CN100358573C

CN100358573C - Medicine composition for treating gastritis, and its prepn. method

Info

Publication number: CN100358573C
Application number: CNB2005100722850A
Authority: CN
Inventors: 张学军
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-05-27
Filing date: 2005-05-27
Publication date: 2008-01-02
Anticipated expiration: 2025-05-27
Also published as: CN1868529A

Abstract

The present invention discloses a medicine compound for treating gastritis, which is prepared from cuttlebone, dandelion, rhizoma coptidis from Sichuan of China, lily bulb, red sange root, combined spicebush root, orange fruit, nutgrass galingale rhizome, white peony alba, dried tangerine peel, tuber of hyacinth bletilla, corydalis tuber, notoginseng, amomun fruit, chicken's gizzard-membrane and liquorice. The compound of the present invention has the efficacy of soothing the liver, regulating the stomach, inhibiting sourness and relieving pain, and obvious treatment effect on gastritis, acute gastritis, chronic (superficial and atrophic) gastritis, dodecadactylitis, stomach ulcer, duodenal ulcer, etc.

Description

A kind of pharmaceutical composition for the treatment of gastritis and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of gastritis and preparation method thereof.

Background technology

Along with the development of society, people are subjected to the influence of food, water quality and bad life habits, and the gastric disease that causes various weights to differ is painful bitter, and with the quickening pace of modern life, the gastric disease slight illness is on the increase.In numerous commonly encountered diseases, the sickness rate of gastropathy is higher, and the rate of falling ill is also wider.The gastropathy reasons for seizure is many-sided, wherein mainly contain catch cold, damp and hot, stagnation, irregular eating, emotion is gloomy, health is weak etc.The medicine for the treatment of gastropathy clinically is varied, long powder for stomachache of age, weisen U, CHENXIANG road White Dew is arranged, recently bismuth aluminate compound, WENWEISHU, the happy sheet of YANGWEISHU or the like are also arranged, but because of people's individual variation bigger, cause the curative effect of these medicines unequal, as somebody's instant effect, the somebody takes effect slowly, somebody even invalid.Problems such as the medicine of in addition existing treatment stomachache still exists can not eradicate sufferer, controls table and does not control root, and side effect is big.

Summary of the invention

The object of the invention is to provide a kind of pharmaceutical composition that treatment gastritis is had remarkable result.

Another object of the present invention is to provide a kind of treatment gastritis preparation of drug combination method.

The present invention is achieved through the following technical solutions: choose crude drug

Os Sepiae 15-45 weight portion Herba Taraxaci 7-23 weight portion Rhizoma Coptidis 2-6 weight portion

Bulbus Lilii 15-45 weight portion Radix Salviae Miltiorrhizae 7-23 weight portion Radix Linderae 5-15 weight portion

Fructus Aurantii 5-15 weight portion Rhizoma Cyperi 6-18 weight portion Radix Paeoniae Alba 7-23 weight portion

Pericarpium Citri Reticulatae 3-9 weight portion Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 weight portion Rhizoma Corydalis 5-15 weight portion

Radix Notoginseng 1.5-4.5 weight portion Fructus Amomi 2.5-7.5 weight portion Endothelium Corneum Gigeriae Galli 5-15 weight portion

Radix Glycyrrhizae 1.5-4.5 weight portion

The optimum ratio of pharmaceutical composition of the present invention is: choose crude drug

Os Sepiae 30 weight portion Herba Taraxacis 15 weight portion Rhizoma Coptidis 4 weight portions

The Bulbus Lilii 30 weight portion Radix Salviae Miltiorrhizae 15 weight portion Radixs Linderae 10 weight portions

The Fructus Aurantii 10 weight portion Rhizoma Cyperis 12 weight portion Radix Paeoniae Albas 15 weight portions

The Pericarpium Citri Reticulatae 6 weight portion Pseudobulbus Bletillae (Rhizoma Bletillae)s 10 weight portion Rhizoma Corydalis 10 weight portions

Radix Notoginseng 3 weight portion Fructus Amomis 5 weight portion Endothelium Corneum Gigeriae Galli 10 weight portions

Radix Glycyrrhizae 3 weight portions

Described Os Sepiae is for forging Os Sepiae; The described Radix Linderae is for frying the Radix Linderae; Described Rhizoma Cyperi is a vinegar system; The described Radix Paeoniae Alba is a Radix Paeoniae Alba (parched); Described Endothelium Corneum Gigeriae Galli parching to brown; Described Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.

Preparation of drug combination method of the present invention is that Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae are used cold water soak 20-40 minute; Head fries in shallow oil: Os Sepiae is put into 200-400 bulking value part water be fried boiling with high heat back 8-12 at a simmer minute, Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae after will soaking again put into and is fried boiling hereinafter decocting 10-20 minute with high heat, put into Fructus Amomi and be fried boiling with high heat back 3-7 at a simmer minute, medicinal liquid is leached standby; Two fry in shallow oil: the medicinal residues after head is fried in shallow oil are put into 200-400 bulking value part water and were fried boiling with high heat back 15-25 at a simmer minute, medicinal liquid are leached standby; Three fry in shallow oil: the medicinal residues after frying in shallow oil two are put into 100-300 bulking value part water and were fried boiling with high heat back 10 minutes at a simmer, medicinal liquid are leached standby; Three medicinal liquids are mixed according to a conventional method, filter, precipitate, handle and make oral liquid.

The conventional adjuvant that pharmaceutical composition of the present invention adds is pharmaceutically made clinical acceptable forms, as in tablet, suppository, capsule, granule, spray, ointment, emplastrum or the ointment any.

Pharmaceutical composition of the present invention has the effect of dispersing the stagnated liver-QI for regulating the stomach, relieving gastric hyperacidity to alleviate stomachache, treatment gastritis, acute gastritis, chronic (shallow, atrophic) gastritis, duodenal bulbar inflammation, gastroduodenal ulcer are belonged to hold concurrently syndrome of blood stasis, disease of stagnation of liver-QI and stomach-QI see that the scorching hot distension pain of gastral cavilty portion, belch singultus, noisy pantothenic acid, inappetence etc. are evident in efficacy.

Following experimental example is used to further specify the present invention:

The present invention's " Weisukang oral liquid " has treated chronic gastritis 280 examples since in March, 2000, evident in efficacy, sight is reported as follows:

1, clinical data

280 routine patients all make a definite diagnosis through hospital gastroscope above county level.Chronic superficial gastritis 198 examples wherein, chronic atrophic gastritis 32 examples, bile reflux gastritis 50 examples; Man's 148 examples, women 132 examples; Age reckling 21 years old, the maximum 92 years old, 56 years old mean age; The shortest course of disease 1 year, the longest 25 years.

2, Therapeutic Method

The present invention's " Weisukang oral liquid " prescription consists of: forge Os Sepiae 30g, Herba Taraxaci 15g, Rhizoma Coptidis 4g, Bulbus Lilii 30g, Radix Salviae Miltiorrhizae 15g fries Radix Linderae 10g, Fructus Aurantii 10g, Rhizoma Cyperi 12g (vinegar system), Radix Paeoniae Alba (parched) 15g, Pericarpium Citri Reticulatae 6g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Rhizoma Corydalis 10g, Radix Notoginseng 3g, Fructus Amomi 5g, Endothelium Corneum Gigeriae Galli 10g (parching to brown), Radix Glycyrrhizae Preparata 3g.

Preparation method:

Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae are used cold water soak 30 minutes; Head fries in shallow oil: Os Sepiae is put into 300ml water be fried boiling with high heat back 10 minutes at a simmer, Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae after will soaking again put into the decocting 15 minutes of being fried boiling with high heat hereinafter, put into Fructus Amomi and be fried boiling with high heat back 5 minutes at a simmer, medicinal liquid is leached standby; Two fry in shallow oil: the medicinal residues after head is fried in shallow oil are put into 300ml water and were fried boiling with high heat back 20 minutes at a simmer, medicinal liquid are leached standby; Three fry in shallow oil: the medicinal residues after frying in shallow oil two are put into 200ml water and were fried boiling with high heat back 10 minutes at a simmer, medicinal liquid are leached standby; Three medicinal liquids are mixed, filter, precipitate, handle promptly getting the 500ml medicinal liquid according to a conventional method, oral liquid is made in bottling.

Specification: 500ml/ bottle.

Instructions of taking: each (medicine) being taken before meal 100ml, every day three times.7 days is a course of treatment.

3, efficacy evaluation

Recovery from illness: clinical symptoms all disappears, and drug withdrawal year gastroscope check later six months to one does not see that any pathologic changes:

Produce effects: clinical symptoms all disappears, and gastroscope check pathological change is tending towards curing after drug withdrawal half a year;

Invalid: though clinical symptoms has improvement, gastroscope shows that pathological change does not have and is clearly better.

4, therapeutic effect

In above-mentioned standard 280 routine patients, 254 examples of fully recovering (cure rate 90.9%), produce effects 14 examples (obvious effective rate 5%), 6 examples that take a turn for the better (improvement rate 2.1%), total effective rate 98%.

5, case introduction

Case 1: Miao * *, man, 57 years old, peasant, Jing An people from town, Rudong County, Jiangsu Province.Once suffered from surplus the chronic gastritis history ten year, in JIUYUE in 2002 9 days to Rudong County second the People's Hospital's row gastroscope make a definite diagnosis " atrophy superficial gastritis " (gastroscope number: 2002044).At that time through how tame hospital integrative therapy, it is not imitated and shows, then seek medical advice to here in February, 2003, drink when being admitted to hospital into telling, gastral cavilty portion causalgia is unbearably: body is obviously become thin, and through the dialectical Weisukang oral liquid of the present invention that gives 2 courses of treatment, treats that it takes the back above-mentioned symptom and obviously alleviates, the clothes disease 4 courses of treatment that continues is accused recovery from illness, follows up a case by regular visits to and does not see recurrence so far.

Case 2: the king * *, man, 47 years old, national grass-roots cadre, Huai, Jiangsu Province Chu from state.Once suffered from chronic gastropathy 5 years, made a definite diagnosis " chronic superficial gastritis, pyloric canal inflammation, duodenitis " (gastroscope number: 10331) on January 10th, 2004 to Chu state institute of traditional Chinese medicine row gastroscope.Treated near the bimester state of an illness commentaries on classics of not getting better in Chu state institute of traditional Chinese medicine through Chinese and western drugs at that time, after being illustrated in April, 2004 to here, the people seeks Chinese traditional treatment, satisfy and dialectically give Weisukang oral liquid of the present invention 3 courses of treatment, take the back reflection according to the patient, take the more preceding obvious increase of gastral cavilty portion causalgia transference cure diet after 2 courses of treatment, after take 3 the course of treatment all diseases know flat, existing operate as normal.Follow up a case by regular visits to and do not see disease relapse so far.

Case 3: turn round and look at * *, woman, 29 years old, Rudong County, Jiangsu Province waterside zero people from town, textile worker.Once suffered from the chronic gastritis history 2 years.In on March 5th, 2004 to Rudong County the 3rd the People's Hospital's row gastroscope make a definite diagnosis: " bile reflux gastritis " (gastroscope number: 2004398).In this institute treatment 2 months, it was imitated and shows, and then seeks medical advice in May, 2004 to here at that time, satisfy according to conditions of patients give one the course of treatment Weisukang oral liquid of the present invention, it is susceptible shape if lose that clothes are finished, and continues 2 courses of treatment of clothes and heals diet work now such as ordinary person.

6, conclusion

Gastritis is how not smooth by feelings will, incoordination between the liver and stomach, and the catharsis dereliction of duty is due to the dampness hampering qi movement.Os Sepiae promoting tissue regeneration and ulcer healing in the side, relieving gastric hyperacidity to alleviate stomachache; Herba Taraxaci sweetness and bitterness and trembling with fear, heat-clearing and toxic substances removing is the key medicine of clearing stomach; The Rhizoma Coptidis hardship can be good for the stomach and fall; The product of Bulbus Lilii, the clear light flat benefit of Radix Salviae Miltiorrhizae, during QI invigorating is transferred, hemopoietic, nourishing stomach-YIN; Radix Linderae sending down the abnormal ascending QI promoting the circulation of QI to relieve pain; The Rhizoma Cyperi liver-smoothing, qi-regulating has effect preferably to the stomachache of the liver of incoordination between the liver and stomach; Fructus Aurantii, the Radix Paeoniae Alba is soothing the liver, easing the affected liver stomach function regulating, promoting the circulation of QI to relieve pain; The Pericarpium Citri Reticulatae stomach function regulating reduces phlegm; Rhizoma Corydalis is transferred battalion's pain relieving; Radix Notoginseng both can be stopped blooding, again can the promoting blood circulation to remove blood stasis analgesic therapy; Pseudobulbus Bletillae (Rhizoma Bletillae) convergence, the property of medicine is sticking wet, and it is rather good to stop blooding; Fructus Amomi be good for the stomach regulating QI to relieve pain, relieving dyspepsia long-pending, and can go into kidney, can be as the principal agent of kidney gastropathy; Endothelium Corneum Gigeriae Galli is sweet flat, and activating the spleen is good for the stomach, and has with dirty wonderful of dirty benefit; Non-his medicine can reach; The Radix Glycyrrhizae QI invigorating and in, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.We's 16 flavor medicines are long memorial liver stomach function regulating altogether, the effect of relieving gastric hyperacidity to alleviate stomachache, and it is evident in efficacy to be used for the clinical treatment chronic gastritis, is worth of widely use.

Following embodiment is used to further specify the present invention:

Embodiment 1

Forge Os Sepiae 30g Herba Taraxaci 15g Rhizoma Coptidis 4g Bulbus Lilii 30g

Radix Salviae Miltiorrhizae 15g fries Radix Linderae 10g Fructus Aurantii 10g Rhizoma Cyperi (vinegar system) 12g

Radix Paeoniae Alba (parched) 15g Pericarpium Citri Reticulatae 6g Pseudobulbus Bletillae (Rhizoma Bletillae) 10g Rhizoma Corydalis 10g

Radix Notoginseng 3g Fructus Amomi 5g Endothelium Corneum Gigeriae Galli (parching to brown) 10g Radix Glycyrrhizae Preparata 3g

Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae are used cold water soak 30 minutes; Head fries in shallow oil: Os Sepiae is put into 300ml water be fried boiling with high heat back 10 minutes at a simmer, Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae after will soaking again put into the decocting 15 minutes of being fried boiling with high heat hereinafter, put into Fructus Amomi and be fried boiling with high heat back 5 minutes at a simmer, medicinal liquid is leached standby; Two fry in shallow oil: the medicinal residues after head is fried in shallow oil are put into 300ml water and were fried boiling with high heat back 20 minutes at a simmer, medicinal liquid are leached standby; Three fry in shallow oil: the medicinal residues after frying in shallow oil two are put into 200ml water and were fried boiling with high heat back 10 minutes at a simmer, medicinal liquid are leached standby; Three medicinal liquids are mixed, filter, precipitate, handle promptly getting the 500ml medicinal liquid according to a conventional method, oral liquid is made in bottling.Every bottle of 500ml, each (medicine) being taken before meal 100ml, every day three times, 7 days is a course of treatment.

Embodiment 2

Os Sepiae 20kg Herba Taraxaci 20kg Rhizoma Coptidis 3kg Bulbus Lilii 40kg

Radix Salviae Miltiorrhizae 10kg Radix Linderae 12kg Fructus Aurantii 8kg Rhizoma Cyperi 15kg

Radix Paeoniae Alba 10kg Pericarpium Citri Reticulatae 8kg Pseudobulbus Bletillae (Rhizoma Bletillae) 8kg Rhizoma Corydalis 12kg

Radix Notoginseng 2kg Fructus Amomi 7kg Endothelium Corneum Gigeriae Galli 8kg Radix Glycyrrhizae 4kg

Said medicine technology is routinely made capsule.

Embodiment 3

Os Sepiae 40kg Herba Taraxaci 10kg Rhizoma Coptidis 5kg Bulbus Lilii 20kg

Radix Salviae Miltiorrhizae 22kg Radix Linderae 8kg Fructus Aurantii 12kg Rhizoma Cyperi 8kg

Radix Paeoniae Alba 20kg Pericarpium Citri Reticulatae 4kg Pseudobulbus Bletillae (Rhizoma Bletillae) 12kg Rhizoma Corydalis 8kg

Radix Notoginseng 4kg Fructus Amomi 3kg Endothelium Corneum Gigeriae Galli 12kg

Radix Glycyrrhizae 2kg

Said medicine technology is routinely made tablet.

Claims

1, a kind of pharmaceutical composition for the treatment of gastritis is characterized in that said composition is to be made by following crude drug:

Radix Glycyrrhizae 1.5-4.5 weight portion.

2, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:

Radix Glycyrrhizae 3 weight portions.

3, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:

Os Sepiae 20 weight portion Herba Taraxacis 20 weight portion Rhizoma Coptidis 3 weight portions

The Bulbus Lilii 40 weight portion Radix Salviae Miltiorrhizae 10 weight portion Radixs Linderae 12 weight portions

The Fructus Aurantii 8 weight portion Rhizoma Cyperis 15 weight portion Radix Paeoniae Albas 10 weight portions

The Pericarpium Citri Reticulatae 8 weight portion Pseudobulbus Bletillae (Rhizoma Bletillae)s 8 weight portion Rhizoma Corydalis 12 weight portions

Radix Notoginseng 2 weight portion Fructus Amomis 7 weight portion Endothelium Corneum Gigeriae Galli 8 weight portions

Radix Glycyrrhizae 4 weight portions.

4, pharmaceutical composition according to claim 1 is characterized in that said composition is to be made by following crude drug:

Os Sepiae 40 weight portion Herba Taraxacis 10 weight portion Rhizoma Coptidis 5 weight portions

The Bulbus Lilii 20 weight portion Radix Salviae Miltiorrhizae 22 weight portion Radixs Linderae 8 weight portions

The Fructus Aurantii 12 weight portion Rhizoma Cyperis 8 weight portion Radix Paeoniae Albas 20 weight portions

The Pericarpium Citri Reticulatae 4 weight portion Pseudobulbus Bletillae (Rhizoma Bletillae)s 12 weight portion Rhizoma Corydalis 8 weight portions

Radix Notoginseng 4 weight portion Fructus Amomis 3 weight portion Endothelium Corneum Gigeriae Galli 12 weight portions

Radix Glycyrrhizae 2 weight portions.

5,, it is characterized in that described Os Sepiae is for forging Os Sepiae according to claim 1,2,3 or 4 described pharmaceutical compositions; The described Radix Linderae is for frying the Radix Linderae; Described Rhizoma Cyperi is a vinegar system; The described Radix Paeoniae Alba is a Radix Paeoniae Alba (parched); Described Endothelium Corneum Gigeriae Galli parching to brown; Described Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.

6,, it is characterized in that the conventional adjuvant that said composition adds pharmaceutically makes tablet, suppository, capsule, granule, spray, ointment, emplastrum or ointment according to claim 1,2,3 or 4 described pharmaceutical compositions.

7, according to claim 1,2,3 or 4 described pharmaceutical compositions, it is characterized in that the preparation method of said composition is: Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae are used cold water soak 20-40 minute; Head fries in shallow oil: Os Sepiae is put into 200-400 bulking value part water be fried boiling with high heat back 8-12 at a simmer minute, Herba Taraxaci, Rhizoma Coptidis, Bulbus Lilii, Radix Salviae Miltiorrhizae, the Radix Linderae, Fructus Aurantii, Rhizoma Cyperi, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Corydalis, Radix Notoginseng, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae after will soaking again put into and is fried boiling hereinafter decocting 10-20 minute with high heat, put into Fructus Amomi and be fried boiling with high heat back 3-7 at a simmer minute, medicinal liquid is leached standby; Two fry in shallow oil: the medicinal residues after head is fried in shallow oil are put into 200-400 bulking value part water and were fried boiling with high heat back 15-25 at a simmer minute, medicinal liquid are leached standby; Three fry in shallow oil: the medicinal residues after frying in shallow oil two are put into 100-300 bulking value part water and were fried boiling with high heat back 10 minutes at a simmer, medicinal liquid are leached standby; Three medicinal liquids are mixed according to a conventional method, filter, precipitate, handle and make oral liquid.

8,, it is characterized in that the application of said composition in preparation treatment gastritis, acute gastritis, chronic gastritis, shallow, atrophic gastritis, duodenal bulbar inflammation or gastroduodenal ulcer medicine according to claim 1,2,3 or 4 described pharmaceutical compositions.

9, preparation of drug combination method according to claim 7 is characterized in that this preparation method is: