CA3251997A1 - IMIDAZOPYRIDINES AND SUBSTITUTE IMIDAZOPYRIMIDINES, AND THEIR USE FOR THE TREATMENT, MITIGATION AND/OR PREVENTION OF RETINAL DEGENERATION - Google Patents

IMIDAZOPYRIDINES AND SUBSTITUTE IMIDAZOPYRIMIDINES, AND THEIR USE FOR THE TREATMENT, MITIGATION AND/OR PREVENTION OF RETINAL DEGENERATION

Info

Publication number
CA3251997A1
CA3251997A1 CA3251997A CA3251997A CA3251997A1 CA 3251997 A1 CA3251997 A1 CA 3251997A1 CA 3251997 A CA3251997 A CA 3251997A CA 3251997 A CA3251997 A CA 3251997A CA 3251997 A1 CA3251997 A1 CA 3251997A1
Authority
CA
Canada
Prior art keywords
compound
certain embodiments
subject
group
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3251997A
Other languages
English (en)
French (fr)
Inventor
Mark Fields
Denton Hoyer
Lucian Del Priore
Huey Cai
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of CA3251997A1 publication Critical patent/CA3251997A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA3251997A 2022-05-04 2023-05-04 IMIDAZOPYRIDINES AND SUBSTITUTE IMIDAZOPYRIMIDINES, AND THEIR USE FOR THE TREATMENT, MITIGATION AND/OR PREVENTION OF RETINAL DEGENERATION Pending CA3251997A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263338264P 2022-05-04 2022-05-04
US63/338,264 2022-05-04
US202263411405P 2022-09-29 2022-09-29
US63/411,405 2022-09-29
PCT/US2023/020978 WO2023215465A1 (en) 2022-05-04 2023-05-04 Substituted imidazopyridines and imidazopyrimidines, and use of same for treating, ameliorating, and/or preventing retinal degeneration

Publications (1)

Publication Number Publication Date
CA3251997A1 true CA3251997A1 (en) 2023-11-09

Family

ID=88647025

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3251997A Pending CA3251997A1 (en) 2022-05-04 2023-05-04 IMIDAZOPYRIDINES AND SUBSTITUTE IMIDAZOPYRIMIDINES, AND THEIR USE FOR THE TREATMENT, MITIGATION AND/OR PREVENTION OF RETINAL DEGENERATION

Country Status (7)

Country Link
US (1) US20250288588A1 (cg-RX-API-DMAC10.html)
EP (1) EP4519268A1 (cg-RX-API-DMAC10.html)
JP (1) JP2025516315A (cg-RX-API-DMAC10.html)
CN (1) CN119487033A (cg-RX-API-DMAC10.html)
AU (1) AU2023265523A1 (cg-RX-API-DMAC10.html)
CA (1) CA3251997A1 (cg-RX-API-DMAC10.html)
WO (1) WO2023215465A1 (cg-RX-API-DMAC10.html)

Also Published As

Publication number Publication date
EP4519268A1 (en) 2025-03-12
JP2025516315A (ja) 2025-05-27
WO2023215465A1 (en) 2023-11-09
US20250288588A1 (en) 2025-09-18
AU2023265523A1 (en) 2024-11-21
CN119487033A (zh) 2025-02-18

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