CL2004000686A1 - USE OF THE BASIC CHLORHYDRATE OF THE ACTIVE PRINCIPLE 1- (N2- [3,5-DIBROMO-N - [[4- (3,4-DIHIDRO-2 (1H) -OXOQUINAZOLIN-3-IL) -1-P IPERIDINIL ] -CARBONIL] -D-TIROSIL] -L-LISIL] -4- (4-PIPERIDIN) -PIPERAZINE IN COMBINATION WITH SUMATRIPTAN TO PREPARE A MEDICINAL OR - Google Patents

USE OF THE BASIC CHLORHYDRATE OF THE ACTIVE PRINCIPLE 1- (N2- [3,5-DIBROMO-N - [[4- (3,4-DIHIDRO-2 (1H) -OXOQUINAZOLIN-3-IL) -1-P IPERIDINIL ] -CARBONIL] -D-TIROSIL] -L-LISIL] -4- (4-PIPERIDIN) -PIPERAZINE IN COMBINATION WITH SUMATRIPTAN TO PREPARE A MEDICINAL OR

Info

Publication number
CL2004000686A1
CL2004000686A1 CL200400686A CL2004000686A CL2004000686A1 CL 2004000686 A1 CL2004000686 A1 CL 2004000686A1 CL 200400686 A CL200400686 A CL 200400686A CL 2004000686 A CL2004000686 A CL 2004000686A CL 2004000686 A1 CL2004000686 A1 CL 2004000686A1
Authority
CL
Chile
Prior art keywords
tirosil
lisil
carbonil
dihidro
dibromo
Prior art date
Application number
CL200400686A
Other languages
Spanish (es)
Inventor
Herni Rudolf Klaus Eberl Doods
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2004000686A1 publication Critical patent/CL2004000686A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA EL TRATAMIENTO O LA PREVENCION DE DOLORES DE CABEZA, MIGRANA O UNA CEFALEA ACUMULADA, EN EL QUE EL PROCEDIMIENTO COMPRENDE LA ADMINISTRACION COMUN DE UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DEL HIDROCLORURO DE LA BASE DEL PRINCIPIO ACTIVO 1-(N2-(3,5-DIBROMO-N-((4-(3,4-DIHIDRO-2(1H)-OXO-QUINAZOLIN-3-IL)-1-PIPERIDINIL-CARBONIL)-D-TIROSIL)-L-LISIL)-4-(4-PIPERIDIN)-PIPERAZINA (A) Y UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DEL PRINCIPIO ACTIVO CONTRA LA MIGRANA SUMATRIPTANO, O UNA DE SUS SALES FISIOLOGICAMENTE ACEPTABLES DEL MISMO, ASI COMO LA CORRESPONDIENTE COMPOSICION FARMACEUTICA Y SU PRODUCCION.THE PRESENT INVENTION REFERS TO A PROCEDURE FOR THE TREATMENT OR PREVENTION OF HEAD, MIGRANE, OR A ACCUMULATED HEADACHE, IN WHICH THE PROCEDURE UNDERSTANDS THE COMMON ADMINISTRATION OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF THE HYDROCLORIDE BASE OF THE ASSETS N2- (3,5-DIBROMO-N - ((4- (3,4-DIHIDRO-2 (1H) -OXO-QUINAZOLIN-3-IL) -1-PIPERIDINIL-CARBONIL) -D-TIROSIL) -L- LISIL) -4- (4-PIPERIDIN) -PIPERAZINE (A) AND A THERAPEUTICALLY EFFECTIVE AMOUNT OF THE ACTIVE PRINCIPLE AGAINST SUMMITRIPTAN MIGRANE, OR ONE OF ITS PHYSIOLOGICALLY ACCEPTABLE SALTS OF THE SAME, AS WELL AS THE CORRESPONDING COMPOSITION COMPOSITION.

CL200400686A 2003-04-01 2004-03-30 USE OF THE BASIC CHLORHYDRATE OF THE ACTIVE PRINCIPLE 1- (N2- [3,5-DIBROMO-N - [[4- (3,4-DIHIDRO-2 (1H) -OXOQUINAZOLIN-3-IL) -1-P IPERIDINIL ] -CARBONIL] -D-TIROSIL] -L-LISIL] -4- (4-PIPERIDIN) -PIPERAZINE IN COMBINATION WITH SUMATRIPTAN TO PREPARE A MEDICINAL OR CL2004000686A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10314617A DE10314617A1 (en) 2003-04-01 2003-04-01 Use of the hydrochloride of the active ingredient base 1- [N2- [3,5-dibromo-N - [[4- (3,4-dihydro-2 (1H) -oxoquinazolin-3-yl) -1-piperidinyl] carbonyl] - D-tyrosyl] -L-lysyl] -4- (4-pyridinyl) -piperazine in combination with sumatriptan for the treatment of migraines

Publications (1)

Publication Number Publication Date
CL2004000686A1 true CL2004000686A1 (en) 2005-02-04

Family

ID=32980861

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400686A CL2004000686A1 (en) 2003-04-01 2004-03-30 USE OF THE BASIC CHLORHYDRATE OF THE ACTIVE PRINCIPLE 1- (N2- [3,5-DIBROMO-N - [[4- (3,4-DIHIDRO-2 (1H) -OXOQUINAZOLIN-3-IL) -1-P IPERIDINIL ] -CARBONIL] -D-TIROSIL] -L-LISIL] -4- (4-PIPERIDIN) -PIPERAZINE IN COMBINATION WITH SUMATRIPTAN TO PREPARE A MEDICINAL OR

Country Status (9)

Country Link
EP (1) EP1631282A1 (en)
JP (1) JP2006522044A (en)
AR (1) AR043793A1 (en)
CA (1) CA2520930A1 (en)
CL (1) CL2004000686A1 (en)
DE (1) DE10314617A1 (en)
TW (1) TW200501956A (en)
UY (1) UY28251A1 (en)
WO (1) WO2004087134A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1740175A1 (en) * 2004-04-20 2007-01-10 Boehringer Ingelheim International Gmbh Use of a cgrp-antagonist combined with a serotonin-reuptake inhibitor in order to treat migraines
JP2012506404A (en) * 2008-10-22 2012-03-15 ノバルティス アーゲー Combination for migraine treatment
EP3416618A1 (en) 2016-02-19 2018-12-26 ZP Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10139410A1 (en) * 2001-08-17 2003-02-27 Boehringer Ingelheim Pharma Use of BIBN4096 in combination with other anti-migraine drugs for the treatment of migraines
DE10206770A1 (en) * 2002-02-19 2003-08-28 Boehringer Ingelheim Pharma New, stable acid addition salts of the quinazolinone derivative CGRP antagonist BIBN4096, useful for the treatment of migraine, in the form of an inhalable powder

Also Published As

Publication number Publication date
WO2004087134A1 (en) 2004-10-14
DE10314617A1 (en) 2004-10-14
CA2520930A1 (en) 2004-10-14
JP2006522044A (en) 2006-09-28
EP1631282A1 (en) 2006-03-08
UY28251A1 (en) 2004-11-08
AR043793A1 (en) 2005-08-10
TW200501956A (en) 2005-01-16

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