CL2012002360A1 - Method for preparing a liposomal formulation comprising dissolving a lipid fraction (phospholipids, sterol and a bioactive substance) in an organic solvent, putting together with a removed carrier and introducing a supercritical fluid, discharging the fluid by compression and hydrating; and apparatus for carrying out the method. - Google Patents

Method for preparing a liposomal formulation comprising dissolving a lipid fraction (phospholipids, sterol and a bioactive substance) in an organic solvent, putting together with a removed carrier and introducing a supercritical fluid, discharging the fluid by compression and hydrating; and apparatus for carrying out the method.

Info

Publication number
CL2012002360A1
CL2012002360A1 CL2012002360A CL2012002360A CL2012002360A1 CL 2012002360 A1 CL2012002360 A1 CL 2012002360A1 CL 2012002360 A CL2012002360 A CL 2012002360A CL 2012002360 A CL2012002360 A CL 2012002360A CL 2012002360 A1 CL2012002360 A1 CL 2012002360A1
Authority
CL
Chile
Prior art keywords
fluid
hydrating
sterol
phospholipids
dissolving
Prior art date
Application number
CL2012002360A
Other languages
Spanish (es)
Inventor
Sung Joo Hwang
Hee Jun Park
Wonkyung Cho
Kwang Ho Cha
Junsung Park
Chanhyuk Park
Donggeon Gu
Original Assignee
Bcworld Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bcworld Pharma Co Ltd filed Critical Bcworld Pharma Co Ltd
Publication of CL2012002360A1 publication Critical patent/CL2012002360A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CL2012002360A 2010-02-24 2012-08-24 Method for preparing a liposomal formulation comprising dissolving a lipid fraction (phospholipids, sterol and a bioactive substance) in an organic solvent, putting together with a removed carrier and introducing a supercritical fluid, discharging the fluid by compression and hydrating; and apparatus for carrying out the method. CL2012002360A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020100016555A KR101102834B1 (en) 2010-02-24 2010-02-24 New methods and apparatus for preparing liposomes

Publications (1)

Publication Number Publication Date
CL2012002360A1 true CL2012002360A1 (en) 2013-08-16

Family

ID=44507447

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002360A CL2012002360A1 (en) 2010-02-24 2012-08-24 Method for preparing a liposomal formulation comprising dissolving a lipid fraction (phospholipids, sterol and a bioactive substance) in an organic solvent, putting together with a removed carrier and introducing a supercritical fluid, discharging the fluid by compression and hydrating; and apparatus for carrying out the method.

Country Status (9)

Country Link
US (1) US9579261B2 (en)
EP (1) EP2538921B1 (en)
JP (1) JP5787905B2 (en)
KR (1) KR101102834B1 (en)
CN (1) CN102781428B (en)
BR (1) BR112012021703A2 (en)
CA (1) CA2789320C (en)
CL (1) CL2012002360A1 (en)
WO (1) WO2011105835A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24121B1 (en) * 2012-08-02 2015-08-27 Ct De Ingeniería Genética Y Biotecnología VESICLES THAT INCLUDE EPIDERMAL GROWTH FACTOR AND COMPOSITIONS CONTAINING THEM
CN103143033B (en) * 2013-03-24 2014-06-25 山西医科大学 Targeting liver cell carrier and preparation method thereof
CN105012152B (en) * 2014-04-23 2018-01-02 胡权 The preparation facilities and preparation method of a kind of liposome
US10342747B2 (en) * 2015-12-16 2019-07-09 PPP&C Inc. Apparatus and method for preparing cosmeceutical ingredients containing epi-dermal delivery mechanisms
CN106581695A (en) * 2016-10-27 2017-04-26 山东省分析测试中心 Cationic liposome, preparation method and applications thereof
JP2020508350A (en) * 2017-02-21 2020-03-19 アイシーオー セラピューティクス インコーポレイテッド Solid oral preparation of amphotericin B
US20200230057A1 (en) * 2017-07-10 2020-07-23 Immunovaccine Technologies Inc. Pharmaceutical Compositions, Methods for Preparation using Lipid Vesicle Particles of Defined Size, and Uses Thereof
CN109432008A (en) * 2018-12-07 2019-03-08 河南工业大学 A kind of preparation method of nano liposomes
CA3240291A1 (en) * 2021-12-22 2023-06-29 Michael Carpenter Supercritical ethylene extraction process for selectively recovering phenolic compounds from bio-crude and/or bio-oil

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
US5262168A (en) * 1987-05-22 1993-11-16 The Liposome Company, Inc. Prostaglandin-lipid formulations
US5554382A (en) * 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
AU3715900A (en) * 1999-03-02 2000-09-21 Liposome Company, Inc., The Encapsulation of bioactive complexes in liposomes
FR2797398B1 (en) * 1999-08-11 2002-10-18 Mainelab MICROPARTICLES FOR PULMONARY ADMINISTRATION
DE60236805D1 (en) * 2001-08-03 2010-08-05 Nat Res Council Canada Ottawa LIPOSOMES MADE FROM MYCOBACTERIUM EXTRACTABLE LIPIDS
JP2005511521A (en) * 2001-10-10 2005-04-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Powder processing with pressurized gaseous fluid
CN100471490C (en) 2002-08-01 2009-03-25 谢恬 Sesquiterpene ketone injection, preparing method and use thereof
JP2005162702A (en) * 2003-12-04 2005-06-23 Konica Minolta Medical & Graphic Inc Method for producing liposome preparation, liposome preparation and apparatus for producing the same
FR2874836B1 (en) * 2004-09-09 2007-04-27 Pierre Fabre Medicament Sa PROCESS FOR COATING POWDERS
EP1795184A1 (en) * 2005-12-09 2007-06-13 Ludwig-Maximilians-Universität München Preparation of powders containing colloidal particles

Also Published As

Publication number Publication date
EP2538921A2 (en) 2013-01-02
EP2538921A4 (en) 2014-05-28
JP2013520492A (en) 2013-06-06
CN102781428B (en) 2017-09-19
EP2538921B1 (en) 2017-04-26
JP5787905B2 (en) 2015-09-30
KR20110096962A (en) 2011-08-31
WO2011105835A2 (en) 2011-09-01
CA2789320C (en) 2015-06-02
CN102781428A (en) 2012-11-14
US9579261B2 (en) 2017-02-28
KR101102834B1 (en) 2012-01-05
US20130069261A1 (en) 2013-03-21
CA2789320A1 (en) 2011-09-01
BR112012021703A2 (en) 2019-09-24
WO2011105835A3 (en) 2012-01-12

Similar Documents

Publication Publication Date Title
CL2012002360A1 (en) Method for preparing a liposomal formulation comprising dissolving a lipid fraction (phospholipids, sterol and a bioactive substance) in an organic solvent, putting together with a removed carrier and introducing a supercritical fluid, discharging the fluid by compression and hydrating; and apparatus for carrying out the method.
CL2014002717A1 (en) Composite formulation comprising a spheroid multi-unit tablet (musti) encapsulated in hard capsule and method for preparing it.
BR112014027039A2 (en) non-aqueous topical pharmaceutical formulation; use of non-aqueous pharmaceutical formulation; non-aqueous formulation; and method
CL2009000672A1 (en) Method for the extraction of components, in particular lipids from biological material, comprising a pretreatment and a subsequent extraction in an organic solvent; and an analytical unit to carry out the method, comprising a pre-treatment equipment and an extraction equipment.
CL2007000813A1 (en) Methods for preparing aggregates of whey protein micelles and an active agent; aggregates; food product or cosmetic product; and use of whey protein micelles.
CL2014000183A1 (en) Pharmaceutical formulation containing anti-pcsk9 antibodies; method to prepare said formulation.
CL2014003334A1 (en) Procedures for removing hemicellulose comprising extracting the cellulosic material with an extractant, ionic liquid and a non-solvent, and separating the extracted hemicellulose to form a cellulosic product
CL2013000394A1 (en) Method and apparatus for leak testing of containers filled with a consumer product comprising monitoring the presence in the surrounding environment of an analyte; and method for manufacturing closed containers filled with a consumer product and which are not leaking.
CL2013003615A1 (en) An apparatus and method for managing virtual storage in recovery sites.
BRPI0921429A2 (en) stable freeze-dried pharmaceutical formulation and method for preparing a stable freeze-dried factor
BR112014001135A2 (en) method for imaging an underground region, and system for use in imaging an underground region
CL2013001614A1 (en) A beverage preparation system for preparing a beverage by injecting a liquid into an ingredient capsule, comprises an injection unit, operating means for making the machine prepare a beverage said machine also comprises a cleaning device for automatically cleaning the less an internal input channel; method to prepare beverage; and set.
BR112013033803A2 (en) formulation integrated with microneedle, and method for administering a substance
UY32761A (en) THERMOSTABLE PREPARATIONS AND INSULINIC PREPARATIONS STABLE TO VIBRATIONS
BR112014026800A2 (en) method and system for sprout extraction and system use.
BR112013016415A2 (en) method and apparatus for decorating ingredients in a solvent
CL2014001233A1 (en) Method for dispensing pollen grains comprising introducing a plurality of pollen grains in a solution to create a pollen solution mixture in a pollen storage container, connecting the container containing the mixture to a dispensing device, and propelling minus a portion of the mixture from the container by using the dispensing device to pollinate a plant.
CL2009001479A1 (en) A method of isolating a deglycosylated veratrum alkaloid comprising providing a veratrum plant material, contacting an aqueous solution, and extracting the veratrum plant material with a solvent to provide an extract comprising said alkaloid.
EP2684071A4 (en) Method and device for searching through collapsed ground
AR072685A1 (en) TOPICAL COMPOSITION FOR THE TREATMENT OF ACTINIC KERATOSIS
WO2013052138A3 (en) System and method for electrophoretic decellularization
BRPI0912689A2 (en) apparatus and method for forward observation of ground avoidance (flta) in an aircraft method for a planning phase, method for forward observation ground avoidance (flta) in an aircraft
CL2014003333A1 (en) Methods for removing hemicellulose which comprises extracting the cellulosic material with an extractant, amine oxide and a non-solvent, and separating the extracted hemicellulose to form a cellulosic product.
BR112013008196A2 (en) solvent conduction system, solvent conduction method in a container containing the solvent and apparatus, and beverage preparation method of a solvent and ingredients
CL2014000418A1 (en) Peptide particle comprising a ligand on its outer surface and one or two amphiphilic peptides, which comprise a hydrophobic peptidyl segment and a hydrophilic peptidyl segment; and its use for the supply of an active agent to a cell.