CL2022001477A1 - Using a kv7 potassium channel opener to treat pain - Google Patents
Using a kv7 potassium channel opener to treat painInfo
- Publication number
- CL2022001477A1 CL2022001477A1 CL2022001477A CL2022001477A CL2022001477A1 CL 2022001477 A1 CL2022001477 A1 CL 2022001477A1 CL 2022001477 A CL2022001477 A CL 2022001477A CL 2022001477 A CL2022001477 A CL 2022001477A CL 2022001477 A1 CL2022001477 A1 CL 2022001477A1
- Authority
- CL
- Chile
- Prior art keywords
- potassium channel
- treat pain
- channel opener
- methods
- subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
En ciertas modalidades, la presente descripción se dirige a métodos para tratar el dolor en un sujeto, como un humano, en donde los métodos comprenden administrar oralmente una cantidad efectiva terapéuticamente de N-?4-(6-fluoro-3,4-dihidro-1H-isoquinolin-2-il)-2,6-dimetilfenil?-3,3-dimetilbutanamida (Compuesto A), al sujeto en necesidad de esta. La presente descripción se dirige además a varios métodos mejorados de terapia y administración del Compuesto A.In certain embodiments, the present disclosure is directed to methods of treating pain in a subject, such as a human, wherein the methods comprise orally administering a therapeutically effective amount of N-β4-(6-fluoro-3,4-dihydro -1H-isoquinolin-2-yl)-2,6-dimethylphenyl?-3,3-dimethylbutanamide (Compound A), to the subject in need thereof. The present disclosure is further directed to various improved methods of therapy and administration of Compound A.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962945093P | 2019-12-06 | 2019-12-06 | |
US201962948010P | 2019-12-13 | 2019-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022001477A1 true CL2022001477A1 (en) | 2023-04-28 |
Family
ID=73856375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022001477A CL2022001477A1 (en) | 2019-12-06 | 2022-06-03 | Using a kv7 potassium channel opener to treat pain |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP4069211A1 (en) |
JP (1) | JP2023504166A (en) |
KR (1) | KR20220113411A (en) |
CN (1) | CN114786658A (en) |
AU (1) | AU2020397173A1 (en) |
BR (1) | BR112022010733A2 (en) |
CA (1) | CA3159436A1 (en) |
CL (1) | CL2022001477A1 (en) |
CR (1) | CR20220318A (en) |
IL (1) | IL293504A (en) |
MX (1) | MX2022006877A (en) |
PE (1) | PE20221169A1 (en) |
TW (1) | TW202133847A (en) |
WO (1) | WO2021113757A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113698345B (en) * | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | Compounds as potassium channel modulators, their preparation and use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5419691B2 (en) | 2006-08-23 | 2014-02-19 | バレアント ファーマシューティカルズ インターナショナル | Derivatives of 4- (N-azacycloalkyl) anilide as potassium channel modulators |
US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
US9248122B2 (en) * | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
RS64922B1 (en) * | 2018-05-11 | 2023-12-29 | Xenon Pharmaceuticals Inc | Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener |
-
2020
- 2020-12-04 WO PCT/US2020/063471 patent/WO2021113757A1/en unknown
- 2020-12-04 TW TW109142937A patent/TW202133847A/en unknown
- 2020-12-04 MX MX2022006877A patent/MX2022006877A/en unknown
- 2020-12-04 PE PE2022001015A patent/PE20221169A1/en unknown
- 2020-12-04 CR CR20220318A patent/CR20220318A/en unknown
- 2020-12-04 EP EP20828491.9A patent/EP4069211A1/en active Pending
- 2020-12-04 CN CN202080084722.3A patent/CN114786658A/en active Pending
- 2020-12-04 KR KR1020227021509A patent/KR20220113411A/en active Search and Examination
- 2020-12-04 CA CA3159436A patent/CA3159436A1/en active Pending
- 2020-12-04 AU AU2020397173A patent/AU2020397173A1/en active Pending
- 2020-12-04 JP JP2022532695A patent/JP2023504166A/en active Pending
- 2020-12-04 IL IL293504A patent/IL293504A/en unknown
- 2020-12-04 BR BR112022010733A patent/BR112022010733A2/en unknown
-
2022
- 2022-06-03 CL CL2022001477A patent/CL2022001477A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW202133847A (en) | 2021-09-16 |
KR20220113411A (en) | 2022-08-12 |
CN114786658A (en) | 2022-07-22 |
PE20221169A1 (en) | 2022-07-25 |
CA3159436A1 (en) | 2021-06-10 |
CR20220318A (en) | 2022-10-07 |
JP2023504166A (en) | 2023-02-01 |
AU2020397173A1 (en) | 2022-06-23 |
WO2021113757A1 (en) | 2021-06-10 |
EP4069211A1 (en) | 2022-10-12 |
MX2022006877A (en) | 2022-07-11 |
BR112022010733A2 (en) | 2022-08-23 |
IL293504A (en) | 2022-08-01 |
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