CL2018000300A1 - Proceso para preparar el compuesto 1 derivado de acido benzoico sustituido; compuesto intermediario; util en el tratamiento de la fibrosis quistica. (divisional de la solicitud 201000631).
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Proceso para preparar el compuesto 1 derivado de acido benzoico sustituido; compuesto intermediario; util en el tratamiento de la fibrosis quistica. (divisional de la solicitud 201000631).
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Priority claimed from PCT/US2008/085458external-prioritypatent/WO2009076142A2/en
Application filed by Vertex PharmafiledCriticalVertex Pharma
Publication of CL2018000300A1publicationCriticalpatent/CL2018000300A1/en
PROCESOS PARA PRODUCIR ACIDO BENZOICO DE CICLOALQUILCARBOXAMIDO-PIRIDINAPROCESSES TO PRODUCE BENZOIC ACID OF CYCLALQUILCARBOXAMIDO-PIRIDINA
CL2018000300A2008-12-042018-02-01Proceso para preparar el compuesto 1 derivado de acido benzoico sustituido; compuesto intermediario; util en el tratamiento de la fibrosis quistica. (divisional de la solicitud 201000631).
CL2018000300A1
(en)
Process for preparing form i of 3- (6- (1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropancarboxamido) -3-methylpyridin-2-yl) benzoic acid (compound 1) from 2-bromo-3-methylpyridine (compound 2) and 3- (t-butoxycarbonyl) phenylboronic acid (compound 3).
Proceso para preparar el compuesto 1 derivado de acido benzoico sustituido; compuesto intermediario; util en el tratamiento de la fibrosis quistica. (divisional de la solicitud 201000631).
Propanoic acid compounds derived from k 3- (acetyl-amino-phenyl) -phenyl; compound preparation process; pharmaceutical composition; and use as activators of the heme-free form of soluble guanylate cyclase, in the treatment of heart failure, angina pectoris, hypertension, thromboembolic conditions, ischemia, among others.
N-SUBSTITUTED DERIVATIVES OF 2-METHYL-PROPIONAMIDE; {1- [5-SUSTIUDED-4-SUBSTITUTED-TIAZOL-2-IL-CARBAMOIL] -1-METHYL-ETIL} AMIDAS OF SUBSTITUTED CARBOXYLIC ACIDS, PHARMACEUTICALLY ACCEPTED BY SAME, COMPOSITIONS AND APPLICATIONS.
PROCEDURE FOR THE PREPARATION OF 4- {4 - [({[4-CHLORO-3- (TRIFLUOROMETIL) PHENYL] AMINO} CARBONYL) AMINO] -3-FLUOROPHENOXY} -N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND ITS MONOHYDRATE
Compound derived from substituted pyrazole; and its use to treat diseases or conditions mediated by the receptors pd1, fp, ep1, tp and / or ep4 delivering a general inflammatory response, such as rheumatoid arthritis, psoriasis, atopic dermatitis, endometrosis, allergy, asthma, among others.