CA3229899A1 - Methods of treating clonal hematopoiesis of indeterminate potential (chip) with lymphocyte antigen 75 (ly75), cluster of differentiation 164 (cd164), or poly(adp-ribose) polymeras e 1 (parp1) inhibitors - Google Patents

Methods of treating clonal hematopoiesis of indeterminate potential (chip) with lymphocyte antigen 75 (ly75), cluster of differentiation 164 (cd164), or poly(adp-ribose) polymeras e 1 (parp1) inhibitors Download PDF

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Publication number
CA3229899A1
CA3229899A1 CA3229899A CA3229899A CA3229899A1 CA 3229899 A1 CA3229899 A1 CA 3229899A1 CA 3229899 A CA3229899 A CA 3229899A CA 3229899 A CA3229899 A CA 3229899A CA 3229899 A1 CA3229899 A1 CA 3229899A1
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Canada
Prior art keywords
nucleic acid
acid molecule
subject
parp1
variant
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CA3229899A
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English (en)
French (fr)
Inventor
Eric JORGENSON
Michael Kessler
Amy DAMASK
Sean O'KEEFFE
Ryan White
David Glass
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of CA3229899A1 publication Critical patent/CA3229899A1/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • G01N2800/00—Detection or diagnosis of diseases
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CA3229899A 2021-09-13 2022-09-12 Methods of treating clonal hematopoiesis of indeterminate potential (chip) with lymphocyte antigen 75 (ly75), cluster of differentiation 164 (cd164), or poly(adp-ribose) polymeras e 1 (parp1) inhibitors Pending CA3229899A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163243564P 2021-09-13 2021-09-13
US63/243,564 2021-09-13
US202163271171P 2021-10-24 2021-10-24
US63/271,171 2021-10-24
PCT/US2022/076298 WO2023039580A2 (en) 2021-09-13 2022-09-12 Methods of treating clonal hematopoiesis of indeterminate potential (chip) with lymphocyte antigen 75 (ly75), cluster of differentiation 164 (cd164), or poly(adp-ribose) polymerase 1 (parp1) inhibitors

Publications (1)

Publication Number Publication Date
CA3229899A1 true CA3229899A1 (en) 2023-03-16

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CA3229899A Pending CA3229899A1 (en) 2021-09-13 2022-09-12 Methods of treating clonal hematopoiesis of indeterminate potential (chip) with lymphocyte antigen 75 (ly75), cluster of differentiation 164 (cd164), or poly(adp-ribose) polymeras e 1 (parp1) inhibitors

Country Status (6)

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US (1) US20230113866A1 (enExample)
EP (1) EP4401831A2 (enExample)
JP (1) JP2024533459A (enExample)
CA (1) CA3229899A1 (enExample)
MX (1) MX2024003132A (enExample)
WO (1) WO2023039580A2 (enExample)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060281672A1 (en) * 2002-12-06 2006-12-14 Hart Derek N J Dec-205 (ly 75)/dcl-1 intergenic splice variants associated with hodgkin's disease, and uses thereof
WO2014011465A2 (en) * 2012-07-13 2014-01-16 Albert Einstein College Of Medicine Of Yeshiva University Aptamer-targeted antigen delivery
GB201220010D0 (en) * 2012-11-07 2012-12-19 Oxford Biotherapeutics Ltd Therapeutic amd diagnostic target
WO2017156416A1 (en) * 2016-03-11 2017-09-14 The Brigham And Women's Hospital, Inc. Compositions and methods for treating chemotherapy resistant cancer
GB201703876D0 (en) * 2017-03-10 2017-04-26 Berlin-Chemie Ag Pharmaceutical combinations
EP4660324A3 (en) * 2020-02-24 2026-02-18 The Board of Trustees of the Leland Stanford Junior University Methods of analyzing cell free nucleic acids and applications thereof

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JP2024533459A (ja) 2024-09-12
WO2023039580A2 (en) 2023-03-16
US20230113866A1 (en) 2023-04-13
EP4401831A2 (en) 2024-07-24
MX2024003132A (es) 2024-04-10
WO2023039580A3 (en) 2023-06-08

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