CN100357257C - Production process of 2-amino-methyl-1-propanol - Google Patents
Production process of 2-amino-methyl-1-propanol Download PDFInfo
- Publication number
- CN100357257C CN100357257C CNB2006100383964A CN200610038396A CN100357257C CN 100357257 C CN100357257 C CN 100357257C CN B2006100383964 A CNB2006100383964 A CN B2006100383964A CN 200610038396 A CN200610038396 A CN 200610038396A CN 100357257 C CN100357257 C CN 100357257C
- Authority
- CN
- China
- Prior art keywords
- reaction
- methyl
- propanol
- amino
- consumption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention discloses a method for producing 2-amino-2-methyl-1-propanol, which comprises the following steps: making sodium nitrite react with isopropanol and paraformaldehyde to obtain 2-nitryl-2-methyl-1-propanol crystals; then making the 2-nitryl-2-methyl-1-propanol crystals react with hydrogen to generate 2-amino-2-methyl-1-propanol. The present invention has the advantages of simple technology, easy operation and high product purity (more than 98%).
Description
Technical field:
The present invention relates to a kind of production method of 2-amino-2-methyl-1-propanol.
Background technology:
The production method of existing 2-amino-2-methyl-1-propanol adopts the reaction of 2-nitro-propanol and formaldehyde solution, generates 2-nitro-2-methyl isophthalic acid-propyl alcohol, carries out hydrogenation reaction again under the metallic nickel catalyzer, obtains product.The processing condition complexity, long reaction time, the cost height, the aftertreatment complexity, product purity is low.
Summary of the invention:
The object of the present invention is to provide a kind of technology simple, the production method of easy-operating 2-amino-2-methyl-1-propanol.
Technical solution of the present invention is:
(1) with Sodium Nitrite and Virahol, polyformaldehyde reaction, generate 2-nitro-2-methyl isophthalic acid-propyl alcohol, reaction formula is:
(2) with 2-nitro-2-methyl isophthalic acid-propyl alcohol and hydrogen reaction, generate 2-amino-2-methyl-1-propanol, reaction formula is:
The consumption of Paraformaldehyde 96 is 1～5 times of Virahol consumption in the step (1), and the consumption of Sodium Nitrite is 1～3 times of consumption of Paraformaldehyde 96.The temperature of reaction of step (1) is 0～25 ℃, and the reaction times is 4～14 hours.The temperature of reaction of step (2) is 35～55 ℃, and the reaction times is 3～8 hours, and pressure is 0.5～3Mpa.Step also adds catalyzer ruthenium/molecular sieve in (2).The amount of catalyzer is 3～8 ‰ of 2-nitro-2-methyl isophthalic acid-propyl alcohol amount.
Technology of the present invention is simple, and is easy to operate, and cost is low, and hydrogenation reaction pressure is low, product yield height.
The invention will be further described below in conjunction with embodiment.
Embodiment:
A kind of production method of 2-amino-2-methyl-1-propanol comprises the following steps:
(1) with Sodium Nitrite and Virahol, polyformaldehyde reaction, generate 2-nitro-2-methyl isophthalic acid-propyl alcohol, the consumption of Paraformaldehyde 96 is 1～5 times (1,3,5 times of example) of Virahol consumption, and the consumption of Sodium Nitrite is 1～3 times (1,2,3 times of example) of the consumption of Paraformaldehyde 96.Temperature of reaction is 0～25 ℃ (0 ℃, 15 ℃, 25 ℃ of examples), and the reaction times is 4～14 hours (example 4,10,14 hours).Reaction formula is:
Behind dichloromethane extraction, to neutral, boil off solvent with sodium carbonate solution, water washing, get 2-nitro-2-methyl isophthalic acid-propyl alcohol.
(2) with 2-nitro-2-methyl isophthalic acid-propyl alcohol and hydrogen reaction, there is catalyzer ruthenium/molecular sieve to exist and generates 2-amino-2-methyl-1-propanol down, temperature of reaction is 35～55 ℃ (35 ℃, 45 ℃, 55 ℃ of examples), reaction times is 3～8 hours (example 3,6,8 hours), and pressure is 0.5～3Mpa (routine 0.5Mpa, 2Mpa, 3Mpa).The amount of catalyzer is 3～8 ‰ (examples 3 ‰, 5 ‰, 8 ‰) of 2-nitro-2-methyl isophthalic acid-propyl alcohol amount.Reaction formula is:
Claims (1)
1, a kind of production method of 2-amino-2-methyl-1-propanol is characterized in that: comprise the following steps:
(1) with Sodium Nitrite and Virahol, polyformaldehyde reaction, generate 2-nitro-2-methyl isophthalic acid-propyl alcohol, reaction formula is:
(2) with 2-nitro-2-methyl isophthalic acid-propyl alcohol and hydrogen reaction, generate 2-amino-2-methyl-1-propanol, reaction formula is:
The consumption of Paraformaldehyde 96 is 1～5 times of Virahol consumption in the step (1), and the consumption of Sodium Nitrite is 1～3 times of consumption of Paraformaldehyde 96; The temperature of reaction of step (1) is 0～25 ℃, and the reaction times is 4～14 hours; The temperature of reaction of step (2) is 35～55 ℃, and the reaction times is 3～8 hours, and pressure is 0.5～3Mpa; Step also adds catalyzer ruthenium/molecular sieve in (2), and the amount of catalyzer is 3～8 ‰ of 2-nitro-2-methyl isophthalic acid-propyl alcohol amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100383964A CN100357257C (en) | 2006-02-15 | 2006-02-15 | Production process of 2-amino-methyl-1-propanol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100383964A CN100357257C (en) | 2006-02-15 | 2006-02-15 | Production process of 2-amino-methyl-1-propanol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1810767A CN1810767A (en) | 2006-08-02 |
| CN100357257C true CN100357257C (en) | 2007-12-26 |
Family
ID=36843908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100383964A Expired - Fee Related CN100357257C (en) | 2006-02-15 | 2006-02-15 | Production process of 2-amino-methyl-1-propanol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100357257C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106831451B (en) * | 2017-02-03 | 2018-09-21 | 荆楚理工学院 | A kind of synthetic method of 2- aminoisobutanols |
| CN107129435B (en) * | 2017-04-24 | 2019-07-23 | 万华化学集团股份有限公司 | A method of preparing 2-amino-2-methyl-1-propanol |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1188756A (en) * | 1997-01-20 | 1998-07-29 | 北京市营养源研究所 | Preparation method for 2-methyl-2-nitro-1-propanol crystal |
-
2006
- 2006-02-15 CN CNB2006100383964A patent/CN100357257C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1188756A (en) * | 1997-01-20 | 1998-07-29 | 北京市营养源研究所 | Preparation method for 2-methyl-2-nitro-1-propanol crystal |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1810767A (en) | 2006-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101225319B (en) | Method for preparing hydrocarbon fuel and methanol | |
| CN102286548B (en) | Method for preparing dihydric alcohol from lignocellulosic biomass | |
| CN104557801B (en) | Method for preparing gamma-valerolactone from furfural on metal/solid acid catalyst | |
| CN102617519B (en) | Method for using levulinic acid to prepare gamma-valerolactone by hydrogenation | |
| CN103113246A (en) | Production method of methyl cyclopentenolone via amination and step-by-step reaction | |
| CN102241566B (en) | Method for preparing diphenyl carbinol and derivatives thereof | |
| CN103721709B (en) | A kind of preparation method of producing cyclohexene with benzene selective hydrogenation catalyst | |
| CN100357257C (en) | Production process of 2-amino-methyl-1-propanol | |
| CN107537497A (en) | A kind of preparation method and application for being used to prepare the catalyst of adjacent methyl cyclohexanol | |
| CN112961046A (en) | Method for alkali-free synthesis of glycolic acid by using waste biomass | |
| CN102070693A (en) | Method for preparing ursodesoxycholic acid by chiral catalytic hydrogenation of 7-ketodesoxycholic acid | |
| CN101429129A (en) | Method for extracting admantadine | |
| CN101723984B (en) | Method for preparing carbonyltris(triphenylphosphine)rhodium(I) hydride in batch | |
| CN1915962A (en) | Method for preparing 1,4 - cyclohexanedicarboxylate | |
| CN110396072B (en) | Method for producing(s) -3-hydroxytetrahydrofuran | |
| CN101168520B (en) | Method for producing 1,1'-phenylsulfonyl-4,4'-diallyl (2) ether | |
| CN110483594B (en) | Method for synthesizing azithromycin | |
| CN109824629B (en) | Method for preparing 3-amino-5- (alpha-aminoethyl) tetrahydrofuran by using N-acetylglucosamine | |
| CN109053462B (en) | Preparation method of para-fluoroaniline | |
| CN1184183C (en) | Process for preparing 3-hydroxy propanal by hydrating acrolein | |
| CN101148430A (en) | Preparation method for 4-sulfonamidophenylhydrazine hydrochloride | |
| CN102173979A (en) | Method for preparing p-isopropylcyclohexanol through catalytic hydrogenation | |
| CN102952057A (en) | Preparation method of 4-isobutyl pyrrolidine-2-ketone | |
| CN110396093B (en) | Preparation method of guanine | |
| CN104961625A (en) | Method for synthesizing 1,2-propylene glycol using glucose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Nantong Haiers Pharmaceutical Co., Ltd. Assignor: Fu Aiqing Contract fulfillment period: 2009.6.20 to 2026.2.14 contract change Contract record no.: 2009320001584 Denomination of invention: Production process of 2-amino-methyl-1-propanol Granted publication date: 20071226 License type: Exclusive license Record date: 2009.8.21 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.6.20 TO 2026.2.14; CHANGE OF CONTRACT Name of requester: NANTONG HILES PHARMACEUTICAL CO., LTD. Effective date: 20090821 |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071226 Termination date: 20160215 |