CA3231482A1 - Systeme de distribution de phages - Google Patents
Systeme de distribution de phages Download PDFInfo
- Publication number
- CA3231482A1 CA3231482A1 CA3231482A CA3231482A CA3231482A1 CA 3231482 A1 CA3231482 A1 CA 3231482A1 CA 3231482 A CA3231482 A CA 3231482A CA 3231482 A CA3231482 A CA 3231482A CA 3231482 A1 CA3231482 A1 CA 3231482A1
- Authority
- CA
- Canada
- Prior art keywords
- phage
- dispensing
- vials
- vial
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000356 contaminant Substances 0.000 claims abstract description 166
- 238000003860 storage Methods 0.000 claims abstract description 83
- 238000000034 method Methods 0.000 claims abstract description 62
- 238000002360 preparation method Methods 0.000 claims abstract description 34
- 238000004364 calculation method Methods 0.000 claims abstract description 18
- 238000007726 management method Methods 0.000 claims description 40
- 238000004519 manufacturing process Methods 0.000 claims description 32
- 238000012360 testing method Methods 0.000 claims description 29
- 230000015654 memory Effects 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 25
- 238000004458 analytical method Methods 0.000 claims description 21
- 239000002158 endotoxin Substances 0.000 claims description 20
- 239000013610 patient sample Substances 0.000 claims description 14
- 238000004590 computer program Methods 0.000 claims description 6
- 238000005457 optimization Methods 0.000 claims description 6
- 238000007639 printing Methods 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 2
- 238000012795 verification Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 description 25
- 239000000203 mixture Substances 0.000 description 21
- 208000015181 infectious disease Diseases 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 16
- 238000005259 measurement Methods 0.000 description 11
- 238000009472 formulation Methods 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 238000012545 processing Methods 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- 208000035143 Bacterial infection Diseases 0.000 description 7
- 208000022362 bacterial infectious disease Diseases 0.000 description 7
- 244000052616 bacterial pathogen Species 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 238000003908 quality control method Methods 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 241000588626 Acinetobacter baumannii Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 241001529936 Murinae Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 238000009635 antibiotic susceptibility testing Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 241000282465 Canis Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 206010062255 Soft tissue infection Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- -1 for example Substances 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 229960003085 meticillin Drugs 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000004886 process control Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000013403 standard screening design Methods 0.000 description 2
- 241001515965 unidentified phage Species 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000282575 Gorilla Species 0.000 description 1
- 241000282620 Hylobates sp. Species 0.000 description 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 206010048723 Multiple-drug resistance Diseases 0.000 description 1
- 206010028885 Necrotising fasciitis Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 241001504519 Papio ursinus Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 241000282405 Pongo abelii Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000013474 audit trail Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 208000037815 bloodstream infection Diseases 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007398 colorimetric assay Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000004883 computer application Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000012517 data analytics Methods 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 238000011331 genomic analysis Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 241001515942 marmosets Species 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000007970 necrotizing fasciitis Diseases 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 238000001066 phage therapy Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/20—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Business, Economics & Management (AREA)
- General Business, Economics & Management (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Procédé de distribution de phages, appareil de distribution de phages, système de distribution de phages conçus pour distribuer une ordonnance de phages. Un calcul de dose est effectué à l'aide du poids du patient, de la dose de phages cible, d'un titre d'un flacon de phages et d'un niveau de contaminant d'un flacon de phages afin de déterminer un ensemble de distribution et des volumes de distribution associés à partir de flacons de phages stockés dans un appareil de stockage de phages. Des emplacements de stockage et des instructions de préparation de dose comprenant des volumes de distribution respectifs sont fournis à un pharmacien, et une vérification des flacons est effectuée afin de vérifier que les flacons corrects sont retirés de l'appareil de stockage de phages.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163243513P | 2021-09-13 | 2021-09-13 | |
| US63/243,513 | 2021-09-13 | ||
| PCT/US2022/076284 WO2023039575A1 (fr) | 2021-09-13 | 2022-09-12 | Système de distribution de phages |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3231482A1 true CA3231482A1 (fr) | 2023-03-16 |
Family
ID=83594163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3231482A Pending CA3231482A1 (fr) | 2021-09-13 | 2022-09-12 | Systeme de distribution de phages |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA3231482A1 (fr) |
| WO (1) | WO2023039575A1 (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7247192B2 (ja) * | 2017-12-11 | 2023-03-28 | アダプティブ ファージ セラピューティクス， インコーポレイテッド | ファージ分注システム |
-
2022
- 2022-09-12 WO PCT/US2022/076284 patent/WO2023039575A1/fr active Application Filing
- 2022-09-12 CA CA3231482A patent/CA3231482A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023039575A1 (fr) | 2023-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Haney et al. | Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides | |
| Oloso et al. | Antimicrobial resistance in food animals and the environment in Nigeria: A review | |
| Krishnamoorthy et al. | An understanding of the global status of major bacterial pathogens of milk concerning bovine mastitis: A systematic review and meta-analysis (Scientometrics) | |
| Rahman et al. | An overview of antimicrobial stewardship optimization: the use of antibiotics in humans and animals to prevent resistance | |
| Muteeb et al. | Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review | |
| Maraolo et al. | Daptomycin versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bloodstream infection with or without endocarditis: a systematic review and meta-analysis | |
| Burckhardt | Laboratory automation in clinical microbiology | |
| Tomas et al. | Increase and change in the pattern of antibiotic use in Serbia (2010–2019) | |
| Bolte et al. | In vitro susceptibility of mastitis pathogens isolated from clinical mastitis cases on northern German dairy farms | |
| Jamaluddin et al. | Point prevalence survey of antimicrobial use in a Malaysian tertiary care university hospital | |
| Krämer et al. | Media-fill simulation tests in manual and robotic aseptic preparation of injection solutions in syringes | |
| Gustafsson et al. | Effects of pharmacists’ interventions on inappropriate drug use and drug-related readmissions in people with dementia—a secondary analysis of a randomized controlled trial | |
| Liu et al. | Risk factors of 30-day all-cause mortality in patients with carbapenem-resistant Klebsiella pneumoniae bloodstream infection | |
| Katip et al. | A monocentric retrospective study of AUC/MIC ratio of vancomycin associated with clinical outcomes and nephrotoxicity in patients with enterococcal infections | |
| Kunutsor et al. | Influence of fixation methods on prosthetic joint infection following primary total knee replacement: meta-analysis of observational cohort and randomised intervention studies | |
| Corrigan et al. | Causative pathogens do not differ between early, delayed or late fracture-related infections | |
| Eck et al. | Low dose low-molecular-weight heparin for thrombosis prophylaxis: systematic review with meta-analysis and trial sequential analysis | |
| Abu Hammour et al. | Antimicrobial consumption and resistance in a tertiary care hospital in Jordan: results of an internet-based global point prevalence survey | |
| Suzuki | A view on 20 years of antimicrobial resistance in Japan by two national surveillance systems: The national epidemiological surveillance of infectious diseases and Japan nosocomial infections surveillance | |
| Frenkel et al. | Bistable bacterial growth dynamics in the presence of antimicrobial agents | |
| Muleba et al. | Assessment of anti-bacterial effectiveness of hand sanitizers commonly used in South Africa | |
| Sadeq et al. | Impact of multidisciplinary team escalating approach on antibiotic stewardship in the United Arab Emirates | |
| Lianou et al. | Antibiotic resistance of staphylococci from bulk-tank milk of sheep flocks: Prevalence, patterns, association with biofilm formation, effects on milk quality, and risk factors | |
| CA3231482A1 (fr) | Systeme de distribution de phages | |
| Ting et al. | Antimicrobial use in animals in Timor-Leste based on veterinary antimicrobial imports between 2016 and 2019 |