CL2007003876A1 - INCLUSION COMPLEX THAT IS FORMED BY DISULFIRAM AND CYCLODEXTRINE; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE. - Google Patents

INCLUSION COMPLEX THAT IS FORMED BY DISULFIRAM AND CYCLODEXTRINE; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE.

Info

Publication number
CL2007003876A1
CL2007003876A1 CL200703876A CL2007003876A CL2007003876A1 CL 2007003876 A1 CL2007003876 A1 CL 2007003876A1 CL 200703876 A CL200703876 A CL 200703876A CL 2007003876 A CL2007003876 A CL 2007003876A CL 2007003876 A1 CL2007003876 A1 CL 2007003876A1
Authority
CL
Chile
Prior art keywords
cyclodextrine
disulfiram
alcohol
treatment
pharmaceutical composition
Prior art date
Application number
CL200703876A
Other languages
Spanish (es)
Inventor
Jacqueline Sepulveda Car Maria
Original Assignee
Univ De Concepcion Y Lab Andro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ De Concepcion Y Lab Andro filed Critical Univ De Concepcion Y Lab Andro
Priority to CL200703876A priority Critical patent/CL2007003876A1/en
Publication of CL2007003876A1 publication Critical patent/CL2007003876A1/en
Priority to ARP080105738A priority patent/AR071280A1/en
Priority to ES201090045A priority patent/ES2348887B2/en
Priority to PCT/IB2008/003695 priority patent/WO2009083793A1/en
Priority to KR1020080134495A priority patent/KR101131296B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14Dithiocarbamic acids; Derivatives thereof
    • C07C333/30Dithiocarbamic acids; Derivatives thereof having sulfur atoms of dithiocarbamic groups bound to other sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14Dithiocarbamic acids; Derivatives thereof
    • C07C333/18Esters of dithiocarbamic acids
    • C07C333/20Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16Cyclodextrin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CL200703876A 2007-12-28 2007-12-28 INCLUSION COMPLEX THAT IS FORMED BY DISULFIRAM AND CYCLODEXTRINE; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE. CL2007003876A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CL200703876A CL2007003876A1 (en) 2007-12-28 2007-12-28 INCLUSION COMPLEX THAT IS FORMED BY DISULFIRAM AND CYCLODEXTRINE; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE.
ARP080105738A AR071280A1 (en) 2007-12-28 2008-12-23 INCLUSION COMPLEX FORMED BY DISULFIRAM AND A CYCLODEXTRINE, USEFUL IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE, PREPARATION PROCEDURE, PHARMACEUTICAL COMPOSITION AND USE OF SUCH COMPLEX
ES201090045A ES2348887B2 (en) 2007-12-28 2008-12-23 INCLUSION COMPLEX FORMED BY DISULFIRAM AND A CYCLODEXTRINE, USEFUL IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE.
PCT/IB2008/003695 WO2009083793A1 (en) 2007-12-28 2008-12-23 Inclusion complex formed by disulfiram and a cyclodextrin, which can be used in the treatment of alcohol and cocaine dependence
KR1020080134495A KR101131296B1 (en) 2007-12-28 2008-12-26 An inclusion complex composed of disulfiram and a cyclodextrin, useful for the treatment of alcohol and cocaine dependences

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL200703876A CL2007003876A1 (en) 2007-12-28 2007-12-28 INCLUSION COMPLEX THAT IS FORMED BY DISULFIRAM AND CYCLODEXTRINE; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE.

Publications (1)

Publication Number Publication Date
CL2007003876A1 true CL2007003876A1 (en) 2008-03-07

Family

ID=40261621

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200703876A CL2007003876A1 (en) 2007-12-28 2007-12-28 INCLUSION COMPLEX THAT IS FORMED BY DISULFIRAM AND CYCLODEXTRINE; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF THE ALCOHOL AND COCAINE DEPENDENCE.

Country Status (5)

Country Link
KR (1) KR101131296B1 (en)
AR (1) AR071280A1 (en)
CL (1) CL2007003876A1 (en)
ES (1) ES2348887B2 (en)
WO (1) WO2009083793A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2462235C1 (en) * 2011-05-10 2012-09-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова Федерального агентства по здравоохранению и социальному развитию" Drug form of disulfiram with prolonged action and method of its obtaining
KR20220010855A (en) 2020-07-20 2022-01-27 재단법인 제주테크노파크 A pharmaceutical composition for improving and treating obesity with the effect of suppressing the differentiation of adipocytes using disulfiram and its derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196033B (en) * 1984-02-22 1988-11-10 Chiesi Farma Spa COMPOUND WITH ANTI-INFLAMMATORY ACTIVITY OBTAINED BY COMPLEXATION WITH BETA-CYCLODEXTRINE AND RELATED PHARMACEUTICAL FORMULATIONS
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
KR20030041577A (en) * 2001-11-20 2003-05-27 디디에스텍주식회사 Solid dispersions containing substituted cyclodextrin and insoluble drug and their preparations

Also Published As

Publication number Publication date
ES2348887A1 (en) 2010-12-16
WO2009083793A1 (en) 2009-07-09
KR20090073025A (en) 2009-07-02
KR101131296B1 (en) 2012-03-30
AR071280A1 (en) 2010-06-09
ES2348887B2 (en) 2012-01-23

Similar Documents

Publication Publication Date Title
BRPI0820899A2 (en) COSMETIC FORMULATION, AND, USE OF COMPOSITION
BRPI0818073A2 (en) Well treatment fluid composition and methods of use including a delayed release percarbonate formulation
CL2012003026A1 (en) Pharmaceutical composition comprising pioglitazone and linagliptin; preparation procedure; Use in the treatment of type 2 diabetes or obesity.
CL2012000248A1 (en) Insulin conjugated compound; preparation procedure; pharmaceutical composition comprising it; pharmaceutical combination; pharmaceutical kit; use in the treatment of insulin-mediated disorders.
DOP2007000102A (en) ARILIMIDAZOLONAS AND ARILTRIAZOLONA SUBSTITUTED AS WELL AS ITS USE
BRPI0821732A2 (en) Controlled release formulations, solid dosage form, and use of controlled release formulation
BRPI0814769A2 (en) SYNERGIC COMPOSITION UNDERSTANDING FLAVORING SUBSTANCES AND ORGANIC ACIDS AND USE OF THE SAME
SV2015004969A (en) IMIDAZO [1,2-A] PIRIDINCARBOXAMIDS AMINOSUSTITUIDAS AND ITS USE
BRPI0700738A (en) foldable absorbent article
CL2007003672A1 (en) COMPOUNDS DERIVED FROM HETEROARIL-PIRROLIDINIL-CETONA AND HETEROARIL-PIPERIDINIL-CETONA; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DEPRESSION AND ANXIETY.
BR112012016398A2 (en) Substituted imidazopyridinyl-aminopyridine compound, pharmaceutical composition comprising said compound and use thereof for the treatment of a proliferative cell disease
BRPI0720124A2 (en) PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE.
BRPI0814593A2 (en) COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING AND USE OF THE COMPOUND.
BRPI0717699A2 (en) &#34;COMPOSITION AND ITS PROCESSES FOR PREPARATION, USE OF A COMPOSITION, AND COMESTIC USE OF A COMPOSITION!
CL2007003635A1 (en) COMPOUNDS DERIVED FROM 6-AMINO-PURIN-8-ONA; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION; PROCESS TO PREPARE PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF ALLERGIC, VIRAL OR CANCER DISEASES.
DOP2007000043A (en) SUBSTITUTED CHROMANOL DERIVATIVES AND THEIR USE
BRPI0809667A2 (en) COMPOUND, MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING AND USE OF THE COMPOUND
CL2007003033A1 (en) COMPOUNDS DERIVED FROM BENZOILAMINO HETEROCICLOS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT; AND USE OF THE COMPOUND IN THE TREATMENT OF TYPE II DIABETES.
BRPI0815079A2 (en) 1,2-DIAMIDE-ETHYLENE DERICTED COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING AND USE OF THIS COMPOUND
BRPI0922233A2 (en) compounds, pharmaceutical compositions and methods for use in the treatment of metabolic syndromes.
CL2007002619A1 (en) COMPOUNDS DERIVED FROM 3-AZA-BICICLO [4.1.0] HEPTANO; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DEPRESSION.
CL2007003038A1 (en) COMPOUNDS DERIVED FROM 2-PHENYL-6-AMINOCARBONIL-PYRIMIDINE; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF OCLUSIVE VASCULAR DISORDERS.
CL2008003546A1 (en) Pyridine derived compounds; preparation procedure; pharmaceutical composition of said compounds; and use in the treatment and / or prophylaxis of type I and / or type II diabetes mellitus.
BRPI0917593A2 (en) &#34;Allophanate preparation process of one or more isocyanates, allophanate, uses of an allophanate, composition of tricondensed polyfunctional isocyanates and use of a composition&#34;
CL2007003643A1 (en) PHARMACEUTICAL COMPOSITION OF AZIMILIDINE THAT INCLUDES 0.5% TO APPROXIMATELY 2.5% (W / W) OF WATER; AND USE FOR THE TREATMENT OF CARDIAC ARRITMIAS.