CL2013003807A1 - Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol. - Google Patents

Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.

Info

Publication number
CL2013003807A1
CL2013003807A1 CL2013003807A CL2013003807A CL2013003807A1 CL 2013003807 A1 CL2013003807 A1 CL 2013003807A1 CL 2013003807 A CL2013003807 A CL 2013003807A CL 2013003807 A CL2013003807 A CL 2013003807A CL 2013003807 A1 CL2013003807 A1 CL 2013003807A1
Authority
CL
Chile
Prior art keywords
methoxystradiol
prolonged
suspended
loaded
controlled release
Prior art date
Application number
CL2013003807A
Other languages
Spanish (es)
Inventor
Sankan Hugo Cardenas
Saldivar Patricia Diaz
Perez Paula Galvez
Bustos Francisco Rojas
Marin Camila Segovia
Diaz Pedro Orihuela
Drullinsky Dora Altbir
Original Assignee
Univ Santiago Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Santiago Chile filed Critical Univ Santiago Chile
Priority to CL2013003807A priority Critical patent/CL2013003807A1/en
Publication of CL2013003807A1 publication Critical patent/CL2013003807A1/en
Priority to PCT/CL2014/000079 priority patent/WO2015100508A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se divulga un dispositivo portador de un agente anticancerígenos formado por una estructura tubular pequeña cerrada, cuya pared contenedora es de un polímero de silicona flexible, que contiene en su interior un anticancerígeno para perros, donde la silicona es libre de peróxidos y apta para aplicaciones biotecnológicas y farmacológicas, que almacena una solución del agente anticancerígeno, 2-metoxiestradiol, en aceite de oliva y etanol, y una suspensión de nanopartículas y micropartículas de zeolita natural en donde la zeolita contiene adsorbido en su interior y exterior el agente anticancerígeno hasta una cantidad de 30% de su masa.A device carrying an anticancer agent formed by a small closed tubular structure, whose container wall is made of a flexible silicone polymer, containing inside an anticancer for dogs, where the silicone is free of peroxides and suitable for biotechnological applications is disclosed. and pharmacological, which stores a solution of the anticancer agent, 2-methoxystradiol, in olive oil and ethanol, and a suspension of nanoparticles and microparticles of natural zeolite where the zeolite contains the anticancer agent adsorbed inside and outside up to an amount of 30% of its mass.

CL2013003807A 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol. CL2013003807A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CL2013003807A CL2013003807A1 (en) 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.
PCT/CL2014/000079 WO2015100508A1 (en) 2013-12-31 2014-12-17 Subdermal device for the storage and continuous release of an anti-carcinogenic compound for dogs, contained in nano- and micro-particles of natural zeolites and in an oily medium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2013003807A CL2013003807A1 (en) 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.

Publications (1)

Publication Number Publication Date
CL2013003807A1 true CL2013003807A1 (en) 2014-07-11

Family

ID=53492870

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003807A CL2013003807A1 (en) 2013-12-31 2013-12-31 Small silicone tube devices containing nanoparticles and zeolite microparticles as prolonged and controlled release agents, loaded with 2-methoxystradiol and suspended in an oily medium that also contains 2-methoxystradiol.

Country Status (2)

Country Link
CL (1) CL2013003807A1 (en)
WO (1) WO2015100508A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606468D0 (en) * 1986-03-15 1986-04-23 Sds Biotech Uk Ltd Therapeutic compositions
JPH0341967A (en) * 1989-07-11 1991-02-22 Olympus Optical Co Ltd Gradual drug releasing device
ITRM20010325A1 (en) * 2001-06-08 2002-12-09 Univ Napoli Federico Ii PHARMACEUTICAL COMPOSITIONS BASED ON ZEOLITES CONTAINING ZINC AND ERYTHROMYCIN TO BE USED IN ANTI-ACNE THERAPY.
CA2467763C (en) * 2001-12-21 2011-09-13 Alcon, Inc. Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs
DE60311801T2 (en) * 2002-05-02 2007-11-08 PR Pharmaceuticals, Inc., Fort Collins COMPOSITIONS OF ESTRADIOL METABOLITES WITH CONTROLLED RELEASE
WO2004073643A2 (en) * 2003-02-20 2004-09-02 University Of Pittsburgh Estradiol metabolites for the treatment of pulmonary hypertension
ITMI20071930A1 (en) * 2007-10-05 2009-04-06 Sasol Italy S P A PHARMACEUTICAL COMPOSITIONS BASED ON POROUS ZEOLITES AS MEANS OF RELEASE OF PHARMACOLOGICALLY ACTIVE MOLECULES AND ITS USE

Also Published As

Publication number Publication date
WO2015100508A1 (en) 2015-07-09

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