CH229791A - Process for the preparation of a new ester. - Google Patents

Process for the preparation of a new ester.

Info

Publication number
CH229791A
CH229791A CH229791DA CH229791A CH 229791 A CH229791 A CH 229791A CH 229791D A CH229791D A CH 229791DA CH 229791 A CH229791 A CH 229791A
Authority
CH
Switzerland
Prior art keywords
preparation
new ester
agent
new
deoxycorticosterone
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH229791A publication Critical patent/CH229791A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines neuen Esters.    Es wurde gefunden, dass man zu einem  neuen Ester des     Desoxycorticosterons    gelan  gen kann, wenn man ein     21-Halogenpregnen-          3,20-dion    mit einem     palmitylierenden    Mittel  behandelt.  



  Geeignete     palmitylierende    Mittel sind  z. B. die Salze der     Palmitinsäure,    wie     Na-          triumpalmitat.     



  Das so gewonnene     Desoxycorticosteron-          palmitat    schmilzt bei 60-61 . Die neue Ver  bindung zeichnet sich durch besonders gün  stige physiologische Wirkung aus und soll  deshalb therapeutische Verwendung finden.  <I>Beispiel:</I>  Zu einer Lösung von 0,5 Teilen     21-Chlor-          pregnen-3,20-dion    in 20 Teilen absolutem  Alkohol wird 1 Teil     Natriumpalmitat    zu  gefügt. Man erwärmt hierauf das Gemisch  bis zur beendeten     Kochsalzabscheidung    und  filtriert. Das durch Wasserzusatz zum Filtrat  ausfallende Reaktionsprodukt wird auf der       Nutsche    mit Wasser gewaschen.

   Man gewinnt    so das     Desoxycorticosteron-palmitat,    das nach  Umkristallisation aus     Petroläther    bei 60-61   schmilzt und eine spezifische Drehung von       [a]        D        +    128  (in Chloroform) aufweist.



  Process for the preparation of a new ester. It has been found that a new ester of deoxycorticosterone can be obtained by treating a 21-halopregnene-3,20-dione with a palmitylating agent.



  Suitable palmitylating agents are e.g. B. the salts of palmitic acid, such as sodium palmitate.



  The deoxycorticosterone palmitate obtained in this way melts at 60-61. The new connection is characterized by a particularly favorable physiological effect and should therefore be used therapeutically. <I> Example: </I> 1 part of sodium palmitate is added to a solution of 0.5 part of 21-chloro-pregnen-3,20-dione in 20 parts of absolute alcohol. The mixture is then heated until the separation of sodium chloride has ended and filtered. The reaction product precipitated by adding water to the filtrate is washed with water on the suction filter.

   The deoxycorticosterone palmitate is obtained in this way, which after recrystallization from petroleum ether melts at 60-61 and has a specific rotation of [a] D + 128 (in chloroform).

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines neuen Esters des Desogycorticosterons, dadurch ge kennzeichnet, dass man ein 21-Halogen- pregnen-3,20-dion mit einem palmitylieren- den Mittel behandelt. Das so gewonnene Desoxycorticosteron- palmitat schmilzt bei 60-61 . Die neue Ver bindung zeichnet sich durch besonders gün stige physiologische Wirkung aus und soll deshalb therapeutische Verwendung finden. PATENT CLAIM: Process for the preparation of a new ester of desogycorticosterone, characterized in that a 21-halogen-pregnen-3,20-dione is treated with a palmitylating agent. The deoxycorticosterone palmitate obtained in this way melts at 60-61. The new connection is characterized by a particularly favorable physiological effect and should therefore be used therapeutically. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass als palmitylierendes Mit tel ein palmitinsaures Salz verwendet wird. SUBSTANTIAL CLAIM: Method according to patent claim, characterized in that a palmitic acid salt is used as palmitylierendes agent.
CH229791D 1938-06-27 1938-06-27 Process for the preparation of a new ester. CH229791A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH222901T 1938-06-27
CH229791T 1938-06-27

Publications (1)

Publication Number Publication Date
CH229791A true CH229791A (en) 1943-11-15

Family

ID=25726663

Family Applications (1)

Application Number Title Priority Date Filing Date
CH229791D CH229791A (en) 1938-06-27 1938-06-27 Process for the preparation of a new ester.

Country Status (1)

Country Link
CH (1) CH229791A (en)

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