CA954522A - Amidine derivatives - Google Patents

Amidine derivatives

Info

Publication number
CA954522A
CA954522A CA096,672A CA96672A CA954522A CA 954522 A CA954522 A CA 954522A CA 96672 A CA96672 A CA 96672A CA 954522 A CA954522 A CA 954522A
Authority
CA
Canada
Prior art keywords
amidine derivatives
amidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA096,672A
Other languages
English (en)
Other versions
CA96672S (en
Inventor
John C. Emmett
James W. Black
Charon R. Ganellin
Graham J. Durant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Priority to CA126,676A priority Critical patent/CA945171A/en
Priority to CA126,677A priority patent/CA983853A/en
Application granted granted Critical
Publication of CA954522A publication Critical patent/CA954522A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA096,672A 1969-10-29 1970-10-27 Amidine derivatives Expired CA954522A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA126,676A CA945171A (en) 1969-10-29 1971-11-02 Thioureas and their production
CA126,677A CA983853A (en) 1969-10-29 1971-11-02 Composition containing guanidine derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5289169 1969-10-29
US8081970A 1970-10-14 1970-10-14
US33054873A 1973-02-08 1973-02-08
US478999A US3881015A (en) 1969-10-29 1974-06-13 Pharmaceutical compositions and methods of inhibiting histamine activity with isothiourea compounds

Publications (1)

Publication Number Publication Date
CA954522A true CA954522A (en) 1974-09-10

Family

ID=27449031

Family Applications (1)

Application Number Title Priority Date Filing Date
CA096,672A Expired CA954522A (en) 1969-10-29 1970-10-27 Amidine derivatives

Country Status (9)

Country Link
US (2) US3736331A (cs)
BE (1) BE758146A (cs)
CA (1) CA954522A (cs)
CH (2) CH544087A (cs)
DE (1) DE2053175A1 (cs)
FR (1) FR2070178B1 (cs)
GB (1) GB1305546A (cs)
NL (1) NL7015660A (cs)
SE (1) SE390967B (cs)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048319A (en) * 1969-10-29 1977-09-13 Smith Kline & French Laboratories Limited Method of inhibiting histamine activity with quanidine compounds
US3905984A (en) * 1971-03-09 1975-09-16 Smith Kline French Lab Pyridyl substituted thioalkyl-and oxyalkyl-thioureas and ureas
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4230865A (en) * 1971-03-09 1980-10-28 Smith Kline & French Laboratories Limited Pharmacologically active triazole and thiadiazole thiourea and urea compounds
US4137234A (en) * 1971-03-09 1979-01-30 Smith Kline & French Laboratories Limited Thiazole, isothiazole, oxazole and isoxazole substituted thiourea and urea compounds
US4069327A (en) * 1971-03-09 1978-01-17 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds as inhibitors of H-2 histamine receptors
US4027026A (en) * 1971-03-09 1977-05-31 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting H-2 histamine receptors with pyridyl substituted thioalkyl- and oxyalkyl-thioureas and ureas
US4053473A (en) * 1971-07-22 1977-10-11 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
US4049672A (en) * 1971-03-09 1977-09-20 Smith Kline & French Laboratories Limited 4-Methyl-5-imidazolylmethylthioethylamine and -S-methylisothiourea
US4018931A (en) * 1971-03-09 1977-04-19 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
US4180583A (en) * 1972-01-28 1979-12-25 Richardson-Merrell Inc. Olefinic 4-substituted piperidino derivatives as therapeutics
US3954982A (en) * 1972-04-20 1976-05-04 Smith Kline & French Laboratories Limited Pharmaceutical compositions and method of inhibiting H-1 and H-2 histamine receptors
US4083988A (en) * 1972-09-05 1978-04-11 Smith Kline & French Laboratories Limited Pharmacologically active compounds
US3971786A (en) * 1972-09-05 1976-07-27 Smith Kline & French Laboratories Limited Pyridyl alkylguanidine compounds, composition therewith, and methods of inhibiting H-2 histamine receptors
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1398426A (en) * 1972-09-05 1975-06-18 Smith Kline French Lab Heterocyclic substituted guanidines
GB1421999A (en) * 1973-02-08 1976-01-21 Smith Kline French Lab Heterocyclic containing sulphoxides
US3979398A (en) * 1973-02-08 1976-09-07 Smith Kline & French Laboratories Limited Sulphoxides
GB1444558A (en) * 1973-02-17 1976-08-04 Beecham Group Ltd Pyridylthioureas
US4399142A (en) * 1973-05-03 1983-08-16 Smith Kline & French Laboratories Limited Pharmacologically active compounds
US4470985A (en) * 1973-05-03 1984-09-11 Smithkline & French Laboratories Limited Pharmacologically active compounds
US4537779A (en) * 1973-05-03 1985-08-27 Smith Kline & French Laboratories Limited Pharmacologically active compounds
US4341787A (en) * 1973-05-03 1982-07-27 Smith Kline & French Laboratories Limited Pharmacologically active compounds
US4600720A (en) * 1973-05-03 1986-07-15 Smith Kline & French Laboratories Ltd. Pharmacologically active compounds
US4002759A (en) * 1973-05-17 1977-01-11 Smith Kline & French Laboratories Limited Pyridylbutylamino ethylene compounds
US4024260A (en) * 1973-05-17 1977-05-17 Smith Kline & French Laboratories Limited Ethylene derivatives
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4152443A (en) * 1973-07-13 1979-05-01 Smith Kline & French Laboratories Limited Imidazolyl thioureas, ureas and guanidines
US4025527A (en) * 1973-07-13 1977-05-24 Smith Kline & French Laboratories Limited Certain thiazoles and oxazoles
GB1431589A (en) * 1973-07-13 1976-04-07 Smith Kline French Lab Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
US4215125A (en) * 1973-07-13 1980-07-29 Smith Kline & French Laboratories Limited Pyridyl ureas, thioureas and guanidines
US4013659A (en) * 1973-07-13 1977-03-22 Smith Kline & French Laboratories Limited Certain n,n'-disubstituted guanidine compounds and their use
US4191769A (en) * 1974-03-12 1980-03-04 Smith Kline & French Laboratories Limited Isothiourea compounds and pharmacological use
GB1496787A (en) * 1974-03-12 1978-01-05 Smith Kline French Lab Heteroalkylthioalkyl amidine derivatives
US4118496A (en) * 1974-03-12 1978-10-03 Smith Kline & French Laboratories Limited Heterocyclic-methylthioalkyl-amidines
US4013769A (en) * 1974-05-09 1977-03-22 Smith Kline & French Laboratories Limited Pyridyl-alkylaminoethylene compounds
IE42214B1 (en) * 1974-06-18 1980-07-02 Smith Kline French Lab Hydrazinopyredazines
GB1497260A (en) * 1974-06-28 1978-01-05 Smith Kline French Lab Guanidine derivatives
US4160030A (en) * 1974-06-28 1979-07-03 Smith Kline & French Laboratories Limited N-oxy and N-amino guanidines
US4090026A (en) * 1974-09-02 1978-05-16 Smith Kline & French Laboratories Limited Certain nitrogen heterocyclic isothiocyanate esters
US4120966A (en) * 1975-02-03 1978-10-17 Smith Kline & French Laboratories Limited Heterocyclic-methylthioethyl-dithiocarbamates and isothioureas
GB1542840A (en) * 1975-02-03 1979-03-28 Smith Kline French Lab Heterocyclic dithiocarbamates and isothioureas
US4129657A (en) * 1975-03-21 1978-12-12 Smith, Kline & French Laboratories Limited Imidazole guanidines and use as inhibitors of histamine activity
US4080459A (en) * 1975-11-05 1978-03-21 Smith Kline & French Laboratories Limited Pyridyl-alkylaminoethylene compounds
US4067984A (en) * 1975-11-05 1978-01-10 Smith Kline & French Laboratories Limited Pyridylbutylamino ethylene compounds
US4082843A (en) * 1975-11-26 1978-04-04 Smith Kline & French Laboratories Limited 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents
GB1574214A (en) 1976-03-11 1980-09-03 Smith Kline French Lab Amidines
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
US4210658A (en) * 1977-09-08 1980-07-01 Smith Kline & French Laboratories Limited Amidinosulphonic acid derivatives
EP0006679B1 (en) 1978-05-24 1982-07-21 Imperial Chemical Industries Plc Antisecretory thiadiazole derivatives, processes for their manufacture and pharmaceutical compositions containing them
ZA792608B (en) * 1978-05-30 1980-06-25 Smith Kline French Lab Nitro compounds
US4324789A (en) * 1978-05-30 1982-04-13 Smith Kline & French Laboratories Limited 1-Benzyl-5-nitro-4-(pyridyl or imidazolyl) alkylamino-1,2,3,6-tetrahydropyrimidines and blocking of histamine H2
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4242351A (en) * 1979-05-07 1980-12-30 Imperial Chemical Industries Limited Antisecretory oxadiazoles and pharmaceutical compositions containing them
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
DE3579000D1 (de) * 1985-04-02 1990-09-06 Heumann Pharma Gmbh & Co Imidazolylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3726381A1 (de) * 1987-08-07 1989-02-16 Heumann Pharma Gmbh & Co Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
NL8800998A (nl) * 1988-04-18 1989-11-16 Cedona Pharm Bv Werkwijze voor het bereiden van een al of niet gesubstitueerd 4(5)-(omega-aminoalkyl) imidazool.
US20030203944A1 (en) * 2000-08-21 2003-10-30 Suh Young Ger Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same
GB0404434D0 (en) * 2004-02-27 2004-03-31 Novartis Ag Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6501742A (cs) * 1964-02-19 1965-08-20
US3399197A (en) * 1966-04-05 1968-08-27 Richardson Merrell Inc Alkylguanidines
US3558640A (en) * 1967-12-20 1971-01-26 Merck & Co Inc Certain pyridyl and thiazolyl methylthiopropionic acids and derivatives

Also Published As

Publication number Publication date
FR2070178B1 (cs) 1975-08-01
US3736331A (en) 1973-05-29
CH529751A (fr) 1972-10-31
DE2053175A1 (de) 1971-07-08
SE390967B (sv) 1977-01-31
FR2070178A1 (cs) 1971-09-10
BE758146A (fr) 1971-04-28
US3881015A (en) 1975-04-29
CH544087A (fr) 1973-12-28
NL7015660A (cs) 1971-05-04
GB1305546A (cs) 1973-02-07

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