CL2010000744A1 - Compounds derived from substituted phenylsulfonylamines calpain inhibitors; pharmaceutical compositions, useful in the treatment of diseases associated with calpain activity, such as male infertility, testicular torsion; varicocele, oligospermia, Alzheimer's disease, Parkinson's disease, Hunintong, AIDS. - Google Patents
Compounds derived from substituted phenylsulfonylamines calpain inhibitors; pharmaceutical compositions, useful in the treatment of diseases associated with calpain activity, such as male infertility, testicular torsion; varicocele, oligospermia, Alzheimer's disease, Parkinson's disease, Hunintong, AIDS.Info
- Publication number
- CL2010000744A1 CL2010000744A1 CL2010000744A CL2010000744A CL2010000744A1 CL 2010000744 A1 CL2010000744 A1 CL 2010000744A1 CL 2010000744 A CL2010000744 A CL 2010000744A CL 2010000744 A CL2010000744 A CL 2010000744A CL 2010000744 A1 CL2010000744 A1 CL 2010000744A1
- Authority
- CL
- Chile
- Prior art keywords
- disease
- calpain
- parkinson
- alzheimer
- aids
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN DESCRIBE COMPUESTOS INHIBIDORES DE CALPAÍNA, DERIVADOS FENILSULFONILAMINAS SUSTITUIDAS DE FÓRMULA (I), EN QUE R1, R2 Y A SON COMO SE DEFINEN EN LA PRESENTE INVENCIÓN. LA INVENCIÓN SE REFIERE TAMBIÉN A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS, PROCEDIMIENTOS E INTERMEDIOS ÚTILES PARA PREPARAR DICHOS COMPUESTOS Y A SU USO EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON ACTIVIDAD DE CALPAÍNA, TALES COMO INFERTILIDAD MASCULINA, TORSIÓN TESTICULAR, VARICOCELE, OLIGOSPERMIA, INFARTO CEREBRAL Y CARDIACO, ESCLEROSIS MÚLTIPLE, CÁNCER, ENFERMEDAD DE ALZHEIMER, ENFERMEDAD DE PARKINSON, ENFERMEDAD DE HUNTINGTON, SIDA, LESIONES NEUROLÓGICAS, DESORDEN OBSESIVO-COMPULSIVO, ISQUEMIA/REPERFUSIÓN, REMODELAMIENTO CARDIACO, INSUFICIENCIA CARDIACA, LA ATEROESCLEROSIS, LA DIABETES Y LAS CATARATAS.THIS INVENTION DESCRIBES CALPAINE INHIBITING COMPOUNDS, SUBSTITUTED PHENYLSULPHONYLAMINE DERIVATIVES OF FORMULA (I), IN WHICH R1, R2 AND A ARE AS DEFINED IN THIS INVENTION. THE INVENTION IS ALSO REFERRED TO PHARMACEUTICAL COMPOSITIONS THAT INCLUDE SUCH COMPOUNDS, PROCEDURES AND INTERMEDIATE INTERMEDIATES TO PREPARE SUCH COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ACTIVITY OF CALPAIN, SUCH AS CELLULAR, INFERTIMARITY AND OLIVERTICARITY. CARDIAC, MULTIPLE SCLEROSIS, CANCER, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, AIDS, NEUROLOGICAL INJURY, OBSESSIVE-COMPULSIVE DISORDER, ISCHEMIA / REPERFUSION, CARDING AND REMOVAL LAYOUT, CARDING THROUGHTING, CARDING THROUGHTING, CARDING THROUGHT, CARDING INSTRUCTION
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2010000744A CL2010000744A1 (en) | 2010-07-12 | 2010-07-12 | Compounds derived from substituted phenylsulfonylamines calpain inhibitors; pharmaceutical compositions, useful in the treatment of diseases associated with calpain activity, such as male infertility, testicular torsion; varicocele, oligospermia, Alzheimer's disease, Parkinson's disease, Hunintong, AIDS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2010000744A CL2010000744A1 (en) | 2010-07-12 | 2010-07-12 | Compounds derived from substituted phenylsulfonylamines calpain inhibitors; pharmaceutical compositions, useful in the treatment of diseases associated with calpain activity, such as male infertility, testicular torsion; varicocele, oligospermia, Alzheimer's disease, Parkinson's disease, Hunintong, AIDS. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2010000744A1 true CL2010000744A1 (en) | 2010-12-10 |
Family
ID=66221089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2010000744A CL2010000744A1 (en) | 2010-07-12 | 2010-07-12 | Compounds derived from substituted phenylsulfonylamines calpain inhibitors; pharmaceutical compositions, useful in the treatment of diseases associated with calpain activity, such as male infertility, testicular torsion; varicocele, oligospermia, Alzheimer's disease, Parkinson's disease, Hunintong, AIDS. |
Country Status (1)
| Country | Link |
|---|---|
| CL (1) | CL2010000744A1 (en) |
-
2010
- 2010-07-12 CL CL2010000744A patent/CL2010000744A1/en unknown
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| CL2010000744A1 (en) | Compounds derived from substituted phenylsulfonylamines calpain inhibitors; pharmaceutical compositions, useful in the treatment of diseases associated with calpain activity, such as male infertility, testicular torsion; varicocele, oligospermia, Alzheimer's disease, Parkinson's disease, Hunintong, AIDS. |