CN100382860C - Magnetic thermal synergetic electric aid transdermal medicine administration device - Google Patents
Magnetic thermal synergetic electric aid transdermal medicine administration device Download PDFInfo
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- CN100382860C CN100382860C CNB2005100940291A CN200510094029A CN100382860C CN 100382860 C CN100382860 C CN 100382860C CN B2005100940291 A CNB2005100940291 A CN B2005100940291A CN 200510094029 A CN200510094029 A CN 200510094029A CN 100382860 C CN100382860 C CN 100382860C
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Abstract
The present invention discloses a magnetically heating synergetic electric assisted transdermal administration device used for administration from dermal surfaces, which relates to transdermal administration technology in biomedical engineering. The present invention is composed of a back surface protection casing (1), an attaching layer (2), a magnetic gelatin substrate medicine house (3), an electrode (4) and plane coils (5), wherein the electrode (4) is arranged on the upper part in the back surface protection casing (1), the attaching layer (2) is arranged on the lower part in the back surface protection casing (1), the plane coils (5) are arranged on the attaching layer (2), and an inner space formed by the back surface protection casing (1) and the attaching layer (2) is the magnetic gelatin substrate medicine house (3); the present invention has one or a plurality of plane coils (5), the plane coils (5) are respectively connected with a medium-high-frequency magnetic field generation circuit outside the plane coils (5), the number of turns of each plane coil is 3 to 30, and the external diameter of each plane coil is 30 to 60 millimeters. The additional alternating magnetic field is combined with the magnetic hydrogel to increase the transdermal degree of the medicine.
Description
Technical field
The present invention is a kind of being used for from the device of skin surface administration, relates to the transdermal administration technology in the biomedical engineering.
Background technology
Transdermal administration safety is controlled, is the new way of noinvasive administration, broad market prospect.Because the barrier action of skin makes most drug.Even the medicine that dosage is low, curative effect is high, transdermal penetration speed also are difficult to satisfy the treatment needs.Therefore overcome the skin barrier effect, promotion medicine transdermal penetration within a certain period of time reaches therapeutic dose, is one of key issue of many drug transdermal drug-supplying systems researchs.
Existing transdermal drug is limited to the micromolecule low concentration, stratum corneum barrier make most drug be difficult to by or be difficult to reach valid density and effective speed.The key of transdermal administration is to promote drug osmotic, makes the medicine Transdermal absorption advance blood capillary.Main means have: use chemical penetrating agent, medicine is carried out chemical modification make prodrug, use physical method and pharmaceutical carrier is increased medicine to see through skin.The principle of these methods roughly is divided into three kinds: change the horny layer structure, the external force drives medication is modified medicine or wrap up.The catalogue that these technology or device use be to increase percutaneous medicine transit dose, regulate percutaneous rate and enlarge the medicine scope, and do not cause the stimulation etc. of skin.
Electric aid transdermal medicine administration is an important class in the physical method drives medication transdermal technology, comprises iontophoresis, electroporation and electret (electrostatic field) method etc.Wherein, iontophoresis is that a kind of very strong transdermal that grows up so far promotes means, and it utilizes electric current that ion medicine is imported skin appendages via positioning of electrode.When two electrodes and contact skin, the electron stream of power supply arrives drug depot and is transformed into medicine ion stream, and ion flow returns skin and enters return-flow system by skin.The drug delivery amount depends on current intensity, persistent period and electrode area with proportional by electric charge.Can the program administration by the control electric current, for example control medicine-feeding rate, control administration and drug withdrawal are selected continuously or pulsatile administration etc.The factor that influences iontophoresis has medicine, electric current and pH.U.S. FDA has been ratified lignocaine (Lidocaine) iontophoretic injection type releasing medicine through skin penetration system (the LidoSite Topical System) listing of Vyteris company, and it is (several minutes to a few days) control drug release within the predetermined time.Also there is the research will be with the bin of ion-exchange fibre ion-exchange fiber as ion medicine, the coupled ion introductory technique, the result shows the release that can control and promote medicine.
Electric aid transdermal medicine administration is because polarization or need reason such as high electric field also exists certain space of improving at aspects such as increasing medicine transit dose and control transmission rates.Because the continuous progress of new material technology and Micrometer-Nanometer Processing Technology recently for we bring the very big possibility that can be correlated with and improve, can be that the transdermal administration development of technology is injected new content thus.
Summary of the invention
Technical problem: the purpose of this invention is to provide a kind of magnetic thermal synergetic electric aid transdermal medicine administration device, this administrator adopts planar coil partly to form the zone that a temperature improves in conjunction with magnetic gel substrate at Drug Storage, in conjunction with electric aid transdermal medicine administration, the amount that medicine sees through can be strengthened, and the adjusting of medicine transmission rates can be reached in conjunction with the adjusting of coil intermediate magnetic field intensity, the adjusting of frequency etc.
Technical scheme: magnetic thermal synergetic electric aid transdermal medicine administration device of the present invention is made up of back-protective shell, adhered layer, magnetic gel substrate Drug Storage, electrode, planar coil; Top in the protecting sheathing is provided with electrode overleaf, and the bottom in the protecting sheathing is provided with adhered layer overleaf, is provided with planar coil on adhered layer, and the inner space that back-protective shell and adhered layer are formed is a magnetic gel substrate Drug Storage.
Planar coil has one or more, joins with the medium-high frequency magnetic generation circuit of outside respectively, and this coil turn is the 3-30 circle, and the outer warp of coil is the 30-60 millimeter.Magnetic gel in the magnetic gel substrate Drug Storage is made of macromolecular material mixing nano magnetic material, perhaps adopts high polymer monomer to obtain in conjunction with the magnetic Nano material post polymerization.Magnetic Nano material comprises nano magnetic ferrite body, nanometer nickel, nanometer cobalt, nano-iron material; Macromolecular material comprises PNIPAM, polyacrylamide aquogel polymer, Polyethylene Glycol, glycan substrate.
Main contents are included on the basis of electric field driven iontophoresis medicine, original hydrogel Drug Storage is changed into (super paramagnetic) magnetic gel Drug Storage, arranging one or more groups planar coil near adhered layer place (near the skin place), the external medium-high frequency magnetic generation circuit of this planar coil, can be by this device according under the alternating magnetic field in Drug Storage, the principle of super paramagnetic gel heating forms a hot-zone (Drug Storage), can be according to concrete pharmaceutical properties and transdermal requirement, magnetic field intensity, frequency are set and in conjunction with character such as magnetic gels, the temperature that control raises.In conjunction with the alternating magnetic field in temperature rising and close percutaneous drug delivery zone, can reach and improve transdermal administration amount, reduction administration time, and the purpose of further controlling medicine-feeding rate.This device is applicable to ionic drug, example hydrochloric acid lignocaine, Propranolol, verapamil, brinase, insulin, heparin etc.
Planar coil partly comprises: gold, silver, copper and outside coat the coil of nickel, cobalt metal wire, and single group coil number of turn 3-30 outward through the 30-60 millimeter, can adopt 3～4 groups of planar coils.
The magnetic hydrogel can comprise macromolecular material mixing nano-magnetic (superparamagnetism) material or adopt high polymer monomer combining nano magnetic material post polymerization to obtain.Magnetic Nano material comprises materials such as magnetic ferrites (ferroso-ferric oxide, iron sesquioxide), nanometer nickel, cobalt, ferrum; Macromolecular material comprises carbopol, sodium alginate, PNIPAM polyacrylamides such as (PIPAAm) aquogel polymer, Polyethylene Glycol, glycan substrate etc.
Temperature controlled alternating magnetic field parameter area in the coil: planar coil center field intensity:: more than the tens millioersted magnitudes; Frequency 200-800kHz.(1KA/m＝12.56Oe)。
Beneficial effect:
By can further strengthening the transdermal amount of medicine in conjunction with adding alternating magnetic field and magnetic hydrogel;
The ratio of controlling magnetic field exciting circuit parameter and magnetic material, macromolecular material and dependency structure, may reach sustained release or control percutaneous rate purpose.
Description of drawings
Fig. 1 is the structured flowchart of the hot administration parts of mangneto.
Fig. 2 is a magnetic thermal synergetic electric aid transdermal medicine administration device spare structural representation
Fig. 3 is the structured flowchart of controller part.
Fig. 4 is external magnetic field excitation circuit block diagram.
The specific embodiment
Magnetic thermal synergetic electric aid transdermal medicine administration device of the present invention is made up of back-protective shell 1, adhered layer 2, magnetic gel substrate Drug Storage 3, electrode 4, planar coil 5; Top in the protecting sheathing 1 is provided with electrode 4 overleaf, and the bottom in the protecting sheathing 1 is provided with adhered layer 2 overleaf, is provided with planar coil 5 on adhered layer 2, and back-protective shell 1 is a magnetic gel substrate Drug Storage 3 with the inner space that adhered layer 2 is formed.With benefit caine drug transdermal is example,
1. controller part: be made up of come off testing circuit, warning circuit, power supply etc. of microprocessor, light-emitting diode display, electrode, system possesses following function:
1. determine to import the composition of medicine by button, medicine lead-in mode (iontophoresis will be selected automatically according to drug type by system, electroporation+iontophoresis), current waveform and operating frequency, as: for lignocaine, system will determine that working method is that frequency is the pulse direct current about 10Hz;
2. determine the intensity of working time and output signal by button;
3. parameter is determined to finish, and system detects the body surface impedance automatically and regulates automatically;
4. the soft start program is opened by system, and promptly the intensity of output signal progressively becomes big by little, so that human body has a procedure of adaptation;
5. system is according to the regularly administration of giving parameter
The automatic control of 6. administration process
7. administration real-time process monitoring, bad or when obscission was arranged, system was with break-off (being electrode place no-output) and preserve current data automatically, starts warning system simultaneously when generating electrodes and contact skin.When detect electrode and contact skin good after, system will proceed work according to selected scheme according to the data of being preserved.
8. be administered systemically and close automatically and voice suggestion when finishing
The magnetic gel part:
Magnetic gel in the magnetic gel substrate Drug Storage 3 is made of macromolecular material mixing nano magnetic material, perhaps adopts high polymer monomer to obtain in conjunction with the magnetic Nano material post polymerization.Magnetic Nano material comprises nano magnetic ferrite body, nanometer nickel, nanometer cobalt, nano-iron material; Macromolecular material comprises PNIPAM, polyacrylamide aquogel polymer, Polyethylene Glycol, glycan substrate.
Adopt coprecipitation method commonly used to prepare the ferric oxide nano particles of superparamagnetism, product by magnetic separating, washing 4 times after, be diluted with water to the water base Fe of 3g/l
3O
4Magnetic liquid is regulated pH=3 with hydrochloric acid then, adds glutamic acid by 5% of total ferrum amount and carry out finishing under stirring condition, stir 4h after, magnetic separating, washing 4 times is diluted with water to the water base Fe of 20g/l steady concentration at last
3O
4/ Glu magnetic liquid.
Select medical carbopol 2940 or sodium alginate as the polymer matrix that forms gel.In 2% carbopol, 2940 swelling solution 50ml, add 50ml Fe
3O
4/ Glu magnetic liquid, or in 4% sodium alginate 50ml solution, add 50ml Fe
3O
4/ Glu magnetic liquid, adjusting pH is 6-7, forms the high-molecular gel that comprises ferric oxide nano particles, i.e. magnetic gel by transpiring moisture or adding electrolyte then.
Produce alternating magnetic field part in the Drug Storage in conjunction with planar coil:
Planar coil can adopt general microfabrication to prepare the mode of plane component, and planar coil 5 has one or more, joins with the medium-high frequency magnetic generation circuit of outside respectively, and this coil turn is the 3-30 circle, and the outer warp of coil is the 30-60 millimeter.Directly be made in the adhered layer back side, perhaps on silicon, resin substrate, finish, treat behind the substrate attenuate docile and obedient in the adhered layer back side.Coil lead is drawn through back-protective shell (plastics) by coil holder again and is connected in external magnetic field excitation circuit.
The major parameter of this external magnetic field excitation circuit is: as being defined as 5 amperes on the working current value, during operate as normal, according to the change of frequency, the variation of working current value is bigger, generally between 0.3～5A.Operating frequency can be selected according to designing requirement in segmentation, and scope is 200k～850kHz.Temperature controlled alternating magnetic field parameter area in the coil: planar coil center field intensity: more than the millioersted magnitude; Frequency 200-800kHz.
Claims (3)
1. a magnetic thermal synergetic electric aid transdermal medicine administration device is characterized in that this administrator is made up of back-protective shell (1), adhered layer (2), magnetic gel substrate Drug Storage (3), electrode (4), planar coil (5); Top in the protecting sheathing (1) is provided with electrode (4) overleaf, bottom in the protecting sheathing (1) is provided with adhered layer (2) overleaf, be provided with planar coil (5) on adhered layer (2), back-protective shell (1) is a magnetic gel substrate Drug Storage (3) with the inner space that adhered layer (2) is formed; Planar coil (5) has one or more, joins with the medium-high frequency magnetic generation circuit of outside respectively, and this coil turn is the 3-30 circle, and the outer warp of coil is the 30-60 millimeter.
2. magnetic thermal synergetic electric aid transdermal medicine administration device according to claim 1, it is characterized in that the magnetic gel in the magnetic gel substrate Drug Storage (3) is made of macromolecular material mixing nano magnetic material, perhaps adopts high polymer monomer to obtain in conjunction with the magnetic Nano material post polymerization.
3. magnetic thermal synergetic electric aid transdermal medicine administration device according to claim 2 is characterized in that magnetic Nano material comprises nano magnetic ferrite body, nanometer nickel, nanometer cobalt, nano-iron material; Macromolecular material comprises PNIPAM, polyacrylamide aquogel polymer, Polyethylene Glycol, glycan substrate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100940291A CN100382860C (en) | 2005-08-26 | 2005-08-26 | Magnetic thermal synergetic electric aid transdermal medicine administration device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100940291A CN100382860C (en) | 2005-08-26 | 2005-08-26 | Magnetic thermal synergetic electric aid transdermal medicine administration device |
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| CN1748809A CN1748809A (en) | 2006-03-22 |
| CN100382860C true CN100382860C (en) | 2008-04-23 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110229271B (en) * | 2019-06-19 | 2021-06-29 | 哈尔滨工业大学（深圳） | Preparation and application of micro magnetic rod-shaped gel for measuring viscosity of trace liquid |
| CN110314275B (en) * | 2019-07-09 | 2020-04-17 | 清华大学 | Degradable flexible medicine controlled release device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4233965A (en) * | 1978-01-16 | 1980-11-18 | Cas Products, Inc. | Method and apparatus for the therapeutic treatment of living tissue |
| CN1037833A (en) * | 1989-06-06 | 1989-12-13 | 徐州重型机械厂 | Medicine-stick therapeutic appliance and cooperating medicinal liquor |
| CN2221425Y (en) * | 1994-12-24 | 1996-03-06 | 翁春晓 | Percutaneous film with electrode |
| CN1171278A (en) * | 1996-06-20 | 1998-01-28 | 久光制药株式会社 | Device structure for iontophoresis |
| CN2345230Y (en) * | 1998-04-01 | 1999-10-27 | 赵建立 | External electrode of dose therapeutic instrument through skin |
| CN1234231A (en) * | 1998-04-30 | 1999-11-10 | 任光友 | Intensified magnetic medicinal plaster |
| US6597947B1 (en) * | 1999-04-13 | 2003-07-22 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis device |
-
2005
- 2005-08-26 CN CNB2005100940291A patent/CN100382860C/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4233965A (en) * | 1978-01-16 | 1980-11-18 | Cas Products, Inc. | Method and apparatus for the therapeutic treatment of living tissue |
| CN1037833A (en) * | 1989-06-06 | 1989-12-13 | 徐州重型机械厂 | Medicine-stick therapeutic appliance and cooperating medicinal liquor |
| CN2221425Y (en) * | 1994-12-24 | 1996-03-06 | 翁春晓 | Percutaneous film with electrode |
| CN1171278A (en) * | 1996-06-20 | 1998-01-28 | 久光制药株式会社 | Device structure for iontophoresis |
| CN2345230Y (en) * | 1998-04-01 | 1999-10-27 | 赵建立 | External electrode of dose therapeutic instrument through skin |
| CN1234231A (en) * | 1998-04-30 | 1999-11-10 | 任光友 | Intensified magnetic medicinal plaster |
| US6597947B1 (en) * | 1999-04-13 | 2003-07-22 | Hisamitsu Pharmaceutical Co., Inc. | Iontophoresis device |
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Granted publication date: 20080423 Termination date: 20100826 |