CL2022001777A1 - 2-Oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors - Google Patents
2-Oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitorsInfo
- Publication number
- CL2022001777A1 CL2022001777A1 CL2022001777A CL2022001777A CL2022001777A1 CL 2022001777 A1 CL2022001777 A1 CL 2022001777A1 CL 2022001777 A CL2022001777 A CL 2022001777A CL 2022001777 A CL2022001777 A CL 2022001777A CL 2022001777 A1 CL2022001777 A1 CL 2022001777A1
- Authority
- CL
- Chile
- Prior art keywords
- inhibitors
- methionine adenosyltransferase
- oxoquinazoline derivatives
- oxoquinazoline
- derivatives
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En el presente documento se describen ciertos derivados de 2-oxoquinazolina de Fórmula (IA): los cuales son inhibidores de la metionina adenosiltransferasa 2A (MAT2A). También, se describen composiciones farmacéuticas que comprenden dichos compuestos y métodos para tratar enfermedades tratables mediante la inhibición de MAT2A, tales como cáncer, incluidos los cánceres caracterizados por una actividad reducida o la ausencia de metiltioadenosina fosforilasa (MTAP).Described herein are certain 2-oxoquinazoline derivatives of Formula (IA): which are inhibitors of methionine adenosyltransferase 2A (MAT2A). Also described are pharmaceutical compositions comprising said compounds and methods for treating diseases treatable by MAT2A inhibition, such as cancer, including cancers characterized by reduced or absent methylthioadenosine phosphorylase (MTAP) activity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2022001777A CL2022001777A1 (en) | 2022-06-29 | 2022-06-29 | 2-Oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CL2022001777A CL2022001777A1 (en) | 2022-06-29 | 2022-06-29 | 2-Oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022001777A1 true CL2022001777A1 (en) | 2023-03-10 |
Family
ID=85792744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022001777A CL2022001777A1 (en) | 2022-06-29 | 2022-06-29 | 2-Oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors |
Country Status (1)
Country | Link |
---|---|
CL (1) | CL2022001777A1 (en) |
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2022
- 2022-06-29 CL CL2022001777A patent/CL2022001777A1/en unknown
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