CN100337628C - Nimodipine oral disintegrant tablet for curing dementia and its preparation method - Google Patents
Nimodipine oral disintegrant tablet for curing dementia and its preparation method Download PDFInfo
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- CN100337628C CN100337628C CNB021254311A CN02125431A CN100337628C CN 100337628 C CN100337628 C CN 100337628C CN B021254311 A CNB021254311 A CN B021254311A CN 02125431 A CN02125431 A CN 02125431A CN 100337628 C CN100337628 C CN 100337628C
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- nimodipine
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Abstract
The present invention relates to a nimodipine oral disintegrating tablet for treating dementia and a method for preparing the nimodipine oral disintegrating tablet. All the drugs for treating patients with dementia need to be taken with water in the prior art. The nimodipine oral disintegrating tablet is prepared from a main drug and auxiliary materials, wherein the auxiliary materials comprise four or eight raw materials made into freeze drying tablets or compressed tablets by two methods. The nimodipine oral disintegrating tablet has the advantages that patients can take the tablet without water, and the tablet can disintegrate in 5 seconds or 30 seconds in the oral cavity, so that patients can be treated in time, and the trouble for fetching water is omitted. The product of the nimodipine oral disintegrating tablet is used for treating senile dementia, hypertension, cerebrovascular diseases, migraine, cerebrovascular spasm, apoplexy, etc.
Description
Technical field
The present invention relates to pharmaceutical, particularly treat dementia and hypertensive Nimodipine oral disintegrant tablet, and preparation method thereof.
Background technology
People suffer from dementia, hypertension, ischemic cerebrovascular etc. when taking medicine, and must take medicine with boiled water.Take medicine when patient's water on the one hand, particularly old age and women and children patient are usually very inconvenient; Medicine can improve drug effect (bioavailability) widely and also play a role rapidly at the rapid disintegrate in oral cavity (common below 30 seconds) on the other hand.Therefore, medicine oral disintegrated preparation technology has become one of contemporary medical high-tech, is with a wide range of applications.
Summary of the invention
The object of the present invention is to provide a kind of taking medicine conveniently, the obvious results oral cavity disintegration tablet, and preparation method thereof.
Purpose of the present invention can reach by following measure.Treatment dementia and hypertensive Nimodipine oral disintegrant tablet are made up of principal agent and adjuvant, wherein:
One, principal agent: every contains 10 milligrams of nimodipine, 20 milligrams, 30 milligrams totally three kinds of specifications;
Two, adjuvant: mixture ratio by weight percent and raw material are formed, and according to preparation technology's difference, can adopt following two kinds of prescriptions:
(1) forms by four kinds of adjuvants
A) mannitol 5-80%
B) sucrose 5-80%
C) gelatin 0.1-10%
D) hydroxyethyl-cellulose 0.1-7.5%
(2) form by eight kinds of adjuvants
A) glucose 10-50%
B) compressibility sorbitol 10-50%
C) mannitol 10-40%
D) sucrose 10-40%
E) sodium bicarbonate 5-20%
F) citric acid 5-10%
G) saccharin sodium 0.05%
H) aspartame 0.05%.
The preparation method of the Nimodipine oral disintegrant tablet of treatment dementia is suspended in the principal agent nimodipine in the hydroxyethyl cellulose aqueous solution, forms solution A, press the prescription in the adjuvant (1),, form solution B gelatin, mannitol and sucrose mixed dissolution, solution A and solution B are mixed, and add an amount of water dilution, and abundant mixing, join sharp freezing in the mould, put into the freeze dryer evacuation, and subliming up into the material bone dry, press seal, packing are the lyophilizing sheet.
Another preparation method of Nimodipine oral disintegrant tablet of treatment dementia press prescription mix homogeneously in the adjuvant (2) to principal agent nimodipine and eight kinds of adjuvants, and adding wetting agent or binding agent are made soft material, sieve oven dry, granulate, tabletting, packing are compressed tablet behind the adding lubricant.
The present invention has following advantage compared to existing technology: with the disintegrating tablet that two kinds of preparation methoies make, all need not take medicine by water, put into the oral cavity with the lyophilizing sheet, disintegrate below 5 seconds.Use compressed tablet, disintegrate below 30 seconds in the oral cavity is taken medicine and is saved trouble, and saves the trouble with the water delivery service medicine, and treatment in time, and is effective.
Description of drawings
Fig. 1: nimodipine C
21H
26N
2O
7Molecular structure.
The specific embodiment
Enumerate three embodiment below, the present invention is further specified.
Embodiment 1
10 gram nimodipine are suspended in the 7.5 gram hydroxyethyl cellulose aqueous solutions, make solution A, then 2.5 gram gelatin, 25 gram sucrose and 65 gram mannitol mixed dissolutions, make solution B, solution A and solution B are mixed, add the suitable quantity of water mixing, put into the mould sharp freezing, evacuation in freeze dryer, and sublime up into the material bone dry, press seal, packing.
The gross weight of four kinds of adjuvants is 100 grams, makes 1000,100 milligrams of every adjuvants, and 10 milligrams of nimodipine of principal agent, promptly oral cavity disintegration tablet heavily is 110 milligrams, this sheet is the lyophilizing sheet.
Embodiment 2
20 gram nimodipine, 10 gram gelatin, 1 gram hydroxyethyl-cellulose, 15 gram mannitol and 74 gram sucrose replace to be implemented the raw material consumption in 1, method is with embodiment 1, the gross weight of four kinds of adjuvants is 100 grams, make 1000,100 milligrams of every adjuvants, 20 milligrams of nimodipine, promptly every heavy 120 milligrams, every contains 20 milligrams of nimodipine.
Embodiment 3
Glucose 30 grams, compressibility sorbitol 10 grams, mannitol 20 grams, sucrose 20 grams, sodium bicarbonate 10 grams, citric acid 9.9 grams, saccharin sodium 0.05 gram and aspartame 0.05 gram be totally eight kinds of adjuvant 100 grams, with nimodipine 30 gram mix homogeneously, add wetting agent and make soft material, sieve, oven dry, granulate, tabletting behind the adding lubricant is made 1000, every heavy 130mg, wherein nimodipine contains 30mg, and adjuvant 100mg, this sheet are compressed tablet.
When preparing this product, every sheet is heavy variable.
Product of the present invention is used for the treatment of senile dementia, mild or moderate hypertension, ischemic cerebrovascular, sudden deafness, migraine, subarachnoid hemorrhage and causes diseases such as cerebral vasospasm, cerebral infarction.
Claims (3)
1. the Nimodipine oral disintegrant tablet of treatment dementia, it is characterized in that it mainly is made up of following component: 10 gram nimodipine, 7.5 gram hydroxyethyl-celluloses, 2.5 gram gelatin, 25 gram sucrose and 65 restrain mannitol.
2. the Nimodipine oral disintegrant tablet of treatment dementia, it is characterized in that it mainly is made up of following component: 20 gram nimodipine, 1 gram hydroxyethyl-cellulose, 10 gram gelatin, 74 gram sucrose and 15 restrain mannitol.
3. the preparation method of the Nimodipine oral disintegrant tablet of claim 1 or 2 described treatment dementias is characterized in that, nimodipine is suspended in the hydroxyethyl cellulose aqueous solution, make solution A,, make solution B gelatin, mannitol and sucrose mixed dissolution, solution A and solution B are mixed, and add an amount of water dilution, fully mixing joins sharp freezing in the mould, put into the freeze dryer evacuation, and subliming up into the material bone dry, press seal, packing are the lyophilizing sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021254311A CN100337628C (en) | 2002-08-07 | 2002-08-07 | Nimodipine oral disintegrant tablet for curing dementia and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021254311A CN100337628C (en) | 2002-08-07 | 2002-08-07 | Nimodipine oral disintegrant tablet for curing dementia and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1394605A CN1394605A (en) | 2003-02-05 |
| CN100337628C true CN100337628C (en) | 2007-09-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021254311A Expired - Fee Related CN100337628C (en) | 2002-08-07 | 2002-08-07 | Nimodipine oral disintegrant tablet for curing dementia and its preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN100337628C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450470C (en) * | 2003-06-28 | 2009-01-14 | 南昌弘益科技有限公司 | Rapid disintegrate tablet in oral and its preparation method |
| EA200601666A1 (en) * | 2004-03-12 | 2007-04-27 | Эгиш Дьёдьсердьяр Нирт. | COMBINED PHARMACEUTICAL COMPOSITION FOR INHIBITING THE DEGREING COGNITIVE FUNCTIONS |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286631A (en) * | 1998-03-16 | 2001-03-07 | 山之内制药株式会社 | Tablets quickly disintegrating in oral cavity and process for producing same |
| CN1328446A (en) * | 1998-11-06 | 2001-12-26 | 埃迪克埃迪法姆药品实验室 | Improved fast disintegrating tablet |
| CN1336827A (en) * | 1999-10-12 | 2002-02-20 | 三得利株式会社 | Medicinal compositions for oral use |
-
2002
- 2002-08-07 CN CNB021254311A patent/CN100337628C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286631A (en) * | 1998-03-16 | 2001-03-07 | 山之内制药株式会社 | Tablets quickly disintegrating in oral cavity and process for producing same |
| CN1328446A (en) * | 1998-11-06 | 2001-12-26 | 埃迪克埃迪法姆药品实验室 | Improved fast disintegrating tablet |
| CN1336827A (en) * | 1999-10-12 | 2002-02-20 | 三得利株式会社 | Medicinal compositions for oral use |
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| Publication number | Publication date |
|---|---|
| CN1394605A (en) | 2003-02-05 |
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