CA3227223A1 - Combinaison de radioimmunotherapie et de blocage de cd47 dans le traitement du cancer - Google Patents
Combinaison de radioimmunotherapie et de blocage de cd47 dans le traitement du cancer Download PDFInfo
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- CA3227223A1 CA3227223A1 CA3227223A CA3227223A CA3227223A1 CA 3227223 A1 CA3227223 A1 CA 3227223A1 CA 3227223 A CA3227223 A CA 3227223A CA 3227223 A CA3227223 A CA 3227223A CA 3227223 A1 CA3227223 A1 CA 3227223A1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Abstract
L'invention concerne des compositions et des procédés pour traiter des cancers et des troubles prolifératifs précancéreux chez un sujet mammifère qui impliquent l'utilisation combinée d'un agent radiothérapeutique, tel qu'un agent ciblant CD33, DR5, 5T4, HER2, HER3 ou TROP2 radiomarqué, et un inhibiteur de point de contrôle CD47, tel qu'une protéine de fusion Fc de SIRP?-IgG ou un anticorps monoclonal contre CD47 ou SIRP?.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163226699P | 2021-07-28 | 2021-07-28 | |
US63/226,699 | 2021-07-28 | ||
US202163250725P | 2021-09-30 | 2021-09-30 | |
US63/250,725 | 2021-09-30 | ||
USPCT/US2021/056259 | 2021-10-22 | ||
PCT/US2021/056259 WO2022087416A1 (fr) | 2020-10-22 | 2021-10-22 | Combinaison de radioimmunothérapie et de blocage de cd47 dans le traitement du cancer |
US17/702,648 US20220211886A1 (en) | 2020-10-22 | 2022-03-23 | Combination radioimmunotherapy and cd47 blockade in the treatment of cancer |
US17/702,648 | 2022-03-23 | ||
PCT/US2022/025655 WO2023009189A1 (fr) | 2021-07-28 | 2022-04-20 | Combinaison de radioimmunothérapie et de blocage de cd47 dans le traitement du cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3227223A1 true CA3227223A1 (fr) | 2023-02-02 |
Family
ID=85087177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3227223A Pending CA3227223A1 (fr) | 2021-07-28 | 2022-04-20 | Combinaison de radioimmunotherapie et de blocage de cd47 dans le traitement du cancer |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP4376856A1 (fr) |
CA (1) | CA3227223A1 (fr) |
WO (1) | WO2023009189A1 (fr) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014149477A1 (fr) * | 2013-03-15 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Procédés d'obtention de doses thérapeutiquement efficaces d'agents anti-cd47 |
CA3087346A1 (fr) * | 2018-01-08 | 2019-07-11 | Actinum Pharmaceuticals, Inc. | Immunotherapie et chimiotherapie combinees pour le traitement d'une malignite hematologique |
-
2022
- 2022-04-20 CA CA3227223A patent/CA3227223A1/fr active Pending
- 2022-04-20 WO PCT/US2022/025655 patent/WO2023009189A1/fr active Application Filing
- 2022-04-20 EP EP22850033.6A patent/EP4376856A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2023009189A1 (fr) | 2023-02-02 |
EP4376856A1 (fr) | 2024-06-05 |
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