CN100340605C - Thin-wall degradable tubular polymer material and its melting and injection molding process - Google Patents
Thin-wall degradable tubular polymer material and its melting and injection molding process Download PDFInfo
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- CN100340605C CN100340605C CNB031419658A CN03141965A CN100340605C CN 100340605 C CN100340605 C CN 100340605C CN B031419658 A CNB031419658 A CN B031419658A CN 03141965 A CN03141965 A CN 03141965A CN 100340605 C CN100340605 C CN 100340605C
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- degradable
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Abstract
The present invention relates to a degradable pipy polymer material with a small caliber and a thin wall and a preparation method thereof through low-pressure injection molding, which belong to the technical field of polymer materials and the field of biomedical engineering. The preparation method is convenient and practical, and pipy materials with different sizes can be prepared through injection molding at low pressure. The materials are degradable macromolecules with favorable biocompatibility, and the pipy material is suitable for the fields of blood vessel restoration, nerve restoration, etc.
Description
Technical field
The invention belongs to technical field of polymer materials and biomedical engineering technology field, be specifically related to a kind of small-bore thin-walled degradable tubular macromolecular material and low-pressure injection molding preparation method thereof.
Technical background
Tubular material is widely used in many fields such as chemical industry, pharmacy, biomedical engineering.In recent years, needs along with tissue repair such as blood vessel, nerves, demand to degradation material with good biocompatibility constantly increases, and the degradable high polymer material with certain geometrical shape is subjected to people's attention all the more, particularly requirement has been proposed small-bore thin-walled degradable tubular material, yet the preparation to small-bore thin-walled degradable tubular material at present still lacks effective, practical method.
The preparation of small-bore thin-walled degradable macromolecule tubular material mainly contains the problem that is faced with injections difficult.At present, it is poor that majority has self-adhesive, resolvability, plastic degradable high polymer material normality current downflow, and degraded obviously during high temperature.We take intermediate openings to irritate the method for mould for this reason, have reduced injection temperature, and need not use large-scale high-pressure injection moulding equipment.
Summary of the invention
The objective of the invention is to propose a kind of small-bore thin-walled degradable tubular macromolecular material and low-pressure injection molding preparation method thereof, and the required tubular die of this preparation method.
The small-bore thin-walled degraded tubular high polymer material that the present invention proposes, its size range is wide, not only comprises the tubular material of stock size, also comprises the tubular material of minor diameter, thin-walled.Be limited to 1mm under the internal diameter of pipe, be limited to 0.3mm under the thickness of pipe, general, its inside diameter ranges is 1-15mm, and the thickness of pipe scope is 0.3-3mm.
The tubular high polymer material that the present invention proposes, its basic material is the degradable high polymer material with self-adhesive, resolvability.Its molecular weight is 10,000～3,000,000, is generally 3～1,000,000.
The used degradable high polymer material of the present invention comprises aliphatic polyesters such as polylactone and polyhydroxycarboxyliacid acid ester, polycarbonate, poe, poly-acid anhydrides or the multipolymer of being made up of them, blend or contains mixture any of additive.Above aliphatic polyester comprises poly-(D, L-lactic acid) (PDLLA), poly-(L-lactic acid) (PLLA), polyglycolic acid (PGA), polycaprolactone homopolymer such as (PCL) and poly lactic coglycolic acid (PLGA), lactic acid-caprolactone copolymer or other multipolymer a kind of.The degradation rate of above degradable macromolecule can be as required, and by changing high molecular structure or form and adjusted, the degradation time scope is 1 thoughtful 2 years, is generally 1 month to 6 months.
The tubular high polymer material that the present invention proposes, the tubular die of employing intermediate openings, and in conjunction with injection moulding method; Even do not adopt elevated pressures, can prepare yet by the low-pressure injection molding method.Concrete steps are as follows:
(1) a kind of mould with tubulose die cavity is connected with injection moulding machine;
(2) degradable macromolecule is charged in the injection moulding machine hopper, after the degradable high polymer material fusion, under the injection pressure effect, charge into die cavity rapidly;
(3) obtain tubular body after cooling, the demoulding.
The aperture position of mould therefor is located in the middle of the mould among the present invention, makes the filling mould more convenient; This mould also is convenient to the demoulding.
When carrying out low pressure injection formaing among the present invention, can adopt small injecting machine, also can adopt any equipment with shot capacity of design voluntarily.
The present invention has following characteristics:
When 1, the tubular material of the present invention's proposition is used for the bio-medical field, adopt the good biodegradable polymer preparation of biocompatibility that has obtained extensively approval, the generation of toxic side effect such as can avoiding or diminish inflammation after implanting is to meet biomedical requirement better.
2, the used macromolecular material degradation cycle of the present invention can be by changing high molecular structure or form and adjusted, and the degradation time scope is 1 thoughtful 2 years, is generally 1 month to 6 months.
3, the present invention is processing object with the degradable high polymer material, under low pressure carries out injection moulding, and tool is easy to the demoulding, and the goods that obtain after the demoulding have good shape hold facility.
When 4, carrying out injection moulding among the present invention, can under low pressure carry out, can adopt small injecting machine, also can adopt any equipment with shot capacity of design voluntarily.
5, the present invention proposes the tubular material that macromolecular material low-pressure injection molding preparation method not only can prepare stock size, the more important thing is, can prepare the tubular material of minor diameter, thin-walled.
Description of drawings
Fig. 1 is an internal diameter 4mm, the photo of the small-bore thin-walled PLGA85/15 tubular high polymer material of wall thickness 0.5mm.
Embodiment
The embodiment that the invention is further illustrated by the following examples, but be not limited to these embodiment.
Embodiment 1, is that 300,000 PLGA85/15 charges in the small injecting machine hopper with 0.5 gram molecular weight, installs tubulose injection moulding mould, is warming up to 200 ℃, and the polymkeric substance that is in molten state charges into die cavity rapidly under manual injection pressure effect; The tubular body that obtains after the demoulding, internal diameter 4mm, wall thickness 0.5mm, as shown in Figure 1.
Embodiment 2, are that 300,000 PLGA85/15 charges in the small injecting machine hopper with 1 gram molecular weight, install tubulose injection moulding mould, are warming up to 180 ℃, and the polymkeric substance that is in molten state charges into die cavity rapidly under manual injection pressure effect; The tubular body that obtains after the demoulding, internal diameter 4mm, wall thickness 1mm.
Embodiment 3, are that 300,000 PLGA85/15 charges in the small injecting machine hopper with 2 gram molecular weights, install tubulose injection moulding mould, are warming up to 160 ℃, and the polymkeric substance that is in molten state charges into die cavity rapidly under manual injection pressure effect; The tubular body that obtains after the demoulding, internal diameter 5mm, wall thickness 2mm.
Embodiment 4, are that 380,000 PLGA charges in the small injecting machine hopper with 1 gram molecular weight, install tubulose injection moulding mould, are warming up to 160 ℃, and the polymkeric substance that is in molten state charges into die cavity rapidly under manual injection pressure effect; The tubular body that obtains after the demoulding, internal diameter 5mm, wall thickness 1mm.
Embodiment 5, are that 6.5 ten thousand PLGA charges in the small injecting machine hopper with 1 gram molecular weight, install tubulose injection moulding mould, are warming up to 160 ℃, and the polymkeric substance that is in molten state charges into die cavity rapidly under manual injection pressure effect; The tubular body that obtains after the demoulding, internal diameter 5mm, wall thickness 1mm.
Embodiment 6, are that 380,000 PLGA charges in the small injecting machine hopper with 1 gram molecular weight, install tubulose injection moulding mould, are warming up to 160 ℃, and the polymkeric substance that is in molten state charges into die cavity rapidly under manual injection pressure effect; The tubular body that obtains after the demoulding, internal diameter 5mm, wall thickness 1mm.
Claims (4)
1, a kind of small-bore thin-walled degradable tubular macromolecular material is characterized in that basic material for having self-adhesive, resolvability, plastic degradable high polymer material, and the molecular weight of this macromolecular material is 30,000-1,000,000; Dissolve injection moulding method by low pressure and obtain, its internal diameter is 1-15mm, and thickness of pipe is 0.3-3mm.
2, small-bore thin-walled degradable tubular macromolecular material according to claim 1, the degradable high polymer material that it is characterized in that constituting pipe is polyhydroxycarboxyliacid acid ester, poe, poly-acid anhydrides, and multipolymer, the blend be made up of them or the mixture that contains additive.
3, small-bore thin-walled degradable tubular macromolecular material according to claim 1, it is characterized in that constituting the degradable high polymer material of pipe for gathering a kind of of (D, L-lactic acid), poly-(L-lactic acid), polyglycolic acid, polycaprolactone homopolymer and poly lactic coglycolic acid, lactic acid-caprolactone copolymer.
4, a kind of tubular high polymer preparation methods as claimed in claim 1 is characterized in that adopting the low pressure melt injection molding, and concrete steps are as follows:
(1) a kind of mould with tubulose die cavity is connected with injection moulding machine, its mould openings position is located in the middle of the mould;
(2) degradable macromolecule is charged in the injection moulding machine hopper, after the degradable high polymer material fusion, under the injection pressure effect, charge into die cavity rapidly;
(3) obtain tubular body after cooling, the demoulding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031419658A CN100340605C (en) | 2003-07-30 | 2003-07-30 | Thin-wall degradable tubular polymer material and its melting and injection molding process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031419658A CN100340605C (en) | 2003-07-30 | 2003-07-30 | Thin-wall degradable tubular polymer material and its melting and injection molding process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1487025A CN1487025A (en) | 2004-04-07 |
| CN100340605C true CN100340605C (en) | 2007-10-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031419658A Expired - Fee Related CN100340605C (en) | 2003-07-30 | 2003-07-30 | Thin-wall degradable tubular polymer material and its melting and injection molding process |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102532834B (en) * | 2011-12-22 | 2013-07-03 | 哈尔滨工程大学 | In-vivo degradable polymer tubular material for subcutaneous implantation of capsules and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11227147A (en) * | 1998-02-12 | 1999-08-24 | Dainippon Printing Co Ltd | Laminate decoration method |
| JP2002069206A (en) * | 2000-08-31 | 2002-03-08 | Daicel Chem Ind Ltd | Aliphatic polyester resin composition |
| CN1339289A (en) * | 2000-08-17 | 2002-03-13 | 中国科学院化学研究所 | Tissue enginering induction rack for repairing peripheral nerve |
| CN1363399A (en) * | 2002-01-29 | 2002-08-14 | 清华大学 | Process for preparing internally degradable tubular liver tissue frame material |
| CN1105004C (en) * | 1995-03-31 | 2003-04-09 | 维尔蒂斯公司 | Process and apparatus for manufacturing biodegradable products, and biodegradable products |
-
2003
- 2003-07-30 CN CNB031419658A patent/CN100340605C/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105004C (en) * | 1995-03-31 | 2003-04-09 | 维尔蒂斯公司 | Process and apparatus for manufacturing biodegradable products, and biodegradable products |
| JPH11227147A (en) * | 1998-02-12 | 1999-08-24 | Dainippon Printing Co Ltd | Laminate decoration method |
| CN1339289A (en) * | 2000-08-17 | 2002-03-13 | 中国科学院化学研究所 | Tissue enginering induction rack for repairing peripheral nerve |
| JP2002069206A (en) * | 2000-08-31 | 2002-03-08 | Daicel Chem Ind Ltd | Aliphatic polyester resin composition |
| CN1363399A (en) * | 2002-01-29 | 2002-08-14 | 清华大学 | Process for preparing internally degradable tubular liver tissue frame material |
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| Publication number | Publication date |
|---|---|
| CN1487025A (en) | 2004-04-07 |
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