CL2013003807A1 - Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol. - Google Patents

Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.

Info

Publication number
CL2013003807A1
CL2013003807A1 CL2013003807A CL2013003807A CL2013003807A1 CL 2013003807 A1 CL2013003807 A1 CL 2013003807A1 CL 2013003807 A CL2013003807 A CL 2013003807A CL 2013003807 A CL2013003807 A CL 2013003807A CL 2013003807 A1 CL2013003807 A1 CL 2013003807A1
Authority
CL
Chile
Prior art keywords
methoxystradiol
prolonged
suspended
loaded
controlled release
Prior art date
Application number
CL2013003807A
Other languages
Spanish (es)
Inventor
Sankan Hugo Cardenas
Saldivar Patricia Diaz
Perez Paula Galvez
Bustos Francisco Rojas
Marin Camila Segovia
Diaz Pedro Orihuela
Drullinsky Dora Altbir
Original Assignee
Univ Santiago Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Santiago Chile filed Critical Univ Santiago Chile
Priority to CL2013003807A priority Critical patent/CL2013003807A1/en
Publication of CL2013003807A1 publication Critical patent/CL2013003807A1/en
Priority to PCT/CL2014/000079 priority patent/WO2015100508A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments

Abstract

Se divulga un dispositivo portador de un agente anticancerígenos formado por una estructura tubular pequeña cerrada, cuya pared contenedora es de un polímero de silicona flexible, que contiene en su interior un anticancerígeno para perros, donde la silicona es libre de peróxidos y apta para aplicaciones biotecnológicas y farmacológicas, que almacena una solución del agente anticancerígeno, 2-metoxiestradiol, en aceite de oliva y etanol, y una suspensión de nanopartículas y micropartículas de zeolita natural en donde la zeolita contiene adsorbido en su interior y exterior el agente anticancerígeno hasta una cantidad de 30% de su masa.A device carrying an anticancer agent formed by a small closed tubular structure, whose container wall is made of a flexible silicone polymer, containing inside an anticancer for dogs, where the silicone is free of peroxides and suitable for biotechnological applications is disclosed. and pharmacological, which stores a solution of the anticancer agent, 2-methoxystradiol, in olive oil and ethanol, and a suspension of nanoparticles and microparticles of natural zeolite where the zeolite contains the anticancer agent adsorbed inside and outside up to an amount of 30% of its mass.

CL2013003807A 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol. CL2013003807A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CL2013003807A CL2013003807A1 (en) 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.
PCT/CL2014/000079 WO2015100508A1 (en) 2013-12-31 2014-12-17 Subdermal device for the storage and continuous release of an anti-carcinogenic compound for dogs, contained in nano- and micro-particles of natural zeolites and in an oily medium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2013003807A CL2013003807A1 (en) 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.

Publications (1)

Publication Number Publication Date
CL2013003807A1 true CL2013003807A1 (en) 2014-07-11

Family

ID=53492870

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003807A CL2013003807A1 (en) 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.

Country Status (2)

Country Link
CL (1) CL2013003807A1 (en)
WO (1) WO2015100508A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606468D0 (en) * 1986-03-15 1986-04-23 Sds Biotech Uk Ltd Therapeutic compositions
JPH0341967A (en) * 1989-07-11 1991-02-22 Olympus Optical Co Ltd Gradual drug releasing device
ITRM20010325A1 (en) * 2001-06-08 2002-12-09 Univ Napoli Federico Ii PHARMACEUTICAL COMPOSITIONS BASED ON ZEOLITES CONTAINING ZINC AND ERYTHROMYCIN TO BE USED IN ANTI-ACNE THERAPY.
PL211494B1 (en) * 2001-12-21 2012-05-31 Alcon Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs
DE60311801T2 (en) * 2002-05-02 2007-11-08 PR Pharmaceuticals, Inc., Fort Collins COMPOSITIONS OF ESTRADIOL METABOLITES WITH CONTROLLED RELEASE
CN100406015C (en) * 2003-02-20 2008-07-30 匹兹堡大学 Estradiol metabolites for the treatment of pulmonary hypertension
ITMI20071930A1 (en) * 2007-10-05 2009-04-06 Sasol Italy S P A PHARMACEUTICAL COMPOSITIONS BASED ON POROUS ZEOLITES AS MEANS OF RELEASE OF PHARMACOLOGICALLY ACTIVE MOLECULES AND ITS USE

Also Published As

Publication number Publication date
WO2015100508A1 (en) 2015-07-09

Similar Documents

Publication Publication Date Title
CL2013002331A1 (en) Article manipulation apparatus because it comprises a manipulation frame having a central body comprising a side wall defining an interior space within the central body and a plurality of arm members each arm member having an end adapted to be attached to the central body and an outer end adapted to hold the article; device.
PH12015502369A1 (en) Cleansing compositions with improved dispensing and suspension properties
MX2020004735A (en) Injector and method of assembly.
BR112016006983A8 (en) DEVICE FOR DISINFECTION OF CATHETER CONNECTORS
ES2721256T3 (en) Aerosol generating system with a heating unit and a cartridge for an aerosol generating system with a fluid permeable heating unit
CY1124447T1 (en) MEDICAL PRODUCT CONTAINING A PLACENTA COMPOSITION CONSISTING OF ARIPIPRAZOLE AS AN ACTIVE SUBSTANCE, AND A PLACENTA COMPOSITION CONSISTING OF ARIPIPRAZOLE AS AN ACTIVE SUBSTANCE
CR20140067A (en) SYSTEM FOR LOADING A FOLDING CARDIAC VALVE
MY174507A (en) Adjustable flow control device
AR107138A1 (en) DRY FIBERS OF CITRUSES AND USES OF THE SAME
CO7380752A2 (en) Mineral suspension agent, manufacturing method and use thereof
CO7240351A2 (en) Buffer for days between periods
BR112014026015A2 (en) fluid reservoir and a dispenser using such a reservoir
MX2016004553A (en) Viscous wall coupling damper for use in an outrigger building configuration.
AR095583A1 (en) CONTAINER THAT HAS A USE INDICATOR
CL2017001634A1 (en) Container for viscous liquids coated internally with oil with emulsifier
AR093171A1 (en) COMPOSITIONS OF PERFORATION FLUIDS AND METHODS FOR USE IN UNDERGROUND FORMATIONS
CL2015003183A1 (en) Container
BR112013011535A2 (en) dispensing set
CL2013003807A1 (en) Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.
BR112017022191A2 (en) small volume sampling device
MX2017012669A (en) Methods for emitting and refills for holding two or more compositions.
CL2011003334A1 (en) Process to make a natural nano-reinforcement, from natural silicate of volcanic origin of the sodium montmorillonite type with a size under 2 µm that includes fractionation and wet treatment, incorporating only a deflocculant-flocculant at room temperature; nano-reinforcement and its use to produce nanocomposites.
CL2014001492A1 (en) Biocidal formulation capable of preventing the proliferation of microorgamisms on surfaces
BR112014029354A2 (en) system and method of mixing a fluid sample formation obtained in a sampling chamber at the bottom of the well
PL412598A1 (en) Device for biological reclamation of water basins