CA3241703A1 - Enzymes ayant des domaines ruvc - Google Patents
Enzymes ayant des domaines ruvcInfo
- Publication number
- CA3241703A1 CA3241703A1 CA3241703A CA3241703A CA3241703A1 CA 3241703 A1 CA3241703 A1 CA 3241703A1 CA 3241703 A CA3241703 A CA 3241703A CA 3241703 A CA3241703 A CA 3241703A CA 3241703 A1 CA3241703 A1 CA 3241703A1
- Authority
- CA
- Canada
- Prior art keywords
- enzymes
- ruvc domains
- ruvc
- domains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962805878P | 2019-02-14 | 2019-02-14 | |
| US201962805868P | 2019-02-14 | 2019-02-14 | |
| US201962805899P | 2019-02-14 | 2019-02-14 | |
| US62/805,899 | 2019-02-14 | ||
| US62/805,878 | 2019-02-14 | ||
| US62/805,868 | 2019-02-14 | ||
| US201962874414P | 2019-07-15 | 2019-07-15 | |
| US62/874,414 | 2019-07-15 | ||
| CA3130135A CA3130135A1 (fr) | 2019-02-14 | 2020-02-14 | Enzymes ayant des domaines ruvc |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3130135A Division CA3130135A1 (fr) | 2019-02-14 | 2020-02-14 | Enzymes ayant des domaines ruvc |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3241703A1 true CA3241703A1 (fr) | 2020-08-20 |
Family
ID=72045639
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3241703A Pending CA3241703A1 (fr) | 2019-02-14 | 2020-02-14 | Enzymes ayant des domaines ruvc |
| CA3130135A Pending CA3130135A1 (fr) | 2019-02-14 | 2020-02-14 | Enzymes ayant des domaines ruvc |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3130135A Pending CA3130135A1 (fr) | 2019-02-14 | 2020-02-14 | Enzymes ayant des domaines ruvc |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240117330A1 (fr) |
| EP (1) | EP3924482A4 (fr) |
| JP (2) | JP2022520428A (fr) |
| KR (2) | KR20240007322A (fr) |
| CN (2) | CN116515797A (fr) |
| AU (2) | AU2020223370B2 (fr) |
| CA (2) | CA3241703A1 (fr) |
| MX (2) | MX2021009886A (fr) |
| WO (1) | WO2020168291A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3241703A1 (fr) | 2019-02-14 | 2020-08-20 | Metagenomi, Inc. | Enzymes ayant des domaines ruvc |
| US10913941B2 (en) | 2019-02-14 | 2021-02-09 | Metagenomi Ip Technologies, Llc | Enzymes with RuvC domains |
| GB2617659B (en) * | 2020-02-14 | 2024-05-01 | Metagenomi Inc | Enzymes with RuvC domains |
| MX2022011039A (es) | 2020-03-06 | 2022-12-13 | Metagenomi Inc | Sistemas crispr clase ii tipo v. |
| CA3177051A1 (fr) | 2020-03-31 | 2021-10-07 | Metagenomi, Inc. | Systemes crispr de classe ii, type ii |
| WO2022056301A1 (fr) * | 2020-09-11 | 2022-03-17 | Metagenomi Ip Technologies, Llc | Enzymes d'édition de bases |
| WO2022098681A2 (fr) * | 2020-11-03 | 2022-05-12 | Caspr Biotech Corporation | Nouvelles endonucléases guidées par un arn crispr-cas de classe 2 |
| WO2022159742A1 (fr) * | 2021-01-22 | 2022-07-28 | Metagenomi, Inc | Nouvelles nucléases modifiées et chimériques |
| WO2022159758A1 (fr) * | 2021-01-22 | 2022-07-28 | Metagenomi, Inc | Nouvelles nucléases ingéniérisées et chimériques |
| WO2022232638A2 (fr) * | 2021-04-30 | 2022-11-03 | Metagenomi, Inc. | Enzymes à domaines ruvc |
| WO2023122663A2 (fr) * | 2021-12-23 | 2023-06-29 | Mammoth Biosciences, Inc. | Protéines effectrices et procédés d'utilisation |
| WO2023194359A1 (fr) * | 2022-04-04 | 2023-10-12 | Alia Therapeutics Srl | Compositions et méthodes de traitement du syndrome d'usher de type 2a |
| WO2023245141A2 (fr) * | 2022-06-15 | 2023-12-21 | Beam Therapeutics Inc. | Compositions et procédés pour réduire l'activation du complément |
| WO2024056880A2 (fr) * | 2022-09-16 | 2024-03-21 | Alia Therapeutics Srl | Protéines cas de type ii enqp et leurs applications |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2898075E (pt) * | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições de enzima melhorados para manipulação de sequências |
| EP3303634B1 (fr) * | 2015-06-03 | 2023-08-30 | The Regents of The University of California | Variants de cas9 et procédés d'utilisation associés |
| WO2016205759A1 (fr) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Modification et optimisation de systèmes, de méthodes, d'enzymes et d'échafaudages guides d'orthologues de cas9 et variant pour la manipulation de séquences |
| US20210166783A1 (en) * | 2016-08-17 | 2021-06-03 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
| US20220010293A1 (en) * | 2018-02-23 | 2022-01-13 | Pioneer Hi-Bred International, Inc. | Novel cas9 orthologs |
| CA3241703A1 (fr) | 2019-02-14 | 2020-08-20 | Metagenomi, Inc. | Enzymes ayant des domaines ruvc |
-
2020
- 2020-02-14 CA CA3241703A patent/CA3241703A1/fr active Pending
- 2020-02-14 CN CN202310441977.6A patent/CN116515797A/zh active Pending
- 2020-02-14 WO PCT/US2020/018432 patent/WO2020168291A1/fr unknown
- 2020-02-14 EP EP20756259.6A patent/EP3924482A4/fr active Pending
- 2020-02-14 KR KR1020247000311A patent/KR20240007322A/ko active Search and Examination
- 2020-02-14 CA CA3130135A patent/CA3130135A1/fr active Pending
- 2020-02-14 AU AU2020223370A patent/AU2020223370B2/en active Active
- 2020-02-14 KR KR1020217028874A patent/KR102623312B1/ko active IP Right Grant
- 2020-02-14 CN CN202080028787.6A patent/CN113728098A/zh active Pending
- 2020-02-14 MX MX2021009886A patent/MX2021009886A/es unknown
- 2020-02-14 JP JP2021547336A patent/JP2022520428A/ja not_active Ceased
-
2021
- 2021-08-16 MX MX2023006575A patent/MX2023006575A/es unknown
-
2023
- 2023-06-15 US US18/335,481 patent/US20240117330A1/en active Pending
- 2023-07-17 AU AU2023206079A patent/AU2023206079A1/en active Pending
- 2023-09-08 JP JP2023146414A patent/JP7502537B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN116515797A (zh) | 2023-08-01 |
| EP3924482A4 (fr) | 2023-04-05 |
| AU2023206079A1 (en) | 2023-08-10 |
| MX2021009886A (es) | 2021-10-13 |
| EP3924482A1 (fr) | 2021-12-22 |
| MX2023006575A (es) | 2023-06-16 |
| CA3130135A1 (fr) | 2020-08-20 |
| KR102623312B1 (ko) | 2024-01-09 |
| WO2020168291A1 (fr) | 2020-08-20 |
| KR20240007322A (ko) | 2024-01-16 |
| CN113728098A (zh) | 2021-11-30 |
| US20240117330A1 (en) | 2024-04-11 |
| JP7502537B2 (ja) | 2024-06-18 |
| JP2022520428A (ja) | 2022-03-30 |
| JP2023179468A (ja) | 2023-12-19 |
| AU2020223370B2 (en) | 2023-04-20 |
| KR20210139254A (ko) | 2021-11-22 |
| AU2020223370A1 (en) | 2021-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20240614 |