CH653255A5 - Perfumes or perfume compositions containing agents to prevent phototoxic reactions - Google Patents
Perfumes or perfume compositions containing agents to prevent phototoxic reactions Download PDFInfo
- Publication number
- CH653255A5 CH653255A5 CH927/83A CH92783A CH653255A5 CH 653255 A5 CH653255 A5 CH 653255A5 CH 927/83 A CH927/83 A CH 927/83A CH 92783 A CH92783 A CH 92783A CH 653255 A5 CH653255 A5 CH 653255A5
- Authority
- CH
- Switzerland
- Prior art keywords
- dimethylethyl
- fragrances
- oil
- fragrance compositions
- skin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 18
- 231100000760 phototoxic Toxicity 0.000 title claims abstract description 17
- 239000002304 perfume Substances 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 title 1
- 239000003205 fragrance Substances 0.000 claims description 32
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 241000700198 Cavia Species 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- NZZIMKJIVMHWJC-UHFFFAOYSA-N dibenzoylmethane Chemical compound C=1C=CC=CC=1C(=O)CC(=O)C1=CC=CC=C1 NZZIMKJIVMHWJC-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 206010015150 Erythema Diseases 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- VDBHOHJWUDKDRW-UHFFFAOYSA-N 1-(1,1,2,3,3,6-hexamethyl-2h-inden-5-yl)ethanone Chemical compound CC1=C(C(C)=O)C=C2C(C)(C)C(C)C(C)(C)C2=C1 VDBHOHJWUDKDRW-UHFFFAOYSA-N 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004264 Petrolatum Substances 0.000 claims description 4
- 206010040914 Skin reaction Diseases 0.000 claims description 4
- 239000006071 cream Substances 0.000 claims description 4
- 231100000321 erythema Toxicity 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 4
- 230000006698 induction Effects 0.000 claims description 4
- 239000006210 lotion Substances 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 235000019198 oils Nutrition 0.000 claims description 4
- 239000002674 ointment Substances 0.000 claims description 4
- 235000019271 petrolatum Nutrition 0.000 claims description 4
- 229940066842 petrolatum Drugs 0.000 claims description 4
- 230000035483 skin reaction Effects 0.000 claims description 4
- 231100000430 skin reaction Toxicity 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000012085 test solution Substances 0.000 claims description 4
- 240000000467 Carum carvi Species 0.000 claims description 3
- 235000005747 Carum carvi Nutrition 0.000 claims description 3
- 240000002045 Guettarda speciosa Species 0.000 claims description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 150000004702 methyl esters Chemical class 0.000 claims description 3
- BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 claims description 2
- 235000019499 Citrus oil Nutrition 0.000 claims description 2
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 235000019501 Lemon oil Nutrition 0.000 claims description 2
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 claims description 2
- 235000019502 Orange oil Nutrition 0.000 claims description 2
- 206010070834 Sensitisation Diseases 0.000 claims description 2
- 230000007815 allergy Effects 0.000 claims description 2
- 238000010171 animal model Methods 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000001279 citrus aurantifolia swingle expressed oil Substances 0.000 claims description 2
- 239000010500 citrus oil Substances 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 230000037213 diet Effects 0.000 claims description 2
- 238000002845 discoloration Methods 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 claims description 2
- 239000013505 freshwater Substances 0.000 claims description 2
- 239000010651 grapefruit oil Substances 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 238000011835 investigation Methods 0.000 claims description 2
- 230000007794 irritation Effects 0.000 claims description 2
- 239000010501 lemon oil Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960004469 methoxsalen Drugs 0.000 claims description 2
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 claims description 2
- 231100000344 non-irritating Toxicity 0.000 claims description 2
- 239000010502 orange oil Substances 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 230000033764 rhythmic process Effects 0.000 claims description 2
- 230000008313 sensitization Effects 0.000 claims description 2
- 239000011877 solvent mixture Substances 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Abstract
A method for preventing phototoxic reactions caused by perfumes or perfume compositions is described; the method is characterised by the use of 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane for this purpose.
Description
**WARNUNG** Anfang DESC Feld konnte Ende CLMS uberlappen **.
PATENTANSPRÜCHE
1. Riechstoffe bzw. Riechstoffkompositionen, gekennzeichnet durch einen Gehalt an 4-(1,1-Dimethyläthyl)-4'- methoxydibenzoylmethan.
2. Komposition nach Anspruch 1, dadurch gekennzeichnet, dass sie Bergamotteöl darstellt oder enthält.
3. Komposition nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass sie 0,1 bis 5 Gewichtsprozent, insbesondere 0,1 bis 2 Gewichtsprozent 4-(l,I-Dimethyläthyl)-4'- methoxydibenzoylmethan enthält.
4. Verwendung von 4-( 1,1 -Dimethyläthyl)-4'-methoxydi- benzoylmethan zur Herstellung von Riechstoffen bzw.
Riechstoffkompositionen zwecks Verhinderung von durch Riechstoffe bzw. Riechstoffkompositionen verursachten phototoxischen Reaktionen.
5. Verwendung von 4-(1,1 -Dimethyläthyl)-4'-methoxydi- benzoylmethan gemäss Anspruch 4, dadurch gekennzeichnet, dass die Riechstoffkomposition Bergamotteöl ist.
Es ist bekannt, dass eine Reihe organoleptisch aktiver Körper, insbesondere Riechstoffe, wenn sie - z. B. als Komponenten von kosmetischen Präparaten - auf die Haut aufgebracht werden und hierauf der Lichteinwirkung ausgesetzt werden, auf oder in der Haut unerwünschte, d. h. phototoxische Reaktionen hervorrufen. Es kann dies in der Folge zu Reizungen, Entzündungen, Schwellungen, Verfärbungen z. B. Rötungen, Sensibilisierungen, Allergien, etc. führen.
Es wurde nun gefunden, dass solche, durch Riechstoffe bzw. Riechstoffkompositionen verursachte phototoxische Reaktionen verhindert werden können, indem man zu diesem Zwecke 4-( 1,1 Dimethyläthyl)-4'-methoxydibenzoylme than verwendet.
Die Erfindung betrifft demgemäss Riechstoffe bzw.
Riechstoffkompositionen, die durch einen Gehalt an 4-(1,1 Dimethyläthyl)-4'-methoxydibenzoylmethan gekennzeichnet sind.
Die Erfindung betrifft auch die Verwendung von 4-(1,1 Dimethyläthyl)-4'-methoxydibenzoylmethan, im folgenden auch Dibenzoylmethan genannt, in Riechstoffen bzw.
Riechstoffkompositionen zwecks Verhinderung von durch Riechstoffe bzw. Riechstoffkompositionen verursachten phototoxischen Reaktionen.
Die wichtigsten, üblicherweise phototoxische Reaktionen hervorrufenden Produkte sind Riechstoffkompositionen natürlichen Ursprungs. Hier wiederum sind es insbesondere eine Reihe von Citrusölen, wie z. B. Bergamotteöl, Citronen öl, Limetteöl, Orangenöl, Grapefruitöl. Aber auch Angelika öl oder Kümmelöl können in diesem Zusammenhang genannt werden.
Als üblicherweise phototoxische Reaktionen hervorrufende synthetische, organoleptisch aktive Körper seien insbesondere der N-Methylanthranylsäuremethylester und das 5-Acetyl-1,1,2,3,3,6-hexamethyl-indan ( Phantolide ) genannt.
Die Menge des zuzusetzenden Dibenzoylmethans liegt zweckmässigerweise im Bereich von 0,1 bis 5 Gewichtsprozent; sie beträgt vorzugsweise 0,1 bis 2 Gewichtsprozent des zu schützenden Produktes.
Das Dibenzoylmethan kann dem Produkt als solches oder gelöst in einem Lösungsmittel oder Lösungsmittelgemisch, z. B. in Äthanol, zugesetzt werden.
Beispiel
Bestimmung des phototoxischen Potentials verschiedener Produkte; als Versuchstiere dienten Meerschweinchen.
Die Untersuchungen wurden unter Standardbedingungen durchgeführt. Mit der Ausnahme der Bestrahlungsperioden wurden die Tiere dauernd in Drahtkäfigen gehalten, und zwar bei einer Temperatur von 22 + 2 C und einer relativen Luftfeuchtigkeit von 45 + 10%. Der Tageslichtrhythmus war 12 Stunden/Tag. Diät: Standardisiertes Futter und frisches Wasser ad libitum.
Lichtquelle: UV-Lampe Westinghouse FS 40 Black Lamp ; Energie: 1 x 104 Erg/cm2/sek., Spektrum: 320-400 nm, Bestrahlungsdosis: 20 J/cm2.
Die eingesetzten männlichen und weiblichen Meerschweinchen wogen zwischen 300-450 g.
Vor den Versuchsperioden wurde sichergestellt, dass alle Versuchstiere gesund waren.
Das zu untersuchende Material wurde in der höchstmöglichen, die Haut primär nicht reizenden Konzentration appliziert. Zwecks Verdünnung oder Suspension des Testmaterials wurden Alkohol, Aceton, Wasser, Petrolatum oder andere geeignete Lösungsmittel verwendet. Zwecks Erhöhung der Hautpenetration wurden den Lösungen zusätzlich 2% Dimethylsulfoxid zugegeben oder in das Präparat eingearbeitet.
Die zu untersuchenden Präparate wurden als solche oder gegebenenfalls verdünnt verwendet.
Dosis: Für die Versuche wurden die alkoholischen, acetonischen oder wässrigen Lösungen in einer Menge von 0,025 ml/cm2 mittels Pipette auf die Haut aufgebracht. Im Falle von Lösungen in Petrolatum oder im Falle von Präparaten wie Cremes, Salben und Lotions, etc. wurde mit Mengen von 0,01 ml/2 cm2 gearbeitet.
Beobachtungsperioden: Beobachtung und Auswertung der Hautreaktion wurde 4,24 und 48 Stunden nach der Applikation des Untersuchungsmaterials durchgeführt.
Versuchsanordnung: Zur Bestimmung der Toleranzschwelle der einzelnen zu untersuchenden Produkte vor der Induktionsphase wurde eine Gruppe von 4 Meerschweinchen verwendet. Zwecks Bestimmung der höchstmöglichen Konzentration wurde das zu untersuchende Produkt sowohl unverdünnt als auch verdünnt oder suspendiert im geeigneten Lösungsmittel bei Konzentrationen von 30, 10, 3 und 1 % (oder wenn nötig noch weniger) auf die Flanke (0,25 ml/ 2 cm2) aufgebracht und unbedeckt belassen.
Versuchsphase (Induktionsphase): Beide Flanken von mindestens 10 Meerschweinchen wurden mindestens 2 Stunden vor Applikation der Chemikalien kahlgeschoren. Hierauf wurden an jeder Flanke maximal 5 Kreise von je 2 cm2 markiert. Auf4 dieser kreisrunden Stellen wurden 0,025 ml alkoholischer, acetonischer oder wässriger Versuchslösung (höchste primär nicht irritierende Konzentration) oder 0,01 ml Versuchslösung, die unter Verwendung anderer Lösungsmittel bzw. von Präparaten, wie Cremen, Salben oder Lotions, appliziert.
Die fünfte Applikationsstelle wurde in jedem Fall mit einer 0,1 %gen alkoholischen Lösung von 8-Methoxypsoralen behandelt und diente als Kontrolle.
30 Minuten nach Applizieren des Untersuchungsmaterials wurde die linke Flanke jedes Versuchstieres einer nichterythemerzeugenden W-A-Bestrahlung (20 J/cm2) ausgesetzt. Die rechte Flanke blieb nach der Applikation des Untersuchungsmaterials unbestrahlt und diente als Kontrolle.
Beobachtung und Auswertung: Die Tiere wurden 4, 24 und 48 Stunden nach der Applikation des Untersuchungsmaterials auf Erythem- und Odembildung untersucht. Die Hautreaktion wurde entweder mit das heisst keine Reaktion, oder mit +, das heisst positive Reaktion, bewertet.
Tabelle
Verhinderung phototoxischer Effekte mittels Dibenzoylmethan
Bestrahlungsdosis: 20 J UV-A/cm2 Dibenzoylmethan O/o 0 0,25 0,5 0,75 1 2 Stunden nach 4 24 48 4 24 48 4 24 48 4 24 48 4 24 48 4 24 48 Applikation Bergamotteessenz 6% + + + + + - + Citronenessenz 6% + + + + Orangenessenz 3% + - - + Limettessenz 15% + - - - - - Kümmelessenz 6% + + - + Angelikaessenz 6% + - - + Rautenessenz 6% + + + + + - + N-Methylanthranylsäuremethylester 3% + + - + - - + - 5-Acetyl-1,1,2,3,3,6- hexamethyl-indan 3% + + + +
** WARNING ** beginning of DESC field could overlap end of CLMS **.
PATENT CLAIMS
1. Fragrances or fragrance compositions, characterized by a content of 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane.
2. Composition according to claim 1, characterized in that it represents or contains bergamot oil.
3. Composition according to claim 1 or 2, characterized in that it contains 0.1 to 5 weight percent, in particular 0.1 to 2 weight percent 4- (l, I-dimethylethyl) -4'- methoxydibenzoylmethane.
4. Use of 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane for the production of fragrances or
Fragrance compositions for the purpose of preventing phototoxic reactions caused by fragrances or fragrance compositions.
5. Use of 4- (1,1-dimethylethyl) -4'-methoxydi- benzoylmethane according to claim 4, characterized in that the fragrance composition is bergamot oil.
It is known that a number of organoleptically active bodies, especially fragrances, if - e.g. B. as components of cosmetic preparations - applied to the skin and then exposed to light, undesirable on or in the skin, d. H. cause phototoxic reactions. This can result in irritation, inflammation, swelling, discoloration z. B. redness, sensitization, allergies, etc. lead.
It has now been found that such phototoxic reactions caused by fragrances or fragrance compositions can be prevented by using 4- (1,1-dimethylethyl) -4'-methoxydibenzoylme than for this purpose.
The invention accordingly relates to odoriferous substances or
Fragrance compositions which are characterized by a content of 4- (1,1 dimethylethyl) -4'-methoxydibenzoylmethane.
The invention also relates to the use of 4- (1,1-dimethylethyl) -4'-methoxydibenzoylmethane, hereinafter also called dibenzoylmethane, in fragrances or
Fragrance compositions for the purpose of preventing phototoxic reactions caused by fragrances or fragrance compositions.
The most important products that usually cause phototoxic reactions are fragrance compositions of natural origin. Here again there are in particular a number of citrus oils, such as. B. bergamot oil, lemon oil, lime oil, orange oil, grapefruit oil. Angelica oil or caraway oil can also be mentioned in this context.
The synthetic, organoleptically active bodies which usually cause phototoxic reactions are, in particular, the N-methylanthranylic acid methyl ester and 5-acetyl-1,1,2,3,3,6-hexamethyl-indane (phantolide).
The amount of dibenzoylmethane to be added is expediently in the range from 0.1 to 5 percent by weight; it is preferably 0.1 to 2 percent by weight of the product to be protected.
The dibenzoylmethane can be the product as such or dissolved in a solvent or solvent mixture, e.g. B. in ethanol.
example
Determination of the phototoxic potential of various products; guinea pigs served as experimental animals.
The investigations were carried out under standard conditions. With the exception of the radiation periods, the animals were kept in wire cages at a temperature of 22 + 2 C and a relative humidity of 45 + 10%. The daylight rhythm was 12 hours / day. Diet: standardized feed and fresh water ad libitum.
Light source: Westinghouse FS 40 Black Lamp UV lamp; Energy: 1 x 104 ergs / cm2 / sec., Spectrum: 320-400 nm, radiation dose: 20 J / cm2.
The male and female guinea pigs used weighed between 300-450 g.
Before the test periods, it was ensured that all test animals were healthy.
The material to be examined was applied in the highest possible concentration that did not primarily irritate the skin. Alcohol, acetone, water, petrolatum or other suitable solvents were used to dilute or suspend the test material. In order to increase skin penetration, 2% dimethyl sulfoxide was added to the solutions or incorporated into the preparation.
The preparations to be examined were used as such or, if appropriate, diluted.
Dose: For the experiments, the alcoholic, acetone or aqueous solutions in an amount of 0.025 ml / cm2 were applied to the skin using a pipette. In the case of solutions in petrolatum or in the case of preparations such as creams, ointments and lotions, etc., amounts of 0.01 ml / 2 cm2 were used.
Observation periods: Observation and evaluation of the skin reaction was carried out 4.24 and 48 hours after the application of the test material.
Experimental arrangement: A group of 4 guinea pigs was used to determine the tolerance threshold of the individual products to be examined before the induction phase. In order to determine the highest possible concentration, the product to be examined was either undiluted or diluted or suspended in the appropriate solvent at concentrations of 30, 10, 3 and 1% (or even less if necessary) on the flank (0.25 ml / 2 cm2) applied and left uncovered.
Trial phase (induction phase): Both flanks of at least 10 guinea pigs were shaved at least 2 hours before the chemicals were applied. A maximum of 5 circles of 2 cm2 were marked on each flank. Four of these circular areas were used to apply 0.025 ml of alcoholic, acetone or aqueous test solution (highest primarily non-irritating concentration) or 0.01 ml of test solution using other solvents or preparations such as creams, ointments or lotions.
The fifth application site was treated with a 0.1% alcoholic solution of 8-methoxypsoralen in each case and served as a control.
30 minutes after application of the test material, the left flank of each test animal was exposed to non-erythema-producing W-A radiation (20 J / cm 2). The right flank remained unirradiated after the application of the test material and served as a control.
Observation and evaluation: The animals were examined for erythema and edema formation 4, 24 and 48 hours after the application of the test material. The skin reaction was either rated with no reaction, or with +, ie positive reaction.
table
Prevention of phototoxic effects using dibenzoylmethane
Irradiation dose: 20 J UV-A / cm2 dibenzoylmethane O / o 0 0.25 0.5 0.75 1 2 hours after 4 24 48 4 24 48 4 24 48 4 24 48 4 24 48 4 24 48 Application bergamot essence 6% + + + + + - + Lemon Essence 6% + + + + Orange Essence 3% + - - + Lime Essence 15% + - - - - - Caraway Essence 6% + + - + Angelica Essence 6% + - - + Diamond Essence 6% + + + + + - + N-methylanthranylic acid methyl ester 3% + + - + - - + - 5-acetyl-1,1,2,3,3,6-hexamethyl-indane 3% + + + +
Claims (5)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH927/83A CH653255A5 (en) | 1983-02-18 | 1983-02-18 | Perfumes or perfume compositions containing agents to prevent phototoxic reactions |
| IL70825A IL70825A (en) | 1983-02-18 | 1984-01-30 | Method and compositions containing a dibenzoylmethane derivative for the prevention of phototoxic reactions |
| IT8419537A IT1209497B (en) | 1983-02-18 | 1984-02-09 | PROCEDURE FOR PREVENTING PHOTOTOXIC REACTIONS. |
| AU24450/84A AU560945B2 (en) | 1983-02-18 | 1984-02-10 | Odorant compositions comprising 4-(1,1-dimethylethyl)-4- methoxydibenzoyl-methane |
| BR8400693A BR8400693A (en) | 1983-02-18 | 1984-02-16 | COMPOSITION OF ODORIFERING SUBSTANCES |
| ES529843A ES8604713A1 (en) | 1983-02-18 | 1984-02-17 | Prevention of phototoxic reactions caused by odorant substances |
| CA000447775A CA1229795A (en) | 1983-02-18 | 1984-02-17 | Method for the prevention of phototoxic reactions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH927/83A CH653255A5 (en) | 1983-02-18 | 1983-02-18 | Perfumes or perfume compositions containing agents to prevent phototoxic reactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH653255A5 true CH653255A5 (en) | 1985-12-31 |
Family
ID=4198406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH927/83A CH653255A5 (en) | 1983-02-18 | 1983-02-18 | Perfumes or perfume compositions containing agents to prevent phototoxic reactions |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU560945B2 (en) |
| BR (1) | BR8400693A (en) |
| CA (1) | CA1229795A (en) |
| CH (1) | CH653255A5 (en) |
| ES (1) | ES8604713A1 (en) |
| IL (1) | IL70825A (en) |
| IT (1) | IT1209497B (en) |
-
1983
- 1983-02-18 CH CH927/83A patent/CH653255A5/en not_active IP Right Cessation
-
1984
- 1984-01-30 IL IL70825A patent/IL70825A/en not_active IP Right Cessation
- 1984-02-09 IT IT8419537A patent/IT1209497B/en active
- 1984-02-10 AU AU24450/84A patent/AU560945B2/en not_active Expired
- 1984-02-16 BR BR8400693A patent/BR8400693A/en not_active IP Right Cessation
- 1984-02-17 CA CA000447775A patent/CA1229795A/en not_active Expired
- 1984-02-17 ES ES529843A patent/ES8604713A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL70825A (en) | 1989-03-31 |
| CA1229795A (en) | 1987-12-01 |
| BR8400693A (en) | 1984-09-25 |
| AU2445084A (en) | 1984-08-23 |
| ES8604713A1 (en) | 1986-02-16 |
| IT1209497B (en) | 1989-08-30 |
| IT8419537A0 (en) | 1984-02-09 |
| ES529843A0 (en) | 1986-02-16 |
| AU560945B2 (en) | 1987-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE68910435T2 (en) | COSMETIC PROCEDURE USING AN EXTRACT OF THE ABOVE GROUND PARTS OF CICHORIUM INTYBUS L. | |
| DE69100591T2 (en) | COSMETIC PRODUCTS CONTAINING AN EXTRACT OF SUNFLOWER OIL CAKE (HELIANTHUS ANNUUS). | |
| DE2019226B2 (en) | Cosmetic agent | |
| EP0071165A1 (en) | Unsaturated aryl ketones as antiseborrhoeic additives for cosmetic compositions | |
| DE2533467B2 (en) | Sun protection cosmetics | |
| DE3302739A1 (en) | OXIDATION STABLE MEDIUM | |
| DE2734823C2 (en) | Sunscreen | |
| DE60128860T2 (en) | Compositions for inhibiting radically initiated polymerization in the skin and hair | |
| EP0081771B1 (en) | Heterocyclic compounds, their preparation, cosmetic preparations containing them and their use in hair and skin care | |
| DE4033563A1 (en) | New use of furoic and thiophenic acid derivs. - as anti-seborrhoeic agents in prodn. of prepn(s) for treatment of acne, dandruff, etc. | |
| CH653255A5 (en) | Perfumes or perfume compositions containing agents to prevent phototoxic reactions | |
| EP0033075A1 (en) | Substituted 1.8-dihydroxy-9-(10H)-anthracenones, process for their preparation and medicines containing these compounds | |
| DE1568320C3 (en) | Cosmetic active ingredient and cosmetic agent with water-retaining properties n | |
| DE3430166A1 (en) | SHAMPOO FOR PREVENTING HAIR LOSS AND PROMOTING HAIR GROWTH | |
| DE3049123C2 (en) | FATTY ACID ESTER OF 4-ISOPROPYLTROPOLON AND SKIN-BEAUTIFULING, COSMETIC AGENT | |
| DE2526312A1 (en) | Antiburning aromatic ketones of cyclic acetals - used in cosmetic compsns. pref. sun protective compsns. with UV filters | |
| DE3049038C2 (en) | ||
| DE2117372B2 (en) | BACTERICIDE AND FUNGICIDE EFFECTIVE PRODUCTS FROM GRAPEFRUIT PULPEN | |
| DE1492023C3 (en) | Skin care products | |
| DE4134888C2 (en) | Use of an oil bath as a bath additive to promote wound healing | |
| DE69206398T2 (en) | COMPOSITION COMPOSITION. | |
| DE1962969C3 (en) | Light stabilizers | |
| DE3528709A1 (en) | ORAL CARE PRODUCTS | |
| DE4033567A1 (en) | Use of di:carboxylic acid mono:ester(s) | |
| DE863805C (en) | Process for the production of fat-soluble tannin pellets |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PFA | Name/firm changed |
Owner name: GIVAUDAN-ROURE (INTERNATIONAL) S.A., VERNIER-GENEV |
|
| PUE | Assignment |
Owner name: GIVAUDAN-ROURE (INTERNATIONAL) S.A., VERNIER-GENEV |
|
| PL | Patent ceased |