CA3233737A1 - Traitement de l'hypertension - Google Patents
Traitement de l'hypertension Download PDFInfo
- Publication number
- CA3233737A1 CA3233737A1 CA3233737A CA3233737A CA3233737A1 CA 3233737 A1 CA3233737 A1 CA 3233737A1 CA 3233737 A CA3233737 A CA 3233737A CA 3233737 A CA3233737 A CA 3233737A CA 3233737 A1 CA3233737 A1 CA 3233737A1
- Authority
- CA
- Canada
- Prior art keywords
- signal
- renal artery
- stimulation
- external device
- implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010020772 Hypertension Diseases 0.000 title claims abstract description 58
- 238000011282 treatment Methods 0.000 title description 37
- 230000000638 stimulation Effects 0.000 claims abstract description 624
- 210000002254 renal artery Anatomy 0.000 claims abstract description 494
- 210000001519 tissue Anatomy 0.000 claims abstract description 358
- 230000024883 vasodilation Effects 0.000 claims abstract description 123
- 210000002460 smooth muscle Anatomy 0.000 claims abstract description 52
- 230000001457 vasomotor Effects 0.000 claims abstract description 50
- 238000004891 communication Methods 0.000 claims description 549
- 239000007943 implant Substances 0.000 claims description 337
- 238000013016 damping Methods 0.000 claims description 269
- 230000036772 blood pressure Effects 0.000 claims description 202
- 210000005036 nerve Anatomy 0.000 claims description 144
- 238000000576 coating method Methods 0.000 claims description 119
- 239000011248 coating agent Substances 0.000 claims description 110
- 230000005540 biological transmission Effects 0.000 claims description 69
- 239000012620 biological material Substances 0.000 claims description 54
- 210000004369 blood Anatomy 0.000 claims description 52
- 239000008280 blood Substances 0.000 claims description 52
- 210000000278 spinal cord Anatomy 0.000 claims description 48
- 229910052751 metal Inorganic materials 0.000 claims description 45
- 239000002184 metal Substances 0.000 claims description 45
- 238000012545 processing Methods 0.000 claims description 44
- 102000009123 Fibrin Human genes 0.000 claims description 37
- 108010073385 Fibrin Proteins 0.000 claims description 37
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 37
- 229950003499 fibrin Drugs 0.000 claims description 37
- 210000005037 parasympathetic nerve Anatomy 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 26
- 230000009885 systemic effect Effects 0.000 claims description 26
- 239000003146 anticoagulant agent Substances 0.000 claims description 25
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 24
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims description 24
- 230000000844 anti-bacterial effect Effects 0.000 claims description 16
- 238000003780 insertion Methods 0.000 claims description 16
- 230000037431 insertion Effects 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 16
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 15
- 230000002785 anti-thrombosis Effects 0.000 claims description 14
- 239000010936 titanium Substances 0.000 claims description 14
- 229910052719 titanium Inorganic materials 0.000 claims description 14
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 12
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 12
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 12
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 12
- 229910017052 cobalt Inorganic materials 0.000 claims description 12
- 239000010941 cobalt Substances 0.000 claims description 12
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 12
- 229910052802 copper Inorganic materials 0.000 claims description 12
- 239000010949 copper Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 229910052750 molybdenum Inorganic materials 0.000 claims description 12
- 239000011733 molybdenum Substances 0.000 claims description 12
- 229910052759 nickel Inorganic materials 0.000 claims description 12
- 229910052718 tin Inorganic materials 0.000 claims description 12
- 229910052725 zinc Inorganic materials 0.000 claims description 12
- 239000011701 zinc Substances 0.000 claims description 12
- 229910052726 zirconium Inorganic materials 0.000 claims description 12
- 230000000702 anti-platelet effect Effects 0.000 claims description 11
- 239000011148 porous material Substances 0.000 claims description 11
- 230000001131 transforming effect Effects 0.000 claims description 10
- 230000001734 parasympathetic effect Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 description 214
- 210000004204 blood vessel Anatomy 0.000 description 161
- 238000004146 energy storage Methods 0.000 description 135
- 230000004044 response Effects 0.000 description 108
- 230000006870 function Effects 0.000 description 105
- 239000010410 layer Substances 0.000 description 100
- 230000035807 sensation Effects 0.000 description 81
- 210000003205 muscle Anatomy 0.000 description 74
- 238000010438 heat treatment Methods 0.000 description 61
- 230000001965 increasing effect Effects 0.000 description 53
- 238000012795 verification Methods 0.000 description 49
- 238000012546 transfer Methods 0.000 description 45
- 210000004027 cell Anatomy 0.000 description 41
- 230000001276 controlling effect Effects 0.000 description 38
- 238000005259 measurement Methods 0.000 description 38
- 230000017531 blood circulation Effects 0.000 description 37
- 210000001367 artery Anatomy 0.000 description 34
- 239000012530 fluid Substances 0.000 description 34
- 108091006146 Channels Proteins 0.000 description 32
- 206010047139 Vasoconstriction Diseases 0.000 description 30
- 230000008859 change Effects 0.000 description 30
- 230000025033 vasoconstriction Effects 0.000 description 30
- 210000003734 kidney Anatomy 0.000 description 28
- 230000007246 mechanism Effects 0.000 description 27
- 230000003387 muscular Effects 0.000 description 26
- 230000002829 reductive effect Effects 0.000 description 26
- 210000003815 abdominal wall Anatomy 0.000 description 25
- 230000036982 action potential Effects 0.000 description 22
- 230000002792 vascular Effects 0.000 description 22
- 230000009471 action Effects 0.000 description 21
- 238000012790 confirmation Methods 0.000 description 21
- 230000000694 effects Effects 0.000 description 21
- 210000004303 peritoneum Anatomy 0.000 description 20
- 230000003176 fibrotic effect Effects 0.000 description 18
- 230000001939 inductive effect Effects 0.000 description 18
- 238000010168 coupling process Methods 0.000 description 17
- 238000006243 chemical reaction Methods 0.000 description 16
- 230000008602 contraction Effects 0.000 description 16
- 230000008878 coupling Effects 0.000 description 16
- 238000005859 coupling reaction Methods 0.000 description 16
- 238000005516 engineering process Methods 0.000 description 16
- 230000003287 optical effect Effects 0.000 description 16
- 230000004913 activation Effects 0.000 description 15
- 230000010339 dilation Effects 0.000 description 15
- 210000000056 organ Anatomy 0.000 description 15
- 230000008569 process Effects 0.000 description 15
- 239000004020 conductor Substances 0.000 description 14
- 230000036541 health Effects 0.000 description 14
- 238000002513 implantation Methods 0.000 description 14
- 239000000463 material Substances 0.000 description 13
- 210000000663 muscle cell Anatomy 0.000 description 13
- 230000036581 peripheral resistance Effects 0.000 description 13
- 239000000523 sample Substances 0.000 description 13
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 13
- 210000000709 aorta Anatomy 0.000 description 12
- 230000006378 damage Effects 0.000 description 12
- 230000003247 decreasing effect Effects 0.000 description 12
- 238000003825 pressing Methods 0.000 description 12
- 230000001902 propagating effect Effects 0.000 description 12
- 238000003860 storage Methods 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 10
- 230000007423 decrease Effects 0.000 description 10
- 210000003195 fascia Anatomy 0.000 description 10
- 230000033001 locomotion Effects 0.000 description 10
- 230000004936 stimulating effect Effects 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 9
- 239000003990 capacitor Substances 0.000 description 9
- 239000002775 capsule Substances 0.000 description 9
- 230000006866 deterioration Effects 0.000 description 9
- 230000007774 longterm Effects 0.000 description 9
- 208000007536 Thrombosis Diseases 0.000 description 8
- 238000006073 displacement reaction Methods 0.000 description 8
- 230000000630 rising effect Effects 0.000 description 8
- 230000002889 sympathetic effect Effects 0.000 description 8
- 206010016654 Fibrosis Diseases 0.000 description 7
- 210000001015 abdomen Anatomy 0.000 description 7
- 239000000560 biocompatible material Substances 0.000 description 7
- 239000000835 fiber Substances 0.000 description 7
- 230000004761 fibrosis Effects 0.000 description 7
- 238000007912 intraperitoneal administration Methods 0.000 description 7
- 150000002739 metals Chemical class 0.000 description 7
- 206010033675 panniculitis Diseases 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000012781 shape memory material Substances 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 210000004304 subcutaneous tissue Anatomy 0.000 description 7
- 210000000707 wrist Anatomy 0.000 description 7
- 239000003989 dielectric material Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000010304 firing Methods 0.000 description 6
- 210000000609 ganglia Anatomy 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 210000004126 nerve fiber Anatomy 0.000 description 6
- 230000007383 nerve stimulation Effects 0.000 description 6
- 210000002569 neuron Anatomy 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- 230000008467 tissue growth Effects 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- 108010049003 Fibrinogen Proteins 0.000 description 5
- 102000008946 Fibrinogen Human genes 0.000 description 5
- 208000005422 Foreign-Body reaction Diseases 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 210000003050 axon Anatomy 0.000 description 5
- 210000002808 connective tissue Anatomy 0.000 description 5
- 238000005265 energy consumption Methods 0.000 description 5
- 229940012952 fibrinogen Drugs 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 230000000977 initiatory effect Effects 0.000 description 5
- 238000009434 installation Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 239000002858 neurotransmitter agent Substances 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 238000002604 ultrasonography Methods 0.000 description 5
- 238000011144 upstream manufacturing Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 108090000783 Renin Proteins 0.000 description 4
- 230000003187 abdominal effect Effects 0.000 description 4
- 210000003489 abdominal muscle Anatomy 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 229910010293 ceramic material Inorganic materials 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000007599 discharging Methods 0.000 description 4
- 230000004064 dysfunction Effects 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 230000001788 irregular Effects 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 230000007257 malfunction Effects 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000000737 periodic effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 230000011664 signaling Effects 0.000 description 4
- 230000008093 supporting effect Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 210000002820 sympathetic nervous system Anatomy 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 230000000451 tissue damage Effects 0.000 description 4
- 231100000827 tissue damage Toxicity 0.000 description 4
- 230000001960 triggered effect Effects 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010070245 Foreign body Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 102100028255 Renin Human genes 0.000 description 3
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 description 3
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000002238 attenuated effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 3
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 210000003451 celiac plexus Anatomy 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 230000008867 communication pathway Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000035487 diastolic blood pressure Effects 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 210000002683 foot Anatomy 0.000 description 3
- 230000003054 hormonal effect Effects 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000004118 muscle contraction Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 230000008520 organization Effects 0.000 description 3
- 230000010355 oscillation Effects 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000002027 skeletal muscle Anatomy 0.000 description 3
- 210000002363 skeletal muscle cell Anatomy 0.000 description 3
- 210000002466 splanchnic nerve Anatomy 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- 210000003932 urinary bladder Anatomy 0.000 description 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
- 102000005862 Angiotensin II Human genes 0.000 description 2
- 101800000733 Angiotensin-2 Proteins 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 101100234002 Drosophila melanogaster Shal gene Proteins 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 230000005355 Hall effect Effects 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 244000035744 Hura crepitans Species 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 235000015076 Shorea robusta Nutrition 0.000 description 2
- 244000166071 Shorea robusta Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000295644 Staphylococcaceae Species 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 102000003790 Thrombin receptors Human genes 0.000 description 2
- 108090000166 Thrombin receptors Proteins 0.000 description 2
- 206010046996 Varicose vein Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 210000004100 adrenal gland Anatomy 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 210000003484 anatomy Anatomy 0.000 description 2
- 229950006323 angiotensin ii Drugs 0.000 description 2
- 230000003510 anti-fibrotic effect Effects 0.000 description 2
- 229940124350 antibacterial drug Drugs 0.000 description 2
- 210000002453 autonomic neuron Anatomy 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000002302 brachial artery Anatomy 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000010351 charge transfer process Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000001010 compromised effect Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 238000013480 data collection Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000003205 diastolic effect Effects 0.000 description 2
- 230000001700 effect on tissue Effects 0.000 description 2
- 238000005868 electrolysis reaction Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 230000034964 establishment of cell polarity Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 210000002149 gonad Anatomy 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000036543 hypotension Effects 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 230000030214 innervation Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 210000004561 lacrimal apparatus Anatomy 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 210000001699 lower leg Anatomy 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 230000000116 mitigating effect Effects 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 229960002748 norepinephrine Drugs 0.000 description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 210000003681 parotid gland Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 210000002321 radial artery Anatomy 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 210000003670 sublingual gland Anatomy 0.000 description 2
- 210000001913 submandibular gland Anatomy 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 210000000225 synapse Anatomy 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 230000002747 voluntary effect Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 102000002585 Contractile Proteins Human genes 0.000 description 1
- 108010068426 Contractile Proteins Proteins 0.000 description 1
- 208000037408 Device failure Diseases 0.000 description 1
- 206010013647 Drowning Diseases 0.000 description 1
- 108010062466 Enzyme Precursors Proteins 0.000 description 1
- 102000010911 Enzyme Precursors Human genes 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 108010071289 Factor XIII Proteins 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 108091005975 Myofilaments Proteins 0.000 description 1
- 230000005679 Peltier effect Effects 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 208000007474 aortic aneurysm Diseases 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 208000037849 arterial hypertension Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000003376 axonal effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 108010055222 clotting enzyme Proteins 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000037020 contractile activity Effects 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000007772 electrode material Substances 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229940012444 factor xiii Drugs 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 235000004280 healthy diet Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 208000008384 ileus Diseases 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000012977 invasive surgical procedure Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000001095 motoneuron effect Effects 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000004457 myocytus nodalis Anatomy 0.000 description 1
- 230000036403 neuro physiology Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- BPUBBGLMJRNUCC-UHFFFAOYSA-N oxygen(2-);tantalum(5+) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ta+5].[Ta+5] BPUBBGLMJRNUCC-UHFFFAOYSA-N 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 210000000063 presynaptic terminal Anatomy 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000001139 rectus abdominis Anatomy 0.000 description 1
- 230000036279 refractory period Effects 0.000 description 1
- 230000004648 relaxation of smooth muscle Effects 0.000 description 1
- 230000008327 renal blood flow Effects 0.000 description 1
- 210000002796 renal vein Anatomy 0.000 description 1
- 239000002461 renin inhibitor Substances 0.000 description 1
- 229940086526 renin-inhibitors Drugs 0.000 description 1
- 230000036390 resting membrane potential Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 210000000574 retroperitoneal space Anatomy 0.000 description 1
- 235000015598 salt intake Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000037152 sensory function Effects 0.000 description 1
- 210000002265 sensory receptor cell Anatomy 0.000 description 1
- 102000027509 sensory receptors Human genes 0.000 description 1
- 108091008691 sensory receptors Proteins 0.000 description 1
- 210000002151 serous membrane Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 108090000250 sortase A Proteins 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000002504 synaptic vesicle Anatomy 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 230000004873 systolic arterial blood pressure Effects 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000004231 tunica media Anatomy 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
- A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0556—Cuff electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
L'invention concerne un système de traitement d'un patient atteint d'hypertension, comprenant un dispositif de stimulation comportant un agencement d'électrodes conçu pour délivrer un signal de stimulation électrique à une partie paroi d'une artère rénale du patient afin d'affecter une tonalité vasomotrice d'un tissu musculaire lisse de l'artère rénale, et une unité de commande connectée de manière fonctionnelle au dispositif de stimulation. L'unité de commande est conçue pour commander un fonctionnement du dispositif de stimulation de telle sorte que le signal de stimulation électrique provoque une vasodilatation de l'artère rénale.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2021/073893 WO2022043555A1 (fr) | 2020-08-31 | 2021-08-30 | Fourniture d'énergie à distance à un implant comprenant un condensateur pour fournir les rafales d'énergie nécessaire aux parties de l'implant consommant de l'énergie |
| EPPCT/EP2021/073893 | 2021-08-30 | ||
| SE2250220-7 | 2022-02-18 | ||
| SE2250220 | 2022-02-18 | ||
| PCT/EP2022/073833 WO2023031056A1 (fr) | 2021-08-30 | 2022-08-26 | Traitement de l'hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3233737A1 true CA3233737A1 (fr) | 2023-03-09 |
Family
ID=83318965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3233737A Pending CA3233737A1 (fr) | 2021-08-30 | 2022-08-26 | Traitement de l'hypertension |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4395882A1 (fr) |
| AU (1) | AU2022340840A1 (fr) |
| CA (1) | CA3233737A1 (fr) |
| WO (2) | WO2023031053A1 (fr) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7162303B2 (en) * | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
| US7292890B2 (en) * | 2002-06-20 | 2007-11-06 | Advanced Bionics Corporation | Vagus nerve stimulation via unidirectional propagation of action potentials |
| KR101862903B1 (ko) * | 2011-08-26 | 2018-05-30 | 사이맵 홀딩 리미티드 | 동맥벽 기능성 신경의 위치 확정과 식별에 사용하는 카테터 및 그 사용 방법 |
-
2022
- 2022-08-26 WO PCT/EP2022/073830 patent/WO2023031053A1/fr unknown
- 2022-08-26 AU AU2022340840A patent/AU2022340840A1/en active Pending
- 2022-08-26 EP EP22772439.0A patent/EP4395882A1/fr active Pending
- 2022-08-26 WO PCT/EP2022/073833 patent/WO2023031056A1/fr active Application Filing
- 2022-08-26 CA CA3233737A patent/CA3233737A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4395882A1 (fr) | 2024-07-10 |
| AU2022340840A1 (en) | 2024-04-11 |
| WO2023031053A1 (fr) | 2023-03-09 |
| WO2023031056A1 (fr) | 2023-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2022340838A1 (en) | Implantable urethra restriction device | |
| WO2023031045A1 (fr) | Dispositif de restriction | |
| CA3230658A1 (fr) | Dispositif pour traiter un anevrisme d'un vaisseau sanguin | |
| CA3233737A1 (fr) | Traitement de l'hypertension | |
| US20230067764A1 (en) | Treatment of gerd | |
| US20230062862A1 (en) | Treatment of gerd | |
| WO2023280859A1 (fr) | Traitement d'une maladie de reflux gastro-oesophagien | |
| CA3228110A1 (fr) | Dispositif de restriction | |
| JP2024526233A (ja) | 胃食道逆流症の治療 | |
| AU2022336957A1 (en) | Apparatus and method for obtaining urinary control | |
| WO2023031032A1 (fr) | Appareil et procédé permettant d'obtenir un contrôle urinaire | |
| WO2023031039A1 (fr) | Dispositif d'étirage | |
| WO2023156529A1 (fr) | Dispositif d'étirage | |
| EP4395718A1 (fr) | Dispositif d'étirage | |
| AU2022338977A1 (en) | Restriction device | |
| WO2023156574A1 (fr) | Appareil et procédé pour obtenir un contrôle urinaire | |
| CN118354725A (zh) | 胃食管反流病的治疗 | |
| WO2024041758A1 (fr) | Pompe hydraulique ou pneumatique implantable | |
| WO2024132177A1 (fr) | Traitement d'une maladie de reflux gastro-oesophagien | |
| WO2023031049A1 (fr) | Dispositif médical alimenté implantable, méthodes et kit associés |