CL2014001709A1 - Nucleotide sequence comprising interference arn (arni) that negatively regulates the expression of the lox-1 receptor; and use it to block the growth and progression of tumor cells. - Google Patents

Nucleotide sequence comprising interference arn (arni) that negatively regulates the expression of the lox-1 receptor; and use it to block the growth and progression of tumor cells.

Info

Publication number
CL2014001709A1
CL2014001709A1 CL2014001709A CL2014001709A CL2014001709A1 CL 2014001709 A1 CL2014001709 A1 CL 2014001709A1 CL 2014001709 A CL2014001709 A CL 2014001709A CL 2014001709 A CL2014001709 A CL 2014001709A CL 2014001709 A1 CL2014001709 A1 CL 2014001709A1
Authority
CL
Chile
Prior art keywords
arni
arn
lox
progression
receptor
Prior art date
Application number
CL2014001709A
Other languages
Spanish (es)
Inventor
Alonso Jorge Toledo
Chavarria Ivan Gonzalez
Garrido Rita Cerro
Carcamo Juan Vera
Albarti Felipe Zuñiga
Fernandez Liliana Lamperti
Valladares Valeska Ormazabal
Pereira Natalie Parra
Ramos Oliberto Sanchez
Chavez Silvana Jimenez
Betancour Sergio Oñate
Rocco Coralia Rivas
Original Assignee
Univ Concepcion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Concepcion filed Critical Univ Concepcion
Priority to CL2014001709A priority Critical patent/CL2014001709A1/en
Publication of CL2014001709A1 publication Critical patent/CL2014001709A1/en
Priority to PCT/CL2015/000036 priority patent/WO2015196312A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2014001709A 2014-06-24 2014-06-24 Nucleotide sequence comprising interference arn (arni) that negatively regulates the expression of the lox-1 receptor; and use it to block the growth and progression of tumor cells. CL2014001709A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CL2014001709A CL2014001709A1 (en) 2014-06-24 2014-06-24 Nucleotide sequence comprising interference arn (arni) that negatively regulates the expression of the lox-1 receptor; and use it to block the growth and progression of tumor cells.
PCT/CL2015/000036 WO2015196312A1 (en) 2014-06-24 2015-06-15 Receptor lox-1 inhibitor molecules and the direct effect thereof on controlling tumour progression in different types of human cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2014001709A CL2014001709A1 (en) 2014-06-24 2014-06-24 Nucleotide sequence comprising interference arn (arni) that negatively regulates the expression of the lox-1 receptor; and use it to block the growth and progression of tumor cells.

Publications (1)

Publication Number Publication Date
CL2014001709A1 true CL2014001709A1 (en) 2014-09-12

Family

ID=52002413

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014001709A CL2014001709A1 (en) 2014-06-24 2014-06-24 Nucleotide sequence comprising interference arn (arni) that negatively regulates the expression of the lox-1 receptor; and use it to block the growth and progression of tumor cells.

Country Status (2)

Country Link
CL (1) CL2014001709A1 (en)
WO (1) WO2015196312A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090311271A1 (en) * 2008-05-29 2009-12-17 Wyeth Methods and Compositions for Selective Inhibition of Ligand Binding to the Lectin-Like Receptor for Oxidized Low Density Lipoprotein (LOX-1)
TWI421084B (en) * 2011-04-01 2014-01-01 Univ Kaohsiung Medical A new use of microrna let-7g
US9220721B2 (en) * 2012-10-11 2015-12-29 Salk Institute For Biological Studies Methods for heart regeneration

Also Published As

Publication number Publication date
WO2015196312A1 (en) 2015-12-30

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