CL2015000370A1 - Compounds derived from pyrazolo [3,4-c] cinoline and 3h-2,3,4,5-tetraazacyclopenta [a] naphthalene, phosphodiesterase inhibitors of type 10a (pde10a); and pharmaceutical composition that includes them. - Google Patents

Compounds derived from pyrazolo [3,4-c] cinoline and 3h-2,3,4,5-tetraazacyclopenta [a] naphthalene, phosphodiesterase inhibitors of type 10a (pde10a); and pharmaceutical composition that includes them.

Info

Publication number
CL2015000370A1
CL2015000370A1 CL2015000370A CL2015000370A CL2015000370A1 CL 2015000370 A1 CL2015000370 A1 CL 2015000370A1 CL 2015000370 A CL2015000370 A CL 2015000370A CL 2015000370 A CL2015000370 A CL 2015000370A CL 2015000370 A1 CL2015000370 A1 CL 2015000370A1
Authority
CL
Chile
Prior art keywords
tetraazacyclopenta
cinoline
pde10a
pyrazolo
naphthalene
Prior art date
Application number
CL2015000370A
Other languages
Spanish (es)
Inventor
Hervé Geneste
Michael Ochse
Karla Drescher
Clarissa Jakob
Original Assignee
Abbvie Inc
Abbvie Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48986145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000370(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc, Abbvie Deutschland filed Critical Abbvie Inc
Publication of CL2015000370A1 publication Critical patent/CL2015000370A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
CL2015000370A 2012-08-17 2015-02-16 Compounds derived from pyrazolo [3,4-c] cinoline and 3h-2,3,4,5-tetraazacyclopenta [a] naphthalene, phosphodiesterase inhibitors of type 10a (pde10a); and pharmaceutical composition that includes them. CL2015000370A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261684290P 2012-08-17 2012-08-17

Publications (1)

Publication Number Publication Date
CL2015000370A1 true CL2015000370A1 (en) 2015-10-02

Family

ID=48986145

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000370A CL2015000370A1 (en) 2012-08-17 2015-02-16 Compounds derived from pyrazolo [3,4-c] cinoline and 3h-2,3,4,5-tetraazacyclopenta [a] naphthalene, phosphodiesterase inhibitors of type 10a (pde10a); and pharmaceutical composition that includes them.

Country Status (24)

Country Link
US (1) US9464085B2 (en)
EP (1) EP2885299B1 (en)
JP (1) JP2015524833A (en)
KR (1) KR20150042798A (en)
CN (1) CN104684912A (en)
AR (1) AR092167A1 (en)
AU (1) AU2013304043A1 (en)
BR (1) BR112015003236A2 (en)
CA (1) CA2879485A1 (en)
CL (1) CL2015000370A1 (en)
CR (1) CR20150082A (en)
DO (1) DOP2015000029A (en)
EC (1) ECSP15010205A (en)
HK (1) HK1211284A1 (en)
IL (1) IL236946A0 (en)
IN (1) IN2015DN00337A (en)
MX (1) MX2015002000A (en)
PE (1) PE20151069A1 (en)
PH (1) PH12015500348A1 (en)
RU (1) RU2015109135A (en)
SG (1) SG11201501111YA (en)
TW (1) TW201412742A (en)
UY (1) UY34980A (en)
WO (1) WO2014027078A1 (en)

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
US20030166476A1 (en) 2002-01-31 2003-09-04 Winemiller Mark D. Lubricating oil compositions with improved friction properties
US20070032404A1 (en) 2003-07-31 2007-02-08 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
US20090075980A1 (en) 2003-10-03 2009-03-19 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and Analogs Thereof
WO2005120514A1 (en) 2004-06-07 2005-12-22 Pfizer Products Inc. Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
EP1802585A1 (en) 2004-09-03 2007-07-04 Memory Pharmaceuticals Corporation 4-substituted 4,6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
WO2007022280A1 (en) 2005-08-16 2007-02-22 Memory Pharmaceuticals Corporation Phosphodiesterase 10 inhibitors
NL2000397C2 (en) 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclic heteroaryl compounds as PDE10 inhibitors.
WO2007082546A1 (en) 2006-01-20 2007-07-26 H. Lundbeck A/S Use of tofisopam as a pde10a inhibitor
WO2007085954A2 (en) 2006-01-27 2007-08-02 Pfizer Products Inc. Aminophthalazine derivative compounds
CA2643963A1 (en) 2006-02-21 2007-08-30 Amgen Inc. Cinnoline derivatives as phosphodiesterase 10 inhibitors
EP1991540A1 (en) 2006-02-21 2008-11-19 Amgen Inc. Cinnoline derivatives as phosphodiesterase 10 inhibitors
CA2641670A1 (en) 2006-02-23 2007-08-30 Pfizer Products Inc. Substituted quinazolines as pde10 inhibitors
AU2007221049A1 (en) 2006-02-28 2007-09-07 Amgen Inc. Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
US20070265258A1 (en) 2006-03-06 2007-11-15 Ruiping Liu Quinazoline derivatives as phosphodiesterase 10 inhibitors
AU2007223801A1 (en) 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
TW200817400A (en) 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
TW200815436A (en) * 2006-05-30 2008-04-01 Elbion Ag 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
JP2009541481A (en) 2006-06-26 2009-11-26 ファイザー・プロダクツ・インク Tricyclic heteroaryl compounds as PDE10 inhibitors
US20080090834A1 (en) 2006-07-06 2008-04-17 Pfizer Inc Selective azole pde10a inhibitor compounds
ES2392553T3 (en) 2006-07-10 2012-12-11 H. Lundbeck A/S Derivatives (3-aryl-piperazine-1-yl) of 6,7-dialkoxyquinazoline, 6,7-dialkoxyphthalazine and 6,7-dialkoxyisoquinoline
WO2008020302A2 (en) 2006-08-17 2008-02-21 Pfizer Products Inc. Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
WO2009025823A1 (en) 2007-08-21 2009-02-26 Amgen Inc. Phosphodiesterase 10 inhibitors
WO2009025839A2 (en) 2007-08-22 2009-02-26 Amgen Inc. Phosphodiesterase 10 inhibitors
WO2009029214A1 (en) 2007-08-23 2009-03-05 Amgen Inc. Isoquinolone derivatives as phosphodiesterase 10 inhibitors
TW200918519A (en) 2007-09-19 2009-05-01 Lundbeck & Co As H Cyanoisoquinoline
US20090143361A1 (en) 2007-11-30 2009-06-04 Elbion Gmbh Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
WO2009068320A1 (en) 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
EP2225248A1 (en) 2007-11-30 2010-09-08 Wyeth LLC Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
US20090143392A1 (en) 2007-11-30 2009-06-04 Elbion Gmbh Methods of Treating Obesity and Metabolic Disorders
US20100120763A1 (en) 2008-11-07 2010-05-13 Wyeth Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
WO2011008597A1 (en) 2009-07-14 2011-01-20 Schering Corporation Dihydroimidazoisoquinoline derivatives useful as pde10 inhibitors
TW201204727A (en) 2010-03-10 2012-02-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease
DE102010025786A1 (en) 2010-07-01 2012-01-05 Merck Patent Gmbh Pyrazolochinoline

Also Published As

Publication number Publication date
AU2013304043A1 (en) 2015-02-05
US9464085B2 (en) 2016-10-11
MX2015002000A (en) 2015-10-09
KR20150042798A (en) 2015-04-21
PH12015500348A1 (en) 2015-04-20
PE20151069A1 (en) 2015-08-29
CA2879485A1 (en) 2014-02-20
IL236946A0 (en) 2015-03-31
CN104684912A (en) 2015-06-03
TW201412742A (en) 2014-04-01
DOP2015000029A (en) 2015-03-15
ECSP15010205A (en) 2016-01-29
BR112015003236A2 (en) 2017-07-04
EP2885299A1 (en) 2015-06-24
JP2015524833A (en) 2015-08-27
UY34980A (en) 2014-03-31
RU2015109135A (en) 2016-10-10
IN2015DN00337A (en) 2015-06-12
EP2885299B1 (en) 2017-04-05
CR20150082A (en) 2015-05-25
WO2014027078A1 (en) 2014-02-20
AR092167A1 (en) 2015-03-25
HK1211284A1 (en) 2016-05-20
US20140051695A1 (en) 2014-02-20
SG11201501111YA (en) 2015-03-30

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