CH622619A5 - Isotonic, osmotically balanced aqueous solution which can be used in haematological determinations - Google Patents
Isotonic, osmotically balanced aqueous solution which can be used in haematological determinations Download PDFInfo
- Publication number
- CH622619A5 CH622619A5 CH391377A CH391377A CH622619A5 CH 622619 A5 CH622619 A5 CH 622619A5 CH 391377 A CH391377 A CH 391377A CH 391377 A CH391377 A CH 391377A CH 622619 A5 CH622619 A5 CH 622619A5
- Authority
- CH
- Switzerland
- Prior art keywords
- sodium
- solution according
- phenoxyethanol
- alkali metal
- solution
- Prior art date
Links
- 230000002489 hematologic effect Effects 0.000 title claims description 5
- 239000007864 aqueous solution Substances 0.000 title claims description 3
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 26
- 239000000243 solution Substances 0.000 claims description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 19
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 17
- 229960005323 phenoxyethanol Drugs 0.000 claims description 17
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 16
- 239000011775 sodium fluoride Substances 0.000 claims description 13
- 235000013024 sodium fluoride Nutrition 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 10
- 235000002639 sodium chloride Nutrition 0.000 claims description 10
- 239000001103 potassium chloride Substances 0.000 claims description 8
- 235000011164 potassium chloride Nutrition 0.000 claims description 8
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 8
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 6
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 6
- 235000019800 disodium phosphate Nutrition 0.000 claims description 6
- 239000001488 sodium phosphate Substances 0.000 claims description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims description 4
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims description 4
- 235000010288 sodium nitrite Nutrition 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- -1 alkali metal salts Chemical class 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims description 2
- 229910001515 alkali metal fluoride Inorganic materials 0.000 claims 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229960001484 edetic acid Drugs 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 description 11
- 102000001554 Hemoglobins Human genes 0.000 description 9
- 108010054147 Hemoglobins Proteins 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000009089 cytolysis Effects 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000000022 bacteriostatic agent Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000003429 antifungal agent Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- CMDLYHXLYMIGIH-UHFFFAOYSA-N C.S.S Chemical compound C.S.S CMDLYHXLYMIGIH-UHFFFAOYSA-N 0.000 description 2
- XMEKHKCRNHDFOW-UHFFFAOYSA-N O.O.[Na].[Na] Chemical compound O.O.[Na].[Na] XMEKHKCRNHDFOW-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 239000012482 calibration solution Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- VUFOSBDICLTFMS-UHFFFAOYSA-M ethyl-hexadecyl-dimethylazanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CC VUFOSBDICLTFMS-UHFFFAOYSA-M 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000001279 citrus aurantifolia swingle expressed oil Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000001046 green dye Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/670,924 US4102810A (en) | 1975-01-13 | 1976-03-26 | Stabilized hematological reagent solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH622619A5 true CH622619A5 (en) | 1981-04-15 |
Family
ID=24692448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH391377A CH622619A5 (en) | 1976-03-26 | 1977-03-25 | Isotonic, osmotically balanced aqueous solution which can be used in haematological determinations |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS52117434A (enExample) |
| AU (1) | AU511980B2 (enExample) |
| BE (1) | BE849701A (enExample) |
| CA (1) | CA1076008A (enExample) |
| CH (1) | CH622619A5 (enExample) |
| DE (1) | DE2709576A1 (enExample) |
| DK (1) | DK62977A (enExample) |
| FI (1) | FI770587A7 (enExample) |
| FR (1) | FR2345164A1 (enExample) |
| GB (1) | GB1572509A (enExample) |
| HK (1) | HK90985A (enExample) |
| IL (1) | IL50858A (enExample) |
| IT (1) | IT1066691B (enExample) |
| MX (1) | MX3977E (enExample) |
| NL (1) | NL7613738A (enExample) |
| NO (1) | NO770897L (enExample) |
| SE (1) | SE7701509L (enExample) |
| ZA (1) | ZA771549B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132598A (en) * | 1977-06-03 | 1979-01-02 | Modrovich Ivan Endre | Stabilized liquid phosphate containing diagnostic compositions and method of preparing same |
| US4346018A (en) | 1980-06-16 | 1982-08-24 | Coulter Electronics, Inc. | Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes |
| US4506018A (en) * | 1982-12-30 | 1985-03-19 | Becton, Dickinson And Company | Blood diluent |
| DE4022878A1 (de) * | 1990-07-18 | 1992-01-23 | Boehringer Mannheim Gmbh | Konservierung von diagnostischen tests |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1493772A (fr) * | 1965-07-28 | 1967-09-01 | Organon Nv | Procédé pour le traitement des érythrocytes |
| US3962125A (en) * | 1975-01-13 | 1976-06-08 | Coulter Diagnostics, Inc. | Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type |
-
1976
- 1976-11-05 CA CA265,047A patent/CA1076008A/en not_active Expired
- 1976-11-05 IL IL50858A patent/IL50858A/xx unknown
- 1976-11-15 IT IT52196/76A patent/IT1066691B/it active
- 1976-11-22 AU AU19871/76A patent/AU511980B2/en not_active Expired
- 1976-11-23 GB GB48832/76A patent/GB1572509A/en not_active Expired
- 1976-11-30 MX MX765179U patent/MX3977E/es unknown
- 1976-12-09 JP JP14720976A patent/JPS52117434A/ja active Pending
- 1976-12-10 NL NL7613738A patent/NL7613738A/xx not_active Application Discontinuation
- 1976-12-21 BE BE6045810A patent/BE849701A/xx unknown
- 1976-12-31 FR FR7639783A patent/FR2345164A1/fr active Granted
-
1977
- 1977-02-10 SE SE7701509A patent/SE7701509L/ not_active Application Discontinuation
- 1977-02-14 DK DK62977A patent/DK62977A/da not_active Application Discontinuation
- 1977-02-23 FI FI770587A patent/FI770587A7/fi not_active Application Discontinuation
- 1977-03-04 DE DE19772709576 patent/DE2709576A1/de not_active Ceased
- 1977-03-14 NO NO770897A patent/NO770897L/no unknown
- 1977-03-15 ZA ZA00771549A patent/ZA771549B/xx unknown
- 1977-03-25 CH CH391377A patent/CH622619A5/fr not_active IP Right Cessation
-
1985
- 1985-11-14 HK HK909/85A patent/HK90985A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2709576A1 (de) | 1977-10-06 |
| AU511980B2 (en) | 1980-09-18 |
| ZA771549B (en) | 1978-10-25 |
| NL7613738A (nl) | 1977-09-28 |
| IL50858A0 (en) | 1977-01-31 |
| GB1572509A (en) | 1980-07-30 |
| SE7701509L (sv) | 1977-09-27 |
| FI770587A7 (enExample) | 1977-09-27 |
| IL50858A (en) | 1979-07-25 |
| BE849701A (fr) | 1977-04-15 |
| FR2345164A1 (fr) | 1977-10-21 |
| JPS52117434A (en) | 1977-10-01 |
| NO770897L (no) | 1977-09-27 |
| HK90985A (en) | 1985-11-22 |
| IT1066691B (it) | 1985-03-12 |
| CA1076008A (en) | 1980-04-22 |
| AU1987176A (en) | 1978-06-01 |
| FR2345164B1 (enExample) | 1982-11-05 |
| MX3977E (es) | 1981-10-20 |
| DK62977A (da) | 1977-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |