CL2013002782A1 - Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine - Google Patents

Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine

Info

Publication number
CL2013002782A1
CL2013002782A1 CL2013002782A CL2013002782A CL2013002782A1 CL 2013002782 A1 CL2013002782 A1 CL 2013002782A1 CL 2013002782 A CL2013002782 A CL 2013002782A CL 2013002782 A CL2013002782 A CL 2013002782A CL 2013002782 A1 CL2013002782 A1 CL 2013002782A1
Authority
CL
Chile
Prior art keywords
vaccine
produce
formulation
induce
subject
Prior art date
Application number
CL2013002782A
Other languages
Spanish (es)
Inventor
Patricia Garcia
Urrutia Daniel Aguirre
Banchero Aniela Wozniak
Original Assignee
Univ Pontificia Catolica Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pontificia Catolica Chile filed Critical Univ Pontificia Catolica Chile
Priority to CL2013002782A priority Critical patent/CL2013002782A1/en
Publication of CL2013002782A1 publication Critical patent/CL2013002782A1/en
Priority to ARP140103580A priority patent/AR097790A1/en
Priority to PCT/IB2014/064870 priority patent/WO2015044909A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCIÓN PROVEE UNA FORMULACIÓN INMJNOGÉNICA PARA INDUCIR LA RESPUESTA INMUNE EN UN SUJETO, QUE COMPRENDE UNA MEZCLA DE CEPAS DE BACTERAS NO PATÓGENAS GENÉTICAMENTE MODIFICADAS QUE EXPRESAN CADA UNA UN SEGMENTO HIPERVARIABLE DE LA PROTEÍNA M DE STREPTOCOCCUS PYOGENES DIFERENTE Y UN DILUYENTE BIOLÓGICAMENTE ACEPTABLE. SE PROVEE ADEMÁS E) USO DE LA FORMULACIÓN INMURTOGÉNICA PARA PREPARAR UNA VACUNA DE ADMINISTRACIÓN INTRANASAL Y UN MÉTODO PARA PRODUCIR DICHA VACUNA.THE PRESENT INVENTION PROVIDES AN IMMJNOGENIC FORMULATION TO INDUCE THE IMMUNE RESPONSE IN A SUBJECT, WHICH INCLUDES A MIXTURE OF GENETICALLY MODIFIED BACTERIA BOTTLES THAT EXPRESS EACH OF A MATERIAL AND PERSONAL PROBLEM. IT IS PROVIDED IN ADDITION E) USE OF THE IMMURTOGENIC FORMULATION TO PREPARE AN INTRANASAL ADMINISTRATION VACCINE AND A METHOD FOR PRODUCING THE VACCINE SUCH.

CL2013002782A 2013-09-27 2013-09-27 Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine CL2013002782A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CL2013002782A CL2013002782A1 (en) 2013-09-27 2013-09-27 Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine
ARP140103580A AR097790A1 (en) 2013-09-27 2014-09-26 NASAL USE VACCINES AGAINST STREPTOCOCCUS PYOGENES BASED ON A WASTE BACTERIAL VECTOR AND SPECIFIC ANTIGENS, PRODUCTION METHOD
PCT/IB2014/064870 WO2015044909A1 (en) 2013-09-27 2014-09-26 Vaccines for intranasal use against streptococcus pyogenes using an innocuous bacterial vector and specific antigens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2013002782A CL2013002782A1 (en) 2013-09-27 2013-09-27 Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine

Publications (1)

Publication Number Publication Date
CL2013002782A1 true CL2013002782A1 (en) 2014-04-25

Family

ID=52742178

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013002782A CL2013002782A1 (en) 2013-09-27 2013-09-27 Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine

Country Status (3)

Country Link
AR (1) AR097790A1 (en)
CL (1) CL2013002782A1 (en)
WO (1) WO2015044909A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112760336A (en) * 2020-12-30 2021-05-07 广州辉园苑医药科技有限公司 Expression system and surface display system of epitope peptide and construction method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5128593A (en) * 1992-09-16 1994-04-12 University Of Tennessee Research Corporation, The Antigen of hybrid m protein and carrier for group a streptococcal vaccine
WO1999013084A1 (en) * 1997-09-12 1999-03-18 Id Vaccine Group a streptococcal vaccines
AU2002365223A1 (en) * 2001-10-26 2003-09-02 Id Biomedical Corporation Of Washington Multivalent streptococcal vaccine compositions and methods for use
US20090010929A1 (en) * 2006-12-04 2009-01-08 Good Michael F Therapeutic Antibodies, Antibody Fragments and Antibody Conjugates

Also Published As

Publication number Publication date
AR097790A1 (en) 2016-04-13
WO2015044909A1 (en) 2015-04-02

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CL2013002782A1 (en) Immunogenic formulation to induce the immune response in a subject comprising a mixture of non-pathogenic bacteria each expressing a hypervariable segment of the m protein of different streptococcus pyogenes; use of the formulation to produce a vaccine; method to produce vaccine