CA3231615A1 - Chimeric antigen receptors comprising interleukin-9 receptor signaling domain - Google Patents

Chimeric antigen receptors comprising interleukin-9 receptor signaling domain Download PDF

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Publication number
CA3231615A1
CA3231615A1 CA3231615A CA3231615A CA3231615A1 CA 3231615 A1 CA3231615 A1 CA 3231615A1 CA 3231615 A CA3231615 A CA 3231615A CA 3231615 A CA3231615 A CA 3231615A CA 3231615 A1 CA3231615 A1 CA 3231615A1
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domain
cells
human
murine
seq
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CA3231615A
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English (en)
French (fr)
Inventor
Mikko SIURALA
Carl H. June
Kenan Christopher GARCIA
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University of Pennsylvania
Leland Stanford Junior University
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University of Pennsylvania
Leland Stanford Junior University
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WO2020227446A1 (en) * 2019-05-07 2020-11-12 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of polypeptides and chimeric antigen receptors via hinge domains
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IL316918A (en) * 2022-05-09 2025-01-01 Minerva Biotechnologies Corp Chimeric antigen receptor and IL-18 receptor compositions and methods of using them
WO2025039159A1 (en) * 2023-08-21 2025-02-27 Hangzhou Hervor Therapeutics Co., Ltd Synthetic cytokine signaling system, preparation method, and uses thereof
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Family Cites Families (16)

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WO2010006111A2 (en) * 2008-07-10 2010-01-14 Merck & Co., Inc. Methods of using compositions comprising mir-192 and/or mir-215 for the treatment of cancer
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CA3285826A1 (en) * 2012-02-22 2026-03-02 The Trustees Of The University Of Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
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US20190241910A1 (en) * 2016-03-11 2019-08-08 Bluebird Bio, Inc. Genome edited immune effector cells
BR112019007100A2 (pt) * 2016-10-07 2019-06-25 Tcr2 Therapeutics Inc composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão
CN110615843B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种包含第三信号受体的嵌合抗原受体及其应用
CA3154589A1 (en) * 2018-10-12 2020-04-16 Mauro CASTELLARIN Compositions and methods for switchable car t cells using surface-bound sortase transpeptidase
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EP4022035A4 (en) * 2019-09-01 2024-03-27 Exuma Biotech Corp. Methods and compositions for the modification and delivery of lymphocytes
WO2021050752A1 (en) * 2019-09-11 2021-03-18 The Board Of Trustees Of The Leland Stanford Junior University Chimeric orthogonal receptor proteins and methods of use
WO2021141986A1 (en) * 2020-01-07 2021-07-15 St. Jude Children's Research Hospital, Inc. Chimeric gmcsf-il18 receptor
JP2023520572A (ja) * 2020-04-06 2023-05-17 シンセカイン インコーポレイテッド オルソゴナルな受容体を発現するようにゲノムが改変されたヒト免疫細胞
WO2021244486A1 (zh) * 2020-06-01 2021-12-09 上海君赛生物科技有限公司 信号转换受体及其用途
EP4305054A4 (en) * 2021-03-09 2025-03-19 The Trustees of The University of Pennsylvania SELECTIVE STIMULATION OF T CELLS IN SOLID TUMORS USING ONCOLYTIC VIRAL ADMINISTRATION OF ORTHOGONAL IL-2
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