CL2008001838A1 - Substituted 2,3-dihydropyrrolo [3,4-b] quinolin-1-one derived compounds, modulators of the activity of a GABA receptor; pharmaceutical composition; and its use in the treatment of anxiety disorders, schizophrenia, cognitive and / or mood disorders. - Google Patents

Substituted 2,3-dihydropyrrolo [3,4-b] quinolin-1-one derived compounds, modulators of the activity of a GABA receptor; pharmaceutical composition; and its use in the treatment of anxiety disorders, schizophrenia, cognitive and / or mood disorders.

Info

Publication number
CL2008001838A1
CL2008001838A1 CL2008001838A CL2008001838A CL2008001838A1 CL 2008001838 A1 CL2008001838 A1 CL 2008001838A1 CL 2008001838 A CL2008001838 A CL 2008001838A CL 2008001838 A CL2008001838 A CL 2008001838A CL 2008001838 A1 CL2008001838 A1 CL 2008001838A1
Authority
CL
Chile
Prior art keywords
schizophrenia
treatment
pharmaceutical composition
dihydropyrrolo
quinolin
Prior art date
Application number
CL2008001838A
Other languages
Spanish (es)
Inventor
Carey Horchler
Hui-Fang Chang
Marc Chapdelaine
Keith Herzog
Richard Schmiesing
Bruce Thomas Dembofsky
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40084145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008001838(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008001838A1 publication Critical patent/CL2008001838A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados de heterociclos de nitrógeno fusionados; composición farmacéutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la esquizofrenia, ansiedad, Parkinson, Alzheimer, trastorno depresivo, entre otros.Compounds derived from fused nitrogen heterocycles; pharmaceutical composition comprising said compounds; and use of the compound in the treatment of schizophrenia, anxiety, Parkinson's, Alzheimer's, depressive disorder, among others.

CL2008001838A 2007-06-19 2008-06-19 Substituted 2,3-dihydropyrrolo [3,4-b] quinolin-1-one derived compounds, modulators of the activity of a GABA receptor; pharmaceutical composition; and its use in the treatment of anxiety disorders, schizophrenia, cognitive and / or mood disorders. CL2008001838A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94487907P 2007-06-19 2007-06-19

Publications (1)

Publication Number Publication Date
CL2008001838A1 true CL2008001838A1 (en) 2009-03-06

Family

ID=40084145

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008001838A CL2008001838A1 (en) 2007-06-19 2008-06-19 Substituted 2,3-dihydropyrrolo [3,4-b] quinolin-1-one derived compounds, modulators of the activity of a GABA receptor; pharmaceutical composition; and its use in the treatment of anxiety disorders, schizophrenia, cognitive and / or mood disorders.

Country Status (15)

Country Link
US (1) US20080318943A1 (en)
EP (1) EP2176263A2 (en)
JP (1) JP2010530405A (en)
KR (1) KR20100039339A (en)
CN (1) CN101778849A (en)
AR (1) AR067027A1 (en)
AU (1) AU2008264984A1 (en)
BR (1) BRPI0813379A2 (en)
CA (1) CA2691237A1 (en)
CL (1) CL2008001838A1 (en)
MX (1) MX2009013885A (en)
PE (1) PE20090693A1 (en)
TW (1) TW200904817A (en)
UY (1) UY31159A1 (en)
WO (1) WO2008155572A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX341704B (en) * 2009-10-26 2016-08-31 Signal Pharm Llc Methods of synthesis and purification of heteroaryl compounds.
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
ES2831625T3 (en) 2013-02-20 2021-06-09 Kala Pharmaceuticals Inc Therapeutic compounds and their uses
MX355330B (en) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS and USES THEREOF.
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
GB201322334D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
KR102621938B1 (en) 2015-01-13 2024-01-05 닛산 가가쿠 가부시키가이샤 Method for treating tin compound in reaction mixture
JP2019533641A (en) 2016-09-08 2019-11-21 カラ ファーマシューティカルズ インコーポレイテッド Crystalline forms of therapeutic compounds and uses thereof
WO2018048747A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN108863917A (en) * 2017-05-16 2018-11-23 穆云 A kind of preparation method of 2,5- dimethoxy-pyridine
WO2019002042A1 (en) * 2017-06-27 2019-01-03 Bayer Aktiengesellschaft Method for preparing substituted 4-aminoindane derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1131227A (en) * 1979-01-22 1982-09-07 Nicholas J. Bach Octahydro-2h-pyrrolo (3,4,-g) quinolines
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
US5190951A (en) * 1990-10-19 1993-03-02 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
US5240934A (en) * 1990-10-19 1993-08-31 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
RU2257385C2 (en) * 2003-08-26 2005-07-27 ООО "Исследовательский институт химического разнообразия" 1,3-dioxo-2,3-dihydro-1h-pyrrolo[3,4-c]quinolines (variants), pharmaceutical compositions (variants), method for their preparing (variants) and method for treatment (variants)

Also Published As

Publication number Publication date
US20080318943A1 (en) 2008-12-25
WO2008155572A3 (en) 2009-02-26
WO2008155572A2 (en) 2008-12-24
CN101778849A (en) 2010-07-14
TW200904817A (en) 2009-02-01
MX2009013885A (en) 2010-01-27
AR067027A1 (en) 2009-09-30
CA2691237A1 (en) 2008-12-24
AU2008264984A1 (en) 2008-12-24
EP2176263A2 (en) 2010-04-21
UY31159A1 (en) 2009-01-30
JP2010530405A (en) 2010-09-09
BRPI0813379A2 (en) 2014-12-30
PE20090693A1 (en) 2009-07-17
KR20100039339A (en) 2010-04-15

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