CN100336491C - Protection device for encephalic micro-dialysis - Google Patents
Protection device for encephalic micro-dialysis Download PDFInfo
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- CN100336491C CN100336491C CNB2006101120909A CN200610112090A CN100336491C CN 100336491 C CN100336491 C CN 100336491C CN B2006101120909 A CNB2006101120909 A CN B2006101120909A CN 200610112090 A CN200610112090 A CN 200610112090A CN 100336491 C CN100336491 C CN 100336491C
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- protective cover
- protection
- dialysis
- base
- microdialysis
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Abstract
A protective device used in the cerebral micro-dialysis for the monitor relative to continuous sampling to prevent the damage to brain tissue and micro-dialysis needle is composed of a protective base matched with local shape of skull and with an internally screwed ring and an open and a closed cylindrical protective covers with a screwed ring matched with the spiral thread on said protective base.
Description
Affiliated technical field:
The present invention is the protector in a kind of encephalic micro-dialysis process, can make that the operator finishes in clear-headed, free active rabbit, cat, Canis familiaris L., the pig etc. smoothly, the relevant monitoring of the Related Experimental Study of the encephalic micro-dialysis continuous sampling of larger animal and brain diseases patient's clinical encephalic micro-dialysis continuous sampling.
Background technology:
The microdialysis technology is a kind of Wicresoft, and the on-line monitoring method of chemical substance dynamic change in the ECS in vivo continuously.Yales in 1972 are applied to microdialysis the research of monkey brain first.After this encephalic micro-dialysis technology is widely used in the animal experiment study of brain diseases, and has illustrated the Changing Pattern of many nervous system activity mesophytization materials.Since the nineties in 20th century, the microdialysis technology is applied in the clinical monitoring of brain diseases more and more, makes clinical monitoring rise to biochemical level from physiological level, and clinical a kind of brand-new monitoring and the treatment means of providing is provided.
The brain microdialysis technology can be carried out diffusion principle along Concentraton gradient by semipermeable membrane based on micromolecule and water, the microdialysis pin is implanted specific region in the brain, flowing into pipe end personnel selection worker cerebrospinal fluid continous perfusion, small-molecule substance spreads from intercellular substance along Concentraton gradient and enters the microdialysis pin, or enter the extracellular fluid of brain cell from dialysis needle, support afterflow through the dialysis solution of exchange from effuser and go out; By the content of material that dialysis is come out and the comparison of dabbling content of material, just can monitor the dynamic change of brain tissue cell gap substance in real time.
In the research of encephalic micro-dialysis, especially clear-headed and can be free active in, in larger animal experiment and dysphoria patient's the clinical monitoring, the protection of brain microdialysis pin is concerning experiment key of success step.If the microdialysis pin is clashed into, needle point is swung in cerebral tissue, not only causes local brain injury, and also influence dialysis result's verity causes whole the failure of an experiment; Also can make the dialysis needle bending, fracture, dialyzer breaks etc., causes dialysis needle to be scrapped, and increases experimental cost.Present used microdialysis pin mainly is Sweden CMA and U.S. BAS company product, costs an arm and a leg.But this technical barrier of the protection of microdialysis pin is never by fine solution in the experimentation.
Summary of the invention:
In order to capture this difficult problem, avoid brain tissue impairment and the damage of microdialysis pin in the experimentation, guarantee experiment smoothly, reduce experiment consumption, this patent has designed a kind of new device, be specifically designed to clear-headed and can be free active in, larger animal experiment and dysphoria patient's clinical monitoring.
Technical scheme that this patent adopts is: described protector comprises protection base, protective cover, a 2-3 skull anchor screw.The protection base has the bone contact surface of making according to the skull local form (is illustration figure explanation with the circular flat base), has round defect at protection base bone contact surface center, damaged periphery has 2-3 groove, be used to settle skull anchor screw usefulness, what be connected with contact surface is interior threaded annulus; Protective cover is a cylindrical shape, is divided into two kinds of enclosed type, styles of opening.Described enclosed type protective cover one end is a blind end, and other end surface has and the mutually disorderly volution that closes of protection whorl of base; Described opening protective cover one end is the open end, and other end surface has and the mutually disorderly volution that closes of protection whorl of base.Above-mentioned article are medical plastic or alloy material is made.After the enclosed type protective cover is used for microdialysis pin location implantation cerebral tissue, the protection of microdialysis needle guide rail when need not the microdialysis sampling.Opening protective cover is used for the protection of microdialysis sampling process microdialysis pin.
Description of drawings:
Fig. 1 is the protection base
Fig. 2 is enclosed type protective cover and opening protective cover
Fig. 3 is for settling the protection base that puts in place
Fig. 4 is arranged to the protector outward appearance that bit strip has the enclosed type protective cover
Fig. 5 is arranged to the protector outward appearance that bit strip has opening protective cover
Fig. 6 is arranged to interior sight of protector that bit strip has opening protective cover
Wherein description of reference numerals is as follows:
1 is the protection base, and 1a is damaged for protection base bone contact surface central circular, and 1b is for settling the groove of skull anchor screw, and 1c is interior threaded annulus
2 is the enclosed type protective cover, and 2a is the blind end of enclosed type protective cover; 2b is and the mutually disorderly volution that closes of protection whorl of base
3 is opening protective cover, and 3a is the open end of opening protective cover; 3b is and the mutually disorderly volution that closes of protection whorl of base
4 is the skull anchor screw
5 is the dentistry material for repairing
6 is microdialysis needle guide rail
7 is hollow fiber conduit
8 is the microdialysis pin
The specific embodiment:
Behind laboratory animal anesthesia, place on the brain solid positioner, cut scalp and expose skull, at selected position sphenotresia, appear cerebral dura mater, implant microdialysis needle guide rail (6), use fixedly microdialysis needle guide rail (6) of dentistry material for repairing (5); On distance microdialysis pin 0.5-1 centimeters skull face, bore 2 or 3 apertures, do not penetrate skull,, see Fig. 3 with the fixing protection of anchor screw (4) base (1).Before microdialysis begins sampling, the protection that enclosed type protective cover (2) is used for microdialysis guide rail (6) is installed, see Fig. 4; When carrying out the microdialysis sampling, at first extract microdialysis guide rail (6), implantation is connected with inflow, flows out the microdialysis pin (8) of two hollow fiber conduits (7), flow into another termination micro pump of hollow fiber conduit, flow out another termination sampling tube of hollow fiber conduit, open micro pump, continuous sampling begins, and sees Fig. 5,6.
Claims (2)
1. the protector in the encephalic micro-dialysis process, can make the operator finish clear-headed, free active in, the relevant monitoring of the Related Experimental Study of the encephalic micro-dialysis continuous sampling of larger animal and brain diseases patient's clinical encephalic micro-dialysis continuous sampling, avoid brain tissue impairment and the damage of microdialysis pin in the operating process, comprise the protection base, protective cover, 2-3 skull anchor screw formed; The protection base has the bone contact surface of making according to the skull local form; the contact surface center is a round defect; the round defect periphery has 2-3 groove that is used to settle the skull anchor screw; threaded annulus in protection base contact surface connects; protective cover is a cylindrical shape, and protective cover one end surfaces has and the mutually disorderly volution that closes of protection base.
2. according to the described protector of claim 1, wherein protective cover is divided into two kinds of enclosed type, styles of opening; Described enclosed type protective cover one end is a blind end, and other end surface has and the mutually disorderly volution that closes of protection whorl of base; Described opening protective cover one end is the open end, and other end surface has and the mutually disorderly volution that closes of protection whorl of base; Above-mentioned article are medical plastic or alloy material is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101120909A CN100336491C (en) | 2006-08-30 | 2006-08-30 | Protection device for encephalic micro-dialysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101120909A CN100336491C (en) | 2006-08-30 | 2006-08-30 | Protection device for encephalic micro-dialysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1911186A CN1911186A (en) | 2007-02-14 |
| CN100336491C true CN100336491C (en) | 2007-09-12 |
Family
ID=37720361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101120909A Expired - Fee Related CN100336491C (en) | 2006-08-30 | 2006-08-30 | Protection device for encephalic micro-dialysis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100336491C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2642215C2 (en) * | 2017-01-17 | 2018-01-24 | Евгений Антонович Юматов | Method and device for endogenous substances microsampling from one structure of brain and subsequent introduction into another structure of brain of animals in free behaviour |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5735832A (en) * | 1994-02-04 | 1998-04-07 | Cma/Microdialysis Holding Ab | Reinforced microdialysis probe |
| CN2281761Y (en) * | 1996-07-09 | 1998-05-20 | 郭述苏 | Micro dialysis probe |
| CN1663628A (en) * | 2005-03-04 | 2005-09-07 | 浙江大学 | Micro-dialysis device with dialysis film protection |
| CN1806530A (en) * | 2005-01-21 | 2006-07-26 | 张绍东 | Rotation cage for micro-dialysis of sober freely-moving rats |
-
2006
- 2006-08-30 CN CNB2006101120909A patent/CN100336491C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5735832A (en) * | 1994-02-04 | 1998-04-07 | Cma/Microdialysis Holding Ab | Reinforced microdialysis probe |
| CN2281761Y (en) * | 1996-07-09 | 1998-05-20 | 郭述苏 | Micro dialysis probe |
| CN1806530A (en) * | 2005-01-21 | 2006-07-26 | 张绍东 | Rotation cage for micro-dialysis of sober freely-moving rats |
| CN1663628A (en) * | 2005-03-04 | 2005-09-07 | 浙江大学 | Micro-dialysis device with dialysis film protection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1911186A (en) | 2007-02-14 |
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Granted publication date: 20070912 Termination date: 20100830 |