CA989845A - Imidazolyl-(2)-carbinols having hypolipidemic action and process for preparing them - Google Patents
Imidazolyl-(2)-carbinols having hypolipidemic action and process for preparing themInfo
- Publication number
- CA989845A CA989845A CA159,944A CA159944A CA989845A CA 989845 A CA989845 A CA 989845A CA 159944 A CA159944 A CA 159944A CA 989845 A CA989845 A CA 989845A
- Authority
- CA
- Canada
- Prior art keywords
- carbinols
- imidazolyl
- preparing
- hypolipidemic action
- hypolipidemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2164919A DE2164919C3 (de) | 1971-12-28 | 1971-12-28 | Imidazolyl-(2)-carbinole, Verfahren zu ihrer Herstellung und pharmazeutische Präparate |
Publications (1)
Publication Number | Publication Date |
---|---|
CA989845A true CA989845A (en) | 1976-05-25 |
Family
ID=5829419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA159,944A Expired CA989845A (en) | 1971-12-28 | 1972-12-27 | Imidazolyl-(2)-carbinols having hypolipidemic action and process for preparing them |
Country Status (16)
Country | Link |
---|---|
US (1) | US4213994A (es) |
JP (1) | JPS4875575A (es) |
KR (1) | KR780000115B1 (es) |
AT (1) | AT330764B (es) |
BE (1) | BE793407A (es) |
CA (1) | CA989845A (es) |
CH (3) | CH615668A5 (es) |
DE (1) | DE2164919C3 (es) |
ES (1) | ES409907A1 (es) |
FR (1) | FR2166117B1 (es) |
GB (1) | GB1421774A (es) |
IL (1) | IL41179A (es) |
NL (1) | NL7217517A (es) |
NO (1) | NO137123C (es) |
SE (1) | SE412388B (es) |
ZA (1) | ZA729141B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE793407A (fr) * | 1971-12-28 | 1973-06-28 | Hoechst Ag | Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation |
JPS4881859A (es) * | 1972-02-04 | 1973-11-01 | ||
FR2292473A1 (fr) * | 1974-11-28 | 1976-06-25 | Expandia Sa | Derives de benzimidazole utiles en tant que medicaments |
FR2467847A1 (fr) * | 1979-10-17 | 1981-04-30 | Bouchara Emile | Nouveaux derives de l'(hydroxybenzyl)-2 benzimidazole et les compositions pharmaceutiques en contenant |
GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
US4348404A (en) | 1980-07-21 | 1982-09-07 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines |
US4372964A (en) * | 1980-10-30 | 1983-02-08 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols |
GB2096987B (en) * | 1981-04-22 | 1984-04-04 | Farmos Oy | Substituted imidazole and imidazole derivatives and their preparation and use |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
US4452987A (en) * | 1981-08-20 | 1984-06-05 | Pfizer Inc. | Haloacetyl imidazoles |
US4532331A (en) * | 1983-04-12 | 1985-07-30 | Smithkline Beckman Corporation | 1-Benzyl-2-aminomethyl imidazole derivatives |
US4661508A (en) * | 1984-06-18 | 1987-04-28 | Eli Lilly And Company | Aromatase inhibiting α,α-diphenyl-4(5)imidazole-methanes or -ethanes |
JPS61145165A (ja) * | 1984-12-18 | 1986-07-02 | Mitsubishi Petrochem Co Ltd | ベンズイミダゾ−ル誘導体の製造法 |
FR2613720B1 (fr) * | 1987-04-10 | 1990-01-19 | Esteve Labor Dr | Derives d'aryl-heteroaryl carbinols avec activite analgesique |
US4869838A (en) * | 1988-08-25 | 1989-09-26 | Exxon Research And Engineering Company | Bis imidazole ethers as metal deactivators |
DE4217124A1 (de) * | 1992-05-23 | 1993-11-25 | Roehm Gmbh | Verfahren zur Herstellung von endständig Stickstoffheterocyclus-substituiertem (Meth)acrylsäureester |
US5455359B1 (en) * | 1993-10-01 | 1998-05-05 | Res Corp Technologies Inc | Metal ion binding monomer and polymer |
WO1998027979A1 (en) * | 1996-12-20 | 1998-07-02 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of microsomal triglyceride transfer protein and method |
CA2375843A1 (en) * | 1999-06-04 | 2000-12-14 | Qi Zhao | Compositions and methods for inhibiting cell death |
DE19951701A1 (de) | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Verwendung von 2-Imidazolyl-substituierten Carbinolen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten |
US6495561B2 (en) | 1999-10-29 | 2002-12-17 | Merck & Co., Inc. | 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists |
US6369076B1 (en) | 1999-10-29 | 2002-04-09 | Merck & Co. Inc. | 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists |
US6432976B1 (en) | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists |
US6489477B1 (en) | 1999-10-29 | 2002-12-03 | Merck & Co., Inc. | 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists |
US6291499B1 (en) | 1999-10-29 | 2001-09-18 | Merck & Co., Inc. | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists |
US6380205B1 (en) | 1999-10-29 | 2002-04-30 | Merck & Co., Inc. | 2-cyclohexyl quinazoline NMDA/NR2B antagonists |
US6316474B1 (en) * | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
ES2402305T3 (es) * | 2006-01-24 | 2013-04-30 | Janssen Pharmaceutica N.V. | Benzimidazolas 2-sustituidas nuevas como moduladores del receptor de andrógeno selectivo (SARMS) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3331739A (en) * | 1961-11-01 | 1967-07-18 | Merck & Co Inc | 2-substituted benzimidazoles and their use in the inhibition of echo 6 and poliomyelitis |
US3652579A (en) * | 1969-06-26 | 1972-03-28 | Hoffmann La Roche | 1-methyl-2-substituted 5-nitroimidazoles |
BE793407A (fr) * | 1971-12-28 | 1973-06-28 | Hoechst Ag | Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation |
US3812189A (en) * | 1972-07-24 | 1974-05-21 | American Cyanamid Co | N-(2,2-diloweralkoxyalkyl)-2,2-dilower-alkoxyloweralkanamidines and their acid addition salts |
-
0
- BE BE793407D patent/BE793407A/xx unknown
-
1971
- 1971-12-28 DE DE2164919A patent/DE2164919C3/de not_active Expired
-
1972
- 1972-12-21 CH CH1866872A patent/CH615668A5/de not_active IP Right Cessation
- 1972-12-21 ES ES409907A patent/ES409907A1/es not_active Expired
- 1972-12-22 NL NL7217517A patent/NL7217517A/xx not_active Application Discontinuation
- 1972-12-26 IL IL41179A patent/IL41179A/xx unknown
- 1972-12-27 AT AT1107972A patent/AT330764B/de not_active IP Right Cessation
- 1972-12-27 CA CA159,944A patent/CA989845A/en not_active Expired
- 1972-12-27 NO NO4779/72A patent/NO137123C/no unknown
- 1972-12-27 SE SE7216999A patent/SE412388B/xx unknown
- 1972-12-27 JP JP48004325A patent/JPS4875575A/ja active Pending
- 1972-12-28 FR FR7246572A patent/FR2166117B1/fr not_active Expired
- 1972-12-28 ZA ZA729141A patent/ZA729141B/xx unknown
- 1972-12-28 GB GB5977272A patent/GB1421774A/en not_active Expired
- 1972-12-28 KR KR7201960A patent/KR780000115B1/ko active
-
1976
- 1976-11-05 CH CH1396976A patent/CH615919A5/de not_active IP Right Cessation
- 1976-11-05 CH CH1397076A patent/CH615920A5/de not_active IP Right Cessation
-
1979
- 1979-01-24 US US06/006,203 patent/US4213994A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GB1421774A (en) | 1976-01-21 |
US4213994A (en) | 1980-07-22 |
AT330764B (de) | 1976-07-26 |
CH615919A5 (es) | 1980-02-29 |
FR2166117A1 (es) | 1973-08-10 |
JPS4875575A (es) | 1973-10-11 |
NL7217517A (es) | 1973-07-02 |
SE412388B (sv) | 1980-03-03 |
DE2164919A1 (de) | 1973-07-12 |
ES409907A1 (es) | 1975-11-16 |
CH615668A5 (es) | 1980-02-15 |
BE793407A (fr) | 1973-06-28 |
DE2164919B2 (de) | 1979-08-09 |
ZA729141B (en) | 1973-09-26 |
CH615920A5 (es) | 1980-02-29 |
KR780000115B1 (en) | 1978-04-15 |
FR2166117B1 (es) | 1977-01-28 |
ATA1107972A (de) | 1975-10-15 |
NO137123B (no) | 1977-09-26 |
NO137123C (no) | 1978-01-04 |
IL41179A0 (en) | 1973-02-28 |
DE2164919C3 (de) | 1980-04-10 |
IL41179A (en) | 1978-06-15 |
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