CA3228099A1 - Ultra-high molecular weight polymers and methods of using the same - Google Patents

Ultra-high molecular weight polymers and methods of using the same Download PDF

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Publication number
CA3228099A1
CA3228099A1 CA3228099A CA3228099A CA3228099A1 CA 3228099 A1 CA3228099 A1 CA 3228099A1 CA 3228099 A CA3228099 A CA 3228099A CA 3228099 A CA3228099 A CA 3228099A CA 3228099 A1 CA3228099 A1 CA 3228099A1
Authority
CA
Canada
Prior art keywords
unit
monomer
water
group
mucin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3228099A
Other languages
English (en)
French (fr)
Inventor
Cullen L. DAVIDSON
Wallace G. Sawyer
Brent S. Sumerlin
Juan M. Uruena Vargas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida Research Foundation Inc
Original Assignee
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida Research Foundation Inc filed Critical University of Florida Research Foundation Inc
Publication of CA3228099A1 publication Critical patent/CA3228099A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L43/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metal; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyethers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Peptides Or Proteins (AREA)
CA3228099A 2021-08-31 2022-08-30 Ultra-high molecular weight polymers and methods of using the same Pending CA3228099A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163239027P 2021-08-31 2021-08-31
US63/239,027 2021-08-31
PCT/US2022/075616 WO2023034765A2 (en) 2021-08-31 2022-08-30 Ultra-high molecular weight polymers and methods of using the same

Publications (1)

Publication Number Publication Date
CA3228099A1 true CA3228099A1 (en) 2023-03-09

Family

ID=85385170

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3228099A Pending CA3228099A1 (en) 2021-08-31 2022-08-30 Ultra-high molecular weight polymers and methods of using the same

Country Status (10)

Country Link
US (1) US12624204B2 (enExample)
EP (1) EP4395791A4 (enExample)
JP (1) JP2024530714A (enExample)
KR (1) KR20240058883A (enExample)
CN (1) CN117999081A (enExample)
AU (1) AU2022339756A1 (enExample)
CA (1) CA3228099A1 (enExample)
MX (1) MX2024002537A (enExample)
TW (1) TW202327629A (enExample)
WO (1) WO2023034765A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250033149A (ko) * 2022-04-29 2025-03-07 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. 초-고분자량 폴리머 및 이를 제조하고 사용하는 방법
CN116333197A (zh) * 2023-04-12 2023-06-27 厦门君德医药科技有限公司 胃肠道粘膜性聚合物、组合物及制备方法和应用
WO2025250735A1 (en) * 2024-05-29 2025-12-04 University Of Florida Research Foundation, Inc. Compositions comprising synthetic mucins and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649722B2 (en) 1999-12-10 2003-11-18 Novartis Ag Contact lens
US8071121B2 (en) 2002-06-05 2011-12-06 University Of Florida Research Foundation, Incorporated Dispersions of microemulsions in hydrogels for drug delivery
US7988988B2 (en) 2005-11-21 2011-08-02 Bausch & Lomb Incorporated Contact lenses with mucin affinity
US7832856B2 (en) * 2006-12-20 2010-11-16 Bausch & Lomb Incorporated Coatings and solutions for contact lenses
EP2364330B1 (en) 2008-11-06 2015-03-25 University Of Washington Multiblock copolymers
US8534031B2 (en) 2008-12-30 2013-09-17 Bausch & Lomb Incorporated Packaging solutions
US8410190B2 (en) 2009-09-22 2013-04-02 Coopervision International Holding Company, Lp Wettable hydrogel materials for use in ophthalmic applications and methods
US9452198B2 (en) * 2012-04-23 2016-09-27 Massachusetts Institute Of Technology Lectin conjugates for mucin hydration
US10196470B2 (en) 2016-05-16 2019-02-05 Benz Research And Development Corp. Hydrophobic intraocular lens
EP3852768A4 (en) * 2018-09-20 2022-09-14 Glyscend, Inc. BORONIC ACID POLYMERS AND METHODS OF USE
EP4066867B1 (en) * 2020-01-16 2023-12-06 Toray Industries, Inc. Method for producing medical device

Also Published As

Publication number Publication date
US12624204B2 (en) 2026-05-12
CN117999081A (zh) 2024-05-07
AU2022339756A1 (en) 2024-02-08
US20230076717A1 (en) 2023-03-09
KR20240058883A (ko) 2024-05-03
MX2024002537A (es) 2024-05-24
WO2023034765A3 (en) 2023-04-13
EP4395791A4 (en) 2025-06-25
WO2023034765A2 (en) 2023-03-09
JP2024530714A (ja) 2024-08-23
TW202327629A (zh) 2023-07-16
EP4395791A2 (en) 2024-07-10

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