CA3230155A1 - Polytherapie a base d'un antagoniste de l'hormone de croissance et d'une composition anticancereuse - Google Patents
Polytherapie a base d'un antagoniste de l'hormone de croissance et d'une composition anticancereuse Download PDFInfo
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- CA3230155A1 CA3230155A1 CA3230155A CA3230155A CA3230155A1 CA 3230155 A1 CA3230155 A1 CA 3230155A1 CA 3230155 A CA3230155 A CA 3230155A CA 3230155 A CA3230155 A CA 3230155A CA 3230155 A1 CA3230155 A1 CA 3230155A1
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
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- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une composition pour le traitement d'une maladie ou d'un état réactif à des antagonistes du récepteur de l'hormone de croissance humaine, comprenant un antagoniste du récepteur de l'hormone de croissance humaine modifiée ; et une composition anticancéreuse. L'invention concerne également une méthode de traitement du cancer à l'aide d'antagonistes de l'hormone de croissance humaine, comprenant le pré-criblage d'un patient par analyse d'une biopsie de tumeur pour confirmer la présence d'un cancer et la présence de certains facteurs prédéterminés indicatifs de la réactivité à des antagonistes de l'hormone de croissance humaine ; et le traitement du patient avec une quantité efficace d'une composition qui comprend un antagoniste du récepteur de l'hormone de croissance humaine modifiée et une composition anticancéreuse.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17/411,497 | 2021-08-25 | ||
US17/411,497 US11857602B2 (en) | 2019-06-17 | 2021-08-25 | Growth hormone antagonist and anti-cancer composition combination therapy |
PCT/US2022/074968 WO2023028430A2 (fr) | 2021-08-25 | 2022-08-15 | Polythérapie à base d'un antagoniste de l'hormone de croissance et d'une composition anticancéreuse |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3230155A1 true CA3230155A1 (fr) | 2023-03-02 |
Family
ID=85323353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3230155A Pending CA3230155A1 (fr) | 2021-08-25 | 2022-08-15 | Polytherapie a base d'un antagoniste de l'hormone de croissance et d'une composition anticancereuse |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA3230155A1 (fr) |
WO (1) | WO2023028430A2 (fr) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090098137A1 (en) * | 2006-04-05 | 2009-04-16 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
US20100166747A1 (en) * | 2007-03-02 | 2010-07-01 | Beltran Pedro J | Methods and compositions for treating tumor diseases |
US20170007711A1 (en) * | 2015-07-07 | 2017-01-12 | Richard S. Brody | Pegylated growth hormone antagonists |
US11473088B2 (en) * | 2016-12-02 | 2022-10-18 | Ohio University | Method of treating cancer and method of sensitizing cancer cells to the action of chemotherapeutic agents via growth hormone receptor antagonists or knock down |
JP2022536788A (ja) * | 2019-06-17 | 2022-08-18 | モレキュラー テクノロジーズ ラボラトリーズ エルエルシー | Peg化された成長ホルモンアンタゴニストの治療薬 |
-
2022
- 2022-08-15 CA CA3230155A patent/CA3230155A1/fr active Pending
- 2022-08-15 WO PCT/US2022/074968 patent/WO2023028430A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2023028430A3 (fr) | 2023-04-06 |
WO2023028430A2 (fr) | 2023-03-02 |
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