CA968348A - Racemic prostaglandins - Google Patents

Racemic prostaglandins

Info

Publication number
CA968348A
CA968348A CA075,313A CA75313A CA968348A CA 968348 A CA968348 A CA 968348A CA 75313 A CA75313 A CA 75313A CA 968348 A CA968348 A CA 968348A
Authority
CA
Canada
Prior art keywords
prostaglandins
racemic
racemic prostaglandins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA075,313A
Inventor
William P. Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to CA152,091A priority Critical patent/CA968349A/en
Application granted granted Critical
Publication of CA968348A publication Critical patent/CA968348A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA075,313A 1969-03-14 1970-02-19 Racemic prostaglandins Expired CA968348A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA152,091A CA968349A (en) 1969-03-14 1972-09-19 Racemic prostaglandins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80740569A 1969-03-14 1969-03-14

Publications (1)

Publication Number Publication Date
CA968348A true CA968348A (en) 1975-05-27

Family

ID=25196294

Family Applications (1)

Application Number Title Priority Date Filing Date
CA075,313A Expired CA968348A (en) 1969-03-14 1970-02-19 Racemic prostaglandins

Country Status (10)

Country Link
BE (1) BE747348A (en)
BR (1) BR6915068D0 (en)
CA (1) CA968348A (en)
CH (3) CH553740A (en)
DE (1) DE2011969A1 (en)
ES (1) ES377342A1 (en)
FR (1) FR2034951B1 (en)
GB (2) GB1282661A (en)
IL (1) IL33949A (en)
NL (1) NL7003298A (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008263A (en) * 1969-03-14 1977-02-15 The Upjohn Company Racemic fluoro-substituted PGF2 .sub.α analogs
US3983153A (en) * 1969-03-14 1976-09-28 The Upjohn Company Racemic fluoro-substituted PGE2 analogs
US3993687A (en) * 1969-03-14 1976-11-23 The Upjohn Company Racemic fluoro-substituted PGB2 analogs
US3940438A (en) * 1971-05-24 1976-02-24 Alza Corporation Crystalline racemic 9α,11α,15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid
US3988361A (en) * 1971-11-16 1976-10-26 The Upjohn Company 8β-PGE2 and related compounds
GB1396207A (en) * 1972-04-27 1975-06-04 Upjohn Co Prostaglandin intermediates and the preparation thereof
US4056555A (en) * 1975-02-24 1977-11-01 The Upjohn Company 2,2-Difluoro-16-phenoxy-PGA2 analogs
US4059614A (en) * 1975-02-24 1977-11-22 The Upjohn Company 2,2-Difluoro-16-phenoxy-PGE1 analogs
US4001300A (en) * 1975-02-24 1977-01-04 The Upjohn Company 2,2-Difluoro-16-phenoxy-PGF2 analogs
US4056557A (en) * 1975-02-24 1977-11-01 The Upjohn Company 2,2-Difluoro-16-phenoxy-PGF1 analogs
US4056554A (en) * 1975-02-24 1977-11-01 The Upjohn Company 2,2-Difluoro-16-phenoxy-13,14-dihydro-PGF1, analogs
US4056556A (en) * 1975-02-24 1977-11-01 The Upjohn Company 2,2-Difluoro-16-phenoxy-PGE2 analogs
US4053502A (en) * 1975-10-02 1977-10-11 The Upjohn Company 4,4,5,5-Tetradehydro-ω-aryl-PGE1 analogs
US4013695A (en) * 1975-10-02 1977-03-22 The Upjohn Company 4,4,5,5-Tetradehydro-PGE1 analogs
US4053500A (en) * 1975-10-02 1977-10-11 The Upjohn Company 4,4,5,5-Tetradehydro-ω-aryl-PGF1α analogs
US5990168A (en) * 1996-04-18 1999-11-23 Alberta Cancer Board Methods and compositions for the treatment of ataxia telangiectasia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3069322A (en) * 1958-05-28 1962-12-18 Bergstrom Sune Pge and pgf

Also Published As

Publication number Publication date
CH553740A (en) 1974-09-13
CH553739A (en) 1974-09-13
IL33949A0 (en) 1970-05-21
GB1282662A (en) 1972-07-19
IL33949A (en) 1976-06-30
FR2034951B1 (en) 1974-02-01
BR6915068D0 (en) 1973-05-24
FR2034951A1 (en) 1970-12-18
BE747348A (en) 1970-09-14
GB1282661A (en) 1972-07-19
DE2011969A1 (en) 1970-10-08
ES377342A1 (en) 1973-01-01
NL7003298A (en) 1970-09-16
CH549549A (en) 1974-05-31

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