameter average out to 1um.
Back scattering medium 5 is an optical filling glue medium sheet, and the amount of its thickness, doping 1um bulky grain light scattering agent can be regulated.Control the basic absorbance that scattering medium that its doping ratio can make same thickness reaches different biological tissues position.In the emulator of Fig. 1, back scattering medium 5 can play the decay of light intensity base fixed and organize emulation scattering dual function, make the more approaching light that sees through biological tissue of emergent light Light Out that sees through back scattering medium 5 by luminescent device 3 transmission, the duty that makes detected pulse blood oxygen instrument is farthest near biological tissue actual measurement state.
The composition of back scattering medium 5: example 2, by volume percentage ratio: WL-700A and WL-700B epoxy resin 96%, light scattering agent 4%, this composition can be simulated the light scattering characteristic and the basic absorbance of human body ear-lobe portion.Example 3, by volume percentage ratio: WL-700A and WL-700B epoxy resin 94.5%, light scattering agent 5.5%, this composition can be simulated the light scattering characteristic and the basic absorbance of human finger end.Example 4, by volume percentage ratio: WL-700A and WL-700B epoxy resin 93.5%, light scattering agent 6.5%, this composition can be simulated the light scattering characteristic and the basic absorbance of the thicker tissue site of human body (as palm part between finger).The light scattering agent that adds in the example 2～4 is a DF-090 epoxy resin, and its colloidal solid average diameter is 1um, thickness 2mm.
The above-mentioned preparation method that is used for the light scattering medium of pulse blood oxygen simulator comprises following operation:
1) percentage ratio is by volume measured optical filling epoxy resin 93.5～98%, light scattering agent 2～6.5%, and wherein optical filling used for epoxy resin WL-700A epoxy resin and WL-700B epoxy resin are measured by 1: 1～1.1 volume ratio, and concrete proportioning is listed in table 1.WL-700A epoxy resin with example 1～example 4 is heated to 50 ℃ earlier, again WL-700B epoxy resin is added in the WL-700A epoxy resin of heating and stirred 10 minutes, be that 1um light scattering agent DF-090 epoxy resin joins in above two kinds of mixed optical filling epoxy resin and to stir 10 minutes then with average particulate diameter, obtain four kinds of different colloid mixtures of forming.
2) above-mentioned colloid mixture is poured into respectively in the mold box of polishing, cast thickness is referring to table 1; Mold box is the aluminum or the stainless steel box of the shape (as finger-shaped) of ready-made emulator probe 6.
3) will pour into a mould good colloid mixture and put into baking oven together with mold box, four kinds of colloid mixtures promptly make light scattering medium respectively 60 ℃, 80 ℃, 80 ℃, 80 ℃ curing taking-ups after 8 hours down after the demoulding; Example 1 is as preceding scattering medium 4, and example 2～4 is as back scattering medium 5.
4) at last solidified light scattering medium is bonded on the difform emulator probe 6.
Table 1
| Form (ml) | WL-700A epoxy resin | WL-700B epoxy resin | DF-090 epoxy resin | Cast thickness (mm) |
| Example 1 | 49 | 49 | 2 | 1.5 |
| Example 2 | 48 | 48 | 4 | 2 |
| Example 3 | 45 | 49.5 | 5.5 | 2 |
| Example 4 | 45 | 48.5 | 6.5 | 2 |
Because the dual-beam wavelength combinations that different pulse blood oxygen instrument adopted is not quite similar, the present invention selects the HONGGUANG of comparatively typical 640nm and the near infrared light of 960nm, test palm basis extinction characteristic between the ear-lobe, finger end, finger of the basic extinction characteristic of scattering medium 5 after the emulation of above example 2～4 and tissue, table 2 is listed in the test result contrast.T (RD), T (IR) represent the transmission coefficient of 640nm HONGGUANG and 960nm near infrared light respectively, promptly see through the light intensity of decay body (tissue or light scattering medium) and the ratio of light source light intensity.
Table 2
In order to reach ideal bionical scattering properties, the present invention also selects to pour into a mould the thickness difference, light scattering medium example 5～8 that the light scattering agent doping is different is tested, and test result is listed in table 3.T (RD), T (IR) represent the transmission coefficient of 640nm HONGGUANG and 960nm near infrared light respectively, promptly see through the light intensity of decay body (tissue or light scattering medium) and the ratio of light source light intensity.The preparation method of light scattering medium example 5～8 is with example 1～4.
Table 3
The average particulate diameter of adulterated light scattering agent DF-090 epoxy resin colloid in the table 3, embodiment 5 and embodiment 7 are 1.5 μ m; Embodiment 6 and embodiment 8 are 0.5 μ m.
Because pulse blood oxygen instrument is when measuring the biological tissue blood oxygen saturation, its emergent light receiving terminal can only detect the intensity through tissue decay back light pulse, causes attenuation factor and can't distinguish.So the present invention is at the attenuation of design photomodulator 1 pair of light pulse and composite scattering medium during to the attenuation of light pulse, but combination in any also, and as long as both resultant effects, promptly emergent light intensity is similar to from the light intensity of biological tissue outgoing and gets final product.In other words, adopt the composite scattering medium of different-thickness and the live body emulation that same photomodulator 1 modulation parameter can realize different parts biological tissue pulse blood oxygen transmission characteristic.
Application example one: carry out timing signal at desk-top and two kinds of transmission pulse blood of finger cot type oxygen instrument, use to applicant's development
INSTRUMENTS, the INDEX H type pulse blood oxygen simulator that INC. produces the phenomenon of overdriving occurs through regular meeting; And use the improved emulator of light scattering medium of the present invention to carry out timing signal, select the back scattering medium 5 of thickness 2mm for use, calibrating in these two kinds of transmission pulse blood oxygen instrument processes does not have the phenomenon of overdriving and occurs, and two kinds of transmission pulse blood oxygen instrument duties and human body actual measurement state are approaching.
Application example two: use the improved pulse blood oxygen simulator of light scattering medium of the present invention that the N100 type pulse blood oxygen instrument that Nellcor company produces is demarcated.Select for use thickness to be respectively scattering medium 5 behind 2mm and 1.5mm 2 kinds, all can normally demarcate this model pulse blood oxygen instrument.
Claims (6)
1. a light scattering medium that is used for pulse blood oxygen simulator is characterized in that, by volume percentage ratio is made of following component: optical filling epoxy resin 91.5～98%, light scattering agent 2～8.5%; Wherein optical filling epoxy resin is that WL-700A epoxy resin mixes composition with WL-700B epoxy resin; Light scattering agent is a DF-090 epoxy resin.
2. the light scattering medium that is used for pulse blood oxygen simulator according to claim 1 is characterized in that, described WL-700A epoxy resin and WL-700B epoxy resin are formed by 1: 1～1.1 volume ratio.
3. the light scattering medium that is used for pulse blood oxygen simulator according to claim 1 is characterized in that, the average particulate diameter of described light scattering agent is 0.5～1.5um.
4. a preparation method that is used for the light scattering medium of pulse blood oxygen simulator is characterized in that, comprises the steps:
1) percentage ratio is by volume measured optical filling epoxy resin 91.5～98% with measuring cup, and light scattering agent 2～8.5% adds light scattering agent in the optical filling epoxy resin and to stir;
2) said mixture is poured in the mold box of polishing, cast thickness is 1～2mm;
3) will pour into a mould good mixture and put into baking oven together with mold box, 60～80 ℃ solidify taking-up after 8 hours down, promptly make light scattering medium after the demoulding;
4) at last solidified light scattering medium is bonded on the emulator probe (6).
5. the preparation method that is used for the light scattering medium of pulse blood oxygen simulator according to claim 4, it is characterized in that, optical filling used for epoxy resin WL-700A epoxy resin and WL-700B epoxy resin are measured by 1: 1～1.1 volume ratio in the described step 1), earlier WL-700A epoxy resin is heated to 50 ℃, then WL-700B epoxy resin is added in the WL-700A epoxy resin of heating and stirs; Described light scattering agent adopts DF-090 epoxy resin, and its average particulate diameter is 0.5～1.5um.
6. the preparation method that is used for the light scattering medium of pulse blood oxygen simulator according to claim 4 is characterized in that, described step 2) in mold box make the shape of emulator probe (6).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11457846B2 (en) | 2019-10-31 | 2022-10-04 | Belun Technology (Ip) Company Limited | Tester for an optical measuring device |
| US11478154B2 (en) | 2017-09-25 | 2022-10-25 | Belun Technology (Ip) Company Limited | Testing device for non-invasive physiological information detecting device and method thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103271745B (en) * | 2013-06-07 | 2015-05-20 | 康泰医学系统（秦皇岛）股份有限公司 | Pulse blood oxygen simulation system and implementation method |
| US9468403B2 (en) * | 2014-01-15 | 2016-10-18 | Hong Kong Applied Science and Technology Research Institute Company Limited | Single-body unit for pulse oximeter calibration |
| CN111493889A (en) * | 2020-05-19 | 2020-08-07 | 重庆市计量质量检测研究院 | Detection simulation device for blood oxygen saturation monitor |
| CN111956235B (en) * | 2020-08-25 | 2022-06-07 | 西安交通大学 | Calibration method of reflection type blood oxygen probe or measuring device |
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