CL2014001452A1 - Compounds derived from dihydro-benzo-oxacin and dihydro-pyrido-oxacin; pharmaceutical composition; method to modulate the activity of pi3k enzymes; method for treatment; and use for the treatment of rheumatoid arthritis, pemphigus vulgaris, multiple sclerosis, myasthenia gravis, allergy and malaria, among other diseases. - Google Patents
Compounds derived from dihydro-benzo-oxacin and dihydro-pyrido-oxacin; pharmaceutical composition; method to modulate the activity of pi3k enzymes; method for treatment; and use for the treatment of rheumatoid arthritis, pemphigus vulgaris, multiple sclerosis, myasthenia gravis, allergy and malaria, among other diseases.Info
- Publication number
- CL2014001452A1 CL2014001452A1 CL2014001452A CL2014001452A CL2014001452A1 CL 2014001452 A1 CL2014001452 A1 CL 2014001452A1 CL 2014001452 A CL2014001452 A CL 2014001452A CL 2014001452 A CL2014001452 A CL 2014001452A CL 2014001452 A1 CL2014001452 A1 CL 2014001452A1
- Authority
- CL
- Chile
- Prior art keywords
- oxacin
- dihydro
- treatment
- pyrido
- malaria
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 206010020751 Hypersensitivity Diseases 0.000 title 1
- 201000011152 Pemphigus Diseases 0.000 title 1
- 208000026935 allergic disease Diseases 0.000 title 1
- 230000007815 allergy Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 201000004792 malaria Diseases 0.000 title 1
- 201000006417 multiple sclerosis Diseases 0.000 title 1
- 206010028417 myasthenia gravis Diseases 0.000 title 1
- 201000001976 pemphigus vulgaris Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 206010039073 rheumatoid arthritis Diseases 0.000 title 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579231P | 2011-12-22 | 2011-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001452A1 true CL2014001452A1 (en) | 2014-10-24 |
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ID=47678928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001452A CL2014001452A1 (en) | 2011-12-22 | 2014-06-03 | Compounds derived from dihydro-benzo-oxacin and dihydro-pyrido-oxacin; pharmaceutical composition; method to modulate the activity of pi3k enzymes; method for treatment; and use for the treatment of rheumatoid arthritis, pemphigus vulgaris, multiple sclerosis, myasthenia gravis, allergy and malaria, among other diseases. |
Country Status (42)
Cited By (2)
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| US11021509B2 (en) | 2011-12-22 | 2021-06-01 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| HRP20180384T1 (en) | 2011-12-22 | 2018-04-06 | Novartis Ag | 2,3-Dihydro-benzo [1,4] oxazine derivatives and appropriate compounds as phosphoinositide-3 (PI3K) kinase inhibitors for the treatment of a rheumatoid arthritis specimen |
| AR089284A1 (en) | 2011-12-22 | 2014-08-13 | Galapagos Nv | DIHYDROPIRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS OF THE SAME FOR THE TREATMENT OF INFLAMMATORY DISORDERS |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| MA38100A1 (en) * | 2012-11-26 | 2017-12-29 | Novartis Ag | Solid form of a dihydro-pyridooxazine derivative |
| TW201422625A (en) * | 2012-11-26 | 2014-06-16 | Novartis Ag | Solid form of dihydro-pyrido-oxazine derivative |
| CN105541698B (en) * | 2015-12-23 | 2018-07-10 | 滨海康杰化学有限公司 | A kind of preparation method of the bromo- 2- trifluoromethyl pyridines of 5- |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| BR112020012644A2 (en) * | 2017-12-22 | 2020-12-01 | Ravenna Pharmaceuticals, Inc. | chromenopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| IL279173B2 (en) | 2018-08-13 | 2025-05-01 | Hoffmann La Roche | Heterocyclic compounds as monoacylglycerol lipase inhibitors, processes for their manufacture, pharmaceutical compositions comprising them, and uses thereof |
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| TW202112784A (en) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | Chromenopyrimidine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| PH12022550339A1 (en) | 2019-09-12 | 2023-03-13 | Hoffmann La Roche | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| CN114728988B (en) * | 2019-11-20 | 2024-12-10 | 豪夫迈·罗氏有限公司 | Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune diseases |
| JP7474861B2 (en) * | 2020-03-19 | 2024-04-25 | アーカス バイオサイエンシーズ，インコーポレーテッド | Tetraline and tetrahydroquinoline compounds as inhibitors of hif-2 alpha - Patents.com |
| ES2982017T3 (en) | 2020-07-15 | 2024-10-14 | Chiesi Farm Spa | Pyrido-oxazine derivatives as ALK5 inhibitors |
| CN119173446A (en) | 2022-03-08 | 2024-12-20 | 赤盾医疗有限公司 | Fluid transfer station in robotic drug preparation system |
| CN116535436B (en) * | 2023-05-06 | 2024-04-30 | 遵义医科大学 | Fluorine ion fluorescent probe and synthesis method and application thereof |
| WO2025099111A1 (en) * | 2023-11-10 | 2025-05-15 | Wella Germany Gmbh | New telescoping syntheses of 6-hydroxy-benzomorpholine (3,4-dihydro-2h-1,4-benzoxazin-6-ol) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11021509B2 (en) | 2011-12-22 | 2021-06-01 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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